Biomechanics and Gait Analysis presents a comprehensive book on biomechanics that focuses on gait analysis. It is written primarily for biomedical engineering students, professionals and biomechanists with a strong emphasis on medical devices and assistive technology, but is also of interest to clinicians and physiologists. It allows novice readers to acquire the basics of gait analysis, while also helping expert readers update their knowledge. The book covers the most up-to-date acquisition and computational methods and advances in the field. Key topics include muscle mechanics and modeling, motor control and coordination, and measurements and assessments. This is the go to resource for an understanding of fundamental concepts and how to collect, analyze and interpret data for research, industry, clinical and sport.

Bioactive Materials for Bone Regeneration summarizes research advances on the topic, including sections on the characteristics of biomaterial-induced microenvironments, interactions of bioactive materials with stem cells and tissues, and the immunomodulatory microenvironment induced by biomaterials and its effects on osteogenesis. As the regeneration of large-size bone tissue defects represents a significant clinical challenge, this book demonstrates how new biomaterials with specific chemical and physical characteristics may interact with the host and create a unique micro-environment that actively facilitates stem cell differentiation along a specific lineage, thus stimulating tissue regeneration.

This book focuses on energy metabolism and brain functions related to Cortical Spreading Depression of Leao (CSD), an important issue in brain pathophysiology. The first part of the book offers a comprehensive overview of the history and early research on CSD, and then discusses the recent advances in the technology used to map and monitor brain mitochondrial NADH redox state and other physiological functions during CSD. The chapters explore the connection between CSD and mitochondrial function under hypoxia, Ischemia and various drugs treatment, and provide a resource to scientists researching the development of CSD during various brain pathophysiological conditions. This book is essential to scientists and students working in the field of bioenergetics of the brain and various organs and tissues in the body. The use of this technology is also crucial and applicable in the neuroscience field.

This innovative textbook brings together modern concepts in mathematical epidemiology, computational modeling, physics-based simulation, data science, and machine learning to understand one of the most significant problems of our current time, the outbreak dynamics and outbreak control of COVID-19. It teaches the relevant tools to model and simulate nonlinear dynamic systems in view of a global pandemic that is acutely relevant to human health. If you are a student, educator, basic scientist, or medical researcher in the natural or social sciences, or someone passionate about big data and human health: This book is for you! It serves as a textbook for undergraduates and graduate students, and a monograph for researchers and scientists. It can be used in the mathematical life sciences suitable for courses in applied mathematics, biomedical engineering, biostatistics, computer science, data science, epidemiology, health sciences, machine learning, mathematical biology, numerical methods, and probabilistic programming. This book is a personal reflection on the role of data-driven modeling during the COVID-19 pandemic, motivated by the curiosity to understand it.

Micro/Nano-robotics for Biomedical Applications features a system approach and incorporates modern methodologies in autonomous mobile robots for programmable and controllable micro/nano-robots aiming at biomedical applications. The book provides chapters of instructional materials in micro/nanorobotics for biomedical applications. The book features lecture units on micro/nanorobot components and techniques, including sensors, actuator, power supply, and micro/nano-fabrication and assembly. It also contains case studies on using micro/nano-robots in biomedical environments and in biomedicine, as well as a design example to conceptually develop a Vitamin-pill sized robot to enter human s gastrointestinal tract. Laboratory modules to teach robot navigation and cooperation methods suitable to biomedical applications will be also provided based on existing simulation and robot platforms."

Many novel technologies have been proposed in the attempt to improve existing food processing methods. Among emerging nonthermal technologies, high intensity pulsed electric fields (PEF) is appealing due to its short treatment times and reduced heating effects. This book presents information accumulated on PEF during the last 15 years by experienced microbiologists, biochemists, food technologists, and electrical and food engineers.

Managing Medical Devices within a Regulatory Framework helps administrators, designers, manufacturers, clinical engineers, and biomedical support staff to navigate worldwide regulation, carefully consider the parameters for medical equipment patient safety, anticipate problems with equipment, and efficiently manage medical device acquisition budgets throughout the total product life cycle. This contributed book contains perspectives from industry professionals and academics providing a comprehensive look at health technology management (HTM) best practices for medical records management, interoperability between and among devices outside of healthcare, and the dynamics of implementation of new devices. Various chapters advise on how to achieve patient confidentiality compliance for medical devices and their software, discuss legal issues surrounding device use in the hospital environment of care, the impact of device failures on patient safety, methods to advance skillsets for HTM professionals, and resources to assess digital technology. The authors bring forth relevant challenges and demonstrate how management can foster increased clinical and non-clinical collaboration to enhance patient outcomes and the bottom line by translating the regulatory impact on operational requirements.

The book covers the integration of Internet of Things (IoT) and Artificial Intelligence (AI) to tackle applications in smart healthcare. The authors discuss efficient means to collect, monitor, control, optimize, model, and predict healthcare data using AI and IoT. The book presents the many advantages and improvements in the smart healthcare field, in which ubiquitous computing and traditional computational methods alone are often inadequate. AI techniques are presented that play a crucial role in dealing with large amounts of heterogeneous, multi-scale and multi-modal data coming from IoT infrastructures. The book is intended to cover how the fusion of IoT and AI allows the design of models, methodologies, algorithms, evaluation benchmarks, and tools can address challenging problems related to health informatics, healthcare, and wellbeing.

This body of work represents the first volume of a book series covering the field of tissue engineering. Tissue engineering, which refers to a category of therapeutic or diagnostic products and processes which are based upon a combination of living cells and biomaterials, was defined as a field only a few years ago (1988). Tissue engineering is an inherently interdisciplinary field, combining bioengineering, life sciences and clinical sciences. The definition of this area of work as the field of tissue engineering brought together scientists from multiple backgrounds who already were working toward the achievement of similar goals. Why a book series exclusively devoted to tissue engineering? The field of tissue engineering is heterogeneous. The cells involved in tissue engineering can be autologous, allogeneic or xenogeneic. The biomaterials utilized can be either naturally occurring, synthetic or a combination of both. The appli cation of the technology can be either for acute or permanent purposes. An attempt to cover the field of tissue engineering in a single volume, with the degree of detail necessary for individuals with different scientific back grounds and disciplines, would be a difficult task to accomplish, particularly when this field is just emerging and changing rapidly. Therefore, addressing different technologies within the field of tissue engineering, in a comprehen sive manner, is the main mission of this series of volumes. A stellar group of scientists has been brought together to form the editorial board of the series."

This edited book explores the use of technology to enable us to visualise the life sciences in a more meaningful and engaging way. It will enable those interested in visualisation techniques to gain a better understanding of the applications that can be used in visualisation, imaging and analysis, education, engagement and training. The reader will also be able to learn about the use of visualisation techniques and technologies for the historical and forensic settings. The chapters presented in this volume cover such a diverse range of topics, with something for everyone. We present here chapters on 3D visualising novel stent grafts to aid treatment of aortic aneuryms; confocal microscopy constructed vascular models in patient education; 3D patient specific virtual reconstructions in surgery; virtual reality in upper limb rehabilitation in patients with multiple sclerosis and virtual clinical wards. In addition, we present chapters in artificial intelligence in ultrasound guided regional anaesthesia; carpal tunnel release visualisation techniques; visualising for embryology education and artificial intelligence data on bone mechanics. Finally we conclude with chapters on visualising patient communication in a general practice setting; digital facial depictions of people from the past; instructor made cadaveric videos, novel cadaveric techniques for enhancing visualisation of the human body and finally interactive educational videos and screencasts. This book explores the use of technologies from a range of fields to provide engaging and meaningful visual representations of the biomedical sciences. It is therefore an interesting read for researchers, developers and educators who want to learn how visualisation techniques can be used successfully for a variety of purposes, such as educating students or training staff, interacting with patients and biomedical procedures in general.

This book highlights contemporary state of research in multidisciplinary areas in computer science, computer engineering, chemical engineering, mechanical engineering, physics, biomedical sciences, life sciences, medicine, and health care. The accepted submissions to the 7th IRC Conference on Science, Engineering and Technology (IRC-SET 2021) that were presented on August 7, 2021, are published in this conference proceedings. The papers presented here were shortlisted after extensive rounds of rigorous reviews by a panel of esteemed individuals who are pioneers and experts in their respective domains.

This book contains contributions from leading researchers in biomechanics, nanomechanics, tribology, contact mechanics, materials science and applications on various experimental techniques including atomic force microscopy (AFM) for studying soft, biomimetic and biological materials and objects. Biologists, physicists, researchers applying methods of contact mechanics and researchers testing materials using indentation techniques along with many other applied scientists will find this book a useful addition to their libraries. Moreover, several reviews in this book are written as introductions to several important and rather sophisticated research areas such as depth-sensing indentation, studying of biological cells by AFM probes, mechanics of adhesive contact and contact between viscoelastic (hereditary elastic) solids. The book containing new theoretical models, results of experimental studies and numerical simulations, along with reviews of above mentioned areas of contact mechanics in application to biological systems, would be beneficial for researchers in many areas of biology, medicine, engineering, mechanics and biomimetics.

This book describes the essential requirements for the realization of neuromorphic systems, where memristive devices play a key role. A comprehensive description to organic memristive devices, including working principles and models of the function, preparation methods, properties and different applications is presented. A comparative analysis of organic and inorganic systems is given. The author discusses all aspects of current research in organic memristive devices: fabrication techniques, properties, synapse mimicking circuits, and neuromorphic systems (including perceptrons), etc. Describes requirements of electronic circuits and systems to be considered as neuromorphic systems; Provides a single-source reference to the state-of-the-art in memristive devices as key elements of neuromorphic systems; Provides a comparative analysis of advantages and drawbacks between organic and inorganic devices and systems; Includes a systematic overview of organic memristive devices, including fabrication methods, properties, synapse mimicking circuits, and neuromorphic systems; Discusses a variety of unconventional applications, based on bio-inspired circuits and neuromorphic systems.

This book gathers the revised and selected contributions to the 6th Dementia Lab Conference, D-Lab 2022, held on September 20-22, 2022, in Leuven. It describes original and innovative research on how design can contribute to the quality of life of people with dementia, their loved ones, and caregivers. The papers highlight the value of participation within design, analyzing it at three levels: personal, product, and organizational. The presented ideas and findings address 'The Residue of Design' and go beyond the initial impact of the design itself by looking at what benefits design research brings for people with dementia. The papers cover topics such as the development of creative design methods to foster participation and engagement from people with dementia, evaluation studies or critical reflections that reveal the impact of products and the built environment in dementia care, and raising awareness and countering stigma in societal views on dementia.

This book summarizes the recent advancements for biomechanics of injury and prevention in mechanism, application and developing frontiers. Biomechanics plays an important role in achieving safety, health, comfort, and a high quality of life by revealing injury mechanism and providing prevention methods. The book covers injury and prevention to the entire human body, from head to toe, including injury and prevention in sports, traffic, accident, clinic and so on. In addition, bionics prevention method inspired by woodpecker is also introduced. The book provides the reader with not only the mechanism of injury but also the advanced injury diagnosis, treatment, and prevention devices based on biomechanics.

This book gathers revised and selected contributions to the 5th Dementia Lab Conference, D-Lab 2021, organized online on January 18-28, 2021, from the Emily Carr University of Art + Design, Vancouver, Canada. It describes original strategies in which design or creative methods have been shown to uncover, support and enhance the abilities of people living with dementia. Papers report on new ideas and findings relating to three main themes: engagement, empowerment and identity. They cover: ethics of inclusion and solutions for shifting the culture of care to be focused on both personal independence and reconnecting with the community; new ways of designing with people living with dementia; strategies for breaking negative stereotypes and preconceived opinions; and approaches to retaining personhood and dignity. Offering a timely source of information on new design and creative methods to a broad community of industrial, communication, interactive and inclusive designers, this book is also meant to address and inspire various stakeholders and organizations in dementia care.

Assurance of Sterility for Sensitive Combination Products and Materials: New Paradigms for the Next Generation of Medical Devices and Pharmaceuticals discusses the medical device industry and existing challenges regarding the exciting new world of sensitive combination products (SCPs) and their terminal sterilization. This book reassesses the current assumptions to assure the patient's best interests are met in the development of increasingly rigorous sterilization methods used to counteract MRSA and other 'super-bugs'. In addition, the book discusses the special challenges faced with implantable medical devices, sterilization requirements and further methods needed for material selection and the design process. This book is unique in taking a holistic, end-to-end approach to sterilization, with a particular focus on materials selection and product design.

Control Systems Design of Bio-Robotics and Bio-Mechatronics with Advanced Applications delivers essential and advanced bioengineering information on the application of control and robotics technologies in the life sciences. Judging by what we have witnessed so far, this exciting field of control systems and robotics in bioengineering is likely to produce revolutionary breakthroughs over the next decade. While this book is intended for senior undergraduate or graduate students in both control engineering and biomedical engineering programs, it will also appeal to medical researchers and practitioners who want to enhance their quantitative understanding of physiological processes.

This book addresses instruments, methodologies and diagnostic methods used to evaluate and diagnose human movement, locomotion and physical status in general. Starting from historical perspective, the idea of understanding human locomotion by applying technical measurement devices and incorporating measurement data into physical representation of gross body movement is presented and explained, an approach known as inverse dynamics. With this approach as a kind of umbrella concept, components of measurement systems including relevant signal and data processing methods are described. Modern instruments to capture body movement by measuring its kinematics, kinetics and surface electromyography (sEMG) are thus described; all systems being used dominantly-if not exclusively-in a movement analysis laboratory setting. Focusing mainly on human posture and gait, but including also examples of movement patterns from selected kinesiological and sports activities, the book attempts to present essentials of biomechanics and biomedical engineering approach to this subject matter. It illustrates how data collected and elaborated by modern engineering technology can complement traditional expert knowledge of a kinesiologist or a medical doctor. The book is applicable in the fields of sports, physical activities, as well as in medical diagnostics and rehabilitation. The examples of this book's practical application might be in evaluation of efficiency of human gait, in evaluation of skeletal muscle fatigue in physical exercise, in biomechanical diagnostics of traumatological conditions requiring orthopaedic treatment and the like. This book can also be used in planning and executing research endeavours, particularly in a clinical context as a reference for various diagnostics procedures. It presents the lecture notes of a course carrying the same name within Medical Studies in English at the University of Zagreb for more than a decade.

Optical Coherence Tomography represents the ultimate noninvasive ocular imaging technique although being in the field for over two-decades. This book encompasses both medical and technical developments and recent achievements. Here, the authors cover the field of application from the anterior to the posterior ocular segments (Part I) and present a comprehensive review on the development of OCT. Important developments towards clinical applications are covered in Part II, ranging from the adaptive optics to the integration on a slit-lamp, and passing through new structural and functional information extraction from OCT data. The book is intended to be informative, coherent and comprehensive for both the medical and technical communities and aims at easing the communication between the two fields and bridging the gap between the two scientific communities.

The Pumps and Pipes collaboration and conference brings together energy, medicine, and higher education in a unique shared effort, exploring ideas and research common to these important fields and stimulating discussion and sharing technologies that can further the reach and goals of each individual area. The Proceedings explores the common attributes of oil and gas technology, computational sciences and cardiovascular medicine and probe the areas where there is room to cross-fertilize and develop research and commercial programs.

The surge in COVID-19 cases leading to hospitalizations around the world quickly depleted hospital resources and reserves, forcing physicians to make extremely difficult life-or-death decisions on ventilator allocation between patients. Leaders in academia and industry have developed numerous ventilator support systems using both consumer- and industry-grade hardware to sustain life and to provide intermediate respiratory relief for hospitalized patients. This book is the first of its kind to discuss the respiratory pathophysiology underlying COVID-19, explain ventilator mechanics, provide and evaluate a repository of innovative ventilator support devices conceived amid the pandemic, and explain both hardware and software components necessary to develop an inexpensive ventilator support device. This book serves both as a historical record of the collaborative and innovative response to the anticipated ventilator shortage during the COVID-19 pandemic and as a guide for physicians, engineers, and DIY'ers interested in developing inexpensive transitory ventilator support devices.

This textbook explores the fundamental qualitative and quantitative aspects of human physiology. It approaches biological and physiological processes and phenomena from a quantitative perspective, revealing how physiological problems can be mathematically formulated starting from simple laws of physics. The book addresses a broad range of topics, including: the statics and dynamics of circulation; muscle and sarcomere force-length and force-velocity relations, together with their mechanisms and functional consequences; subdivisions and meaning of the heat produced by muscle; locomotion, statics and dynamics of respiration; diffusion of gases and acid base equilibrium; phonation; general functions of the kidney and of the different sections of the nephron; changes in clearance with a substance's plasmatic concentration; pH regulation and the kidney; Donnan's equilibrium and its consequences; and the Nernst equation. The book offers the ideal learning resource for students of human physiology courses in medicine and biomedicine, as well as biomedical engineering and biophysics graduate students. An elementary grasp of mathematics and physics is sufficient to understand the content.

In this edited book, we highlight the central players in the Bionanotechnology field, which are the nanostructures and biomolecules. The book starts by describing how nanostructures are synthesized and by describing the wide variety of nanostructures available for biological research and applications. Also shown are the techniques used to synthesize a wide variety of biological molecules. Next, there is a focus on the assembly of nanostructures with biological molecules, which could lead to the design of multi-functional nanosystems. In the following chapters, examples of the unique properties of nanostructures are provided along with the current applications of these nanostructures in biology and medicine. Some applications include the use of gold nanoparticles in diagnostic applications, quantum dots and silica nanoparticles for imaging, and liposomes for drug delivery. In the final chapters of the book, the toxicity of nanostructures are described. This book provides broad examples of current developments in Bionanotechnology research and would be an excellent introduction to the field.