This book summarizes the recent advancements for biomechanics of injury and prevention in mechanism, application and developing frontiers. Biomechanics plays an important role in achieving safety, health, comfort, and a high quality of life by revealing injury mechanism and providing prevention methods. The book covers injury and prevention to the entire human body, from head to toe, including injury and prevention in sports, traffic, accident, clinic and so on. In addition, bionics prevention method inspired by woodpecker is also introduced. The book provides the reader with not only the mechanism of injury but also the advanced injury diagnosis, treatment, and prevention devices based on biomechanics.

This book gathers revised and selected contributions to the 5th Dementia Lab Conference, D-Lab 2021, organized online on January 18-28, 2021, from the Emily Carr University of Art + Design, Vancouver, Canada. It describes original strategies in which design or creative methods have been shown to uncover, support and enhance the abilities of people living with dementia. Papers report on new ideas and findings relating to three main themes: engagement, empowerment and identity. They cover: ethics of inclusion and solutions for shifting the culture of care to be focused on both personal independence and reconnecting with the community; new ways of designing with people living with dementia; strategies for breaking negative stereotypes and preconceived opinions; and approaches to retaining personhood and dignity. Offering a timely source of information on new design and creative methods to a broad community of industrial, communication, interactive and inclusive designers, this book is also meant to address and inspire various stakeholders and organizations in dementia care.

Managing Medical Devices within a Regulatory Framework helps administrators, designers, manufacturers, clinical engineers, and biomedical support staff to navigate worldwide regulation, carefully consider the parameters for medical equipment patient safety, anticipate problems with equipment, and efficiently manage medical device acquisition budgets throughout the total product life cycle. This contributed book contains perspectives from industry professionals and academics providing a comprehensive look at health technology management (HTM) best practices for medical records management, interoperability between and among devices outside of healthcare, and the dynamics of implementation of new devices. Various chapters advise on how to achieve patient confidentiality compliance for medical devices and their software, discuss legal issues surrounding device use in the hospital environment of care, the impact of device failures on patient safety, methods to advance skillsets for HTM professionals, and resources to assess digital technology. The authors bring forth relevant challenges and demonstrate how management can foster increased clinical and non-clinical collaboration to enhance patient outcomes and the bottom line by translating the regulatory impact on operational requirements.

The surge in COVID-19 cases leading to hospitalizations around the world quickly depleted hospital resources and reserves, forcing physicians to make extremely difficult life-or-death decisions on ventilator allocation between patients. Leaders in academia and industry have developed numerous ventilator support systems using both consumer- and industry-grade hardware to sustain life and to provide intermediate respiratory relief for hospitalized patients. This book is the first of its kind to discuss the respiratory pathophysiology underlying COVID-19, explain ventilator mechanics, provide and evaluate a repository of innovative ventilator support devices conceived amid the pandemic, and explain both hardware and software components necessary to develop an inexpensive ventilator support device. This book serves both as a historical record of the collaborative and innovative response to the anticipated ventilator shortage during the COVID-19 pandemic and as a guide for physicians, engineers, and DIY'ers interested in developing inexpensive transitory ventilator support devices.

This book aims to highlight the latest achievements in the use of AI and multimodal artificial intelligence in biomedicine and healthcare. Multimodal AI is a relatively new concept in AI, in which different types of data (e.g. text, image, video, audio, and numerical data) are collected, integrated, and processed through a series of intelligence processing algorithms to improve performance. The edited volume contains selected papers presented at the 2022 Health Intelligence workshop and the associated Data Hackathon/Challenge, co-located with the Thirty-Sixth Association for the Advancement of Artificial Intelligence (AAAI) conference, and presents an overview of the issues, challenges, and potentials in the field, along with new research results. This book provides information for researchers, students, industry professionals, clinicians, and public health agencies interested in the applications of AI and Multimodal AI in public health and medicine.

Optical Coherence Tomography represents the ultimate noninvasive ocular imaging technique although being in the field for over two-decades. This book encompasses both medical and technical developments and recent achievements. Here, the authors cover the field of application from the anterior to the posterior ocular segments (Part I) and present a comprehensive review on the development of OCT. Important developments towards clinical applications are covered in Part II, ranging from the adaptive optics to the integration on a slit-lamp, and passing through new structural and functional information extraction from OCT data. The book is intended to be informative, coherent and comprehensive for both the medical and technical communities and aims at easing the communication between the two fields and bridging the gap between the two scientific communities.

This volume contains the papers of the 1st Workshop IFToMM for Sustainable Development Goals (I4SDG), held online on November 25-26, 2021. The main topics of the workshop include the aspects of theory, design and practice of mechanism and machine science which are instrumental in reaching a sustainable development, such as: biomechanical engineering, sustainable energy systems, robotics and mechatronics, green tribology, computational kinematics, dynamics of machinery, industrial applications of mechanism design, gearing and transmissions, multibody dynamics rotor dynamics, vibrations, humanitarian engineering, and socio-technical systems for sustainable and inclusive development. The contributions, which were selected by means of a rigorous international peer-review process, highlight numerous exciting ideas that will spur novel research directions and foster multidisciplinary collaboration among different specialists, demonstrating that medical and service robotics will drive the technological and societal change in the coming decades.

This book presents the state of the art of Internet of Things (IoT) from the perspective of healthcare and Ambient Assisted Living (AAL). It discusses the emerging technologies in healthcare services used for healthcare professionals and patients for enhanced living environments and public health. The topics covered in this book include emerging eHealth IoT applications, Internet of Medical Things, health sensors, and wearable sensors for pervasive and personalized healthcare, and smart homes applications for enhanced health and well-being. The book also presents various ideas for the design and development of IoT solutions for healthcare and AAL. It will be useful for bioengineers and professionals working in the areas of healthcare as well as health informatics.

This volume gives an overview on recent developments for various applications of modern engineering design. Different engineering disciplines such as mechanical, materials, computer and process engineering provide the foundation for the design and development of improved structures, materials and processes. The modern design cycle is characterized by an interaction of different disciplines and a strong shift to computer-based approaches where only a few experiments are performed for verification purposes. A major driver for this development is the increased demand for cost reduction, which is also connected to environmental demands. In the transportation industry (e.g. automotive or aerospace), this is connected with the demand for higher fuel efficiency, which is related to the operational costs and the lower harm for the environment. One way to fulfil such requirements are lighter structures and/or improved processes for energy conversion. Another emerging area is the interaction of classical engineering with the health and medical sector. In this book, many examples of the mentioned design applications are presented.

In this edited book, we highlight the central players in the Bionanotechnology field, which are the nanostructures and biomolecules. The book starts by describing how nanostructures are synthesized and by describing the wide variety of nanostructures available for biological research and applications. Also shown are the techniques used to synthesize a wide variety of biological molecules. Next, there is a focus on the assembly of nanostructures with biological molecules, which could lead to the design of multi-functional nanosystems. In the following chapters, examples of the unique properties of nanostructures are provided along with the current applications of these nanostructures in biology and medicine. Some applications include the use of gold nanoparticles in diagnostic applications, quantum dots and silica nanoparticles for imaging, and liposomes for drug delivery. In the final chapters of the book, the toxicity of nanostructures are described. This book provides broad examples of current developments in Bionanotechnology research and would be an excellent introduction to the field.

The rapid urbanization and industrialization of developing countries across the globe have necessitated for substantial resource utilization and development in the areas of Healthcare, Environment, and Renewable energy. In this context ,this resourceful book serves as a definitive source of information for the recent developments in application of microbial enzymes in various sectors. It covers applications in fermentation processes and their products, extraction and utilisation of enzymes from various sources and their application in health and biomass conversion for production of value added products. Different chapters discuss various areas of bioprospecting in enzyme technology, and describe why these are the mainstays for industrial production of value added products. The rich compilation of the cutting-edge advances and applications of the modern industrial based techniques hold feasible solutions for a range of current issues in enzyme technology. This book will be of particular interest for scientists, academicians, technical resource persons, engineers and members of industry. Undergraduate and graduate students pursuing courses in the area of industrial biotechnology will find the information in the book valuable. General readers having interest towards biofuels, enzyme technology, fermented food and value added products, phytochemicals and phytopharmaceutical products will also find the book appealing. Readers will discover modern concepts of enzymatic bioprocess technology for production of therapeutics and industrial value added products.

This book covers some fundamental aspects and frontiers in non-equilibrium physics and soft matter research. Apart from the basic knowledge on nonlinear statistic physics, dynamics, computer simulations, and main approaches and emerging systems in soft matter research, particular attention is devoted to new conceptual flexible functional materials and the enriching areas, such as silk meso-molecular materials, molecular gels, liquid crystals, flexible electronics and new types of catalysis, etc. One of the main characteristics of this book is to start with the structure formation dynamics and the correlation between the structures and macroscopic performance. This lays down the foundation for the mesoscopic materials design and functionalization. The book is intended for upper undergraduate students, graduate students, and researchers who are interested in soft matter researches. As one of main references, the basic principles and technologies of computer simulations and experimental methods adopted in soft matter research are also explained. Illustrations and tables are included in this book to improve the readability, and examples and exercises are added to help understanding.

SERS for Point-of-care and Clinical Applications focuses on the use of Surface-Enhanced Raman Spectroscopy (also known as Surface-Enhanced Raman Scattering) techniques in clinical and point-of-care settings. Sections provide an overview of SERS biomedical applications, providing in-depth information about point-of-care and clinical applications of SERS using specific examples from current literature. These applications are not always immediately evident to newcomers in the field, as Raman and SERS are often introduced as analytical methods for chemical analysis. This book offers a concise introduction to the biomedical applications of SERS for graduate students, scientists and researchers in all related fields.

This contributed volume reviews the latest advances in all the new technologies currently developed for MagnetoEncephaloGraphy (MEG) recordings, as well as sensor technologies and integrated sensor arrays for on-scalp MEG. The book gives an account of the first MEG imaging studies and explores the new field of feasible, experimental paradigms of on-scalp MEG. This is an ideal book for engineers, researchers, and students in the neurosciences interested in MEG imaging.

This book addresses instruments, methodologies and diagnostic methods used to evaluate and diagnose human movement, locomotion and physical status in general. Starting from historical perspective, the idea of understanding human locomotion by applying technical measurement devices and incorporating measurement data into physical representation of gross body movement is presented and explained, an approach known as inverse dynamics. With this approach as a kind of umbrella concept, components of measurement systems including relevant signal and data processing methods are described. Modern instruments to capture body movement by measuring its kinematics, kinetics and surface electromyography (sEMG) are thus described; all systems being used dominantly-if not exclusively-in a movement analysis laboratory setting. Focusing mainly on human posture and gait, but including also examples of movement patterns from selected kinesiological and sports activities, the book attempts to present essentials of biomechanics and biomedical engineering approach to this subject matter. It illustrates how data collected and elaborated by modern engineering technology can complement traditional expert knowledge of a kinesiologist or a medical doctor. The book is applicable in the fields of sports, physical activities, as well as in medical diagnostics and rehabilitation. The examples of this book's practical application might be in evaluation of efficiency of human gait, in evaluation of skeletal muscle fatigue in physical exercise, in biomechanical diagnostics of traumatological conditions requiring orthopaedic treatment and the like. This book can also be used in planning and executing research endeavours, particularly in a clinical context as a reference for various diagnostics procedures. It presents the lecture notes of a course carrying the same name within Medical Studies in English at the University of Zagreb for more than a decade.

The COVID-19 pandemic that started in 2019-2020 has led to a gigantic increase in modeling and simulation of infectious diseases. There are numerous topics associated with this epoch-changing event, such as (a) disease propagation, (b) transmission, (c) decontamination, and (d) vaccines. This is an evolving field. The targeted objective of this book is to expose researchers to key topics in this area, in a very concise manner. The topics selected for discussion have evolved with the progression of the pandemic. Beyond the introductory chapter on basic mathematics, optimization, and machine learning, the book covers four themes in modeling and simulation infectious diseases, specifically: Part 1: Macroscale disease propagation, Part 2: Microscale disease transmission and ventilation system design, Part 3: Ultraviolet viral decontamination, and Part 4: Vaccine design and immune response. It is important to emphasize that the rapid speed at which the simulations operate makes the presented computational tools easily deployable as digital twins, i.e., digital replicas of complex systems that can be inexpensively and safely optimized in a virtual setting and then used in the physical world afterward, thus reducing the costs of experiments and also accelerating development of new technologies.

Interactions of Bone with Orthopedic Implants and Possible Failures focuses on the mechanical and biological issues that may cause failure of the implant-bone construct. The book provides discussions on the effects of the design, process, surface and other engineering parameters of implants and their interaction with bone tissue. For implant designers, it is highly crucial to know the final effects of what they are designing or aiming to design, along with performance parameters. It is also crucial for orthopedic surgeons to be familiar with the background of the design and process parameters of the implant they will insert in a patient's body. With the understanding brought forth in this book, surgeons can have better implant options and implant designers can create and develop new implant designs. This book can also help biomechanical and mechanical engineers who are normally dealing with testing and analysis of orthopedic implants examine the biomechanical behavior of the implants and their interaction with bone tissue.

This book reports on the state of the art in the field of aerial-aquatic locomotion, focusing on the main challenges concerning the translation of this important ability from nature to synthetic systems, and describing innovative engineering solutions that have been applied in practice by the authors at the Aerial Robotics Lab of Imperial College London. After a general introduction to aerial-aquatic locomotion in nature, and a summary of the most important engineering achievements, the book introduces readers to important physical and mathematical aspects of the multimodal locomotion problem. Besides the basic physics involved in aerial-aquatic locomotion, the role of different phenomena happening in fluids, or those due to structural mechanics effects or to power provision, are presented in depth, across a large dimension range, from millimeters to hundreds of meters. In turn, a practice-oriented discussion on the obstacles and opportunities of miniaturization, for both robots and animals is carried out. This is followed by applied engineering considerations, which describe relevant hardware considerations involved in propulsion, control, communication and fabrication. Different case studies are analyzed in detail, reporting on the latest research carried out by the authors, and covering topics such as propulsive aquatic escape, the challenging mechanics of water impact, and a hybrid sailing and flying aircraft. Offering extensive and timely information on the design, construction and operation of small-scale robots, and on multimodal locomotion, this book provides researchers, students and professionals with a comprehensive and timely reference guide to the topic of aerial-aquatic locomotion, and the relevant bioinspired approaches. It is also expected to inspire future research and foster a stronger multidisciplinary discussion in the field.

This textbook explores the fundamental qualitative and quantitative aspects of human physiology. It approaches biological and physiological processes and phenomena from a quantitative perspective, revealing how physiological problems can be mathematically formulated starting from simple laws of physics. The book addresses a broad range of topics, including: the statics and dynamics of circulation; muscle and sarcomere force-length and force-velocity relations, together with their mechanisms and functional consequences; subdivisions and meaning of the heat produced by muscle; locomotion, statics and dynamics of respiration; diffusion of gases and acid base equilibrium; phonation; general functions of the kidney and of the different sections of the nephron; changes in clearance with a substance's plasmatic concentration; pH regulation and the kidney; Donnan's equilibrium and its consequences; and the Nernst equation. The book offers the ideal learning resource for students of human physiology courses in medicine and biomedicine, as well as biomedical engineering and biophysics graduate students. An elementary grasp of mathematics and physics is sufficient to understand the content.

This book delves into the field of immobilizing biologically active and non-active molecules. It discusses the designing strategy of immobilization and the current state-of-the-art applications for advancing biomedical, agricultural, environmental and industrial practices. It focuses on aspects ranging from fundamental principles to current technological advances at multi-scale levels (macro, micro, and nano) which are suitable for cell, enzyme, and nano-catalyst based applications. Written by experts from across the globe, the contents deal with illustrated examples of molecular and cellular interactions with materials/scaffolds and discussions on factors that can affect the functionality and yield of the process. With its discussions on material science, design of delivery vehicles, separation science, additive manufacturing, agriculture and environmental science, this book will be a useful reference for researchers across multiple disciplines.

The 4th World Congress on Genetics, Geriatrics and Neurodegenerative Diseases Research (GeNeDis 2020) focuses on the latest major challenges in scientific research, new drug targets, the development of novel biomarkers, new imaging techniques, novel protocols for early diagnosis of neurodegenerative diseases, and several other scientific advances, with the aim of better, safer, and healthier aging. Computational methodologies for implementation on the discovery of biomarkers for neurodegenerative diseases are extensively discussed. This volume focuses on the sessions from the conference regarding computational biology and bioinformatics.

The future of gene editing in humans will involve the use of CRISPR. How we think about the combination of the scientific, ethical, and moral aspects of this technology is paramount to the success or failure of CRISPR in humans. Unfortunately, the current scientific discussion around CRISPR in humans has left ethics trailing behind due to the rapid pace of innovation. New modes of ethics and stakeholder participation are needed to keep pace with rapid scientific advances and provide the necessary policy and ethical frameworks necessary to help CRISPR flourish as an important health care tool to treat human disease. This requires intense interdisciplinary collaboration and discussion between scientists and philosophers, policymakers and legal scholars, and the public. Dr. Michael W. Nestor (a neuroscientist who actively uses CRISPR in pre-clinical research) and Professor Richard Wilson (a philosopher who focuses on anticipatory ethics) set out to develop a new ethical approach considering the use of CRISPR in human targeted therapies. The field of anticipatory ethics is uniquely poised to tackle questions in fast-evolving technical areas where the pace of innovation outstrips traditional philosophical approaches. Furthermore, because of its "anticipatory" nature, this type of analysis provides the opportunity to look ahead and into the future concerning potential uses of CRISPR in humans, uses that are not currently possible. Nestor and Wilson collaborate both scientifically and philosophically in this book to forecast potential outcomes as the scientific and medical community goes beyond using CRISPR to correct genes that underlie diseases where a single gene is involved. Instead, Nestor and Wilson envision CRISPR in complex, multigenic disorders with a specific focus on the use of CRISPR to edit genes involved in mental traits like IQ or other cognitive characteristics. They argue that the use of CRISPR to modify genes that are potentially important for mental traits represents a particular category for special consideration from scientists, policymakers, the public, and other stakeholders. Nestor and Wilson explain why using CRISPR to alter mental states is very different from treating a disease like cancer by combining the latest scientific advancements with anticipatory ethics and philosophical phenomenology. Their analysis considers the role that mental states play in personhood and the lived experience-as genes that can change mental/cognitive attributes like IQ have wide-ranging effects on the lived experience in ways that are categorically different from other attributes. This book was written to set a non-exhaustive framework for shared understanding and discussion across disciplines and appeal to scientists and non-scientists alike. This appeal is made inclusively, inviting all stakeholders to engage in active dialogue about the appropriate context for using CRISPR and other gene-editing technologies in humans. It provides policy analysis and recommendations for assuring the most inclusive, equitable, and ethically sound use of CRISPR in humans, concerning its positive potential to treat mental conditions like depression, schizophrenia, Alzheimer's disease, autism, and the potential to induce other cognitive enhancements.

This book addresses emerging questions concerning who should bear responsibility for shouldering risk, as well as the viability of existing and experimental governance mechanisms in connection with new technologies. Scholars from 14 jurisdictions unite their efforts in this edited collection to provide a comparative analysis of how various legal systems are tackling the challenges produced by the legal aspects of genetic testing in insurance and employment. They cover the diverse set of norms that surround this issue, and share insights into relevant international, regional and national incursions into the field. By doing so, the authors offer a basis for comparative reflection, including on whether transnational standard setting might be useful or necessary for the legal aspects of genetic testing as they relate to the insurance and employment contexts. The respective texts cover a broad range of topics, including the prevalence of genetic testing in the contexts of insurance and employment, and policy factors that might affect this prevalence, such as the design of national health or social insurance systems, of private insurance schemes or the availability of low-cost direct-to-consumer genetic testing. Further, the field of genetics is gaining in importance at the international and regional levels. Relevant concepts - mainly genetic tests and genetic data/information - have been internationally defined, and these definitions have influenced definitions adopted nationally. International law also recognizes a "special status" for human genetic data. The authors therefore also consider these definitions and the recognition of the special status of human genetic data within regional and national legal orders. They investigate the range of norms that specifically address the use of genetic testing in employment and insurance, encompassing international sources - including human rights norms - that may be binding or non-binding, as well national statutory, regulatory and soft-law mechanisms. Accordingly, some of the texts examine general frameworks relevant to genetic testing in each country, including those that stem from general anti-discrimination rules and norms protecting rights to autonomy, self-determination, confidentiality and privacy. In closing, the authors provide an overview of the efficiency of their respective legal regimes' approaches - specific and generalist - to genetic testing or disclosure of genetic information in the employment or insurance contexts, including the effect of lack of legal guidance. In this regard, some of the authors highlight the need for transnational action in the field and make recommendation for future legal developments.

This book covers virtually all aspects of image formation in medical imaging, including systems based on ionizing radiation (x-rays, gamma rays) and non-ionizing techniques (ultrasound, optical, thermal, magnetic resonance, and magnetic particle imaging) alike. In addition, it discusses the development and application of computer-aided detection and diagnosis (CAD) systems in medical imaging. Also there will be a special track on computer-aided diagnosis on COVID-19 by CT and X-rays images. Given its coverage, the book provides both a forum and valuable resource for researchers involved in image formation, experimental methods, image performance, segmentation, pattern recognition, feature extraction, classifier design, machine learning / deep learning, radiomics, CAD workstation design, human-computer interaction, databases, and performance evaluation.