Fatty acids play an important role in the barrier function of skin and represent a major source of proinflammatory mediators such as prostaglandins, leukotrienes and other lipids in inflammatory skin disorders. This book combines the two major functions of fatty acids in skin biology. In the first part the biosynthesis of fatty acids in skin with its role in barrier function as well as the role of dietary fatty acids on skin cell function and in the treatment of inflammatory skin diseases is presented. The second part deals with skin as a source of proinflammatory eicosanoids, especially with the keratinocyte as a major cellular source. Metabolism of eicosanoids in skin, its role in psoriasis and atopic dermatitis as well as pharmacological inhibition of eicosanoid biosynthesis is reviewed. The book finishes with a chapter describing the methods used for quantification of fatty acids and derivatives in skin inflammation. Anyone interested in skin physiology would benefit from the overviews about the two sites of fatty acids' function in skin integrity and in skin inflammation.

Epidermolysis bullosa (EB) is a heterogenous group of genodermatoses characterized by the formation of blisters and erosions on skin and mucous membrans from birth on. The cause are mutations in the genes of structural proteins of the junction between epidermis and dermis. This book deals with the treatment of this skin disease itself and its many extracutaneous complications. There is no previous book which has been focused on the therapy and it will be based on evidence-based data derived from the worlds largest cohort of inherited EB-patients, the American EB Registry. An important chapter will discuss gene therapy in hereditary EB which has been recently successfully performed within a localized skin site on a single EB patient as a proof-of-principle test. Given its unique collective contents, the monograph will provide the primary source for clinical informations of this oftentimes severe multiorgan disease."

In the past decade it has become increasingly clear that psoriatic disease, both of the skin and joints, can be a significant diagnostic and therapeutic challenge for the physician and a debilitating illness for the patient. At the same time, advances in genetics and immunology have increased our understanding of the pathophysiology of psoriasis and psoriatic arthritis. This text contains a comprehensive discussion by an international group of experts in psoriatic disease of the pathomechanisms, genetics, diagnosis, and treatment of psoriasis and psoriatic arthritis. The information is presented in parallel in order to emphasize the similarities and differences between these two diseases that so commonly occur together. We believe that this approach will make this text an important resource for all practitioners who treat patients with psoriasis and psoriatic arthritis.

""Sun Protection in Man"" looks at the beneficial and harmful effects of solar radiation. The physiological consequences of sun exposure have been systematically studied starting at the end of the nineteenth century and we now have accumulated knowledge about how Caucasian and Asian skins reacts to solar radiation. The chemical effects of solar ultraviolet radiation have been analyzed with particular emphasis during the second half of the twentieth century. Research on micro-organisms has allowed us to understand the mechanisms of UV-induced mutagenesis and photosensitization. Studies with laboratory rodents have opened the path to the understanding of UV-induced immune-depression, carcinogenesis, photo-damage and photo-aging. The results of these studies have enabled other scientists to investigate the same phenomena in human organs such as the skin and the eye. UV radiation damages hair, as well. The present knowledge in these fields is summarized in some of the chapters of this monograph.
Mass phenomenon in Europe with the generalization of summer vacations which were a consequence of social reforms introducing the concept of "paid vacations." This created a need for protection and opened a market for sunscreens.
This monograph is concerned with sun protection as a whole and is not just "another book on sunscreens." Nonetheless, in these days of general concern, it is important to learn about the efficiency of sunscreens. Several authors discuss how to reduce the number of impinging photons and explain why sunscreens seem to offer less protection than expected. Guidelines are given on how to use sunscreens in everyday life, which are expressed rigorously though clearly, for access to the common reader.
Our knowledge on the relationship between sun and humans is at the early stages of development. Industrial and commercial activities are concerned by the development of this knowledge, and rules have been and will be promulgated to guarantee efficacy and safety of sun-products. It is hoped that this monograph will be of interest to the scholar, the layman and the legislator.

Dermoscopy is a rapidly expanding imaging technique that has caught the fancy of clinicians and patients alike. New observations are still being made to open exciting opportunities for clinical research. This is the revised and updated second edition. Several new chapters have been added and some have been completely rewritten by experts in the field. The authors have taken efforts to introduce new dermoscopic images to cover recently described signs and conditions. This should make it instructive to go through this update. A handy, concise textbook of dermoscopy. Begins with a section on Basics of Principles and Techniques of Dermoscopy giving a sense of evolution of dermoscopy instrument over the last century. This is followed by a compilation of terminologies, the pros and cons of various available dermoscopy equipments. A new addition is the devoted chapter on regional variation in dermoscopy of normal skin, which has never been described yet. A separate section is devoted to Disorders of Hyperpigmentation like melasma, exogenous ochronosis, Schamberg's disease, etc. This is followed by a section on Disorders of Hypopigmentation like leprosy, vitiligo, and idiopathic guttate hypomelanosis and then a section of inflammatory papulosquamous disorders. Another novel addition to this book is a devoted section on onychoscopy. A focused chapter on onychoscopy of nail psoriasis and onychomycosis and neoplastic nail disorders is added. The section on Trichoscopy is also updated. The last section describes some unique disorders such as granulomas, benign and malignant neoplasms of skin and dermoscopy of vascular lesions of skin, and dermoscopy of infections and infestations. A chapter on unconventional practices in dermoscopy using a mobile phone or self-illumination lenses is best for those inclined toward adapting new technology. Enhanced by more than 1,000 clinical and dermoscopic images.

The Indian Society of Mesotherapy (ISM) was later established under the aegis of the International Society of Mesotherapy (ISM) and the French Society of Mesotherapy (FSM) to promote mesotherapy in the Indian subcontinent. The ISM’s mission is to promote research and teach medical practitioners clinical as well as esthetic aspects of Mesotherapy. Through its courses, practitioners in India gain comprehensive education and technical training in the evolving science of mesotherapy. Mesotherapy is a remarkable technique involving painless microinjections into the skin, of conventional or homeopathic medicines, vitamins, minerals, and amino acids. Among many applications, mesotherapy can be used for many purposes, mainly for the relief of painful pathologies: arthritis and joint problems, sport injuries, and many other indications. It is also used in aesthetic and dermatologic indications: fat and cellulite reduction, weight loss, wrinkle elimination, scar improvement, and stretch marks. There are many advantages using mesotherapy, such as lnnocuity or rare side effects; Economical for the health system; Efficiency, painless injections. Mesotherapy technique is taught in France by members of the French Society of Mesotherapy and in India, the Indian Society of Mesotherapy founded by Dr Ajay Rana, Eminent Dermatologist in New Delhi (India), organizes many workshops to train young physicians. This is the first time that a book handling indications and techniques of mesotherapy is published in English language. Clinical pictures are clear, precise and the protocols are very well explained. This book will be a precious help for all the mesotherapists who will be able to improve their knowledge and techniques.

The second edition of this much-awaited book has been thoroughly revised and updated, keeping in mind the recent advances in the field of contact and occupational dermatology. It is supplemented with clinical photographs, tables, flowcharts and informative boxes. Provides updated knowledge of the subject in a concise and comprehensive manner. Updated as per the current understanding in the field. Special emphasis on allergic contact dermatitis and dermatitis due to contact with topical medicaments, cosmetics, ornaments, footwear and other daily usage objects. A chapter is dedicated to chemical leukoderma as the subject has had a lot of advances in recent years. Includes chapters on detailed discussion of differential diagnoses, investigations and management of contact dermatitis. Each chapter includes key points highlighting the clinical experience of the authors.

This yearbook on acne has collection of original abstract of path breaking research published in high impact factor journals that were published in the previous year. It presents breakthrough developments articles which were reviewed thoroughly and commented on the value of the article. This book brings to you a collection of meticulously chosen articles focusing on the recent advances in the management of acne. Articles selected from various peer-reviewed journals that were published in the last 12 month period. In-depth evidence based discussion on clinical management of acne with a variety of treatment options such as hormonal, pharmacological and nonpharmacological therapy provides useful insights. Each article has been reviewed by subject reviewers who have written comments on value of the article, previous knowledge on the subject, what the article add to the prevailing knowledge and practices, strong points and weaknesses of the article and other similar observations that have come in the last 12-month period. Each article is accompanied by key messages, summarizing the article as well as highlighting the clinical experience of the reviewers. A must read book for dermatologists, physicians and postgraduate students.

This book is divided into various sections starting from basic trichology to surgical trichology. The articles are selected on the basis of merit and usefulness to both researchers and practicing clinical dermatologists. It includes 118 articles, scanned over 250 publications. The articles are judged and edited by experts in the field of trichology. Brings to you a collection of meticulously chosen articles focusing on the recent advances in the field of trichology. Articles selected from various peer reviewed journals that were published in the last 12-month period. The book is divided into sections covering articles on basics, clinical, therapeutic, diagnostic and surgical aspects of trichology. Each article has been reviewed by subject reviewers who have written comments on value of the article, previous knowledge on the subject, what the article adds to the prevailing knowledge and practices, strong points and weaknesses of the article and other similar observations that have come in the last 12-month period. Each article is accompanied by key messages, summarizing the article as well as highlighting the clinical experience of the reviewers.

Dermoscopy is a non-invasive, widely used diagnostic tool that aids the diagnosis of skin lesions and is proven to increase the accuracy of melanoma diagnosis. This book is a practical guide to dermoscopy for clinicians. The text begins with an overview of the technique, how it links clinical dermatology and histopathology, the dermoscope, and pattern recognition. The following sections provide in depth coverage of the application of dermoscopy and clinical features in the diagnosis of different dermatologic disorders, including vascular lesions, skin tumours, autoimmune dermatoses, pigmentary disorders, and much more. The final chapters discuss dermoscopy in diagnostic dilemmas and in therapeutic monitoring, also providing a selection of algorithms to assist learning. The text is highly illustrated with more than 500 clinical images and each topic concludes with a keynote message summarising the salient dermoscopic features. Key points Practical guide to diagnostic dermoscopy for clinicians In depth discussion on use of the dermoscope, histopathology, and pattern recognition Covers numerous dermatologic disorders Keynote messages summarise salient points to assist learning

This book is a comprehensive guide to hair transplantation for dermatologists and hair transplant surgeons. The text begins with an introduction to evaluation, workup and postoperative care, and anaesthesia and pain management. The next chapters guide clinicians step by step through direct hair transplantation, design, and reconstruction, followed by discussion on follicular unit excision (FUE), a technique using grafts. In addition to detailed coverage of hair transplantation on the scalp, the book also explores body hair transplants and eyebrow and eyelash transplantation, concluding with a chapter on setting up a hair transplant centre. The book is further enhanced by nearly 400 descriptive photographs, diagrams and tables. Key points Comprehensive, step by step guide to hair transplantation Includes discussion on follicular unit excision (FUE) and its complications Covers body hair and eyebrow/eyelash transplantation as well as scalp Features nearly 400 clinical photographs, diagrams and tables

Trichoscopy is the dermoscopic imaging of the scalp and hair. The method is based on dermoscopy and videodermoscopy and is used for the evaluation and diagnosis of hair and scalp diseases. This book provides clinicians and trainees with the latest advances in trichoscopy. Divided into seventeen chapters, the text begins with an overview of the normal scalp and devices used in trichoscopy, both handheld and digital. The following chapters examine numerous hair and scalp disorders including alopecia, hair shaft disorders, genetic skin diseases, autoimmune bullous disorders, tumours and much more. Each chapter concludes with a summary of key points from the topic. Edited by recognised experts in the field from the USA and Brazil, this comprehensive guide features more than 1000 clinical images, diagrams and tables to enhance learning. Key points Comprehensive guide to trichoscopy for clinicians and trainees Covers numerous disorders and emphasises key learning points for each topic Recognised editor team from USA and Brazil Includes more than 1000 images, diagrams and tables

Urticaria, commonly known as 'hives', is a skin rash which can have allergic and non-allergic causes. This new edition is a concise guide to the diagnosis and treatment of urticaria for dermatologists and trainees. Divided into eight sections, the text begins with an introduction to the classification and diagnosis of urticaria. The following chapters cover different types of urticaria and treatment methods. The second edition has been fully updated and new topics added to provide the latest information in the field. Photographs, illustrations and tables further enhance learning. Key points Concise guide to diagnosis and treatment of urticaria (hives) Fully revised second edition with new topics and treatments added Includes photographs, diagrams and tables to enhance learning Previous edition (9789351529057) published in 2016

Hair transplantation is in demand worldwide, but because Asian hair tends to be more sparse and coarse than Caucasian hair, transplantation procedures need to be adapted to Asian patients. This book, exclusively devoted to Asian hair, is a complete and comprehensive text written by a group of authors sharing their experience in their specialized fields of hair restoration. Included are many practical tips as well as chapters on regional transplantation such as eyebrows, eyelashes, sideburns, beards, and mustaches, in addition to the usual scalp hair restoration. With its many illustrations, the book gives readers a complete knowledge of hair restoration surgery and provides a quick, easy-to-use reference on Asian hair and the differences in patients' demands. With an influx of new physicians in this challenging field of medicine, further education and training are imperative and must be available to provide a high standard of medical practice. This compilation meets that objective and ultimately makes the valuable contribution of restoring patients' self-confidence.

This volume contains a collection of writings from the leaders in the fields of Molecular Biology and Melanoma Research which will begin to tell the ever-expanding story of the most recent findings, discoveries, and potential of BRAF-directed targets in melanoma. Recent research has shown that BRAF inhibitors are effective for a short period of time, but there is little hope that this drugs as single agents will lead to durable benefit in a majority of patients. Among scientists and researchers who work in drug discovery, there is a lot of interest in the development of molecularly targeted cancer agents. Namely, the identification of a molecular target, the selection of molecules which effectively inhibit this target. What is starkly different about the development of this class of compounds, however, is that the mechanism of action of these agents are not as straightforward as was once previously assumed and the mechanisms of resistance that tumor cells employ to evade complete destruction are unlike any that have been described before. These discoveries in addition to utilization of modern molecular biology techniques have led to a series of hypotheses regarding which other types of molecules could be used in combination with BRAF-inhibitors in hopes of revolutionizing the potential of therapeutics in melanoma.

Melanoma is one of the most types of cancer. When melanoma is detected at an early stage, treatment is highly successful, but outcomes can be poor when the disease is advanced. There has been significant progress in our understanding of the molecular biology, genetics, and immunology of melanoma over the past decade. This has been accompanied by rapid advances in therapeutic strategies for patients with melanoma. This book provides the clinician and the researcher with a broad understanding of the molecular and cellular pathogenesis of melanoma, explores the clinical characteristics and criteria for clinical and pathological staging of the disease, and provides an overview of current and evolving treatment strategies in the adjuvant, metastatic, and preventive settings. The treatment of special populations and rare variants of melanoma that often present particular clinical challenges is also covered. Authored by international experts in melanoma biology and clinical management, this volume concisely explains how to diagnose, treat, and prevent melanoma while reviewing advances in basic science and providing an overview of innovative approaches still under development.

Strong body odor is a condition for which, until now, there have been few treatment methods. The Japanese authors, encouraged by the willingness of Oriental patients to undergo radical treatment, have developed the subcutaneous tissue shaving method, which eliminates the condition in a very short period of time without ugly scarring. The book Human Body Odor not only introduces the completely new subcutaneous tissue shaving method, it also questions conventional theories on the hair cycle itself and throws a new hypothesis about the process of hair generation and regeneration into the scientific arena. This could even lead in the future to a formula for retarding hair loss! Developed over the past twenty years, the authors' new surgical method for the radical treatment of bromidrosis represents a landmark in cosmetic surgery and dermatology!

Trichology is the science of the structure, function and diseases of the human hair. This book is a comprehensive guide to the diagnosis and treatment of diseases and disorders of the hair and scalp. Divided into six sections, the text begins with an overview of hair and the normal scalp, factors controlling hair growth and changes that occur during the aging process. The next section discusses diagnostic trichology methods including microscopy and trichoscopy. The following chapters detail the diagnosis and treatment of numerous hair disorders covering both clinical and surgical procedures, for common and more complex conditions. A chapter on recent advances in surgical management is included. The final section discusses interdisciplinary issues in the management of hair disorders such as paediatric, psychiatric, gynaecologic and endocrinologic liaison therapy. Each chapter begins with a ‘key messages’ box and concludes with a summary of the topic. The book is highly illustrated with clinical photographs, diagrams and tables. Key points Comprehensive guide to the diagnosis and management of diseases and disorders of the hair and scalp Covers both clinical and surgical treatment methods Features discussion on liaison therapy between different medical disciplines Highly illustrated with clinical photographs, diagrams, tables and boxes

Sclerotherapy is an injection procedure to treat blood vessel malformations including spider veins and varicose veins. The procedure involves injection of a sterile solution into the veins using a very fine needle. This solution irritates the vein lining causing it to undergo fibrosis and eventually disappear. This book provides an introduction to sclerotherapy for practising dermatologists. Beginning with an overview of venous anatomy, the next chapters examine the pathophysiology of varicose veins and clinical signs of venous insufficiency. The following sections explain the techniques of sclerotherapy and potential complications. The book concludes with discussion on sclerotherapy for cystic and benign vascular lesions, and surgical treatment of varicose veins. Clinical photographs and figures further enhance the comprehensive text. Key points Provides an overview of sclerotherapy techniques for dermatologists Detailed discussion on venous anatomy, pathophysiology and clinical signs Includes chapter on sclerotherapy for cystic and benign vascular lesions Highly illustrated with clinical photographs and diagrams

Dermatologists commonly treat acne, which affects 40 to 50 million Americans each year and about 85 percent of all patients at some point in their lives. Dermatologists, primary care doctors, and pediatricians see these patients every day in practice. It is important to treat the skin effectively not only to reduce the risk of physical scarring, but also to address the negative psychosocial impact this disease carries. Improving the skin can improve self-confidence, interpersonal relationships, and performance in school or at work. Acneiform Eruptions in Dermatology is a practical, full-color guide to the differential diagnosis of acne vulgaris and the treatment of acne-like conditions. It is organized into sections by subtype of condition (e.g., infections, genetic syndromes, medication-caused) and includes a section of variants of acne that may be misdiagnosed. Within the sections, individual chapters discuss each variant of the condition and begin with a helpful bulleted summary of its defining clinical features. Extensive color clinical images appear throughout the book.

This 3rd edition provides updated information on side effects of cosmetic products, topical and systemic drugs used in dermatology, and other therapeutic modalities used by dermatologists including PUVA therapy and (new in this edition) dermal implants, laser therapy, chemical face peels and cryotherapy.

Because of the explosion of new knowledge since the last edition (the 2nd edition of this book was published 8 years ago), the section on cosmetics has largely been rewritten and extended, the section on side effects of systemic drugs used in dermatology has also been expanded, and the index of drugs has been made comprehensive.

This book will be of great value to the practising physician who is confronted with a (possible) adverse reaction to a cosmetic or drug used in dermatological practice as well as to those who are scientifically interested, by providing access to recent relevant literature.

This book is a complete guide to dermatologic surgery for clinicians. Divided into 52 sections, the text begins with an overview of surgical instruments, local anaesthesia, sutures, dressings and skin biopsy. The following chapters cover numerous techniques for different dermatologic conditions, from mole surgery, vitiligo, and nail surgery, to Mohs surgery, laser scar revision, fillers, and much more. Each procedure is described with a step by step approach and includes tips and tricks, modifications, potential complications and recent advances. Both common and more complex disorders and techniques are explained in detail. The comprehensive text is further enhanced by more than 1800 clinical and surgical photographs, diagrams and tables. Key points Comprehensive guide to dermatologic surgery Covers numerous common and more complex disorders and techniques Tips and tricks, modifications, complications and recent advances highlighted for each topic Highly illustrated with more than 1800 photographs, diagrams and tables

This is the ninth volume in the New Clinical Applications Der- matology Series. Some important topics that merit discussion are included in this book. Dr Messenger discusses clinicopathological aspects of the common disorder, alopecia areata. Dr Mendelsohn gives a straightforward, clear account of pregnancy eruptions. Dr Graham-Brown gives a comprehensive yet concise survey of that strange condition, lichen planus. Dr Graham treats us to a thorough appraisal of the enigmatic juvenile plantar dermatosis. Mr Walton takes an experienced comprehensive look at ectoparasites of import- ance to man and the concluding chapter by Dr Finlay provides a concise, helpful insight into how modern technology can aid der- matology. JULIAN VERBOV VII ABOUT THE EDITOR Dr Julian Verbov is Consultant Dermatologist to Liverpool Health Authority and Honorary Clinical Lecturer in Dermatology at the University of Liverpool. He is a member of the British Association of Dermatologists, repre- senting the British Society for Paediatric Dermatology on its Executive Committee. He is Editor of the Proceedings of the North of England Dermatological Society. He is a Fellow of the Zoological Society of London and a member of the Society of Authors. He is a popular national and international speaker and author of more than 200 publications. His special interests include paediatric dermatology, inherited disorders, dermatoglyphics, pruritus ani, cutaneous poly- arteritis nodosa, therapeutics, drug abuse, and medical humour. He organizes the British Postgraduate Course in Paediatric Dermatology and is a member of the Editorial Board of Clinical and Experimental Dermatology.

This is the eighth volume in the New Clinical Applications Dermatology Series. Awareness of relationships is of prime importance in der matology. Professor Scully and Dr Porter cover the skin and mouth in a comprehensive and informative manner. Mr Peter Wright effortlessly and concisely brings the eye and the skin together. Dr C. Rowland Payne both relates and speculates on the enigma of sarcoidosis. Pro fessor Elder concludes the book with a scholarly update on porphyria and the skin. I thank all the above for their fine contributions. This volume should have widespread appeal. JULIAN VERBOV ABOUT THE EDITOR Dr Julian Verbov is Consultant Dermatologist to Liverpool Health Authority and Honorary Clinical Lecturer in Dermatology at the University of Liverpool. He is a member of the British Association of Dermatologists, repre senting the British Society for Paediatric Dermatology on its Executive Committee. He is Editor of the Proceedings of the North of England Dermatological Society. He is a Fellow of the Zoological Society of London and a Member of the Society of Authors. He is a popular national and international speaker and author of more than 200 publications."