This book presents a range of current research topics in biological network modeling, as well as its application in studies on human hosts, pathogens, and diseases. Systems biology is a rapidly expanding field that involves the study of biological systems through the mathematical modeling and analysis of large volumes of biological data. Gathering contributions from renowned experts in the field, some of the topics discussed in depth here include networks in systems biology, the computational modeling of multidrug-resistant bacteria, and systems biology of cancer. Given its scope, the book is intended for researchers, advanced students, and practitioners of systems biology. The chapters are research-oriented, and present some of the latest findings on their respective topics.

Agent-Based Modeling/Simulation (ABM/ABS) is an emerging field that enables bottom-up and experimental analysis in social sciences such as economics, management, sociology and politics. The chapters of this book are the selected papers from those presented the Third International Workshop on Agent-Based Approaches in Economic and Social Complex Systems held in Tokyo, Japan in 2005. Articles in this book covers methodological issues, computational model/software, combination with gaming simulation, and real-world applications to economic, management/organizational and social issues.

This edited book explores the use of technology to enable us to visualise the life sciences in a more meaningful and engaging way. It will enable those interested in visualisation techniques to gain a better understanding of the applications that can be used in visualisation, imaging and analysis, education, engagement and training. The reader will also be able to learn about the use of visualisation techniques and technologies for the historical and forensic settings. The reader will be able to explore the utilisation of technologies from a number of fields to enable an engaging and meaningful visual representation of the biomedical sciences. The chapters presented in this volume cover such a diverse range of topics, with something for everyone. We present here chapters on technology enhanced learning in neuroanatomy; 3D printing and surgical planning; changes in higher education utilising technology, decolonising the curriculum and visual representations of the human body in education. We also showcase how not to use protective personal equipment inspired by the pandemic; anatomical and historical visualisation of obstetrics and gynaecology; 3D modelling of carpal bones and augmented reality for arachnid phobias for public engagement. In addition, we also present face modelling for surgical education in a multidisciplinary setting, military medical museum 3D digitising of historical pathology specimens and finally computational fluid dynamics.

This book focuses on mathematical theory and numerical simulation related to various areas of continuum mechanics, such as fracture mechanics, (visco)elasticity, optimal shape design, modelling of earthquakes and Tsunami waves, material structure, interface dynamics and complex systems. Written by leading researchers from the fields of applied mathematics, physics, seismology, engineering, and industry with an extensive knowledge of mathematical analysis, it helps readers understand how mathematical theory can be applied to various phenomena, and conversely, how to formulate actual phenomena as mathematical problems. This book is the sequel to the proceedings of the International Conference of Continuum Mechanics Focusing on Singularities (CoMFoS) 15 and CoMFoS16.

With the diversification of Internet services and the increase in mobile users, efficient management of network resources has become an extremely important issue in the field of wireless communication networks (WCNs). Adaptive resource management is an effective tool for improving the economic efficiency of WCN systems as well as network design and construction, especially in view of the surge in mobile device demands. This book presents modelling methods based on queueing theory and Markov processes for a wide variety of WCN systems, as well as precise and approximate analytical solution methods for the numerical evaluation of the system performance. This is the first book to provide an overview of the numerical analyses that can be gleaned by applying queueing theory, traffic theory and other analytical methods to various WCN systems. It also discusses the recent advances in the resource management of WCNs, such as broadband wireless access networks, cognitive radio networks, and green cloud computing. It assumes a basic understanding of computer networks and queueing theory, and familiarity with stochastic processes is also recommended. The analysis methods presented in this book are useful for first-year-graduate or senior computer science and communication engineering students. Providing information on network design and management, performance evaluation, queueing theory, game theory, intelligent optimization, and operations research for researchers and engineers, the book is also a valuable reference resource for students, analysts, managers and anyone in the industry interested in WCN system modelling, performance analysis and numerical evaluation.

This book offers an easy-to-understand introduction to the computational mass transfer (CMT) method. On the basis of the contents of the first edition, this new edition is characterized by the following additional materials. It describes the successful application of this method to the simulation of the mass transfer process in a fluidized bed, as well as recent investigations and computing methods for predictions for the multi-component mass transfer process. It also demonstrates the general issues concerning computational methods for simulating the mass transfer of the rising bubble process. This new edition has been reorganized by moving the preparatory materials for Computational Fluid Dynamics (CFD) and Computational Heat Transfer into appendices, additions of new chapters, and including three new appendices on, respectively, generalized representation of the two-equation model for the CMT, derivation of the equilibrium distribution function in the lattice-Boltzmann method, and derivation of the Navier-Stokes equation using the lattice-Boltzmann model. This book is a valuable resource for researchers and graduate students in the fields of computational methodologies for the numerical simulation of fluid dynamics, mass and/or heat transfer involved in separation processes (distillation, absorption, extraction, adsorption etc.), chemical/biochemical reactions, and other related processes.

This hands-on textbook/reference presents an introduction to the fundamental aspects of modelling and simulation, both for those wishing to learn about this methodology and also for those who have a need to apply it in their work. The text is supported by illustrative examples, drawn from projects formulated within the domains of discrete-event dynamic systems (DEDS) and continuous-time dynamic systems (CTDS). This updated new edition has been enhanced with new illustrative case studies, and additional examples demonstrating some new features and the effectiveness of the ABCmod conceptual modelling framework. Changes that facilitate the development of simulation models with ABSmod/J are illustrated. New material includes a presentation of the experimentation strategy called "design of experiments" and three new chapters that explore the optimization-simulation interface. Topics and features: presents a goal-based and project-oriented perspective of modelling and simulation; describes the ABCmod framework, an activity-based conceptual modelling framework for DEDS; examines the simulation-optimization interface in both the CTDS and DEDS domains; provides numerous illustrative examples, case studies and useful algorithms, as well as exercises and projects at the end of most chapters; includes appendices on probability and statistics, the GPSS programming environment, and relevant MATLAB features; provides supplementary software and teaching support material at an associated website, including lecture slides and a methodology for organizing student projects. Serving as an essential guide to the foundations of modelling and simulation, this practical primer is ideal for senior undergraduate and junior graduate-level students. Also suitable for self-study, the book will be of great benefit to professionals seeking insight into the vast potential of this rapidly evolving problem-solving paradigm.

Discrete-Time and Discrete-Space Dynamical Systems provides a systematic characterization of the similarities and differences of several types of discrete-time and discrete-space dynamical systems, including: Boolean control networks; nondeterministic finite-transition systems; finite automata; labelled Petri nets; and cellular automata. The book's perspective is primarily based on topological properties though it also employs semitensor-product and graph-theoretic methods where appropriate. It presents a series of fundamental results: invertibility, observability, detectability, reversiblity, etc., with applications to systems biology. Academic researchers with backgrounds in applied mathematics, engineering or computer science and practising engineers working with discrete-time and discrete-space systems will find this book a helpful source of new understanding for this increasingly important class of systems. The basic results to be found within are of fundamental importance for further study of related problems such as automated synthesis and safety control in cyber-physical systems using formal methods.

This is the first book offering an in-depth and comprehensive IoT network simulation, supported by OPNET tool. Furthermore, the book presents the simulations of IoT in general, not limited by OPNET. The authors provide rich OPNET IoT simulation codes, with detailed explanation regarding the functionalities of the model. These codes can facilitate readers' fast implementation, and the shared model can guide readers through developing their own research. This book addresses various versions of Internet of Things (IoT), including human-centric IoT, green IoT, Narrow band IoT, Smart IoT, IoT-Cloud integration. The introduced OPNET IoT simulation provides a comprehensive platform to simulate above-mentioned IoT systems. Besides, this book introduces OPNET semi-physical simulation in detail. Based on this technology, simulated IoT and practical cloud are seamlessly connected with each other. On top of this "IoT-cloud-integration" semi-physical simulation environment, various smart IoT applications can be realized.

The model investigated in this work, a particular cellular automaton with stochastic evolution, was introduced as the simplest case of self-organized-criticality, that is, a dynamical system which shows algebraic long-range correlations without any tuning of parameters. The author derives exact results which are potentially also interesting outside the area of critical phenomena. Exact means also site-by-site and not only ensemble average or coarse graining. Very complex and amazingly beautiful periodic patterns are often generated by the dynamics involved, especially in deterministic protocols in which the sand is added at chosen sites. For example, the author studies the appearance of allometric structures, that is, patterns which grow in the same way in their whole body, and not only near their boundaries, as commonly occurs. The local conservation laws which govern the evolution of these patterns are also presented. This work has already attracted interest, not only in non-equilibrium statistical mechanics, but also in mathematics, both in probability and in combinatorics. There are also interesting connections with number theory. Lastly, it also poses new questions about an old subject. As such, it will be of interest to computer practitioners, demonstrating the simplicity with which charming patterns can be obtained, as well as to researchers working in many other areas.

This textbook introduces the concepts and tools that biomedical and chemical engineering students need to know in order to translate engineering problems into a numerical representation using scientific fundamentals. Modeling concepts focus on problems that are directly related to biomedical and chemical engineering. A variety of computational tools are presented, including MATLAB, Excel, Mathcad, and COMSOL, and a brief introduction to each tool is accompanied by multiple computer lab experiences. The numerical methods covered are basic linear algebra and basic statistics, and traditional methods like Newton's method, Euler Integration, and trapezoidal integration. The book presents the reader with numerous examples and worked problems, and practice problems are included at the end of each chapter.

As the first book of a three-part series, this book is offered as a tribute to pioneers in vision, such as Bela Julesz, David Marr, King-Sun Fu, Ulf Grenander, and David Mumford. The authors hope to provide foundation and, perhaps more importantly, further inspiration for continued research in vision. This book covers David Marr's paradigm and various underlying statistical models for vision. The mathematical framework herein integrates three regimes of models (low-, mid-, and high-entropy regimes) and provides foundation for research in visual coding, recognition, and cognition. Concepts are first explained for understanding and then supported by findings in psychology and neuroscience, after which they are established by statistical models and associated learning and inference algorithms. A reader will gain a unified, cross-disciplinary view of research in vision and will accrue knowledge spanning from psychology to neuroscience to statistics.

This open access book demonstrates the application of simulation modelling and network analysis techniques in the field of Roman studies. It summarizes and discusses the results of a 5-year research project carried out by the editors that aimed to apply spatial dynamical modelling to reconstruct and understand the socio-economic development of the Dutch part of the Roman frontier (limes) zone, in particular the agrarian economy and the related development of settlement patterns and transport networks in the area. The project papers are accompanied by invited chapters presenting case studies and reflections from other parts of the Roman Empire focusing on the themes of subsistence economy, demography, transport and mobility, and socio-economic networks in the Roman period. The book shows the added value of state-of-the-art computer modelling techniques and bridges computational and conventional approaches. Topics that will be of particular interest to archaeologists are the question of (forced) surplus production, the demographic and economic effects of the Roman occupation on the local population, and the structuring of transport networks and settlement patterns. For modellers, issues of sensitivity analysis and validation of modelling results are specifically addressed. This book will appeal to students and researchers working in the computational humanities and social sciences, in particular, archaeology and ancient history.

This book, which contains a collection of review articles as well as focus on evidence-based policy making, will serve as a valuable resource not just for all postgraduate students conducting research using systems analysis thinking but also for policy makers. To our knowledge, a book of this nature which also has a strong African focus is currently not available. The book examines environmental and socio-economic risks with the aim of providing an analytical foundation for the management and governance of natural resources, disasters, addressing climate change, and easing the technological and ecological transitions to sustainability. It provides scientific and strategic analysis to better understand the dynamics of future energy transitions, their main driving forces, enabling factors, barriers, as well as their consequences for the social, economic and environmental dimensions of human wellbeing. Science-based policy advice is achieved through an integrated assessment and modeling of how to simultaneously address the major energy policy challenges in the areas of environment (climate change and air pollution), energy poverty (or access to affordable and clean energy for the poor), energy security and reliability. It also aims to improve our understanding of ecosystems and their management in today's changing world-in particular, the current state of ecosystems, and their ecological thresholds and buffering capacities. It provides support for policy makers in developing rational, realistic and science-based regional, national and global strategies for the production of fuel, food and fibre that sustain ecosystem services and safeguard food security. Finally, it addresses the human development dimension of global change based on comprehensive studies on the changing size and composition of human populations around the world by analyzing both their impacts and the differential vulnerabilities by age, gender and level of education.

This book is intended as a guide to and manual on modeling complex problems in Multi Criteria Decision Making (MCDM). It encourages practitioners to consider the practicalities of real-world scenarios when modeling, while at the same time providing tips and examples of how to incorporate these realities into the initial decision matrix. The goal is to help readers build a decision matrix that replicates reality as closely as possible. Once this matrix has been constructed, the Decision Maker (DM) can select from more than a hundred MCDM methods the one that best fits the requirements and conditions of the matrix. The book features cases taken from real-world scenarios, which deal with various fields, aspects, and characteristics, and are solved using the SIMUS (Sequential Interactive Modeling for Urban Systems) method. This book is a valuable tool for practitioners, researchers and students dealing with MCDM problems.

The book summarizes the current state of the solid oxide fuel cell (SOFC) technology in power generation applications. It describes the single cells, SOFC stacks, micro-combined heat and power systems, large-scale stationary power generators and polygeneration units. The principles of modeling, simulation and controls of power systems with solid oxide fuel cells are presented and discussed. Authors provide theoretical background of the technology followed by the essential insights into the integrated power systems. Selected aspects of the design, construction and operation of power units in range from single kilowatts to hundreds of kilowatts are presented. Finally, the book reports the selected studies on prototype systems which have been constructed in Europe. The book discusses the theoretical and practical aspects of operation of power generators with solid oxide fuel cells including fabrication of cells, design of stacks, system modeling, simulation of stationary and non-stationary operation of systems, fuel preparation and controls.

Computerized modeling is a powerful tool to describe the complex interrelations between measured data and the dynamics of sedimentary systems. Complex interaction of environmental factors with natural variations and increasing anthropogenic intervention is reflected in the sedimentary record at varying scales. The understanding of these processes gives way to the reconstruction of the past and is a key to the prediction of future trends. Especially in cases where observations are limited and/or expensive, computer simulations may substitute for the lack of data. State-of-the-art research work requires a thorough knowledge of processes at the interfaces between atmosphere, hydrosphere, biosphere, and lithosphere, and is therefore an interdisciplinary approach.

This book presents an introduction to the analysis of general movements in 3D space, especially for movements of the human body. It is based on the lecture notes of a class on 3D Kinematics, which the author has been holding in the Master Degree Program of his home institution, the University of Applied Sciences Upper Austria. The lecture introduces the mathematics underlying the measurement and analysis of 3D movements. The target audience primarily comprises research experts in the field, but the book may also be beneficial for graduate students alike.

This textbook addresses the most recent advances and main digital technologies used in farming. The reader will be able to understand the main concepts and techniques currently used to efficiently manage agricultural production systems. The book covers topics in a general and intuitive way, with examples and good illustrations.

This book is the result of a NATO sponsored workshop entitled "Student Modelling: The Key to Individualized Knowledge-Based Instruction" which was held May 4-8, 1991 at Ste. Adele, Quebec, Canada. The workshop was co-directed by Gordon McCalla and Jim Greer of the ARIES Laboratory at the University of Saskatchewan. The workshop focused on the problem of student modelling in intelligent tutoring systems. An intelligent tutoring system (ITS) is a computer program that is aimed at providing knowledgeable, individualized instruction in a one-on-one interaction with a learner. In order to individualize this interaction, the ITS must keep track of many aspects of the leamer: how much and what he or she has leamed to date; what leaming styles seem to be successful for the student and what seem to be less successful; what deeper mental models the student may have; motivational and affective dimensions impacting the leamer; and so ono Student modelling is the problem of keeping track of alI of these aspects of a leamer's leaming.

This book describes, from a computer science viewpoint the software, methods of simulating and analysing crowds with a particular focus on the effects of panic in emergency situations. The power of modern technology impacts on modern life in multiple ways every day. A variety of scientific models and computational tools have been developed to improve human safety and comfort in built environments. In particular, understanding pedestrian behaviours during egress situations is of considerable importance in such contexts. Moreover, some places are built for large numbers of people (such as train stations and airports and high volume special activities such as sporting events). Simulating Crowds in Egress Scenarios discusses the use of computational crowd simulation to reproduce and evaluate egress performance in specific scenarios. Several case studies are included, evaluating the work and different analyses, and comparisons of simulation data versus data obtained from real-life experiments are given.

"Soft matter" is nowadays used to describe an increasingly important class of - terials that encompasses polymers, liquid crystals, molecular assemblies building hierarchical structures, organic-inorganic hybrids, and the whole area of colloidal science. Common to all is that ?uctuations, and thus the thermal energy k T and B entropy, play an important role. "Soft" then means that these materials are in a state of matter that is neither a simple liquid nor a hard solid of the type studied in hard condensed matter, hence sometimes many types of soft matter are also named "c- plex ?uids. " Soft matter, either of synthetic or biological origin, has been a subject of physical and chemical research since the early ?nding of Staudinger that long chain mo- cules exist. From then on, synthetic chemistry as well as physical characterization underwent an enormous development. One of the outcomes is the abundant pr- ence of polymeric materials in our everyday life. Nowadays, methods developed for synthetic polymers are being more and more applied to biological soft matter. The link between modern biophysics and soft matter physics is quite close in many respects. This also means that the focus of research has moved from simple - mopolymers to more complex structures, such as branched objects, heteropolymers (random copolymers, proteins), polyelectrolytes, amphiphiles and so on.

This book includes selected peer-reviewed papers presented at the International Conference on Modeling, Simulation and Optimization (CoMSO 2021), organized by National Institute of Technology, Silchar, Assam, India, during December 16-18, 2021. The book covers topics of modeling, simulation and optimization, including computational modeling and simulation, system modeling and simulation, device/VLSI modeling and simulation, control theory and applications, modeling and simulation of energy systems and optimization. The book disseminates various models of diverse systems and includes solutions of emerging challenges of diverse scientific fields.

Fuzzy classi ers are important tools in exploratory data analysis, which is a vital set of methods used in various engineering, scienti c and business applications. Fuzzy classi ers use fuzzy rules and do not require assumptions common to statistical classi cation. Rough set theory is useful when data sets are incomplete. It de nes a formal approximation of crisp sets by providing the lower and the upper approximation of the original set. Systems based on rough sets have natural ability to work on such data and incomplete vectors do not have to be preprocessed before classi cation. To achieve better performance than existing machine learning systems, fuzzy classifiers and rough sets can be combined in ensembles. Such ensembles consist of a nite set of learning models, usually weak learners.

The present book discusses the three aforementioned elds - fuzzy systems, rough sets and ensemble techniques. As the trained ensemble should represent a single hypothesis, a lot of attention is placed on the possibility to combine fuzzy rules from fuzzy systems being members of classi cation ensemble. Furthermore, an emphasis is placed on ensembles that can work on incomplete data, thanks to rough set theory. ."

This open access book summarizes the research done and results obtained in the second funding phase of the Priority Program 1648 "Software for Exascale Computing" (SPPEXA) of the German Research Foundation (DFG) presented at the SPPEXA Symposium in Dresden during October 21-23, 2019. In that respect, it both represents a continuation of Vol. 113 in Springer's series Lecture Notes in Computational Science and Engineering, the corresponding report of SPPEXA's first funding phase, and provides an overview of SPPEXA's contributions towards exascale computing in today's sumpercomputer technology. The individual chapters address one or more of the research directions (1) computational algorithms, (2) system software, (3) application software, (4) data management and exploration, (5) programming, and (6) software tools. The book has an interdisciplinary appeal: scholars from computational sub-fields in computer science, mathematics, physics, or engineering will find it of particular interest.