An increasing number of technologies are being used to detect minute quantities of biomolecules and cells. However, it can be difficult to determine which technologies show the most promise for high-sensitivity and low-limit detection in different applications. Microfluidics and Nanotechnology: Biosensing to the Single Molecule Limit details proven approaches for the detection of single cells and even single molecules-approaches employed by the world's foremost microfluidics and nanotechnology laboratories. While similar books concentrate only on microfluidics or nanotechnology, this book focuses on the combination of soft materials (elastomers and other polymers) with hard materials (semiconductors, metals, and glass) to form integrated detection systems for biological and chemical targets. It explores physical and chemical-as well as contact and noncontact-detection methods, using case studies to demonstrate system capabilities. Presenting a snapshot of the current state of the art, the text: Explains the theory behind different detection techniques, from mechanical resonators for detecting cell density to fiber-optic methods for detecting DNA hybridization, and beyond Examines microfluidic advances, including droplet microfluidics, digital microfluidics for manipulating droplets on the microscale, and more Highlights an array of technologies to allow for a comparison of the fundamental advantages and challenges of each, as well as an appreciation of the power of leveraging scalability and integration to achieve sensitivity at low cost Microfluidics and Nanotechnology: Biosensing to the Single Molecule Limit not only serves as a quick reference for the latest achievements in biochemical detection at the single-cell and single-molecule levels, but also provides researchers with inspiration for further innovation and expansion of the field.

As the field of medical biotechnology grows with new products and discoveries, so does the need for a holistic view of biotechnology in medicine. Biotechnology in Medical Sciences fulfills that need by delivering a detailed overview of medical biotechnology as it relates to human diseases and epidemiology, bacteriology and antibiotics, virology and vaccines, immunology and monoclonal antibodies, recombinant DNA technology and therapeutic proteins, stem cell technology, tissue engineering, molecular diagnostics and forensic science, gene therapy, synthetic biology and nanomedicine, pharmacogenomics, bioethics, biobusiness and intellectual property rights, and career opportunities. Organized to follow the chronology of major medical biotechnology research, breakthroughs, and events, this first-of-its-kind text: Covers all aspects of medical biotechnology, from labs to clinics and basic to advanced applications Describes historical perspectives and modern discoveries in medical biotechnology Explains how various biotechnology products are used to treat and prevent disease Discusses the tools and techniques currently employed in medical biotechnology Includes a bibliography at the end of each chapter to encourage further study Complete with colorful illustrations and examples, Biotechnology in Medical Sciences provides a comprehensive yet accessible treatment of this growing field.

Gleaning information from more than 100 experts in the field of cancer diagnosis, prognosis, and therapy worldwide, Cancer Biomarkers: Non-Invasive Early Diagnosis and Prognosis determines the significance of clinical validation approaches for several markers. This book examines the use of noninvasive or minimally invasive molecular cancer markers that are under development or currently in use. It deals with a majority of commonly prevalent cancers and can help anyone working in the health-care industry to recommend or develop early diagnostics, at-risk tests, and prognostic biomarkers for various cancers. It explores the practice of determining biomarkers by their characteristics and relative methodologies, and presents the most recent data as well as a number of current and upcoming early diagnostic noninvasive molecular markers for many common cancers. It also considers the sensitivity and specificity of markers, biomarker market, test providers, and patent information. Approximately 30-35 Cancer Specific Noninvasive Molecular Diagnostic Markers in a Single Volume The book details the general and technical aspects of noninvasive cancer markers. It covers imaging, cutting-edge molecular technologies for biomarker development, and noninvasive or minimally invasive sources of molecular markers, as well as quality control and ethical issues in cancer biomarker discovery. It also provides a detailed account of brain, head and neck, and oral cancer markers, and provides information on a number of gastrointestinal cancers, lung cancer, and mesothelioma markers. Emphasizes the Importance of Volatile Markers in Early Cancer Diagnosis Presents noninvasive early molecular markers in urological cancers Describes gynecological and endocrine cancer markers Details noninvasive markers of breast, ovarian, cervical, and thyroid cancers Addresses hematological malignancies Contains information on noninvasive molecular markers in myelodysplastic syndromes, acute myeloid leukemia, Hodgkin's lymphoma, and multiple myeloma Provides comprehensive information on diagnostic and prognostic biomarkers in cutaneous melanoma This text considers molecular technologies for biomarker development, noninvasive or minimally invasive sources of molecular markers, and quality control and ethical issues in cancer biomarker discovery.

The science and technology of biomechanics and robotics promise to be some of the most influential research directions of the twenty-first century. Biomechanics and Robotics goes beyond the individual areas of biomechanics, robotics, biomedical engineering, biomechatronics, and biologically inspired robotics to provide the first unified textbook on the subject. It offers a "big picture" look at the state-of-the-art science and technology. With numerous figures, references, and exercises, the book presents a pedagogical introduction to a variety of topics, reviews historical developments, and gives up-to-date insights on modern-day biomechanics and robotics.

Revised, expanded, and updated, Orthopaedic Biomaterials in Research and Practice, Second Edition introduces materials science and applies it to medical research and treatment. This book incorporates math and engineering, which makes it accessible to trainees and others working in the industry who are lacking primary mathematical and engineering training. What's New in the Second Edition: In the second edition, the new material includes regeneration, hybrid and replant materials, tissue engineering, electrical stimulation for tissue growth and repair, modeling of material behavior in service, and long-term function of materials in patients. It explores tools for non-destructive and destructive analysis of explanted devices, and provides updates on all material classes including shape memory and degradable alloys, fracture-resistant ceramics, and bioabsorbable polymers. It provides a compendium for implant host response including in-depth discussion of metallosis and hypersensitive response. It also adds new case studies, worked problems, and a complete self-evaluation test with annotated answers. Includes focused, practical study questions after each chapter Presents extensive, detailed figures accompanying example problems and concepts Provides a one-stop reference for understanding all biomaterials that are used in contemporary orthopaedic surgery and beyond Introduces key concepts of relevance in each chapter Orthopaedic Biomaterials in Research and Practice, Second Edition serves as a textbook for orthopaedic residents. It can also serve as a review for the Orthopaedists In-Training Examination (OITE), the Orthopaedic Self-Assessment Examination, or the Orthopaedic Board Examination.

This volume provides detailed technical protocols on current biomedical technologies and examples of their applications and capabilities. Chapters focus on molecular and cellular analytical methods, experimental new drug delivery approaches, guided surgery, implants and tissue engineering. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and practical, Biomedical Engineering Technologies, Volume 2 provides technical details in descriptions of major technologies by experts in the field.

Conventional computed tomography (CT) techniques employ a narrow array of x-ray detectors and a fan-shaped x-ray beam to rotate around the patient to produce images of thin sections of the patient. Large sections of the body are covered by moving the patient into the rotating x-ray detector and x-ray source gantry. Cone beam CT is an alternative technique using a large area detector and cone-shaped x-ray beam to produce 3D images of a thick section of the body with one full angle (360 degree or 180 degree plus detector coverage) rotation. It finds applications in situations where bulky, conventional CT systems would interfere with clinical procedures or cannot be integrated with the primary treatments or imaging systems. Cone Beam Computed Tomography explores the past, present, and future state of medical x-ray imaging while explaining how cone beam CT, with its superior spatial resolution and compact configuration, is used in clinical applications and animal research. The book: Supplies a detailed introduction to cone beam CT, covering basic principles and applications as well as advanced techniques Explores state-of-the-art research and future developments while examining the fundamental limitations of the technology Addresses issues related to implementation and system characteristics, including image quality, artifacts, radiation dose, and perception Reviews the historical development of medical x-ray imaging, from conventional CT techniques to volumetric 3D imaging Discusses the major components of cone beam CT: image acquisition, reconstruction, processing, and display A reference work for scientists, engineers, students, and imaging professionals, Cone Beam Computed Tomography provides a solid understanding of the theory and implementation of this revolutionary technology.

Dentistry is a branch of medicine with its own peculiarities and very diverse areas of action, which means that it can be considered as an interdisciplinary field. BIODENTAL ENGINEERING II contains the full papers presented at the 2nd International Conference on Biodental Engineering (BioDENTAL 2012, Porto, Portugal, 7-8 December 2012). The contributions from 8 countries provide a comprehensive, multi-disciplinary coverage of the state-of-the-art in biodental engineering, and include the following subjects: * Aesthetics * Bioengineering * Biomaterials * Biomechanical disorders * Biomedical devices * Computational bio-imaging and visualization * Computational methods * Dental medicine * Experimental mechanics * Signal processing and analysis * Implantology * Minimally invasive devices and techniques * Orthodontics * Prosthesis and orthosis * Simulation * Software development * Telemedicine * Tissue engineering * Virtual reality BIODENTAL ENGINEERING II intends to cover recent advances in new techniques and technologies, and will be of interest to academics and others interested in biodental engineering.

Based on an interdisciplinary approach that directly bridges orthopedic concepts to surface science, this book details cutting-edge research in bioceramics science, physical chemistry, biomedical optics, and nanomechanics. The book cites some of the more conventional spectroscopic characterization techniques including Raman and cathodoluminescence spectroscopy. These techniques have been used to unveil molecular scale phenomena of both chemical and mechanical origin occurring at the sliding surfaces of bioceramic joints. These concepts are of critical importance to researchers as they are relevant to the development of new biomaterials.

Enhanced, more reliable, and better understood than in the past, artificial intelligence (AI) systems can make providing healthcare more accurate, affordable, accessible, consistent, and efficient. However, AI technologies have not been as well integrated into medicine as predicted. In order to succeed, medical and computational scientists must develop hybrid systems that can effectively and efficiently integrate the experience of medical care professionals with capabilities of AI systems. After providing a general overview of artificial intelligence concepts, tools, and techniques, Medical Applications of Artificial Intelligence reviews the research, focusing on state-of-the-art projects in the field. The book captures the breadth and depth of the medical applications of artificial intelligence, exploring new developments and persistent challenges.

Developments in CT technology during the last 20 years have impressively improved its diagnostic potentialities. Part of a two-volume set that covers all aspects of CT imaging, Multi-Detector CT Imaging: Abdomen, Pelvis, and CAD Applications contains easily searchable clinical specialty chapters that provide specific information without need of an index. The coverage goes far beyond just a "how-to" or an encyclopedia of findings, however. The authors have uniformly put techniques, clinical findings, pathologic disease presentations, and clinical implications in practical perspective. It is no wonder that with the critical role CT plays and the rapid innovations in computer technology that advances in the capabilities and complexity of CT imaging continue to evolve. While information about these developments may be scattered about in journals and other resources, this two-volume set provides an authoritative, up-to-date, and educational reference that covets the entire spectrum of CT.

Computational Vision and Medical Image Processing. VIPIMAGE 2013 contains invited lectures and full papers presented at VIPIMAGE 2013 - IV ECCOMAS Thematic Conference on Computational Vision and Medical Image Processing (Funchal, Madeira Island, Portugal, 14-16 October 2013). International contributions from 16 countries provide a comprehensive coverage of the current state-of-the-art in the fields of: 3D Vision; Computational Bioimaging and Visualization; Computational Vision and Image Processing applied to Dental Medicine; Computational Vision; Computer Aided Diagnosis, Surgery, Therapy, and Treatment; Data Interpolation, Registration, Acquisition and Compression; Image Processing and Analysis; Image Segmentation; Imaging of Biological Flows; Medical Imaging; Physics of Medical Imaging; Shape Reconstruction; Signal Processing; Simulation and Modeling; Software Development for Image Processing and Analysis; Telemedicine Systems and their Applications; Trabecular Bone Characterization; Tracking and Analysis of Movement; Virtual Reality. Related techniques covered in this book include the level set method, finite element method, modal analyses, stochastic methods, principal and independent components analysis and distribution models. Computational Vision and Medical Image Processing. VIPIMAGE 2013 is useful to academics, researchers and professionals in Biomechanics, Biomedical Engineering, Computational Vision (image processing and analysis), Computer Sciences, Computational Mechanics and Medicine.

Step-by-Step, Color Presentation of CGIP in Everyday Clinical Practice Computer-guided implant placement (CGIP) helps clinicians precisely implement a treatment plan and accurately place implants with the use of three-dimensional interactive imaging software. The software enables the direct link between anatomic interpretation, surgical and prosthetic treatment planning, and precise surgical execution. Bone preparation, in relation to the position, angle, and depth of the implant, is guided through computerized digital procedures and patient-specific surgical guides are developed to obtain the optimum result of the insertion of implants in predetermined, prosthetically acceptable positions. In color throughout, Clinical Application of Computer-Guided Implant Surgery covers the practical application of CGIP in a simple but detailed manner. Step by step, the book guides you on diagnosis and treatment planning, applying the specialized software, and using the necessary instruments and surgical guides. It also explores the strengths and weaknesses of CGIP and discusses literature related to the accuracy and clinical relevance of CGIP. Using numerous images from clinical cases, this color book helps you understand the treatment pathway, radiographic guides, virtual teeth, imaging techniques, and computer software used for CGIP. The authors-experts in periodontics and image-guided surgery-describe this new philosophy in a way that you can incorporate in your daily clinical practice.

Addressing medium- and long-term expectations for human health, this book reviews current scientific and technical developments in nanotechnology for biomedical, agrofood, and environmental applications. This collection of perspectives on the ethical, legal, and societal implications of bionanotechnology provides unique insight into contemporary technological developments. Readers with a technical background will benefit from the overview of the state-of-the-art research in their field, while readers with a social science background will benefit from the discussion of realistic prospects of nanotechnology. The text also includes a glossary as well as extensive end-of-chapter references.

Images from CT, MRI, PET, and other medical instrumentation have become central to the radiotherapy process in the past two decades, thus requiring medical physicists, clinicians, dosimetrists, radiation therapists, and trainees to integrate and segment these images efficiently and accurately in a clinical environment. Image Processing in Radiation Therapy presents an up-to-date, detailed treatment of techniques and algorithms for the registration, segmentation, reconstruction, and evaluation of imaging data. It describes how these tools are used in radiation planning, treatment delivery, and outcomes assessment. The book spans deformable registration, segmentation, and image reconstruction and shows how to incorporate these practices in radiation therapy. The first section explores image processing in adaptive radiotherapy, online monitoring and tracking, dose accumulation, and accuracy assessment. The second section describes the mathematical approach to deformable registration. The book presents similarity metrics used for registration techniques, discussing their effectiveness and applicability in radiation therapy. It also evaluates parametric and nonparametric image registration techniques and their applications in radiation therapy processes. The third section assesses the efficiency, robustness, and breadth of application of image segmentation approaches, including atlas-based, level set, and registration-based techniques. The fourth section focuses on advanced imaging techniques for radiotherapy, such as 3D image reconstruction and image registration using a graphics processor unit. With contributions from an international group of renowned authors, this book provides a comprehensive description of image segmentation and registration, in-room imaging, and advanced reconstruction techniques. Through many practical examples, it illustrates the clinical rationale and implementation of the techniques.

The massive amount of nonstandard high-dimensional brain imaging data being generated is often difficult to analyze using current techniques. This challenge in brain image analysis requires new computational approaches and solutions. But none of the research papers or books in the field describe the quantitative techniques with detailed illustrations of actual imaging data and computer codes. Using MATLAB (R) and case study data sets, Statistical and Computational Methods in Brain Image Analysis is the first book to explicitly explain how to perform statistical analysis on brain imaging data. The book focuses on methodological issues in analyzing structural brain imaging modalities such as MRI and DTI. Real imaging applications and examples elucidate the concepts and methods. In addition, most of the brain imaging data sets and MATLAB codes are available on the author's website. By supplying the data and codes, this book enables researchers to start their statistical analyses immediately. Also suitable for graduate students, it provides an understanding of the various statistical and computational methodologies used in the field as well as important and technically challenging topics.

Implement TMR with Your Patients and Improve Their Quality of Life

Developed by Dr. Todd A. Kuiken and Dr. Gregory A. Dumanian, targeted muscle reinnervation (TMR) is a new approach to accessing motor control signals from peripheral nerves after amputation and providing sensory feedback to prosthesis users. This practical approach has many advantages over other neural-machine interfaces for the improved control of artificial limbs. Targeted Muscle Reinnervation: A Neural Interface for Artificial Limbs provides a template for the clinical implementation of TMR and a resource for further research in this new area of science.

After describing the basic scientific concepts and key principles underlying TMR, the book presents surgical approaches to transhumeral and shoulder disarticulation amputations. It explores the possible role of TMR in the prevention and treatment of end-neuromas and details the principles of rehabilitation, prosthetic fitting, and occupational therapy for TMR patients. The book also describes transfer sensation and discusses the surgical and functional outcomes of the first several TMR patients. It concludes with emerging research on using TMR to further improve the function and quality of life for people with limb loss.

With contributions from renowned leaders in the field, including Drs. Kuiken and Dumanian, this book is a useful guide to implementing TMR in patients with high-level upper limb amputations. It also supplies the foundation to enable improvements in TMR techniques and advances in prosthetic technology.

Hydroxyapatite coatings are of great importance in the biological and biomedical coatings fields, especially in the current era of nanotechnology and bioapplications. With a bonelike structure that promotes osseointegration, hydroxyapatite coating can be applied to otherwise bioinactive implants to make their surface bioactive, thus achieving faster healing and recovery. In addition to applications in orthopedic and dental implants, this coating can also be used in drug delivery. Hydroxyapatite Coatings for Biomedical Applications explores developments in the processing and property characterization and applications of hydroxyapatite to provide timely information for active researchers and newcomers alike. In eight carefully reviewed chapters, hydroxyapatite experts from the United States, Japan, Singapore, and China present the latest on topics ranging from deposition processes to biomedical applications in implants and drug delivery. This book discusses: Magnetron sputtering and electrochemical deposition The modification of hydroxyapatite properties by sol-gel deposition to incorporate other elements found in natural bones, such as zinc, magnesium, and fluorine The use of pure hydroxyapatite in drug delivery applications The growth or self-assembly of hydroxyapatite on shape memory alloy Hydroxyapatite composite coatings-with carbon nanotubes, titanium dioxide (TiO2), and others-on the titanium alloy Offering valuable insights and a wealth of data, including numerous tables and figures, this is a rich source of information for research on hydroxyapatite coatings. Each chapter also covers material that provides an accessible stepping stone for those who are new to the field.

Details on specific imaging modalities for different cellular and tissue engineering applications are scattered throughout articles and chapters in the literature. Gathering this information into a single reference, Imaging in Cellular and Tissue Engineering presents both the fundamentals and state of the art in imaging methods, approaches, and applications in regenerative medicine. The book underscores the broadening scope of imaging applications in cellular and tissue engineering. It covers a wide range of optical and biological applications, including the repair or replacement of whole tissues (such as bone, cartilage, blood vessels, and bladder) and more novel artificially created support systems (such as artificial pancreas and bioartificial liver). Each chapter describes a particular application, relevant optical instrumentation, physical principles governing the imaging method, and strengths and weaknesses of the technique. The book also presents current and emerging data processing procedures. As the field of tissue engineering moves from creating simpler outer body parts to more sophisticated internal organs, researchers need to evaluate and control how well the tissues are engineered and integrated into the living body. Suitable for both experts and newcomers in bioengineering and biomedical imaging, this book shows researchers how to apply imaging techniques to next-generation engineered cells and tissues. It helps them assess the suitability of specific imaging modalities for applications with various functional requirements.

Nucleic acid (NA) therapeutics has been extensively studied both in the academia and in the pharmaceutical industry and is still considered the promise for new therapeutic modalities, especially in personalized medicine. The only hurdle that limits the translation of NA therapeutics from an academic idea to the new therapeutic modality is the lack of efficient and safe delivery strategies.
Nanotechnology for the Delivery of Therapeutic Nucleic Acids, written by world experts in the field of nanotechnology for NA delivery, the contributing authors bring together the state of the art in delivery strategies with strong emphasis on aspects that are of essence to the pharmaceutical industry, such as stability, general toxicity, immune-toxicity, pharmacokinetics, efficacy, and validation of new drug targets using unique approaches based on exquisite nanotechnology strategies.

Global Health continues to provide readers with a comprehensive, up-to-date and thought-provoking outline and understanding of the constantly evolving global health landscape. In this new edition the authors have maintained the successful structure and organisation of the previous edition to examine and explain recent health changes and consider likely future patterns. New or expanded topics covered include: emerging and re-emerging infectious disease threats increasing awareness of, and interest in, antimicrobial resistance and superbugs terrorism, global conflict and health the new UN 2030 Agenda for Sustainable Development the drive for Universal Health Coverage (UHC) the use of information technology in global health substance abuse palliative and end-of-life-care ethical issues in global health. Using clear and original explanations of complex issues, this text makes extensive use of boxed case studies and international examples, with discussion questions posed for readers at the end of each chapter. Readers will also be able to take advantage of the new website that was designed to complement this book. Global Health is essential reading for students and researchers of global health, public health and development studies.

Biomaterials have had a major impact on the practice of contemporary medicine and patient care. Growing into a major interdisciplinary effort involving chemists, biologists, engineers, and physicians, biomaterials development has enabled the creation of high-quality devices, implants, and drug carriers with greater biocompatibility and biofunctionality. The fast-paced research and increasing interest in finding new and improved biocompatible or biodegradable polymers has provided a wealth of new information, transforming this edition of Polymeric Biomaterials into a two-volume set. This volume, Polymeric Biomaterials: Medicinal and Pharmaceutical Applications, contains 28 authoritative chapters written by experts from around the world. Contributors cover the following topics: Processing polymeric biomaterials into specific forms that ensure biocompatibility and biodegradability for use in various applications in the medical and pharmaceutical arenas Use of biomaterials to address medical issues such as pulmonary disease, cancer, heart disease, tissue damage, and bone disease Applications including a variety of drug delivery systems, medical devices, anticancer therapies, biological uses for hydrogels, nanotechnology, bioartificial organs, and tissue engineering Completely revised and expanded, this state-of-the-art reference presents recent developments in polymeric biomaterials and the most up-to-date applications of biomaterials in medicine.

Biomaterials have had a major impact on the practice of contemporary medicine and patient care. Growing into a major interdisciplinary effort involving chemists, biologists, engineers, and physicians, biomaterials development has enabled the creation of high-quality devices, implants, and drug carriers with greater biocompatibility and biofunctionality. The fast-paced research and increasing interest in finding new and improved biocompatible or biodegradable polymers has provided a wealth of new information, transforming this edition of Polymeric Biomaterials into a two-volume set. This volume, Polymeric Biomaterials: Structure and Function, contains 25 authoritative chapters written by experts from around the world. Contributors cover the following topics: The structure and properties of synthetic polymers including polyesters, polyphosphazenes, and elastomers The structure and properties of natural polymers such as mucoadhesives, chitin, lignin, and carbohydrate derivatives Blends and composites-for example, metal-polymer composites and biodegradable polymeric/ceramic composites Bioresorbable hybrid membranes, drug delivery systems, cell bioassay systems, electrospinning for regenerative medicine, and more Completely revised and expanded, this state-of-the-art reference presents recent developments in polymeric biomaterials: from their chemical, physical, and structural properties to polymer synthesis and processing techniques and current applications in the medical and pharmaceutical fields.

Biomaterials have had a major impact on the practice of contemporary medicine and patient care. Growing into a major interdisciplinary effort involving chemists, biologists, engineers, and physicians, biomaterials development has enabled the creation of high-quality devices, implants, and drug carriers with greater biocompatibility and biofunctionality. The fast-paced research and increasing interest in finding new and improved biocompatible or biodegradable polymers has provided a wealth of new information, transforming this edition of Polymeric Biomaterials into a two-volume set. Completely revised and expanded, this state-of-the-art reference presents recent developments in polymeric biomaterials: from their chemical, physical, and structural properties to current applications in the medical and pharmaceutical fields.
The book is organized into two volumes containing 53 authoritative chapters written by experts from around the world. The first volume, Polymeric Biomaterials: Structure and Function, contains information about the structure and properties of synthetic polymers including polyesters, polyphosphazenes, and elastomers and natural polymers such as mucoadhesives, chitin, lignin, and carbohydrate derivatives. It also describes their blends or composites for example, metal polymer composites and biodegradable polymeric/ceramic composites as well as drug carriers and delivery systems, gene and nucleic acids delivery, and polymer synthesis and processing techniques.
The second volume, Polymeric Biomaterials: Medicinal and Pharmaceutical Applications, addresses processing of polymeric biomaterials into specific forms that ensure biocompatibility and biodegradability for various uses in the medical and pharmaceutical arenas. The chapters address numerous medical issues including pulmonary disease, cancer, heart disease, tissue damage, and bone disease. The applications covered include a variety of drug delivery systems, medical devices, anticancer therapies, biological uses for hydrogels, nanotechnology, bioartificial organs, and tissue engineering. This third edition set presents new and substantially revised topics, providing a comprehensive reference of the latest developments and the most up-to-date applications of biomaterials in medicine.

Research on bone remodeling has resulted in much new information and has led to improvements in design and biomedical practices. Mechanics of Cellular Bone Remodeling: Coupled Thermal, Electrical, and Mechanical Field Effects presents a unified exploration of recent advances, giving readers a sound understanding of bone remodeling and its mathematical representation. Beginning with a description of the basic concept of bone remodeling from a mathematical point of view, the book details the development of each of the techniques and ideas. From there it progresses to the derivation and construction of multifield and cellular bone remodeling and shows how they arise naturally in response to external multifield loads. Topics include: Fundamental concepts and basic formulations for bone remodeling Applications of formulations to multifield internal bone remodeling of inhomogeneous long cylindrical bone Theory and solution of multifield surface bone remodeling A hypothetical regulation mechanism on growth factors for bone modeling and remodeling under multifield loading The RANK-RANKL-OPG pathway and formulation for analyzing the bone remodeling process A model of bone cell population dynamics for cortical bone remodeling under mechanical and pulsed electromagnetic stimulus Recent developments in experiments with bone materials Readers will benefit from the thorough coverage of general principles for each topic, followed by detailed mathematical derivations and worked examples, as well as tables and figures where appropriate. The book not only serves as a reliable reference but is also destined to attract interested readers and researchers to a field that offers fascinating and technologically important challenges.