Microfluidics and BioMEMS Applications central idea is on microfluidics, a relatively new research field which finds its niche in biomedical devices, especially on lab-on-a-chip and related products. Being the essential component in providing driving fluidic flows, an example of micropump is chosen to illustrate a complete cycle in development of microfluidic devices which include literature review, designing and modelling, fabrication and testing. A few articles are included to demonstrate the idea of tackling this research problem, and they cover the main development scope discussed earlier as well as other advanced modelling schemes for microfluidics and beyond.

Scientists and students working in the areas of MEMS and microfluidics will benefit from this book, which may serve both communities as both a reference monograph and a textbook for courses in numerical simulation, and design and development of microfluidic devices.

This volume contains a collection of papers from the research program Protective Artificial Respiration (PAR) . In 2005 the German Research Association DFG launched the research program PAR which is a joint initiative of medicine and fluid mechanics. The main long-term objective of this program is the development of a more protective artificial respiratory system to reduce the physical stress of patients undergoing artificial respiration. To satisfy this goal 11 projects have been defined. In each of these projects scientists from medicine and fluid mechanics do collaborate in several experimental and numerical investigations to improve the fundamental knowledge on respiration and to develop a more individual artificial breathing concept. "

This updated fourth edition provides current information on devices and is divided into diagnostic and treatment sections. Devices are described with the theory of operation and relevant anatomical and physiological considerations. Aspects of BMET work including test equipment, standards, and information technology are also discussed. The text covers a wide variety of diagnostic and treatment devices currently used in hospitals that students will likely encounter in their career. Principles of operation and examples of use are provided. This book is unique in that it is written by an experienced biomed tech with 30 years' experience in hospitals rather than by engineers with little frontline experience. It is also unique in that it provides ancillary materials on the web and is the only guide divided into diagnostic and treatment device sections. This new edition also includes two new chapters on computers, information technology, and networking as well as health technology management. From the previous edition: "The book presents a comfortable balance between clinical applications, basic technical information, and various pictures of medical technologies one will encounter in the field. Additionally, related anatomy and physiology principles and essential technical terms are a nice complement to the technologies presented. The everyday duties and responsibilities of a biomed are captured by the various 'true-to-life' scenarios introduced throughout the book." -Joey Jones, Madisonville Community College, Kentucky, USA This book is intended for students in biomedical engineering technology and healthcare technology management (BMET/HTM) programs as well as biomedical engineering students. Field service representatives, medical device designers, and medical device sales representatives will also find it useful.

This is the only single authored text on biological polymers available for bioengineering and biomedical engineering students. The book describes the structure of polymers and how these molecules are put together to make the tissues of the body and also their role in surgical implants and in structural diseases. It provides essential reading for biomedical engineers, biologists, physicians, health care professionals and other biomedical researchers who are interested in understanding how physical forces affect the biology, physiology and pathophysiology of humans. The author is an expert on the effect of mechanical forces on extracellular matrix.

This book sheds light on the large-scale engineering systems that shape and guide our everyday lives. It does this by bringing together the latest research and practice defining the emerging field of Complex Engineered Systems. Understanding, designing, building and controlling such complex systems is going to be a central challenge for engineers in the coming decades. This book is a step toward addressing that challenge.

This book provides an overview of single-cell isolation, separation, injection, lysis and dynamics analysis as well as a study of their heterogeneity using different miniaturized devices. As an important part of single-cell analysis, different techniques including electroporation, microinjection, optical trapping, optoporation, rapid electrokinetic patterning and optoelectronic tweezers are described in detail. It presents different fluidic systems (e.g. continuous micro/nano-fluidic devices, microfluidic cytometry) and their integration with sensor technology, optical and hydrodynamic stretchers etc., and demonstrates the applications of single-cell analysis in systems biology, proteomics, genomics, epigenomics, cancer transcriptomics, metabolomics, biomedicine and drug delivery systems. It also discusses the future challenges for single-cell analysis, including the advantages and limitations. This book is enjoyable reading material while at the same time providing essential information to scientists in academia and professionals in industry working on different aspects of single-cell analysis. Dr. Fan-Gang Tseng is a Distinguished Professor of Engineering and System Science at the National Tsing Hua University, Taiwan. Dr. Tuhin Subhra Santra is a Research Associate at the California Nano Systems Institute, University of California at Los Angeles, USA.

This book describes the history, origin and basic characteristics of bioactive materials. It includes a chapter dedicated to hydroxyapatite mineral, its formation and its bioactive properties. The authors address how cytotoxicity is a determining step for bioactivity. Applications of bioactive materials in the contexts of tissue regeneration, bone regeneration and cancer therapy are also covered. Silicate, metallic and mesoporous glasses are described, as well as the challenges and future prospects of research in this field.

In 1994, in my role as Technical Program Chair for the 17th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, I solicited proposals for mini-symposia to provide delegates with accessible summaries of important issues in research areas outside their particular specializations. Terry Peters and his colleagues submitted a proposal for a symposium on Fourier Trans forms and Biomedical Engineering whose goal was "to demystify the Fourier transform and describe its practical application in biomedi cal situations." This was to be achieved by presenting the concepts in straightforward, physical terms with examples drawn for the parti cipants work in physiological signal analysis and medical imaging. The mini-symposia proved to be a great success and drew a large and appreciative audience. The only complaint being that the time allocated, 90 minutes, was not adequate to allow the participants to elaborate their ideas adequately. I understand that this feedback helped the authors to develop this book."

This book presents a comprehensive study on a new class of branched polymers, known as hyperbranched polymers (HBPs). It discusses in detail the synthesis strategies for these particular classes of polymers as well as biocompatible and biodegradable HBPs, which are of increasing interest to polymer technologists due to their immense potential in biomedical applications. The book also describes the one-pot synthesis technique for HBPs, which is feasible for large-scale production, as well as HBPs' structure-property relationship, which makes them superior to their linear counterparts. The alterable functional groups present at the terminal ends of the branches make HBPs promising candidates in the biomedical domain, and the book specifically elaborates on the suitable characteristic properties of each of the potential biological HBPs' applications. As such, the book offers a valuable reference guide for all scientists and technologists who are interested in using these newly developed techniques to achieve faster and better treatments.

This book provides an introduction to next generation smart screening technology for medical image analysis that combines artificial intelligence (AI) techniques with digital screening to develop innovative methods for detecting breast cancer. The authors begin with a discussion of breast cancer, its characteristics and symptoms, and the importance of early screening.They then provide insight on the role of artificial intelligence in global healthcare, screening methods for breast cancer using mammogram, ultrasound, and thermogram images, and the potential benefits of using AI-based systems for clinical screening to more accurately detect, diagnose, and treat breast cancer. Discusses various existing screening methods for breast cancer Presents deep information on artificial intelligence-based screening methods Discusses cancer treatment based on geographical differences and cultural characteristics

This book presents the refereed proceedings of the Fourth Italian Forum on Ambient Assisted Living (AAL), held in Ancona, Italy, in October 2013. A wide range of issues are covered and new technological developments are described which will support the autonomy and independence of individuals with special needs through an innovative and integrated approach, designed to respond to the socio-economic challenges of an aging population. Topics addressed include: health and well-being, prevention and rehabilitation and support for care providers; active aging and its social implications; services for the frail elderly with health problems and their families; nutrition; ICT platforms/technologies for the benefit of the elderly; home automation and control technologies (autonomy, safety and energy saving); smart cities and smart communities; telemedicine, telerehabilitation, and telecare; mobility, participation and social inclusion; games and fun for the elderly; building design; social housing; interface design and interaction (accessibility, acceptance); social policies to encourage and support active aging; business models, market analysis and development of sustainable financing and business and ethics, privacy and data protection. Many experimental validations based on user trials and usability testing are presented and discussed. The knowledge and insights provided in this book will help researchers and others involved in AAL to understand relevant societal trends, novel technological developments and pressing challenges.

This unique text introduces students and researchers to the world of misfolded proteins, toxic oligomers, and amyloid assemblages, and the diseases of the brain that result. During the past few years the connections between failures in protein quality control and neurological disorders have been reinforced and strengthened by discoveries on multiple fronts. These findings provide novel insights on how amyloidogenic oligomers and fibrils form, interconvert from one state to another, and propagate from cell to cell and region to region. Starting with protein folding and protein quality control basics, the reader will learn how misfolded proteins can cause diseases ranging from prion diseases to Alzheimer's disease and Parkinson's disease to Huntington's disease, amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Authoritative but written in a clear and engaging style, Fundamentals of Neurodegeneration and Protein Misfolding Disorders addresses one of today's forefront areas of science and medicine. The text emphasizes the new groundbreaking biophysical and biochemical methods that enable molecular-level explorations and the conceptual breakthroughs that result. It contains separate chapters on each of the major disease classes. Special emphasis is placed on those factors and themes that are common to the diseases, especially failures in synaptic transmission, mitochondrial control, and axonal transport; breakdowns in RNA processing; the potential role of environmental factors; and the confounding effects of neuroinflammation. The book is ideal for use in teaching at the advanced undergraduate and graduate levels, and serves as a comprehensive reference for a broad audience of students and researchers in neuroscience, molecular biology, biological physics and biomedical engineering.

This volume presents the latest research in Virtual Reality (VR), as it is being applied in psychotherapy, rehabilitation, and the analysis of behaviour for neurological assessment. This book will be of value to anyone already in the field and to those who are interested in the development of VR systems for therapeutic purposes. The contents include: * The latest literature reviews on VR in psychotherapy, psychological wellbeing, and rehabilitation * VR and cognitive behavior therapy * Increasing presence in VR for effective exposure therapy and treatment of anxiety disorders * VR military training for managing combat stress and preventing post traumatic stress * VR, mixed reality systems, and games for stroke rehabilitation * VR systems for improving vision in children with amblyopia * Therapeutic play in virtual environments * Healing potential of online virtual worlds such as Second Life * Neuropsychological assessment using virtual environments * Detailed accounts on how VR systems are designed, implemented, and best evaluated * Discussions of limitations, problems, and ethical concerns using VR in mental and physical therapy

This book reviews and discusses the development of self-assembled nanomaterials applied in biomedical fields. Based on self-assembled nanomaterial constructions, it highlights the mechanisms of the stimuli-response-induced assembly/disassembly and transformation. Moreover, it examines healthcare-related diseases, the applications of nanomaterials and therapy/detection strategies, providing readers with both a deeper understanding of the subject and inspirations for future research. The book is primarily intended for researchers and graduate students in the fields of material sciences and chemistry who wish to learn about the principles, methods, mechanisms and biomedical applications of self-assembled nanomaterials.

Quantitative Perfusion MRI: Techniques, Applications, and Practical Considerations, Volume 11 clearly and carefully explains the basic theory and MRI techniques for quantifying perfusion non-invasively in deep tissue, covering all aspects of perfusion imaging, from acquisition requirements to selection of contrast agents and appropriate pharmacokinetic models and for reliable quantification in different diseases and tissue types. Specifically, this book enables the reader to understand what microvascular functional parameters can be measured with perfusion MRI, learn the basic techniques to measure perfusion in different organs, apply the appropriate perfusion MRI technique to the organ of interest, and much more. This complete reference on quantitative perfusion MRI is highly suitable for both early and experienced researchers, graduate students and clinicians wishing to understand how quantitative perfusion MRI can apply to their application area of interest.

This book deals with the adhesion, friction and contact mechanics of living organisms. Further, it presents the remarkable adhesive abilities of the living organisms which inspired the design of novel micro- and nanostructured adhesives that can be used in various applications, such as climbing robots, reusable tapes, and biomedical bandages. The technologies for both the synthesis and construction of bio-inspired adhesive micro- and nanostructures, as well as their performance, are discussed in detail. Representatives of several animal groups, such as insects, spiders, tree frogs, and lizards, are able to walk on (and therefore attach to) tilted, vertical surfaces, and even ceilings in different environments. Studies have demonstrated that their highly specialized micro- and nanostructures, in combination with particular surface chemistries, are responsible for this impressive and reversible adhesion. These structures can maximize the formation of large effective contact areas on surfaces of varying roughness and chemical composition under different environmental conditions.

- Presents the reasons behind the decisions taken by automated algorithms - Frames eXplainable AI as a bridge between computer scientists and physicians - Emphasizes transparency in data analysis within healthcare - Covers computer vision and deep learning in tandem - Creates space to discuss human-AI relationships in future healthcare

"The Imperial Quest and Modern Memory" explores relationships between narrative and imperium in the context of Western Modernism by examining the Quest as a vexed trope in "Heart of Darkness," "Passage to India," "The Sheltering Sky," and "The Quiet American," The book takes stock of twentieth century theory regarding the Quest--as archetype, trope, and construct, considers the dominant expression and the imperial organization of this trope in Western culture and iconography from the Dark Ages to the Age of Empire, explores the ways in which this trope both lingers and changes in the context of Western Modernism, and finally gauges its permutations in Modern discourse. "The Imperial Quest and Modern Memory's" central claim is that the Modern novel simultaneously reinscribes and subverts Western and imperial manifestations of the Quest. "Heart" "of Darkness," "Passage to India," "The Sheltering Sky," and "The Quiet American "are remarkably Modern and subversive narratives. They participate in the revolutionary projects of early and high Modernism and are often in marked opposition to imperial praxis. Yet they are also profoundly influenced by the deep ideological and metaphoric structures of Western culture. Thus, the Quest trope--specifically in its Western and imperial manifestations--lingers in Modern Memory and certainly in the Modern novel. This expansive study emphasizes intriguing intersections between past and present, culture and archetype, norm and narrative, memory and contemporaneity.

Resident Stem Cells and Regenerative Therapy: Sources and Clinical Applications, Second Edition presents the main findings to date and the important factors to be considered when contemplating resident stem cells in regenerative therapies. Chapters on cardiac, brain, neural, liver, kidney, skeletal muscle, bone, pancreatic, skin and lung resident stem cells will assist in defining the level of success that has been achieved and the direction for the road ahead. With contributions from leading laboratories, open questions related to resident stem cells and regenerative therapies will also be presented for debate. In the last several decades, stem cells have greatly impacted the scientific and lay communities, providing huge advances in the treatment of devastating human diseases, including myocardial infarction, diabetes, muscular dystrophy, cystic fibrosis, cirrhosis, and osteoporosis. Alongside debates of induced pluripotent stem cells and embryonic stem cells has been the discovery of adult stem cells in many different tissues. While these organ resident or progenitor stem cells offer prospects to contribute to tissue regeneration, they also present challenges because of the complexity of organ structures.

Artificial Intelligence to Solve Pervasive Internet of Things Issues discusses standards and technologies and wide-ranging technology areas and their applications and challenges, including discussions on architectures, frameworks, applications, best practices, methods and techniques required for integrating AI to resolve IoT issues. Chapters also provide step-by-step measures, practices and solutions to tackle vital decision-making and practical issues affecting IoT technology, including autonomous devices and computerized systems. Such issues range from adopting, mitigating, maintaining, modernizing and protecting AI and IoT infrastructure components such as scalability, sustainability, latency, system decentralization and maintainability. The book enables readers to explore, discover and implement new solutions for integrating AI to solve IoT issues. Resolving these issues will help readers address many real-world applications in areas such as scientific research, healthcare, defense, aeronautics, engineering, social media, and many others.

This book presents authoritative recent research on Biomedical Informatics, bringing together contributions from some of the most respected researchers in this field. Biomedical Informatics represents a growing area of interest and innovation in the management of health-related data, and is essential to the development of focused computational models. Outlining the direction of current research, the book will be of considerable interest to theoreticians and application scientists alike. Further, as all chapters are self-contained, it also provides a valuable sourcebook for graduate students.

This book offers a comprehensive report on the technological aspects of Mobile Health (mHealth) and discusses the main challenges and future directions in the field. It is divided into eight parts: (1) preventive and curative medicine; (2) remote health monitoring; (3) interoperability; (4) framework, architecture, and software/hardware systems; (5) cloud applications; (6) radio technologies and applications; (7) communication networks and systems; and (8) security and privacy mechanisms. The first two parts cover sensor-based and bedside systems for remotely monitoring patients' health condition, which aim at preventing the development of health problems and managing the prognosis of acute and chronic diseases. The related chapters discuss how new sensing and wireless technologies can offer accurate and cost-effective means for monitoring and evaluating behavior of individuals with dementia and psychiatric disorders, such as wandering behavior and sleep impairments. The following two parts focus on architectures and higher level systems, and on the challenges associated with their interoperability and scalability, two important aspects that stand in the way of the widespread deployment of mHealth systems. The remaining parts focus on telecommunication support systems for mHealth, including radio technologies, communication and cloud networks, and secure health-related applications and systems. All in all, the book offers a snapshot of the state-of-art in mHealth systems, and addresses the needs of a multidisciplinary audience, including engineers, computer scientists, healthcare providers, and medical professionals, working in both academia and the industry, as well as stakeholders at government agencies and non-profit organizations.

This book focuses on advanced research and technologies in dairy processing, one of the most important branches of the food industry. It addresses various topics, ranging from the basics of dairy technology to the opportunities and challenges in the industry. Following an introduction to dairy processing, the book takes readers through various aspects of dairy engineering, such as dairy-based peptides, novel milk products and bio-fortification. It also describes the essential role of microorganisms in the industry and ways to detect them, as well as the use of prebiotics, and food safety. Lastly, the book examines the challenges faced, especially in terms of maintaining quality across the supply chain. Covering all significant areas of dairy science and processing, this interesting and informative book is a valuable resource for post-graduate students, research scholars and industry experts.

Terahertz biomedical imaging has become an area of interest due to its ability to simultaneously acquire both image and spectral information. Terahertz imaging systems are being commercialized, with increasing trials performed in a biomedical setting. As a result, advanced digital image processing algorithms are needed to assist screening, diagnosis, and treatment. "Pattern Recognition and Tomographic Reconstruction" presents these necessary algorithms, which will play a critical role in the accurate detection of abnormalities present in biomedical imaging. Terhazertz tomographic imaging and detection technology contributes to the ability to identify opaque objects with clear boundaries, and would be useful to both in vivo and ex vivo environments, making this book a must-read for anyone in the field of biomedical engineering and digital imaging.

The current generation of imaging nanoparticles is diverse and dependent on its myriad of applications. This book provides an overview of how these imaging particles can be designed to fulfill specific requirements for applications across different imaging modalities. It presents, for the first time, a comprehensive interdisciplinary overview of the impact nanoparticles have on biomedical imaging and is a common central resource for researchers and teachers.