This book addresses the application of nanotechnology to cosmetics. Edited by three respected experts in the field, the book begins with a general overview of the science behind cosmetics and skin care today, and of the status quo of nanotechnology in cosmetics. Subsequent chapters provide detailed information on the different nanoparticles currently used in cosmetics; the production and characterization of nanoparticles and nanocosmetics; and regulatory, safety and commercialization aspects. Given its scope, the book offers an indispensable guide for scientists in academia and industry, technicians and students, as well as a useful resource for decision-makers in the field and consumer organizations. Chapter 6 of this book is available open access under a CC BY 4.0 licence at link.springer.com.

Immunofluorescence is a key diagnostic tool in dermatopathology, and essential in the diagnosis of connective tissue diseases, vasculitis and other cutaneous disorders. The need to interpret the results of immunofluorescence testing, and correlate these with histopathological results, is a key skill required not just of dermatopathologists but also, increasingly, of dermatologists who either read the slides themselves or use a pathology lab or academic referral centre. Handbook of Direct Immunofluorescence covers not only day-to-day findings but also less common patterns and rarities, and gives information on important diagnostic pitfalls. Each chapter is dedicated to a specific disease and is introduced by concise text that describes the clinical presentation and pathogenesis: then, multiple images show the range of histopathological and immunofluorescence findings associated with the disease in question. Key points Practical, clinically oriented coverage provides invaluable resource for dermato-, oral and general pathologists, as well as dermatologists Includes invaluable information on technical aspects (specimen procurement, transportation, etc) as well as guidance on interpreting histopathological and immunofluorescence findings Pattern-based approach serves as logical framework for reaching a diagnosis, as well as understanding when to order additional tests and how to recognise nonspecific findings

This issue of Facial Plastic Surgery CLinics, guest edited by Dr. James B. Lucas, is devoted to Facial Reconstruction Post-Mohs Surgery. Articles in this issue include Anatomy of the Skin and the Pathogenesis of Non-Melanoma Skin Cancer; Mohs Micrographic Surgery: the Essentials; Physiology and Biomechanics of Skin Flaps; Flap Basics I: Rotation and Transposition Flaps; Flap Basics II: Advancement Flaps; Flap Basics III: Interpolated Flaps; Skin and Composite Grafting Techniques; Scalp and Forehead Defects; Defects of the Eyelids; Auricular Defects; Cutaneous Nasal Defects; Defects of the Lips and Chin; Cheek Defects; and Scar Revision and Recontouring Post-Mohs Surgery.

This issue of Immunology and Allergy Clinics, guest edited by Mariana Castells, is devoted to Drug Hypersensitivity and Desensitizations. Articles in this issue include: Principles and Practice of Drug Desensitization; Incidence and Prevalence of Drug Hypersensitivity; Drug-Induced Anaphylaxis; Penicillin and Beta Lactam Hypersensitivity; Platins Chemotherapy Hypersensitivity: Prevalence and Management; Monoclonal Antibodies Hypersensitivity: Prevalence and Management; Injectable Drugs and MoAbs Reactions and Management with Desensitization; Delayed Cutaneous Reactions to Antibiotics, Management with Desensitization; Management of Children with Hypersensitivity to Antibiotics and MoAbs; Taxenes Hypersensitivity and Management; Progesterone Autoimmune Dermatitis; Severe Delayed Drug Reaction: Role of Genetics and Viral Infections; andAspirin and NSAIDS Hypersensitivity and Management.

This issue of Dermatologic Clinics, guested edited by Drs.Jonathan I. Silverberg and Nanette Silverberg, is devoted to Atopic Dermatitis. Articles in this outstanding issue include: How to Define Atopic Dermatitis; Public Health Burden and Epidemiology of Atopic Dermatitis; Long-term Course of Atopic Dermatitis; Allergic and Non-Allergic Comorbidities of Atopic Dermatitis; Patient-burden of Atopic Dermatitis; Assessment of Atopic Dermatitis Severity in Clinical Practice; An Update on the Pathophysiology of Atopic Dermatitis; Long-term Treatment of Atopic Dermatitis; Special Considerations for Management of Atopic Dermatitis in Young Children; Management of Adult Onset Atopic Dermatitis; Management of Atopic Hand Dermatitis; Adjunctive Management of Itch in Atopic Dermatitis; and Racial and Ethnic Differences of Atopic Dermatitis.

A brand-new title in the field of dermatology, Therapy for Severe Psoriasis provides the ultimate coverage of the treatment options available for today's most serious cases, including biologics and oral therapies. It features discussions of the newest drug therapies, recent FDA-approved biosimilars, and combination approaches to care, while an overview chapter was designed to aid those new to the field in understanding the nuances of difficult-to-treat subtypes of psoriasis. Comprehensive and focused, Therapy for Severe Psoriasis will be a welcome addition to the library of any dermatologist seeking in-depth information on the challenges of this condition. Each of the 16 chapters includes either an in-depth focus on a single therapy or an overview of a unique aspect of psoriasis, including: UVB therapy, methotrexate, acitretin, cyclosporine, apremilast, etanercept, infliximab, adalimumab, ustekinumab, secukinumab, and ixekizumab. Takes an evidence-based approach to hard-to-treat severe psoriasis. Discusses the newest drug therapies (such as ixekizumab), plus recent FDA-approved biosimilars, a topic unique to this particular psoriasis text. Presents combination approaches for instances when standard treatments are not successful. Includes an overview chapter to help beginners understand the nuances of the disorder. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, and references from the book on a variety of devices.

This book focuses on skin photoaging, the premature aging of skin due to environmental effects such as exposure to UV (UVA, UVB) radiation from the sun.

This issue of Dermatologic Clinics, guest edited by Jane M. Grant-Kels, Giovanni Pellacani, and Caterina Longo, is devoted to Confocal Microscopy. Articles in this timely issue include: Basics of Confocal Microscopy and the Complexity of Diagnosing Skin Tumors: New Imaging Tools in Clinical Practice, Diagnostic Workflows, Cost-estimate and New Trends; Opening a Window Into Living Tissue: Histopathologic Features of Confocal Microscopic Findings in Skin Tumors; Addressing the Issue of Discriminating Nevi from Early Melanomas: Dues and Pitfalls; Melanoma Types and Melanoma Progression: The Different Faces; Lentigo Maligna, Macules of the Face and Lesions on Sun-damaged Skin: Confocal makes the Difference; Glowing in the dark: use of confocal microscopy in dark pigmented lesions; Enlightening the Pink: Use of Confocal Microscopy in Pink Lesions; Shining into the White: The Spectrum of Epithelial Tumors from Actinic Keratosis to SCC; Application of Wide-probe and Handy-probe for Skin Cancer Diagnosis: Pros and Cons; Confocal Microscopy for Special Sites and Special Uses; Confocal Algorithms for Inflammatory Skin Diseases and Hair Diseases; In Vivo and Ex Vivo Confocal Microscopy for Dermatologic and Mohs' Surgeons; Telediagnosis with Confocal Microscopy: A Reality or a Dream?; "Well-aging": Early Detection of Skin Aging Signs; The Role of Confocal Microscopy in Clinical Trials for Treatment Monitoring; and Fluorescence (multiwave) Confocal Microscopy.

Written to address the growing trend of hair loss in ethnic populations, The Fundamentals of Ethnic Hair: A Dermatologist's Perspective elucidates the science of curly hair, demystifies prevailing hair styling trends, and presents practical advice for minimizing the harmful effects of these hair styling practices. Written from a dermatologist's perspective, this textbook seamlessly blends science and practical management. Chapters include physical and chemical properties of the hair, thermal and chemical straightening, extensions, razor bumps and special cultural considerations.

This issue of Clinics in Podiatric Medicine and Surgery will focus on the dermatologic manifestations of the lower extremity. Articles will include: Fungal, Nail Surgery, Psoriasis, Eczema, Drug Reactions, Melanoma, and many more.

Michael Sand gives the reader an overview of current techniques in expression profiling of miRNAs and their maturation machinery in the skin. This book is a postdoctoral thesis on miRNAs in cutaneous malignant melanoma and non-melanoma skin cancer with a focus on the miRNA processing machinery and miRNA expression profiling. The research presented in this book was performed in the Dermatologic Surgery Section at the Department of Dermatology, Venereology and Allergology of the Ruhr-University Bochum, Germany and gives the reader an overview of current techniques in expression profiling of miRNAs and their maturation machinery in the skin.

This book addresses all aspects of photodermatology by providing a clear straightforward introduction to these diseases, their investigation, diagnosis and management, including the use of lasers. Each light sensitive disorder and each type of phototherapy is supported by the principles of the underlying photophysics, chemistry and biology. Doctors, nurses and technicians all have an important role to play in the diagnosis of photodermatoses and in the administration of phototherapy. This concise, richly illustrated text provides them with valuable insights and a good working overview of the light related areas of dermatology.

Rapid progress has been made in our understanding of the molecular mechanisms of cell growth and oncogenesis during the past decade. Special attention has been given to the presentation of the frequently neglected close correlation between changes in signal transduction and metabolic pathways during oncogenesis. This book advances the knowledge of mechanisms regulating metabolism and functioning of vitamin A and offers the most recent results of research on the clinical efficiency of retinoids in skin disorders and cancer. The book presents recent findings on the regulation of cell growth in normal and neoplastic tissues by growth factors including hormones, and by the activation and inactivation of oncogenes and tumor suppressor genes, respectively. It also offers a survey of the molecular and cell biochemistry of retinoids. Basic researchers in biochemistry, pharmacology and cell biology as well as clinicians will find this book very informative and up-to-date. This book advances the knowledge of mechanisms regulating metabolism and functioning of vitamin A and offers the most recent results of research on clinical efficiency of retinoids in skin disorders and cancer. Basic researchers in biochemistry, pharmacology, cell biology, and clinicians will find this book very informative and up-to-date. The chapters, organized in six sections, are contributed by leading scientists who have been working in the retinoid field for decades. Their experience and competence is aknowledged worldwide.

This indispensable volume highlights recent studies identifying epigenetic mechanisms as essential regulators of skin development, stem cell activity and regeneration. Chapters are contributed by leading experts and promote the skin as an accessible model system for studying mechanisms that control organ development and regeneration. The timely discussions contained throughout are of broad relevance to other areas of biology and medicine and can help inform the development of novel therapeutics for skin disorders as well as new approaches to skin regeneration that target the epigenome. Part of the highly successful Stem Cells and Regenerative Medicine series, Epigenetic Regulation of Skin Development and Regeneration uncovers the fundamental significance of epigenetic mechanisms in skin development and regeneration, and emphasizes the development of new therapies for a number of skin disorders, such as pathological conditions of epidermal differentiation, pigmentation and carcinogenesis. At least six categories of researchers will find this book essential, including stem cell, developmental, hair follicle or molecular biologists, and gerontologists or clinical dermatologists.

This issue of Dermatologic Clinics, Guest Edited by Dr. Murad Alam, is devoted to Practice Gaps in Dermatology. Articles in this issue include: Psoriasis and Papulosquamous Disorders; Blistering Diseases; Disorders of the Nails; Disorders of the Hair; Infections; Abnormal Pigmentation; Lupus, Scleroderma, Dermatomyositis; Genodermatoses; Pruritus; Drug Reactions; Dermatoses of Pregnancy; Contact Dermatitis; Acne and Rosacea; Radiation Therapy; Surgery for Skin Cancer; Cosmetic Dermatologic Surgery; Light, Laser and Energy Treatments; and Melanocytic Lesions and Melanoma.

This book presents new methods of analyzing and processing hyperspectral medical images, which can be used in diagnostics, for example for dermatological images. The algorithms proposed are fully automatic and the results obtained are fully reproducible. Their operation was tested on a set of several thousands of hyperspectral images and they were implemented in Matlab. The presented source code can be used without licensing restrictions. This is a valuable resource for computer scientists, bioengineers, doctoral students, and dermatologists interested in contemporary analysis methods.

The painful and often scarring disease hidradenitis suppurtiva is presented comprehensively in this issue of Dermatologic Clinics led by expert Gregor Borut Ernst Jemec. Topics include: Diagnosing hidradentis suppurativa; Prevalence, risk factors and co-morbidities of hidradentis suppurativa; Genetics of hidradentis suppurativa; Histopathology and imaging; Inflammatory mechanisms in hidradentis suppurativa; Microbiology of hidradentis suppurativa; Endocrinological aspects of hidradentis suppurativa; Role of mechanical stress in hidradenitis suppurativa; Randomized controlled trials of hidradentis suppurativa treatment; Antibiotic treatment of hidradentis suppurativa; Other medical treatments of hidradentis suppurativa; Surgical interventions in hidradentis suppurativa; Lasers and IPL in hidradenitis suppurativa; The Handicap of hidradentis suppurativa.

This issue of Primary Care: Clinics in Office Practice, Guest Edited by George G.A. Pujalte, MD, is devoted to Primary Care Dermatology. Dr. Pujalte has assembled a group of expert authors to review the following topics: Urticaria and allergy-mediated conditions; Dermatologic manifestations of systemic diseases; Viral skin infections; Fungal skin infections; Bacterial skin infections; Parasitic skin infections; Pressure and friction injuries to the skin; Sunburn, thermal, and chemical injuries to the skin; Acne; Alopecia; Nail deformities and injuries; and Skin cancer.

The fourth edition of this atlas in a comprehensive guide to the diagnosis and treatment of dermatologic diseases and disorders. Comprising nine sections, the book covers 75 common skin conditions and growths, organised by anatomic region. The final sections discuss diagnostic procedures, formulary, and patient guides. Authored by renowned New York and San Francisco-based experts, this comprehensive guide is highly illustrated with a multitude of clinical photographs and figures.

The Editor of this publication is Dr Elise Olsen, Director of the Duke University Cutaneous Lymphoma Research and Treatment Center and professor of Dermatology and Oncology. In 2014, cutaneous lymphoma (CL) is considered a chronic, non-life threatening disease since the majority of patients are diagnosed at early stage, though progression to later stages does result in death from the disease. This issue covers T-cell and B-cell lymphomas, with content emphasis on Mycoides fungoides and Sezary syndrome, the two most common clinically encountered subtypes of CL. Pharmaceutical treatment of the disease is a part of each article and the issue uses the following Treatment outline: Mechanisms of action - Pharmacokinetics - Typical dosing - Response to therapy - Adverse effects - and Pearls to help management using the agent under discussion. Beyond Dermatologists, specialists who would find the information useful are Cancer specialists, Hematologists/Oncologists, Physician Assistants, Nurse Practitioners, and Pharmacists. Some of the topics, written by the word's top experts in this disease, are: Overview of primary cutaneous lymphomas and the applicable staging and classification; Pathologic diagnosis of cutaneous lymphomas; in the section on Mycosis Fungoides and Sezary Syndrome, the clinician and researcher will find such topics as Skin directed medications; Phototherapy; Systemic retinoids; Interferons; HDAC inhibiotrs, Methotrexate and praletexate, along with other chemotherapeutic agents. Also, Bone marrow transplant; Diagnosis and management of CD30+ Lymphoproliferative disorders; and Diagnosis and management of primary cutaneous B cell lymphomas.

Scleroderma, or systemic sclerosis, is a chronic connective tissue disease generally classified as one of the autoimmune rheumatic diseases. Hardening of the skin is one of the most visible manifestations of the disease. It's estimated that about 300,000 Americans have scleroderma. About one third of those people have the systemic form of scleroderma. Since scleroderma presents with symptoms similar to other autoimmune diseases, diagnosis is difficult. This issue will cover: The Genetic Basis of SSc: Genetics, Epigenetics, Mechanisms of Pathogenesis - linking fibrosis, vasculopathy and immune dysregulation, The Role of Autoantibodies in Diagnosis and Prognosis/survival, Managing Raynaud's phenomenon and ischemic ulcers Managing SSc Lung Disease, Monitoring for and Managing Pulmonary Arterial Hypertension, and many more!

Expert on diseases of the nails and also disorders of the nail that indicate systemic disease, Dr Antonella Tosti leads this issue of Dermatologic Clinics. In the article "Tips to Treat 5 Most Common Nail Disorders" readers will find treatment options for brittle nails, onycholysis, paronychia, psoriasis, and onychomycosis, with a practical treatment algorithm. In the article "Tips for Diagnosis and Treatment of Nail Pigmentation" physicians will be able to determine when to wait and see, when to biopsy, and when to excise a pigmented nail lesion. In "Tips to Diagnose Uncommon Nail Disorders" physicians will understand nail disorders that are not very common and should be able to easily diagnose after reading this article. A novel and unique approach in "Tips to Diagnose Nail Diseases from Localization" covers Proximal and lateral nail folds, Nail matrix, and Nail bed/hyponichium. The section on "Tips that Make Nail Surgery Easy" presents practical and simple methods to Obtain a good anesthesia, Perform a punch biopsy; Treat an ingrown toenail, and Best way to remove a subungual tumor; each is accompanied by a technique video. The issue concludes with "Tips to Obtain the Best from your Lab," addressing submitting specimens the right way and using nail clippings for diagnosis beyond fungal diseases; topics are What can be diagnosed with a nail clipping and How to submit a nail specimen.

Granulomatous disorders represent a unique group of diseases both non-infectious and infectious that require the utmost clinical pathologic correlation combined with a keen sense of inquiry for underlying systemic disease. Some of these diseases are common and some are rare; however all dermatologists need to diagnose and manage these diseases whether common or rare. This issue of Dermatology Clinics "Granulomatous Disorders of the Adult Skin" supplies the readers with a comprehensive, up to date, and evidence based review of multiple granulomatous disorders (i.e. palisdaing, epitheliod, xanthomatous, casseating, supprative, vasculitic, lymphoproliferative, foreign body). Dermatologists need to be able to differentiate the entities, evaluate patients for specific underlying systemic diseases (diabetes to cancer) and treat with a wide range of immunosuppressant to anti-infectious agents. This issue will help the dermatologist learn the most current etiopathogenesis, clinical/systemic manifestations and therapeutic modalities for these diseases. Other specialists who would find the information useful: Rheumatologists, Infectious Disease specialists, Hematologists/Oncologists, Endocrinologists, Pulmonologists, Oral-maxillary surgeons, and Pharmacists.