This book provides readers with an introduction to the materials and devices necessary for flexible sensors and electronics, followed by common techniques for fabrication of such devices and system-level integration. Key insights into fabrication and processing will guide readers through the tradeoff choices in designing such platforms. A comprehensive review of two specific, flexible bioelectronic platforms, related to smart bandages for wound monitoring and thread-based diagnostics for wearable health, will demonstrate practical application at the system level. The book also provides a unique electrical engineering perspective by reviewing circuit architectures for low noise signal conditioning of weak signals from sensors,, and for low power analog to digital converters for signal acquisition. To achieve energy autonomy, authors provide several example of CMOS energy harvesting front end circuits and voltage boosters. Beyond circuit architectures, the book also provides a review of the modern theory of sampling and recovery of sparse signals, also known as compressed sensing. They then highlight how these principles can be leveraged for design and implementation of efficient signal acquisition hardware and reliable processing of acquired data for flexible electronic platforms.

Presents recent developments in sustainable materials from various engineering fields and industry applications. Emphasizes analytical strategies, computational, and simulation approaches develop innovative sustainable materials. Discusses an artificial intelligence approach, rapid prototyping, and customized production. Chapters are written by global experts. Includes case studies and research outcomes.

This book presents select proceedings of the International Conference on Future Learning Aspects of Mechanical Engineering (FLAME 2018). The book discusses interdisciplinary areas such as automobile engineering, mechatronics, applied and structural mechanics, bio-mechanics, biomedical instrumentation, ergonomics, biodynamic modeling, nuclear engineering, agriculture engineering, and farm machineries. The contents of the book will benefit both researchers and professionals.

This volume comprises the latest developments in both fundamental science and patient-specific applications, discussing topics such as: cellular mechanics, injury biomechanics, biomechanics of the heart and vascular system, algorithms of computational biomechanics for medical image analysis, and both patient-specific fluid dynamics and solid mechanics simulations. With contributions from researchers world-wide, Computational Biomechanics for Medicine: Measurments, Models, and Predictions provides an opportunity for specialists in the field to present their latest methodologies and advancements.

* Covers topics such as fundamentals of sensors and their working principles * Details recent materials and technologies used for flexible and wearable sensors * Covers emerging applications

This book discusses applications of pluripotent stem cells to study eye disease in vitro and to create novel therapies for degenerative eye diseases. Chapters are contributed by experts in the field and cover such topics as the use of pluripotent stem cells in 2D and 3D engineering of ocular tissues for disease modelling and drug testing as well as approaches to replace degenerated RPE and photoreceptors in macular degeneration and retinitis pigmentosa. Pluripotent Stem Cells in Eye Disease Therapy presents a comprehensive discussion of basic science and clinical applications and is an indispensable resource for everyone from advanced graduate students to advanced professionals who want to learn about the potential of stem cell biology and its role in the field of retinal diseases.

In 2019 the world was struck with the Coronavirus (COVID-19) infecting major portions of the world's population. There were no vaccines or treatments available to help mitigate the disease or offer a cure. The world's health systems were inundated with massive numbers of patients with varying ranges of symptoms, acuity, and levels of criticality. The world's healthcare organizations soon found themselves in an unmanageable situation, directly impacting the ability to manage patients across the entire healthcare environment. Most healthcare institutions had plans for emergency preparedness and procedures to deal with temporary crises, none of which were effective against the impact of COVID-19. COVID-19 was a highly contagious disease, resulting in high volumes of admissions with long lengths of stay. The virus quickly overwhelmed institutions with large patient volumes, resulting in shortages of patient beds, medical equipment, personal protective devices, cleaning agents, and other critical supplies. Hospital operations were further impacted by staff shortages due to exposure, resulting contagion, the shutdown of transit systems, and responsibilities at home due to school and business closures. This timely and important book describes the impact on the hospital ability to provide patient care and how healthcare institutions leveraged diverse technology solutions to combat the impact of COVID-19 on providing patient care. The authors also discuss implementation of these technology solutions and the many lessons learned of how healthcare institutions can enhance their emergency preparedness in the future from the COVID experience. The authors would like to acknowledge, thank, and dedicate this book to the hundreds of thousands of healthcare workers around the world who spent countless hours and put their own lives and families lives at risk to help patients though this pandemic.

This book covers various aspects of cancer chemoprevention, including an overview of chemoprevention in the process of tumorigenesis; the roles of various phytochemicals, functional foods, and dietary interventions in disease prevention; and techniques such as cancer stem cell targeting, nano-formulations, and so forth. The nutrigenomic and epigenetic effects of natural products at the molecular and genetic levels are also covered alongside their potential for additive and synergistic effect, as well as overcoming drug resistance. The key selling features of the book are as follows: Discusses holistic and comprehensive areas of chemoprevention Includes diverse techniques, such as cancer stem cell targeting, nano-formulations, and nanotechnology-based drug delivery systems Introduces various mechanisms involved in prevention of the diseases, including targeting cancer stem cells Reviews various aspects which can reduce the toxicity and cost of treatment of diseases by alternative medicine Explores various sources, mechanisms, and ways to develop cancer chemopreventive agents with minimal toxicity compared to traditional cancer therapy drugs This book is focused on researchers and graduate students in drug delivery and formulation, nanobiotechnology, cancer chemoprevention, prevention, and therapeutics.

Focuses on the Internet of Healthcare Things and innovative solutions developed for use in the application of healthcare services Discusses artificial intelligence applications, experiments, core concepts, and cutting-edge themes Demonstrates new approaches to analysing medical data and identifying ailments using AI to improve overall quality of life Introduces fundamental concepts for designing the Internet of Healthcare Things solutions Includes pertinent case studies and applications

Bioelectromagnetics in Healthcare: Advanced sensing and communication applications is a collection of twelve invited chapters from international experts from the UK, Japan, Switzerland, and the United States of America. The book forms a cohesive architecture that covers the state-of-the-art in terms of sensing and communications with relevance to bioelectromagnetics in healthcare. The book provides a valuable insight into the current and future possibilities where electromagnetics engineers will need to keep improving radiofrequency device performance in terms of better efficiency, greater sensitivity, reduced unintended power absorption by the body, smaller size, and lower power consumption. Topics covered include dielectric measurements, dosimetry for bioelectromagnetics, phantom recipes for implanted and wearable antenna applications, antennas for implants, electromagnetic coupling in biological media, electromagnetic resonators and metamaterials-based structures for chemical and biological sensing in body-centric wireless applications, bone fracture monitoring using implanted antennas, wearable antennas for sensing, epidermal and conformal electronics, radar for healthcare technology, therapeutic applications of electromagnetic waves, and optoelectronic sensing of physiological monitoring. The book is aimed at electromagnetics engineers and advanced students in electromagnetics working on healthcare and medical applications.

This book is the first comprehensive overview of the emerging field of cuffless blood pressure monitoring. Increasing clinical evidence proves that longitudinal measurements of blood pressure allow for earlier detection and better management of multiple medical conditions and for superior prediction of cardiovascular events. Unfortunately, today's clinical and industry standards for blood pressure monitoring still require the inflation of a pneumatic cuff around a limb each time a measurement is taken. Over the last decades clinicians, scientists and device manufacturers have explored the feasibility of technologies that reduce or even completely eliminate the need of cuffs, initiating the era of cuffless blood pressure monitoring. Among the existing literature, this book is intended to be a practical guide to navigate across this emerging field. The chapters of the handbook have been elaborated by experts and key opinion leaders in the domain, and will guide the reader along the clinical, scientific, technical, and regulatory aspects of cuffless blood pressure monitoring.

This book is based on the best contributions to the advancement of bioimpedance knowledge and use from the Latin American Congress series, CLABIO. Basic bioimpedance facts as well as promising and original contributions to bioimpedance theory and applications are presented, giving the reader stimulating material for reflection, decision making, and further experiments. Contributions come from a diverse international pool of experts and address topics on electrode and skin impedance modelling, tomography, spectroscopy, instrumentation, and clinical applications.

In this work, an international panel of RNAi experts critically reviews the most interesting advances in basic applied RNAi research, highlighting the applications in RNAi-based therapies and discussing the technical hurdles that remain.

This book provides an overview of biocomposite chemistry, chemical modifications, characterization and applications in biomedicine, with emphasis on recent advances in the field. Authored by experts, the chapters discuss the design, development and selection of biomedical composites for a particular therapeutic application, as well as providing insight into the regulatory and clinical aspects of biomedical composite use. While this book is primarily intended for scientists from the fields of medical, pharmaceutical, biotechnological and biomedical engineering, it is also useful as an advanced text for students and research scholars.

This book reviews the potential of next-generation point-of-care diagnosis in healthcare. It also discusses the printed chip-based assay (Lab-on-a-Chip, Lab-on-a-PCB) for rapid, inexpensive biomarkers detection. The book presents the development of sensory systems based on the use of nanomaterials. It examines different biosensors for medical diagnosis using surface modification strategies of transducers. It presents electrochemical concepts based on different nanobiomaterials and nanocomposites for cancer theranostics. Notably, the book examines the recent advances in wearable, cost-effective hemodynamic sensors to detect diseases at an early stage. It further explores the combination of redox cycling and electrochemical detection to develop ultrasensitive and reproducible biosensors for point-of-care testing. Finally, the book summarizes the significant challenges in the point of care diagnostics and its future opportunities in healthcare.

Bioelectronics is emerging as a new area of research where electronics can selectively detect, record, and monitor physiological signals. This is a rapidly expanding area of medical research, that relies heavily on multidisciplinary technology development and cutting-edge research in chemical, biological, engineering, and physical science. This book provides extensive information on the (i) fundamental concepts of bioelectronics, (ii) materials for the developments of bioelectronics such as implantable electronics, self-powered devices, bioelectronic sensors, flexible bioelectronics, etc, and (iii) an overview of the trends and gathering of the latest bioelectronic progress. This book will broaden our knowledge about newer technologies and processes used in bioelectronics.

Presents the state of the art in conductive composite materials and their application in flexible strain sensors Uniquely combines the processing, structure, properties, and applications of conductive polymer composites Integrates theory and practice Benefits plastics converters who wish to take full advantage of the potential of conductive plastic materials

Explains theory and practical applications of nanomaterials as antiviral agents Reviews upscaling of nanomaterials from laboratory to fabrication stage Illustrates nanocurcumin, silver nanoparticles, and carbon nanoparticles for biomedical applications Highlights role of nanotechnology in effectively combating viral infections and pandemics Includes case studies of specific pharma companies

This book offers a timely review of modern technologies for health, with a special emphasis on wireless and wearable technologies, GIS tools and machine learning methods for managing the impacts of pandemics. It describes new strategies for forecasting evolution of pandemics, optimizing contract tracing, and for detection and diagnosis of diseases, among others. Written by researchers and professionals with different backgrounds, this book offers a extensive information and a source of inspiration for physiologists, engineers, IT scientists and policy makers in the health and technology sector.

This book offers a much-needed discussion on the targeting of biofilm-related infections. Chapters include discussions on the impact of biofilm on medical implants, industrial applications, as well as wound and tissue infections. It also offers discussions on regulatory management for industrial sectors and medical environments. Given that there continues to be a paucity of effective antimicrobial products, devices, and coatings in clinical and industrial use that effectively reduce rates of infection or biofilm-related problems, Targeting Biofilms in Translational Research, Device Development, and Industrial Sectors, offers a fresh and much-needed perspective aimed at helping create healthier controlled environments and safer devices. This comprehensive book is indispensable for industrial and academic translational researchers, device developers, and regulatory experts looking to create more effective antimicrobial products.

This book provides a thorough overview of cutting-edge research on electronics applications relevant to industry, the environment, and society at large. It covers a broad spectrum of application domains, from automotive to space and from health to security, while devoting special attention to the use of embedded devices and sensors for imaging, communication and control. The book is based on the 2017 ApplePies Conference, held in Rome, Italy in September 2017, which brought together researchers and stakeholders to consider the most significant current trends in the field of applied electronics and to debate visions for the future. Areas addressed by the conference included information communication technology; biotechnology and biomedical imaging; space; secure, clean and efficient energy; the environment; and smart, green and integrated transport. As electronics technology continues to develop apace, constantly meeting previously unthinkable targets, further attention needs to be directed toward the electronics applications and the development of systems that facilitate human activities. This book, written by industrial and academic professionals, represents a valuable contribution in this endeavor.

This is the second volume of the comprehensive, two-volume work on oxidative stress in lung diseases. Adopting a multidisciplinary approach, it demonstrates the cellular and molecular mechanisms associated with ROS (reactive oxygen species)-induced initiation and progression of a variety of lung diseases, such as COPD, emphysema, asthma, cystic fibrosis, occupational pulmonary diseases and pulmonary hypertension and discusses points for therapeutic intervention. The book also covers translational research and the latest research on prevention and therapeutics. Each chapter includes in-depth insights into the mechanisms associated with lung diseases and into identifying targets for drug development. Bridging the gap between fundamental and translational research, and examining applications in the biomedical and pharmaceutical industry, it is a thought- provoking read for basic and applied scientists engaged in biomedical research.

This book provides a guiding thread between the distant fields of fluid mechanics and clinical cardiology. Well rooted in the science of fluid dynamics, it drives the reader across progressively more realistic scenarios up to the complexity of routine medical applications. Based on the author's 25 years of collaborations with cardiologists, it helps engineers learn communicating with clinicians, yet maintaining the rigor of scientific disciplines. This book starts with a description of the fundamental elements of fluid dynamics in large blood vessels. This is achieved by introducing a rigorous physical background accompanied by examples applied to the circulation, and by presenting classic and recent results related to the application of fluid dynamics to the cardiovascular physiology. It then explores more advanced topics for a physics-based understanding of phenomena effectively encountered in clinical cardiology. It stands as an ideal learning resource for physicists and engineers working in cardiovascular fluid dynamics, industry engineers working on biomedical/cardiovascular technology, and students in bio-fluid dynamics. Written with a concise style, this textbook is accessible to a broad readership, including students, physical scientists and engineers, offering an entry point into this multi-disciplinary field. It includes key concepts exemplified by illustrations using cutting-edge imaging, references to modelling and measurement technologies, and includes unique original insights.

This book reports on advanced topics in the areas of wearable robotics research and practice. It focuses on new technologies, including neural interfaces, soft wearable robots, sensors and actuators technologies, discussing industrially and medically-relevant issues, as well as legal and ethical aspects. It covers exemplary case studies highlighting challenges related to the implementation of wearable robots for different purposes, and describing advanced solutions. Based on the 5th International Symposium on Wearable Robotics, WeRob2020, and on WearRacon Europe 2020, which were both held online on October 13-16, 2020, the book addresses a large audience of academics and professionals working in for the government, in the industry, and in medical centers, as well as end-users alike. By merging together engineering, medical, ethical and industrial perspectives, it offers a multidisciplinary, timely snapshot of the field of wearable technologies.

Thanks to their unique properties, chitosan and chitosan-based materials have numerous applications in the field of biomedicine, especially in drug delivery. This book examines biomedical applications of functional chitosan, exploring the various functions and applications in the development of chitosan-based biomaterials. It also describes the chemical structure of chitosan and discusses the relationship between their structure and functions, providing a theoretical basis for the design of biomaterials. Lastly, it reviews chemically modified and composite materials of chitin and chitosan derivatives for biomedical applications, such as tissue engineering, nanomedicine, drug delivery, and gene delivery.