Drug discovery originating in Africa has the potential to provide significantly improved treatment of endemic diseases such as malaria, tuberculosis and HIV/AIDS. This book critically reviews the current status of drug discovery research and development in Africa, for diseases that are a major threat to the health of people living in Africa. Compiled by leading African and international experts, this book presents the science and strategies of modern drug discovery. It explores how the use of natural products and traditional medicines can benefit from conventional drug discovery approaches, and proposes solutions to current technological, infrastructural, human resources, and economic challenges, which are presented when attempting to engage in full-scale drug discovery. Topics addressed are varied; from African medicinal plants to marine bioprospecting, pharmacogenetics and the use of nanotechnology. This book brings together for the first time a collection of strategies and techniques that need to be considered when developing drugs in an African setting. It is an unprecedented and truly international effort, highlighting the remarkable effort made so far in the area of drug discovery research by African scientists, and scientists from other parts of the world working on African health problems.

This is the fourth updated and revised edition of a well-received book that emphasises on fungal diversity, plant productivity and sustainability. It contains new chapters written by leading experts in the field. This book is an up-to-date overview of current progress in mycorrhiza and association with plant productivity and environmental sustainability. The result is a must hands-on guide, ideally suited for agri-biotechnology, soil biology, fungal biology including mycorrhiza and stress management, academia and researchers. The topic of this book is particularly relevant to researchers involved in mycorrhiza, especially to food security and environmental protection. Mycorrhizas are symbioses between fungi and the roots of higher plants. As more than 90% of all known species of plants have the potential to form mycorrhizal associations, the productivity and species composition and the diversity of natural ecosystems are frequently dependent upon the pre sence and activity of mycorrhizas. The biotechnological application of mycorrhizas is expected to promote the production of food while maintaining ecologically and economically sustainable production systems.

The book provides basic knowledge in mycorrhizal ecology, knitted with novel conceptual frameworks and contemporary perspectives, especially in the context of global change. In a fast changing world wherein anthropogenic climate change, biological invasions, deforestation, desertification, and frequent droughts have become routine hard realities, the contents of this book urge readers to rethink basic notions of setting and accomplishing objectives in mycorrhizal research to make sense vis-a-vis contemporary challenges. In this book, a global perspective of mycorrhizal diversity and distribution is provided, followed by some insights into the impact of various global change elements such as climate change, plant invasion, and extreme environmental conditions on mycorrhizas and the role of these mutualists in turn to help their host plants to withstand such novel selection pressures. Special attention here is given to the interesting, but largely neglected, topics such as the role of mycorrhizas in ecological restoration of degraded environments and mycorrhizal status of aquatic plants. The basic idea is to unify various topical areas in mycorrhizal science in an integrated framework. This book can be used by the undergraduate and graduate level students studying mycorrhizal symbioses in the context of current ecological applications. The materials in this book will benefit biological scientists actively involved in research on mycorrhizal ecology and global environmental change. Besides, the contents of the book could be of special interest to restoration ecologists and biodiversity managers. "

Plant taxonomy is an ancient discipline facing new challenges with the current availability of a vast array of molecular approaches which allow reliable genealogy-based classifications. Although the primary focus of plant taxonomy is on the delimitation of species, molecular approaches also provide a better understanding of evolutionary processes, a particularly important issue for some taxonomic complex groups."Molecular Plant Taxonomy: Methods and Protocols"describes laboratory protocols based on the use of nucleic acids and chromosomes for plant taxonomy, as well as guidelines for phylogenetic analysis of molecular data. Experts in the field also contribute review and application chapters that will encourage the reader to develop an integrative taxonomy approach, combining nucleic acid and cytogenetic data together with other crucial information (taxonomy, morphology, anatomy, ecology, reproductive biology, biogeography, paleobotany), which will help not only to best circumvent species delimitation but also to resolve the evolutionary processes in play.Written in the successful"Methods in Molecular Biology"series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.

Authoritative and easily accessible, "Molecular Plant Taxonomy: Methods and Protocols"seeks to provide conceptual as well as technical guidelines to plant taxonomists and geneticists."

This volume presents a collection of tools currently used for the characterization of rust, the host plant wheat, and their interactions. This book is divided into five parts: Parts I and II discuss advanced techniques for characterizing rust pathogens in rust surveillance, genotyping, and molecular pathogenicity; Part III describes protocols for genetic analysis of rust resistance; Part IV covers methods on rust resistance gene cloning; and Part V talks about the isolation and screening of bacterial endophytes as biocontrol agents for rust disease management. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and authoritative, Wheat Rust Disease: Methods and Protocols is a valuable resource for both established and novel wheat rust researchers and also the plant science and microbial research community.

Pennsylvania, a state of diverse geography and geology, is rich in flora. The second edition of The Plants of Pennsylvania identifies the nearly 3,400 species of trees, wildflowers, ferns, grasses, sedges, aquatic plants, and weeds native to or naturalized in the Commonwealth. Retaining the clearly written identification keys and descriptions that made the first edition such an essential reference, this new edition has been reorganized to reflect recent advances in our understanding of plant relationships. Families and genera are listed in a sequence determined by current studies of plant molecular genetics, thus providing new insights for the study of botany. In addition, species have been added to the book as a result of new discoveries. The botanical illustrations of Anna Anisko continue to complement the descriptions and add an element of beauty to the volume. Developed in conjunction with the Pennsylvania Flora Project, and compiled by botanists at the Morris Arboretum, the official arboretum of the Commonwealth of Pennsylvania, the second edition of The Plants of Pennsylvania is the authoritative guide to Pennsylvania's plant life. It will be indispensable to taxonomists, conservationists, ecologists, foresters, land planners, teachers, agricultural county agents, students, and amateur naturalists.

Plants possess a range of potential cellular mechanisms that may be involved in the detoxification of heavy metals and thus tolerance to metal stress. Metal toxicity causes multiple direct and indirect effects in plants that concern practically all physiological functions. The main purpose of this book is to present comprehensive and concise information on recent advances in the field of metal transport and how genetic diversity affects heavy metal transport in plants. Other key futures of the book are related to metal toxicity and detoxification mechanisms, biochemical tools for HM remediation processes, molecular mechanisms for HM detoxification, how metallomics and metalloproteomics are affected by heavy metal stress in plants, and the role of ROS metabolism in the alleviation of heavy metals. Some chapters also focus on recent developments in the field of phytoremediation. Overall the book presents in-depth information and the most essential advances in the field of heavy metal toxicity in plants in recent years.

Plant-based medicines play an important role in all cultures, and have been indispensable in maintaining health and combating diseases. The identification of active principles and their molecular targets from traditional medicine provides an enormous opportunity for drug development. Using modern biotechnology, plants with specific chemical compositions can be mass propagated and genetically improved for the extraction of bulk active pharmaceuticals. Although there has been significant progress in the use of biotechnology, using tissue cultures and genetic transformation to investigate and alter pathways for the biosynthesis of target metabolites, there are many challenges involved in bringing plants from the laboratory to successful commercial cultivation. This book presents the latest advances in the development of medicinal drugs, including topics such as plant tissue cultures, secondary metabolite production, metabolomics, metabolic engineering, bioinformatics and future biotechnological directions.

This book covers many facets of plant selenium (Se) accumulation: molecular genetics, biochemistry, physiology, and ecological and evolutionary aspects. Broader impacts and applications of plant Se accumulation also receive attention. Plant Se accumulation is very relevant for environmental and human health. Selenium is both essential at low levels and toxic at high levels, and both Se deficiency and toxicity are problems worldwide. Selenium can positively affect crop productivity and nutritional value. Plants may also be used to clean up excess environmental Se. Selenium in plants has profound ecological impact, and likely contributes to Se movement in ecosystems and global Se cycling.

The mystique of the rainforest has captured the imaginations of generations of young people, explorers, authors, and biologists. It is a delicate ecosystem whose myriad sounds and smells, whose vibrancy of life, is balanced by constant cycles of death and decay. It is a place of fierce competition where unusual partnerships are forged and creative survival strategies are the norm. In this book, you will meet the scientific pioneers who first attempted to quantify and understand the vast diversity of these tropical forests, as well as their successors, who utilize modern tools and technologies to dissect the chemical nature of rainforest interactions.

This book provides a general background on biodiversity and the study of chemical ecology before moving into specific chemical examples of insect defenses and microbial communication. It finishes with first-hand accounts of the trials and tribulations of a canopy biology pioneer and a rainforest research novice, while assessing the state of modern tropical research, its importance to humanity, and the ecological, political, and ethical issues that need to be tackled in order to move the field forward.

This book highlights the implications of nanotechnology in plant sciences, particularly its potential to improve food and agricultural systems, through innovative, eco-friendly approaches, and as a result to increase plant productivity. Topics include various aspects of nanomaterials: biophysical and biochemical properties; methods of treatment, detection and quantification; methods of quantifying the uptake of nanomaterials and their translocation and accumulation in plants. In addition, the effects on plant growth and development, the role of nanoparticles in changes in gene and protein expression, and delivery of genetic materials for genetic improvement are discussed. It also explores how nanotechnology can improve plant protection and plant nutrition, and addresses concerns about using nanoparticles and their compliances. This book provides a comprehensive overview of the application potential of nanoparticles in plant science and serves as a valuable resource for students, teachers, researchers and professionals working on nanotechnology.

Crop production in greenhouses is a growing industry, especially in mild climates, and is very important for the population as a source of income and clean, fresh food. Greenhouses create optimal climate conditions for crop growth and protect crops from outside pests. At the same time greenhouse production increases water use efficiency and makes integrated production and protection (IPP) possible. This book provides technical instructions for practice (what to do and what not to do) and gives answers to the question: How to produce more clean crops and better quality with less water, less land and less pesticide. Suitable greenhouse constructions and their design, adapted to local climates in subtropical, tropical and arid regions and infrastructure conditions are presented. The necessary climate control measures - light transmittance, ventilation, cooling, heating, and CO2 enrichment - and physical measures for pest control, as well as methods for using solar energy to desalinate salty water are described. The results of theoretical research are transferred into methods for practical use, so that readers are equipped to solve their problems in practice as well as to get stimulation for further research and development.

After the generation of genome sequence data from a wide variety of plants, databases are filled with sequence information of genes with no known biological function, and while bioinformatics tools can help analyze genome sequences and predict gene structures, experimental approaches to discover gene functions need to be widely implemented. In Plant Reverse Genetics: Methods and Protocols, leading researchers in the field describe cutting-edge methods, both high-throughput and genome-wide, involving the models Arabidopsis and rice as well as several other plants to provide comparative functional genomics information. With chapters on the analysis of high-throughput genome sequence data, the identification of non-coding RNA from sequence information, the comprehensive analysis of gene expression by microarrays, and metabolomic analysis, the thorough methods of the book are fully supported by scripts to aid their computational use. Written in the highly successful Methods in Molecular Biology (TM) series format, the chapters contain introductions to their respective topics, lists of the necessary materials, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and essential, Plant Reverse Genetics: Methods and Protocols is an ideal guide for researchers seeking an understanding of how the complex web of plant genes work together in a systems biology view.

This volume examines the interrelated fields of food security, energy security and sustainable agriculture as the key to a stable global agricultural platform and is arranged in six parts. The first part is focused on policy considerations relating to food and energy security and sustainable agriculture. The authors from this part include Former Under Secretary of Agriculture Gale Buchanan, Former Under Secretary of Energy Raymond Orbach (Chapter 1), Stephen Hughes, Bryan Moser and William Gibbons (Chapter 2) and Thomas Redick (Chapter 3). Part II addresses soil and water, which are two of the key components in secure and sustainable food production. Authors from this part are Jerry Hatfield (Chapter 4) and Mahbub Alam, Sharon Megdal et al. (Chapter 5). The third part covers sustainable and secure food production specifically addressing genetically modified traits in Chapter 6 (James McWilliams) and omega-3 fatty acids in Chapter 7 (Jay Whelan et al.). Agronomic implications relative to food security and sustainable agriculture are described in Part IV. Authors include Ravi Sripada, Pradip Das et al. (Chapter 8), Duska Stojsin, Kevin Matson and Richard Leitz (Chapter 9) and S.H. Lee, David Clay and Sharon Clay (Chapter 10). International sustainable agriculture and food security is addressed in Part V with authors Jeff Vitale and John Greenplate (Chapter 11), Julie Borlaug et al. (Chapter 12) and Sylvester Oikeh et al. (Chapter 13). The final part covers the use of chemicals in sustainable agriculture and food/energy security with Leonard Gianessi and Ashley Williams communicating the role of herbicides and Harold Reetz emphasizing the importance of fertilizers both in maximizing crop yields to maintain a sustainable secure source for food production."

This edited volume provides insight into temperate fruits, with an emphasis on postharvest physiology, storage, packaging and technologies for maintaining fruit quality. Chapters are devoted to individual fruits and focus on fundamental issues such as methods for maintaining or enhancing quality, minimizing postharvest losses, and recommended technologies to boost demand. Contributions come from experts in the field, making this a key reference for all aspects of postharvest management of temperate fruits. The volume is unique in its focus on the biodiversity, nutritional and health benefits, and postharvest technologies for shelf life enhancement of temperate fruits. Contributing authors address the postharvest biology and technology of individual temperate fruits such as plum, cherry, peach, apricot, apple, pear, quince, loquat, kiwi, persimmon and berries. There has been tremendous growth in the research and development of new techniques to maintain the quality of temperate fruits from farm to table. Contributions from experts in the field cover these recent advances, providing up-to-date and relevant information for researchers, postharvest/fruit technologists, food scientists, postgraduate students, and others working in the industry.

This book includes contributions from scientists and representatives from government and non-governmental organisations working in the field of land management and use and on management of fires. The book is truly interdisciplinary and has both a research and application-oriented dimension. The list of topics includes sustainability and water management; sustainability and biodiversity conservation; the future sustainability of nature-based industries such as agriculture, mining, tourism, fisheries and forestry; sustainability, people and livelihoods; sustainability and landscapes planning; sustainability and land use planning; handling and managing forest fires. The papers are innovative and cross-cutting, and many have practice-based experiences. Also, this book, prepared by the Inter-University Sustainable Development Research Programme (IUSDRP) and the World Sustainable Development Research and Transfer Centre (WSD-RTC), reiterates the need to promote a sustainable use of land resources today.

Volume 2 covers nitrogen fertilizer efficiency, acid tolerance of the legume symbiosis, fruit tree nutrition, rhizosphere pH change, iron deficiency in crop production, the effects of nutrient deficiences on seed production, the elemental composition of plants, and the role of potassium. The articles in this volume join together both the fundamental and the applied parts of this discipline. The editors' aim to make the reviews comprehensible to scientists in relevant disciplines, rather than purely to the specialist. The format of each volume is a small number of full-length reviews of important topics, plus an editorial which briefly mentions other rapidly developing topics that may therefore be reviewed in future volumes.

This book highlights state-of-the-art research and practices for adaptation to climate change in food production systems (agriculture in particular) as observed in Japan and neighboring Asian countries. The main topics covered include the current scientific understanding of observed and projected climate change impacts on crop production and quality, modeling of autonomous and planned adaptation, and development of early warning and/or support systems for climate-related decision-making. Drawing on concrete real-world examples, the book provides readers with an essential overview of adaptation, from research to system development to practices, taking agriculture in Asia as the example. As such, it offers a valuable asset for all researchers and policymakers whose work involves adaptation planning, climate negotiations, and/or agricultural developments.

This book covers studies on the systematics of plant taxa and will include general vegetational aspects and ecological characteristics of plant life at altitudes above 1000 m. from different parts of the world. This volume also addresses how upcoming climate change scenarios will impact high altitude plant life. It presents case studies from the most important mountainous areas like the Himalayas, Caucasus and South America covering the countries like Malaysia, Sri Lanka, India, Nepal, Pakistan, Kirghizia, Georgia, Russia,Turkey, Indonesia, Malaysia and the Americas. The book will serve as an invaluable resource source undergraduates, graduate students, and researchers.

"Use of Microbes for the Alleviation of Soil Stresses, Volume 1" describes the most important details and advances related to the alleviation of soil stresses by soil microbes. Comprised of seven chapters, the book reviews the mechanisms by which plant growth promoting rhizobacteria (PGPR) alleviate plant growth under stress; the role of mycorrhizal fungi on the alleviation of drought stress in host plants; how PGPR may alleviate salinity stress on the growth of host plants; and the role of PGPR on the growth of the host plant under the stress of sub optimal root zone temperature.

Written by experts in their respective fields, "Use of Microbes for the Alleviation of Soil Stresses, Volume 1 "is a comprehensive and valuable resource for researchers and students interested in the field of microbiology and soil stresses.