This book reviews the latest technological developments of bioengineering approaches in cell and tissue research. It is meant to have life and spirit, and to become a pioneer in technology and sciences, especially the life science. The chapters are written by excellent scientists on advanced, frontier technology and address scientific questions that need considerable thinking in terms of engineering. The aims are to provide the readers, including students, faculty, and all scientists working in academia and industry, new information on bioengineering in cell and tissue research to enhance their understanding and innovation.

Plastic is one of the widely used polymers around the globe since its discovery. It is highly impossible to think the ease of life without the aid of plastic. Every year billion tons of plastic waste gets accumulated in the environment and leads to death of both marine and terrestrial animals. Plastic is very durable and needs around 1000 years to degrade under the natural environment. The present book illustrates the importance and significance of the bioremediation to tackle the problem of plastic waste. Previously, we have reported elite rhizobacterial isolates (Lysinibacillus fusiformis strain VASB14/WL and Bacillus cereus strain VASB1/TS) of Avicennia marina Vierh (Forsk.) from the West Coast of India with the potential to degrade plastic (polythene). The present book attempted to address the bioremediation scenario of plastic waste (including micro plastic) using microbes with bacteria in particular. Various strategies used to tackle with the plastic waste were highlighted with case studies of plastic waste management, including in vitro, in situ and ex situ with a special reference to biodegradation technology. After the biodegradation of the plastic using microbes, the generated plastic (polythene) degradation products (PE-DPs) were also documented using GC-MS technique followed by their deleterious effect on both animal and plant systems. The book also enhances the awareness of the plastic-free society and also suggests some alternative materials to be used instead of plastic. Lastly, the book suggests/recommends the strategies to be followed by the lawmakers in the government organizations/non-government organizations/social organizations to frame the regulations and guidelines to implement at mass level to reduce the generation of plastic waste.

Presents the state of the art in conductive composite materials and their application in flexible strain sensors Uniquely combines the processing, structure, properties, and applications of conductive polymer composites Integrates theory and practice Benefits plastics converters who wish to take full advantage of the potential of conductive plastic materials

Explains theory and practical applications of nanomaterials as antiviral agents Reviews upscaling of nanomaterials from laboratory to fabrication stage Illustrates nanocurcumin, silver nanoparticles, and carbon nanoparticles for biomedical applications Highlights role of nanotechnology in effectively combating viral infections and pandemics Includes case studies of specific pharma companies

This book coherently presents advances in design principles, processes, and methods in healthcare product design. It captures the implications of technological advances on designing healthcare products especially when market and societal needs pull each other in opposite directions. The contents focus on innovative design thinking processes and methods in developing healthcare products, applications of digital technologies in healthcare product design, amalgamation of artificial intelligence and design thinking for healthcare product design and quality, sustainability, and regulatory aspects in the design process. This book is a useful reference for those in the industry and academia.

Applications of Big Data in Healthcare: Theory and Practice begins with the basics of Big Data analysis and introduces the tools, processes and procedures associated with Big Data analytics. The book unites healthcare with Big Data analysis and uses the advantages of the latter to solve the problems faced by the former. The authors present the challenges faced by the healthcare industry, including capturing, storing, searching, sharing and analyzing data. This book illustrates the challenges in the applications of Big Data and suggests ways to overcome them, with a primary emphasis on data repositories, challenges, and concepts for data scientists, engineers and clinicians. The applications of Big Data have grown tremendously within the past few years and its growth can not only be attributed to its competence to handle large data streams but also to its abilities to find insights from complex, noisy, heterogeneous, longitudinal and voluminous data. The main objectives of Big Data in the healthcare sector is to come up with ways to provide personalized healthcare to patients by taking into account the enormous amounts of already existing data.

Artificial Protein and Peptide Nanofibers: Design, Fabrication, Characterization, and Applications provides comprehensive knowledge of the preparation, modification and applications of protein and peptide nanofibers. The book reviews the synthesis and strategies necessary to create protein and peptide nanofibers, such as self-assembly (including supramolecular assembly), electrospinning, template synthesis, and enzymatic synthesis. Then, the key chemical modification and molecular design methods are highlighted that can be utilized to improve the bio-functions of these synthetic fibers. Finally, fabrication methods for key applications, such as sensing, drug delivery, imaging, tissue engineering and electronic devices are reviewed. This book will be an ideal resource for those working in materials science, polymer science, chemical engineering, nanotechnology and biomedicine.

Second-Order Consensus of Continuous-Time Multi-Agent Systems focuses on the characteristics and features of second-order agents, communication networks, and control protocols/algorithms in continuous consensus of multi-agent systems. The book provides readers with background on consensus control of multi-agent systems and introduces the intrinsic characteristics of second-order agents' behavior, including the development of continuous control protocols/algorithms over various types of underlying communication networks, as well as the implementation of computation- and communication-efficient strategies in the execution of protocols/algorithms. The book's authors also provide coverage of the frameworks of stability analysis, algebraic criteria and performance evaluation. On this basis, the book provides an in-depth study of intrinsic nonlinear dynamics from agents' perspective, coverage of unbalanced directed topology, random switching topology, event-triggered communication, and random link failure, from a communication networks' perspective, as well as leader-following control, finite-time control, and global consensus control, from a protocols/algorithms' perspective. Finally, simulation results including practical application examples are presented to illustrate the effectiveness and the practicability of the control protocols and algorithms proposed in this book.

This open access book establishes a dialog among the medical and intelligent system domains for igniting transition toward a sustainable and cost-effective healthcare. The Person-Centered Care (PCC) positions a person in the center of a healthcare system, instead of defining a patient as a set of diagnoses and treatment episodes. The PCC-based conceptual background triggers enhanced application of Artificial Intelligence, as it dissolves the limits of processing traditional medical data records, clinical tests and surveys. Enhanced knowledge for diagnosing, treatment and rehabilitation is captured and utilized by inclusion of data sources characterizing personal lifestyle, and health literacy, and it involves insights derived from smart ambience and wearables data, community networks, and the caregivers' feedback. The book discusses intelligent systems and their applications for healthcare data analysis, decision making and process design tasks. The measurement systems and efficiency evaluation models analyze ability of intelligent healthcare system to monitor person health and improving quality of life.

This book covers the nutritional and nutraceutical profiles of a wide range of popularly consumed vegetables and nuts. The first half of the book focuses on popular vegetables, and describes how higher vegetable consumption reduces the risk of diseases ranging from diabetes to osteoporosis, diseases of the gastrointestinal tract, cardiovascular diseases, autoimmune diseases and cancer. The book also includes an interesting section on the antioxidant potential of mushrooms. In turn, the second half discusses the nutritional value of various nuts. Nuts are nutrient-dense foods with complex matrices rich in unsaturated fats, high-quality protein, fiber, minerals, tocopherols, phytosterols and phenolics. The respective chapters illustrate how the consumption of nuts could ward off chronic diseases like hypertension, cancer, inflammation, oxidative stress, high blood pressure, coronary heart disease etc. In order to effectively promote vegetable and nut consumption, it is necessary to know and understand the nutritional and nutraceutical profiles of vegetables & nuts. Given its scope, the book will be of interest to students, researchers, food scientists, olericulturists, dietitians and agricultural scientists alike. Those working in the vegetable and nut processing industries, horticultural departments and other agricultural departments will also find the comprehensive information relevant to their work.

The book provides an overview of bio-manufacturing techniques for the production, purification, characterization and modification of chito/chitin oligosaccharides and their monomers. In addition, it explores potential applications in the food, biomedical and agricultural industry on the basis of their bioactivities and biomaterial properties. Lastly, it shares a range of cutting-edge insights to help solve problems in industrial processes and promote further academic investigation. Given its scope, it offers a valuable resource for researchers and graduate students in the fields of bioengineering, food science, biochemistry, etc.

Personalized Computational Hemodynamics: Models, Methods, and Applications for Vascular Surgery and Antitumor Therapy offers practices and advances surrounding the multiscale modeling of hemodynamics and their personalization with conventional clinical data. Focusing on three physiological disciplines, readers will learn how to derive a suitable mathematical model and personalize its parameters to account for pathologies and diseases. Written by leading experts, this book mirrors the top trends in mathematical modeling with clinical applications. In addition, the book features the major results of the "Research group in simulation of blood flow and vascular pathologies" at the Institute of Numerical Mathematics of the Russian Academy of Sciences. Two important features distinguish this book from other monographs on numerical methods for biomedical applications. First, the variety of medical disciplines targeted by the mathematical modeling and computer simulations, including cardiology, vascular neurology and oncology. Second, for all mathematical models, the authors consider extensions and parameter tuning that account for vascular pathologies.

This book discusses fundamentally new biomedical imaging methods, such as holography, holographic and resonant interferometry, and speckle optics. It focuses on the development of holographic interference microscopy and its use in the study of phase objects such as nerve and muscle fibers subjected to the influence of laser radiation, magnetic fields, and hyperbaric conditions. The book shows how the myelin sheath and even the axon itself exhibit waveguide properties, enabling a fresh new look at the mechanisms of information transmission in the human body. The book presents theoretically and experimentally tested holographic and speckle-optical methods and devices used for investigating complex, diffusely scattering surfaces such as skin and muscle tissue. Additionally, it gives broad discussion of the authors' own original fundamental and applied research dedicated to helping physicians introduce new contact-less methods of diagnosis and treatment of diseases of the cardiovascular and neuromuscular systems into medical practice. The book is aimed at a broad spectrum of scientific specialists in the fields of speckle optics, holography, laser physics, morphology and cytochemistry, as well as medical professionals such as physiologists, neuropathologists, neurosurgeons, cardiologists and dentists.

The book Intelligent Healthcare: Infrastructure, Algorithms, and Management (R) cover a wide range of research topics on innovative intelligent healthcare solutions and advancements with the latest research developments. Data analytics are relevant for healthcare to meet many technical challenges and issues that need to be addressed to realize this potential. The advanced healthcare systems have to be upgraded with new capabilities such as data analytics, machine learning, intelligent decision making, and more professional services. The Internet of Things helps to design and develop intelligent healthcare solutions assisted by security, data analytics, and machine learning.This book will provide federated learning, Data-driven infrastructure design, analytical approaches, and technological solutions with case studies for smart healthcare. This book aims to attract works on multidisciplinary research spanning across computer science and engineering, environmental studies, services, urban planning and development, Healthcare, social sciences, and industrial engineering on technologies, case studies, novel approaches, and visionary ideas related to data-driven innovative learning and computing solutions and big medical data-powered applications to cope with the real-world challenges for building smart healthcare sectors. Main Features: O Immersive technologies in healthcare O Internet of medical things O Federated learning algorithms O Explainable AI in Pervasive Healthcare O New management principles using biomedical data O Secured healthcare management systems This book aims to set up a better understanding of data scientists, researchers, and technologists under innovative digital health. The reader can find out existing research challenges, current market trends, and low-cost technologies to smoothly address the digital health issue.

Osseoconductive Surface Engineering for Orthopedic Implants provides a comprehensive overview of the state of the art of osseointegration based on surface-mediated engineering. It offers a practical approach to the design and development of implant surface engineering, by reviewing and discussing the usability and efficacy of each processing technique. The reader can learn about the variety, characteristics, advantages, challenges, and optimum parameters for each process-enabling targeted selection of coatings and technologies to enhance long-term implant-bone integration.

An Introduction to Hypergeometric, Supertigonometric, and Superhyperbolic Functions gives a basic introduction to the newly established hypergeometric, supertrigonometric, and superhyperbolic functions from the special functions viewpoint. The special functions, such as the Euler Gamma function, the Euler Beta function, the Clausen hypergeometric series, and the Gauss hypergeometric have been successfully applied to describe the real-world phenomena that involve complex behaviors arising in mathematics, physics, chemistry, and engineering.

This book reviews the current knowledge on tunable hydrogels, including the range of different materials and applications, as well as the existing challenges and limitations in the field. It covers various aspects of the material design, particularly highlighting biological responsiveness, degradability and responsiveness to external stimuli. In this book, readers will discover original research data and state-of-the-art reviews in the area of hydrogel technology, with a specific focus on biotechnology and medicine. Written by leading experts, the contributions outline strategies for designing tunable hydrogels and offer a detailed evaluation of the physical and synthetic methods currently employed to achieve specific hydrogel properties and responsiveness. This highly informative book provides important theoretical and practical insights for scholars and researchers working with hydrogels for biomedical and biotechnological applications.

This book highlights emerging trends in terahertz engineering and system technologies, mainly, devices, advanced materials, and various applications in THz technology. It includes advanced topics such as terahertz biomedical imaging, pattern recognition and tomographic reconstruction for THz biomedical imaging by use of machine learning and artificial intelligence, THz imaging radars for autonomous vehicle applications, THZ imaging system for security and surveillance. It also discusses theoretical, experimental, established and validated empirical work on these topics and the intended audience is both academic and professional.

Biomaterials for Cancer Therapeutics: Evolution and Innovation, Second Edition, discusses the role and potential of biomaterials in treating this prevalent disease. The first part of the book discusses the fundamentals of biomaterials for cancer therapeutics. Part Two discusses synthetic vaccines, proteins and polymers for cancer therapeutics. Part Three focuses on theranosis and drug delivery systems, while the final set of chapters look at biomaterial therapies and cancer cell interaction. Cancer affects people of all ages, and approximately one in three people are estimated to be diagnosed with cancer during their lifetime. Extensive research is being undertaken by many different institutions to explore potential new therapeutics, and biomaterials technology is being developed to target, treat and prevent cancer. Hence, this book is a welcomed resource to the discussion.

Metal-Organic Frameworks for Biomedical Applications is a comprehensive, authoritative reference that offers a substantial and complete treatment of published results that have yet to be critically reviewed. It offers a summary of current research and provides in-depth understanding of the role of metal-organic frameworks in biomedical engineering. The title consists of twenty-two chapters presented by leading international researchers in the field. Chapters are arranged by target-application in biomedical engineering, allowing medical and pharmaceutic specialists to translate current materials and engineering science on metal-organic frameworks into their work.

This book covers the latest research development in heart valve biomechanics and bioengineering, with an emphasis on novel experimentation, computational simulation, and applications in heart valve bioengineering. The most current research accomplishments are covered in detail, including novel concepts in valvular viscoelasticity, fibril/molecular mechanisms of tissue behavior, fibril kinematics-based constitutive models, mechano-interaction of valvular interstitial and endothelial cells, biomechanical behavior of acellular valves and tissue engineered valves, novel bioreactor designs, biomechanics of transcatheter valves, and 3D heart valve printing. This is an ideal book for biomedical engineers, biomechanics, surgeons, clinicians, business managers in the biomedical industry, graduate and undergraduate students studying biomedical engineering, and medical students.

This book addresses essential principles of research according to the scientific method for medical imaging technology research. The scope of this book covers the nature of scientific research; quantitative and qualitative approaches essentials; research planning; literature review fundamentals; research methods; data collection, analysis, and interpretation; and communicating research findings. The book meets the educational requirements on Research Principles and Concepts (for entry to practice) of the following professional radiologic technology associations: the American Society of Radiologic Technologists (ASRT), the Canadian Association of Medical Radiation Technologists (CAMRT), the College of Radiographers in the United Kingdom, and radiography societies and associations in Asia, Australia, Europe, and Africa. This is an ideal book for radiologic technologists, nuclear medicine technologists, and radiation therapists seeking to get started in research in their profession. Additionally, biomedical imaging engineering technologists, radiologists, and medical imaging physicists may use this as a "guiding principles" textbook.

This book is the first of two volumes that offer a comprehensive, up-to-date account of current knowledge regarding high-density lipoprotein (HDL), the changes that occur in HDL under different conditions, the clinical applications of HDL, and means of enhancing HDL functionality. HDL comprises a diverse group of lipoproteins and its composition and metabolism are dynamic. In this volume, the focus is on the changes observed in HDL under different health statuses, with particular attention to the functional and structural correlations of HDL and apolipoprotein A-1. The impacts of a wide variety of factors on HDL are examined in depth, covering, for example, diet, exercise, smoking, age, diverse diseases, and different forms of environmental pollution. It has long been known that HDL has anti-atherosclerotic and antidiabetic properties, and more recently its anti-aging activities have been recognized. These benefits of HDL are highly dependent on its lipids, proteins, apolipoproteins, and enzymes, and specifically their composition and ratios. In documenting the latest knowledge in this field, this volume will be of interest to both researchers and clinicians.

This book examines the basic cellular and molecular mechanisms associated with aging. It comprehensively describes the genetic, epigenetic, biochemical and metabolic regulation of aging, as well as some important age-related diseases. Divided into two major sections, it takes readers through the various aspects of aging in a story-like manner and suggests various interventions for healthy aging, such as dietary restriction, regular exercise, nutrition and maintaining a balanced and a non-stressful lifestyle. It describes the implications of aging on the nervous system, metabolism, immunity and stem cells as well as care for the elderly. The book is an ideal companion for both new and established researchers in the field and is also useful for educators, clinicians and policy makers.

This book offers a snapshot of cutting-edge applications of digital phenotyping and mobile sensing for studying human behavior and planning innovative e-healthcare interventions. The respective chapters, written by authoritative researchers, cover both theoretical perspectives and good scientific and professional practices related to the use and development of these technologies. They share novel insights into established applications of mobile sensing, such as predicting personality or mental and behavioral health on the basis of smartphone usage patterns, and highlight emerging trends, such as the use of machine learning, big data and deep learning approaches, and the combination of mobile sensing with AI and expert systems. Important issues relating to privacy and ethics are analyzed, together with selected case studies. This thoroughly revised and extended second edition provides researchers and professionals with extensive information on the latest developments in the field of digital phenotyping and mobile sensing. It gives a special emphasis to trends in diagnostics systems and AI applications, suggesting important future directions for research in public health and social sciences.