Skin physiology assessment is moving rapidly from a descriptive approach to a deeper understanding of biophysical and biochemical processes in the stratum corneum, e.g. on stratum corneum barrier function as well on stratum corneum hydration. The research with bioengineering methods offers now reliable and reproducible approaches for product testing in the pharmaceutical and cosmetic industry as well as in basic research. This cookbook is intended to give basic information regarding skin physiology, the assessment of skin functions in controlled studies using non-invasive biophysical instruments. It provides basic knowledge on how to plan, perform and evaluate scientific studies. The authors are recognized expert in the field and provide comprehensive chapters with specific emphasis on the practical aspects of non-invasive measurements.

Dermatophytosis, also known as ringworm, is a fungal infection of the skin. Typically, it results in a red, itchy, scaly, circular rash. Hair loss may occur in the affected area. This atlas is an image bank of more than 500 photographs presenting the clinical features of fungal infectious diseases. Divided into 15 sections, the book covers fungal infections in different parts of the body, from scalp and face, trunk and limbs, to hand, nail, feet and groin. Images are presented in alphabetical order, each with a brief description explaining the disease. The book also covers fungal infections in specific sectors of the population – pregnant women, children, adolescents, and people who are immunocompromised. Separate chapters are dedicated to steroid-modified disease and mimickers of dermatophytosis. Key points Colour Atlas presenting clinical features of fungal infectious diseases More than 500 photographs, ordered alphabetically, each with brief explanatory description Covers infections in different parts of the body and in different sectors of the population Includes discussion on steroid-modified disease and mimickers of dermatophytosis

Epidermolysis bullosa (EB) is a heterogenous group of genodermatoses characterized by the formation of blisters and erosions on skin and mucous membrans from birth on. The cause are mutations in the genes of structural proteins of the junction between epidermis and dermis. This book deals with the treatment of this skin disease itself and its many extracutaneous complications. There is no previous book which has been focused on the therapy and it will be based on evidence-based data derived from the worlds largest cohort of inherited EB-patients, the American EB Registry. An important chapter will discuss gene therapy in hereditary EB which has been recently successfully performed within a localized skin site on a single EB patient as a proof-of-principle test. Given its unique collective contents, the monograph will provide the primary source for clinical informations of this oftentimes severe multiorgan disease."

Fatty acids play an important role in the barrier function of skin and represent a major source of proinflammatory mediators such as prostaglandins, leukotrienes and other lipids in inflammatory skin disorders. This book combines the two major functions of fatty acids in skin biology. In the first part the biosynthesis of fatty acids in skin with its role in barrier function as well as the role of dietary fatty acids on skin cell function and in the treatment of inflammatory skin diseases is presented. The second part deals with skin as a source of proinflammatory eicosanoids, especially with the keratinocyte as a major cellular source. Metabolism of eicosanoids in skin, its role in psoriasis and atopic dermatitis as well as pharmacological inhibition of eicosanoid biosynthesis is reviewed. The book finishes with a chapter describing the methods used for quantification of fatty acids and derivatives in skin inflammation. Anyone interested in skin physiology would benefit from the overviews about the two sites of fatty acids' function in skin integrity and in skin inflammation.

In the past decade it has become increasingly clear that psoriatic disease, both of the skin and joints, can be a significant diagnostic and therapeutic challenge for the physician and a debilitating illness for the patient. At the same time, advances in genetics and immunology have increased our understanding of the pathophysiology of psoriasis and psoriatic arthritis. This text contains a comprehensive discussion by an international group of experts in psoriatic disease of the pathomechanisms, genetics, diagnosis, and treatment of psoriasis and psoriatic arthritis. The information is presented in parallel in order to emphasize the similarities and differences between these two diseases that so commonly occur together. We believe that this approach will make this text an important resource for all practitioners who treat patients with psoriasis and psoriatic arthritis.

Lipids and Skin Health is the first effort to summarize and review the studies, ideas, and research that link lipid metabolism to the largest organ of our body, the skin. The book covers the fundamental biology of the skin, and the major involvement of the transcriptional factors that govern lipid synthesis and the bioactive lipids in this intriguing organ. All layers of skin are presented, as well as their relevant lipids from the epidermis to dermis and even to the hypodermis. The important and unique-to-skin biological pathways are laid out, with a special focus on the various models that demonstrate the essential role of lipid synthesis in skin pathophysiology. The use of lipids in the cosmetic industry is emphasized, and last but not least the involvement of lipids in the clinical setting is also discussed. This book will appeal to healthcare professionals, researchers and dermatology professionals, and will help them to brainstorm new products and opportunities that will target the emerging importance of lipid metabolism in skin for acne, aging, and healthy skin. Apostolos Pappas, Ph.D., is a professional member of the Institute of Food Technology. He started his professional career as a research biochemist in the Skin Research Center of Johnson & Johnson and later served as a group leader at Munich Biotech, where he worked on cancer research. Thereafter he returned to Johnson & Johnson, where he is currently a Research Manager and Fellow focusing on lipid metabolism research. He has authored numerous scientific publications, patent applications, and books.

This volume contains a collection of writings from the leaders in the fields of Molecular Biology and Melanoma Research which will begin to tell the ever-expanding story of the most recent findings, discoveries, and potential of BRAF-directed targets in melanoma. Recent research has shown that BRAF inhibitors are effective for a short period of time, but there is little hope that this drugs as single agents will lead to durable benefit in a majority of patients. Among scientists and researchers who work in drug discovery, there is a lot of interest in the development of molecularly targeted cancer agents. Namely, the identification of a molecular target, the selection of molecules which effectively inhibit this target. What is starkly different about the development of this class of compounds, however, is that the mechanism of action of these agents are not as straightforward as was once previously assumed and the mechanisms of resistance that tumor cells employ to evade complete destruction are unlike any that have been described before. These discoveries in addition to utilization of modern molecular biology techniques have led to a series of hypotheses regarding which other types of molecules could be used in combination with BRAF-inhibitors in hopes of revolutionizing the potential of therapeutics in melanoma.

Hair transplantation is in demand worldwide, but because Asian hair tends to be more sparse and coarse than Caucasian hair, transplantation procedures need to be adapted to Asian patients. This book, exclusively devoted to Asian hair, is a complete and comprehensive text written by a group of authors sharing their experience in their specialized fields of hair restoration. Included are many practical tips as well as chapters on regional transplantation such as eyebrows, eyelashes, sideburns, beards, and mustaches, in addition to the usual scalp hair restoration. With its many illustrations, the book gives readers a complete knowledge of hair restoration surgery and provides a quick, easy-to-use reference on Asian hair and the differences in patients' demands. With an influx of new physicians in this challenging field of medicine, further education and training are imperative and must be available to provide a high standard of medical practice. This compilation meets that objective and ultimately makes the valuable contribution of restoring patients' self-confidence.

Melanoma is one of the most types of cancer. When melanoma is detected at an early stage, treatment is highly successful, but outcomes can be poor when the disease is advanced. There has been significant progress in our understanding of the molecular biology, genetics, and immunology of melanoma over the past decade. This has been accompanied by rapid advances in therapeutic strategies for patients with melanoma. This book provides the clinician and the researcher with a broad understanding of the molecular and cellular pathogenesis of melanoma, explores the clinical characteristics and criteria for clinical and pathological staging of the disease, and provides an overview of current and evolving treatment strategies in the adjuvant, metastatic, and preventive settings. The treatment of special populations and rare variants of melanoma that often present particular clinical challenges is also covered. Authored by international experts in melanoma biology and clinical management, this volume concisely explains how to diagnose, treat, and prevent melanoma while reviewing advances in basic science and providing an overview of innovative approaches still under development.

Strong body odor is a condition for which, until now, there have been few treatment methods. The Japanese authors, encouraged by the willingness of Oriental patients to undergo radical treatment, have developed the subcutaneous tissue shaving method, which eliminates the condition in a very short period of time without ugly scarring. The book Human Body Odor not only introduces the completely new subcutaneous tissue shaving method, it also questions conventional theories on the hair cycle itself and throws a new hypothesis about the process of hair generation and regeneration into the scientific arena. This could even lead in the future to a formula for retarding hair loss! Developed over the past twenty years, the authors' new surgical method for the radical treatment of bromidrosis represents a landmark in cosmetic surgery and dermatology!

Dermatologists commonly treat acne, which affects 40 to 50 million Americans each year and about 85 percent of all patients at some point in their lives. Dermatologists, primary care doctors, and pediatricians see these patients every day in practice. It is important to treat the skin effectively not only to reduce the risk of physical scarring, but also to address the negative psychosocial impact this disease carries. Improving the skin can improve self-confidence, interpersonal relationships, and performance in school or at work. Acneiform Eruptions in Dermatology is a practical, full-color guide to the differential diagnosis of acne vulgaris and the treatment of acne-like conditions. It is organized into sections by subtype of condition (e.g., infections, genetic syndromes, medication-caused) and includes a section of variants of acne that may be misdiagnosed. Within the sections, individual chapters discuss each variant of the condition and begin with a helpful bulleted summary of its defining clinical features. Extensive color clinical images appear throughout the book.

Urticaria, commonly known as ‘hives’, is a skin rash which can have allergic and non-allergic causes. This handbook is an initiative of the Global Allergy and Asthma European Network (GA2LEN) Urticaria Centers of Reference and Excellence (UCARE). Divided into 22 sections, the text begins with an overview of urticaria, its classification, and aetiopathogenesis. The next chapters describe different types of urticaria, diagnostic measures, and therapeutic management. The final sections examine urticaria in children, in the elderly, in pregnancy and lactation, and in kidney, liver and cardiac disease. A separate chapter covers patient education material. Authored by renowned worldwide experts, the text is further enhanced by clinical images, tables and figures to assist learning.

This book provides the dermatologist with the essential information needed to properly treat all skin types cosmetically.

All chapters have been written by female dermatologists with many years of personal experience in the field.

The volume includes an overview of the systemic, intrinsic and extrinsic aging process, essential information on anti-aging skin care product ingredients, detailed discussions of patient selection and indications, and a wide range of cosmetic procedures.

This concise book allows you - through its well-organized use of sidebars, photographs and illustrations - to extract any information you may need quickly and easily.

This is the ninth volume in the New Clinical Applications Der- matology Series. Some important topics that merit discussion are included in this book. Dr Messenger discusses clinicopathological aspects of the common disorder, alopecia areata. Dr Mendelsohn gives a straightforward, clear account of pregnancy eruptions. Dr Graham-Brown gives a comprehensive yet concise survey of that strange condition, lichen planus. Dr Graham treats us to a thorough appraisal of the enigmatic juvenile plantar dermatosis. Mr Walton takes an experienced comprehensive look at ectoparasites of import- ance to man and the concluding chapter by Dr Finlay provides a concise, helpful insight into how modern technology can aid der- matology. JULIAN VERBOV VII ABOUT THE EDITOR Dr Julian Verbov is Consultant Dermatologist to Liverpool Health Authority and Honorary Clinical Lecturer in Dermatology at the University of Liverpool. He is a member of the British Association of Dermatologists, repre- senting the British Society for Paediatric Dermatology on its Executive Committee. He is Editor of the Proceedings of the North of England Dermatological Society. He is a Fellow of the Zoological Society of London and a member of the Society of Authors. He is a popular national and international speaker and author of more than 200 publications. His special interests include paediatric dermatology, inherited disorders, dermatoglyphics, pruritus ani, cutaneous poly- arteritis nodosa, therapeutics, drug abuse, and medical humour. He organizes the British Postgraduate Course in Paediatric Dermatology and is a member of the Editorial Board of Clinical and Experimental Dermatology.

This is the eighth volume in the New Clinical Applications Dermatology Series. Awareness of relationships is of prime importance in der matology. Professor Scully and Dr Porter cover the skin and mouth in a comprehensive and informative manner. Mr Peter Wright effortlessly and concisely brings the eye and the skin together. Dr C. Rowland Payne both relates and speculates on the enigma of sarcoidosis. Pro fessor Elder concludes the book with a scholarly update on porphyria and the skin. I thank all the above for their fine contributions. This volume should have widespread appeal. JULIAN VERBOV ABOUT THE EDITOR Dr Julian Verbov is Consultant Dermatologist to Liverpool Health Authority and Honorary Clinical Lecturer in Dermatology at the University of Liverpool. He is a member of the British Association of Dermatologists, repre senting the British Society for Paediatric Dermatology on its Executive Committee. He is Editor of the Proceedings of the North of England Dermatological Society. He is a Fellow of the Zoological Society of London and a Member of the Society of Authors. He is a popular national and international speaker and author of more than 200 publications."

CONTENTS - IN FAVOUR OF COSMETICS - THE SKIN - 1. THE SKIN - 2. ALLERGY AND DERMATITIS - 3. DIET AND SKIN HEALTH - 4. SKIN PENETRATION AND SKIN NUTRITION - THE CARE OF THE FACE - 5. COLD AND CLEANSING CREAMS, CLEANSING MILKS AND LOTIONS - 6. ACID CREAMS, MILKS AND LOTIONS - 7. ASTRINGENT ("PORE") LOTIONS AND SKIN "TONICS" - 8. FACE PACKS AND MASKS - 9. VANISHING, POWDER AND ALL-PURPOSE CREAMS; FOUNDATION CREAMS AND FOUNDATION MAKE-UP PREPARATIONS - 10. SKIN FOODS, LUBRICATING AND SKIN CONDITIONING CREAMS - 11. FACE POWDERS, COMPACT POWDERS AND CAKE MAKE-UP - 12. MAKE-UP PREPARATIONS - 13. SUNBURN AND SUN-TAN PREPARATIONS - 14. ACNE PREPARATIONS - 15. THE APPLICATION OF COSMETICS - THE CARE OF THE MOUTH - 16. THE TOOTH AND PATHOLOGICAL DENTAL CONDITIONS - 17. TOOTH PASTES AND TOOTH POWDERS, DENTURE CLEANSERS - 18. MOUTHWASHES - THE CARE OF THE EYES - 19. EYE LOTIONS - THE CARE OF THE HAIR - 20. THE HAIR - 21. HAIR TONICS AND LOTIONS - 22. HAIR SHAMPOOS, RINSES AND CONDITIONERS - 23* PERMANENT WAVING - 24* HAIR-SETTING LOTIONS AND LACQUERS - 25* HAIR BRILLIANTINES, CREAMS AND FIXATIVES - 26. HAIR DYES - THE CARE OF THE BODY - 27. THE PROCESSING OF TOILET SOAP - 28. BATH PREPARATIONS - 29* SHAVING PREPARATIONS - 30. ANTIPERSPIRANTS AND DEODORANTS - 31. DEPILATORIES - 32. COSMETIC STOCKINGS - 33. FOOT PREPARATIONS - 34. INSECT REPELLENT AND INSECT BITE PREPARATIONS - 35. BABY PREPARATIONS - THE CARE OF THE HANDS - 36. THE NAILS - 37* MANICURE PREPARATIONS - 38. HAND CREAMS AND LOTIONS - 39* PROTECTIVE CREAMS AND HAND CLEANSERS - COSMETIC FACTS AND FALLACIES - 40. COSMETIC FACTS AND FALLACIES - GENERAL ASPECTS OF COSMETIC FORMULATION - 41. EMULSIONS AND TRANSPARENT DISPERSIONS - 42. ANTISEPTICS AND PRESERVATIVES - 43. ANTIOXIDANTS - 44. HUMECTANTS - 45. "MODUS OPERANDI " - APPENDICES - INDEX -

Leading researchers and clinicians join forces to explain how malignant melanoma develops from its benign precursor cell type. The authors focus on the molecular mechanisms involved in melanogenesis, in the malignant transformation of melanocytes, and in the further progression of primary melanomas into invasive and metastatic melanomas. They also review recent advances in our understanding of the basic biology of melanocytes and the development, migration, and differentiation of melanoblasts into melanocytes. The book provides an up-to-date understanding of the progressive mechanisms of oncological development in malignant melanoma, a likely model of malignant progress for other types of cancer, and the ongoing development of novel therapeutics.

This book discusses recent advances in theoretical-computational studies on the biosynthesis of melanin pigment (melanogenesis). These advances are being driven by the development of high-performance computers, new experimental findings, and extensive work on medical applications involving the control of pigmentation and the treatment of challenging dermatological diseases. Understanding the elementary processes involved in chemical reactions at the atomic scale is important in biochemical reaction design for effective control of the pigmentary system. Accordingly, the book focuses on the elementary steps involved in melanogenesis, which crucially affect the composition of the resulting melanin pigment by means of competitive reactions. The book also addresses reactions analogous to melanogenesis, with a focus on o-quinone reactions, which are especially important for understanding melanogenesis-associated cytotoxicity.

Behcet s Syndrome has seen great strides over the last two decades in the availability of new treatments and the understanding of underlying pathogenesis. Only 30 years ago the majority of particularly young men with Behcet s lost total eye sight, now only a minority do. This book covers the most recent developments in the basic and clinical aspects of Behcet s Syndrome. International authorities have collaborated to offer their diverse expert knowledge on the multiple affected organs and systems, including the skin, the eye, the brain, the lungs and not the least the gastrointestinal and the locomotor systems. A special chapter is devoted to juvenile disease. The definitive resource on Behcet s Syndrome, this book is well suited for rheumatologists, dermatologists, ophthalmologists, neurologists, and health professionals caring for Behcet s patients."

Biometrics in dermatology is an essential tool where data evaluation results in valid interpretations. This book will be the first in this area. One part of the book will describe principal aspects of dermatological research focussing on practical advice. A special part will cover applied biometrics to provide the clinician and researcher with state-of-the-art guidelines to assess the severity of common skin diseases. An additional aspect that will be of interest to pharmacologists addresses pharmacologic assays.

Cell Biology: Gammadelta T Lymphocytes in Mice and Man: A Review; J. Borst, et al. Ontogeny: Features and Functions of Epidermal T Lymphocytes; G. Stingl, et al. Lymphocyte Homing: Cytokine Neuropeptide Interactions in the Skin; T.A. Luger, et al. Effect of UV Light on Cytokine Production by Epidermal Cells; T. Schwarz, et al. Viruses: A New Retrovirus from Cutaneous Tcell Lymphoma; V. Manzari, et al. Survey of Cutaneous Tcell Lymphomas for Human Tlymphotropic Virus Infection; M. D'Incan, et al. Histology: Inflammatory Precursors of Mycosis Fungoides; W.C. Lambert. The Histological Spectrum of Cutaneous Tcell Lymphoma; N. Smith. Genotyping: BCL2 Gene Rearrangement and Protein Expression in Primary Cutaneous Bcell Lymphomas; F. Pezzella, et al. Immunomodulation and Tumor Progression. 35 additional articles. Index.

It is estimated that around 15% of the population suffer from atopic dermatitis or eczematous disorders at some point in their lifetime, causing a significant percentage of visits to dermatologists, primary care physicians, and allergists. Despite much current research interest, the pathophysiology of these disorders and their optimum treatment remain uncertain. In Atopic Dermatitis & Eczematous Disorders, the authors discuss all clinical aspects and treatment of atopic dermatitis and other eczema variants, including: Seborrheic dermatitis Nummular eczema Stasis dermatitis Exfoliative erythroderma HIV-related dermatoses Ichthyosis vulgaris Hand dermatitis Immunodeficiency disorders The book also discusses complications such as secondary infection and ophthalmic disease, as well as legal aspects. It contains almost 300 high-quality color clinical images, making it an invaluable visual reference for dermatologists in practice and training, candidates for post-registration qualifications, primary care practitioners, medical students, and allergists.