This textbook introduces the concepts and tools that biomedical and chemical engineering students need to know in order to translate engineering problems into a numerical representation using scientific fundamentals. Modeling concepts focus on problems that are directly related to biomedical and chemical engineering. A variety of computational tools are presented, including MATLAB, Excel, Mathcad, and COMSOL, and a brief introduction to each tool is accompanied by multiple computer lab experiences. The numerical methods covered are basic linear algebra and basic statistics, and traditional methods like Newton's method, Euler Integration, and trapezoidal integration. The book presents the reader with numerous examples and worked problems, and practice problems are included at the end of each chapter.

This book explains theoretical and technological aspects of amorphous drug formulations. It is intended for all those wishing to increase their knowledge in the field of amorphous pharmaceuticals. Conversion of crystalline material into the amorphous state, as described in this book, is a way to overcome limited water solubility of drug formulations, in this way enhancing the chemical activity and bioavailability inside the body. Written by experts from various fields and backgrounds, the book introduces to fundamental physical aspects (explaining differences between the ordered and the disordered solid states, the enhancement of solubility resulting from drugs amorphization, physical instability and how it can be overcome) as well as preparation and formulation procedures to produce and stabilize amorphous pharmaceuticals. Readers will thus gain a well-funded understanding and find a multi-faceted discussion of the properties and advantages of amorphous drugs and of the challenges in producing and stabilizing them. The book is an ideal source of information for researchers and students as well as professionals engaged in research and development of amorphous pharmaceutical products.

Foundations of Biomaterials Engineering provides readers with an introduction to biomaterials engineering. With a strong focus on the essentials of materials science, the book also examines the physiological mechanisms of defense and repair, tissue engineering and the basics of biotechnology. An introductory section covers materials, their properties, processing and engineering methods. The second section, dedicated to Biomaterials and Biocompatibility, deals with issues related to the use and application of the various classes of materials in the biomedical field, particularly within the human body, the mechanisms underlying the physiological processes of defense and repair, and the phenomenology of the interaction between the biological environment and biomaterials. The last part of the book addresses two areas of growing importance: Tissue Engineering and Biotechnology. This book is a valuable resource for researchers, students and all those looking for a comprehensive and concise introduction to biomaterials engineering.

Intelligent Data Analysis for Biomedical Applications: Challenges and Solutions presents specialized statistical, pattern recognition, machine learning, data abstraction and visualization tools for the analysis of data and discovery of mechanisms that create data. It provides computational methods and tools for intelligent data analysis, with an emphasis on problem-solving relating to automated data collection, such as computer-based patient records, data warehousing tools, intelligent alarming, effective and efficient monitoring, and more. This book provides useful references for educational institutions, industry professionals, researchers, scientists, engineers and practitioners interested in intelligent data analysis, knowledge discovery, and decision support in databases.

Today, over 500,000 medical technologies are available in hospitals, homes, and community care settings. They range from simple bandages to complex, multi-part body scanners that cost millions of dollars to develop. Yet a typical technology has a lifecycle of just 21 months before an improved product usurps it-the healthcare ecosystem is rapidly advancing and driven by a constant flow of innovation. And those innovations need innovators. With $21 billion made available for investment in the digital healthcare industry in 2020 (a 20x increase on 2010), entrepreneurs, investors, and related actors are entering the healthcare ecosystem in greater numbers than ever before. Last year alone, over 17,000 medical technology patents were filed, the third highest of all patent types. Each of those has a dedicated team of entrepreneurs behind it. Yet with increasingly strict regulations and pharmaceutical giants growing more aggressive, many thousands of entrepreneurs fail before even the patent stage: just 2% secure revenue or adoption. Healthtech Innovation: How Entrepreneurs Can Define and Build the Value of Their New Products is a down-to-earth survival guide for entrepreneurs struggling to secure a strategic position within the healthtech ecosystem. Which is expected that by 2026, the global digital health market size will be around $657 billion. This book is designed to help innovators navigate this complex and newly volatile landscape. It covers business strategy, marketing, funding acquisition, and operation in a global regulatory context. It is written in simple language, evidenced by the latest academic and industry research, and explained using real-world examples and case studies.

Biomedical Applications of Nanoparticles describes the most interesting and investigated biomedical applications of nanoparticles, emphasizing their therapeutic impact. Progress made in the therapy of severe diseases, such as cancer and difficult infections is strictly correlated to the scientific progress and technological development in the field of materials science. Nanoparticles have numerous therapeutic applications, starting with the design of new drugs, delivery systems, therapeutic materials, and their contribution to the development of preventive strategies. The book highlights the impact of nanoparticles on the therapy of infections, antimicrobial effect and also anti-cancer strategies. Successful examples are given throughout the book, along with analysis in order to improve future outcomes of novel therapies.

Machine Learning in Bio-Signal Analysis and Diagnostic Imaging presents original research on the advanced analysis and classification techniques of biomedical signals and images that cover both supervised and unsupervised machine learning models, standards, algorithms, and their applications, along with the difficulties and challenges faced by healthcare professionals in analyzing biomedical signals and diagnostic images. These intelligent recommender systems are designed based on machine learning, soft computing, computer vision, artificial intelligence and data mining techniques. Classification and clustering techniques, such as PCA, SVM, techniques, Naive Bayes, Neural Network, Decision trees, and Association Rule Mining are among the approaches presented. The design of high accuracy decision support systems assists and eases the job of healthcare practitioners and suits a variety of applications. Integrating Machine Learning (ML) technology with human visual psychometrics helps to meet the demands of radiologists in improving the efficiency and quality of diagnosis in dealing with unique and complex diseases in real time by reducing human errors and allowing fast and rigorous analysis. The book's target audience includes professors and students in biomedical engineering and medical schools, researchers and engineers.

This book showcases the state of the art in the field of sensors and microsystems, revealing the impressive potential of novel methodologies and technologies. It covers a broad range of aspects, including: bio-, physical and chemical sensors, actuators, micro- and nano-structured materials, mechanisms of interaction and signal transduction, polymers and biomaterials, sensor electronics and instrumentation, analytical microsystems, recognition systems and signal analysis and sensor networks as well as manufacturing technologies, environmental, food, energy and biomedical applications. The book gathers a selection of papers presented at the AISEM Regional Workshop on Sensors and Microsystems, held in Portici (Naples), Italy in February 2020.

This book offers a comprehensive and timely overview of the latest developments in the field of biomechanics and extensive knowledge of tissue structure, function, and modeling. Gathering chapters written by authoritative scientists, it reports on a range of continuum and computational models of solids, and related experimental works, for biomechanical applications. It discusses cutting-edge advances such as constitutive modeling and computational simulation of biological tissues and organs under physiological and pathological conditions, and their mechanical characterization. It covers innovative studies on arteries, heart, valvular tissue, and thrombus, brain tumor, muscle, liver, kidney, and stomach, among others. Written in honor of Professor Gerhard A. Holzapfel, the book provides specialized readers with a thorough and timely overview of different types of modeling in biomechanics, and current knowledge about biological structures and function.

This book offers a much-needed discussion on the targeting of biofilm-related infections. Chapters include discussions on the impact of biofilm on medical implants, industrial applications, as well as wound and tissue infections. It also offers discussions on regulatory management for industrial sectors and medical environments. Given that there continues to be a paucity of effective antimicrobial products, devices, and coatings in clinical and industrial use that effectively reduce rates of infection or biofilm-related problems, Targeting Biofilms in Translational Research, Device Development, and Industrial Sectors, offers a fresh and much-needed perspective aimed at helping create healthier controlled environments and safer devices. This comprehensive book is indispensable for industrial and academic translational researchers, device developers, and regulatory experts looking to create more effective antimicrobial products.

An Introduction to Green Nanotechnology, Volume 28, provides students, scientists and chemical engineers with an overview of several types of nanostructures, discusses the synthesis and characterization of nanostructures, and provides applications of nanotechnology in daily life. The book offers a foundation to green nanotechnology by explaining why green nanotechnology is important. Covers biological sources in green nanotechnology, antioxidants, green nanostructures, mechanism, synthesis and characterization. The book ends with an evaluation of the risks of nanotechnology in human life and future perspectives.

Novel Nanomaterials for Biomedical, Environmental, and Energy Applications is a comprehensive study on the cutting-edge progress in the synthesis and characterization of novel nanomaterials and their subsequent advances and uses in biomedical, environmental and energy applications. Covering novel concepts and key points of interest, this book explores the frontier applications of nanomaterials. Chapters discuss the overall progress of novel nanomaterial applications in the biomedical, environmental and energy fields, introduce the synthesis, characterization, properties and applications of novel nanomaterials, discuss biomedical applications, and cover the electrocatalytical and photothermal effects of novel nanomaterials for efficient energy applications. The book will be invaluable to academic researchers and biomedical clinicians working with nanomaterials.

This is the second volume of the comprehensive, two-volume work on oxidative stress in lung diseases. Adopting a multidisciplinary approach, it demonstrates the cellular and molecular mechanisms associated with ROS (reactive oxygen species)-induced initiation and progression of a variety of lung diseases, such as COPD, emphysema, asthma, cystic fibrosis, occupational pulmonary diseases and pulmonary hypertension and discusses points for therapeutic intervention. The book also covers translational research and the latest research on prevention and therapeutics. Each chapter includes in-depth insights into the mechanisms associated with lung diseases and into identifying targets for drug development. Bridging the gap between fundamental and translational research, and examining applications in the biomedical and pharmaceutical industry, it is a thought- provoking read for basic and applied scientists engaged in biomedical research.

Clearly presents the state of the art and future trends in the research of the biodegradable polymers in the context of circular economy Covers entire value chain and life cycle of biopolymers, considering different types of polymers Clarifies the life safety of (bio)degradable polymeric materials Presents novel opportunities and ideas for developing or improving technologies Determines the course of degradation during prediction study

This book provides readers with an introduction to the materials and devices necessary for flexible sensors and electronics, followed by common techniques for fabrication of such devices and system-level integration. Key insights into fabrication and processing will guide readers through the tradeoff choices in designing such platforms. A comprehensive review of two specific, flexible bioelectronic platforms, related to smart bandages for wound monitoring and thread-based diagnostics for wearable health, will demonstrate practical application at the system level. The book also provides a unique electrical engineering perspective by reviewing circuit architectures for low noise signal conditioning of weak signals from sensors,, and for low power analog to digital converters for signal acquisition. To achieve energy autonomy, authors provide several example of CMOS energy harvesting front end circuits and voltage boosters. Beyond circuit architectures, the book also provides a review of the modern theory of sampling and recovery of sparse signals, also known as compressed sensing. They then highlight how these principles can be leveraged for design and implementation of efficient signal acquisition hardware and reliable processing of acquired data for flexible electronic platforms.

Careers in Biomedical Engineering offers readers a comprehensive overview of new career opportunities in the field of biomedical engineering. The book begins with a discussion of the extensive changes which the biomedical engineering profession has undergone in the last 10 years. Subsequent sections explore educational, training and certification options for a range of subspecialty areas and diverse workplace settings. As research organizations are looking to biomedical engineers to provide project-based assistance on new medical devices and/or help on how to comply with FDA guidelines and best practices, this book will be useful for undergraduate and graduate biomedical students, practitioners, academic institutions, and placement services.

This book provides an overview of biocomposite chemistry, chemical modifications, characterization and applications in biomedicine, with emphasis on recent advances in the field. Authored by experts, the chapters discuss the design, development and selection of biomedical composites for a particular therapeutic application, as well as providing insight into the regulatory and clinical aspects of biomedical composite use. While this book is primarily intended for scientists from the fields of medical, pharmaceutical, biotechnological and biomedical engineering, it is also useful as an advanced text for students and research scholars.

Nucleic Acid Nanotheranostics: Biomedical Applications offers a comprehensive overview of improvements and new trends in fabrication of nanostructures as theranostic multifunctional carriers in gene therapy. With a strong focus on medical applications (comprising diagnosis, therapy and imaging), the book also examines gene therapy in an individual patient's cells or tissues to treat genetic diseases. Sections cover Biomedical and Diagnostic applications of Nucleic Acids, Biologic and Synthetic Advanced Nanostructures for nucleic acid delivery, and important considerations of nanomedicine. This book is a valuable guide for materials scientists, physicians, chemists and engineers, but is also ideal for clinicians wishing to expand their knowledge.

Machine Learning (ML) is a sub field of artificial intelligence that uses soft computing and algorithms to enable computers to learn on their own and identify patterns in observed data, build models that explain the world, and predict things without having explicit pre-programmed rules and models. This book discusses various applications of ML in engineering fields and the use of ML algorithms in solving challenging engineering problems ranging from biomedical, transport, supply chain and logistics, to manufacturing and industrial. Through numerous case studies, it will assist researchers and practitioners in selecting the correct options and strategies for managing organizational tasks.

Most of the real-life signals are non-stationary in nature. The examples of such signals include biomedical signals, communication signals, speech, earthquake signals, vibration signals, etc. Time-frequency analysis plays an important role for extracting the meaningful information from these signals. The book presents time-frequency analysis methods together with their various applications. The basic concepts of signals and different ways of representing signals have been provided. The various time-frequency analysis techniques namely, short-time Fourier transform, wavelet transform, quadratic time-frequency transforms, advanced wavelet transforms, and adaptive time-frequency transforms have been explained. The fundamentals related to these methods are included. The various examples have been included in the book to explain the presented concepts effectively. The recently developed time-frequency analysis techniques such as, Fourier-Bessel series expansion-based methods, synchrosqueezed wavelet transform, tunable-Q wavelet transform, iterative eigenvalue decomposition of Hankel matrix, variational mode decomposition, Fourier decomposition method, etc. have been explained in the book. The numerous applications of time-frequency analysis techniques in various research areas have been demonstrated. This book covers basic concepts of signals, time-frequency analysis, and various conventional and advanced time-frequency analysis methods along with their applications. The set of problems included in the book will be helpful to gain an expertise in time-frequency analysis. The material presented in this book will be useful for students, academicians, and researchers to understand the fundamentals and applications related to time-frequency analysis.

This book reviews the development, characterization and applications of aptamers in different areas of biotechnology ranging from therapeutics to diagnostics and protein purification. Hailed as chemical antibodies, these single-stranded nucleic acid receptors were predicted to supersede antibodies in traditional assays, such as ELISA, within a short time. While this has yet to happen, readers will find in this book a deep insight into the progress of aptamer technology and a critical discussion about the limitations that need to be overcome in order to find wider acceptance and use outside of the still relatively small aptamer-community. This book covers all aspects of aptamer generation and application for the aptamer-experienced reader and curious novice alike, with the addition of an industry perspective on the future of aptamer-use in biotechnology.

Thanks to their unique properties, chitosan and chitosan-based materials have numerous applications in the field of biomedicine, especially in drug delivery. This book examines biomedical applications of functional chitosan, exploring the various functions and applications in the development of chitosan-based biomaterials. It also describes the chemical structure of chitosan and discusses the relationship between their structure and functions, providing a theoretical basis for the design of biomaterials. Lastly, it reviews chemically modified and composite materials of chitin and chitosan derivatives for biomedical applications, such as tissue engineering, nanomedicine, drug delivery, and gene delivery.

This book presents the state-of-the-art techniques for the modeling, simulation, testing, compilation and physical synthesis of mVLSI biochips. The authors describe a top-down modeling and synthesis methodology for the mVLSI biochips, inspired by microelectronics VLSI methodologies. They introduce a modeling framework for the components and the biochip architecture, and a high-level microfluidic protocol language. Coverage includes a topology graph-based model for the biochip architecture, and a sequencing graph to model for biochemical application, showing how the application model can be obtained from the protocol language. The techniques described facilitate programmability and automation, enabling developers in the emerging, large biochip market.

Assistive Technology Service Delivery: A Practical Guide for Disability and Employment Professionals provides professionals working in vocational rehabilitation with the guidelines and methodologies they need to carry out their daily work at a high standard. Crucially, the techniques and tools described in the book are based on evidence gathered in rigorous research. Chapters cover an introduction to the accommodations system, the role of assistive technology as an accommodation and evidence-based practice in vocational rehabilitation, the service delivery process, from referral, through technology procurement and implementation, to the monitoring of outcomes. Drawing on their extensive experience, the authors then present techniques, tools and tips for assistive technology service delivery, with illustrative case study examples. Written with practicing assistive technology professionals and students in mind, this book translates technical knowledge into content that professionals can understand and readily apply.

This monograph sketches out a broad spectrum of problems (from evolution and metabolism to morphogenesis and biogeographical dynamics) whose solution has been impacted by mathematical models. Each of the selected examples has led to the recognition-and set direction to further study-of certain fundamental but unintuitive properties of biological systems, such as the making and breaking of specific symmetries that underlie morphogenesis. Whether they are long-established or only recently accepted, these models are selected for being thought-provoking and illuminating both the achievements and the gaps in our current understanding of the given area of biology. The selection of models is also meant to bring to the fore the existing degree of unity in the quantitative approach to diverse general-biological questions and in the systems-level properties that are discovered across the levels of biological organization. It is the thesis of this book that further cultivation of such unity is a way forward as we progress toward a general theory of living matter. This is an ideal book for students (in the broadest sense) of biology who wish to learn from this attempt to present the exemplary models, their methodological lessons, and the outline of a unified theory of living matter that is now beginning to emerge. In addition to a doctoral student preparing for quantitative biology research, this reader could also be an interdisciplinary scientist transitioning to biology. The latter-for example, a physicist or an engineer-may be comfortable with the mathematical apparatus and prepared to quickly enter the intended area of work, but desires a broader foundation in biology from the quantitative perspective.