Scleroderma, or systemic sclerosis, is a chronic connective tissue disease generally classified as one of the autoimmune rheumatic diseases. Hardening of the skin is one of the most visible manifestations of the disease. It's estimated that about 300,000 Americans have scleroderma. About one third of those people have the systemic form of scleroderma. Since scleroderma presents with symptoms similar to other autoimmune diseases, diagnosis is difficult. This issue will cover: The Genetic Basis of SSc: Genetics, Epigenetics, Mechanisms of Pathogenesis - linking fibrosis, vasculopathy and immune dysregulation, The Role of Autoantibodies in Diagnosis and Prognosis/survival, Managing Raynaud's phenomenon and ischemic ulcers Managing SSc Lung Disease, Monitoring for and Managing Pulmonary Arterial Hypertension, and many more!

Granulomatous disorders represent a unique group of diseases both non-infectious and infectious that require the utmost clinical pathologic correlation combined with a keen sense of inquiry for underlying systemic disease. Some of these diseases are common and some are rare; however all dermatologists need to diagnose and manage these diseases whether common or rare. This issue of Dermatology Clinics "Granulomatous Disorders of the Adult Skin" supplies the readers with a comprehensive, up to date, and evidence based review of multiple granulomatous disorders (i.e. palisdaing, epitheliod, xanthomatous, casseating, supprative, vasculitic, lymphoproliferative, foreign body). Dermatologists need to be able to differentiate the entities, evaluate patients for specific underlying systemic diseases (diabetes to cancer) and treat with a wide range of immunosuppressant to anti-infectious agents. This issue will help the dermatologist learn the most current etiopathogenesis, clinical/systemic manifestations and therapeutic modalities for these diseases. Other specialists who would find the information useful: Rheumatologists, Infectious Disease specialists, Hematologists/Oncologists, Endocrinologists, Pulmonologists, Oral-maxillary surgeons, and Pharmacists.

Expert on diseases of the nails and also disorders of the nail that indicate systemic disease, Dr Antonella Tosti leads this issue of Dermatologic Clinics. In the article "Tips to Treat 5 Most Common Nail Disorders" readers will find treatment options for brittle nails, onycholysis, paronychia, psoriasis, and onychomycosis, with a practical treatment algorithm. In the article "Tips for Diagnosis and Treatment of Nail Pigmentation" physicians will be able to determine when to wait and see, when to biopsy, and when to excise a pigmented nail lesion. In "Tips to Diagnose Uncommon Nail Disorders" physicians will understand nail disorders that are not very common and should be able to easily diagnose after reading this article. A novel and unique approach in "Tips to Diagnose Nail Diseases from Localization" covers Proximal and lateral nail folds, Nail matrix, and Nail bed/hyponichium. The section on "Tips that Make Nail Surgery Easy" presents practical and simple methods to Obtain a good anesthesia, Perform a punch biopsy; Treat an ingrown toenail, and Best way to remove a subungual tumor; each is accompanied by a technique video. The issue concludes with "Tips to Obtain the Best from your Lab," addressing submitting specimens the right way and using nail clippings for diagnosis beyond fungal diseases; topics are What can be diagnosed with a nail clipping and How to submit a nail specimen.

This issue of Surgical Oncology Clinics of North America, edited by Adam Berger, is devoted to Melanoma. Articles in this issue include: Current Staging and Prognostic Factors in Melanoma; Melanoma Pathology; Surgical Treatment of Primary and Recurrent Melanoma; Sentinel Lymph Node Mapping and Its Importance for Melanoma in the 21st Century; Lymph Node Dissection for Stage 3 Melanoma; Metastasectomy for Stage IV Melanoma; Local/Injectional Therapies for Satellite and In-Transit Disease; Regional Therapies for In-Transit Disease; Role for Radiation Therapy in Melanoma; Update on Immunotherapy for Melanoma; Targeted Therapies in Melanoma; and Evidence for Long-Term Follow-up of Melanoma Patients.

Urticaria, commonly known as ‘hives’, is a skin rash which can have allergic and non-allergic causes. This handbook is an initiative of the Global Allergy and Asthma European Network (GA2LEN) Urticaria Centers of Reference and Excellence (UCARE). Divided into 22 sections, the text begins with an overview of urticaria, its classification, and aetiopathogenesis. The next chapters describe different types of urticaria, diagnostic measures, and therapeutic management. The final sections examine urticaria in children, in the elderly, in pregnancy and lactation, and in kidney, liver and cardiac disease. A separate chapter covers patient education material. Authored by renowned worldwide experts, the text is further enhanced by clinical images, tables and figures to assist learning.

Contact urticaria is an immediate but transient localized swelling and redness that occurs on the skin after direct contact with an offending substance. It is caused by a variety of compounds, such as foods, preservatives, fragrances, plant and animal products, metals, and rubber latex and the mechanism by which these provoke an immediate urticarial rash at the area of contact can be divided into two categories: non-immunological contact urticaria and immunological (allergic) contact urticaria. Non-immunological contact urticaria typically causes mild localized reactions that clear within hours, e.g. stinging nettle rash. This type of urticaria occurs without prior exposure of a patient's immune system to an allergen. Immunological contact urticaria occurs most commonly in atopic individuals (people who are prone to allergy). Hence prior exposure to an allergen is required for this type of contact urticaria to occur. While there have been other texts written on the subject over the last decade, this book is intended as an easily accessible guide for dermatologists and residents, as well as general practitioners, summarizing the most important concepts that will help physicians identify the signs and symptoms of Contact Urticaria Syndrome in their daily clinical practice. Each chapter is laid out in the following format: Concepts, Tools and Algorithms of Diagnosis and Management, a Clinical Case for each entry, and Recommendations. Additionally, the Volume Editors have worked to provide a global approach to this syndrome using internationally standardized requirements for diagnosis.

Following the popular success of the first volume published by Dr Azizzadeh and Dr Massry among cosmetic surgeons and physicians, the Editors present a second Multispecialty volume, this one dedicated to Midface and Lower face rejuvenation. The Editors have once again selected an expert team of Editors spanning the practices of Plastic Surgery, Oculoplastic Surgery, Facial Plastic Surgery, and Dermatology, with expert Authors presenting anatomy, techniques, procedure planning, complications, and outcomes in each specialty field. Topics are planned on: Complications of Lower Blepharoplasty and Midface lifting; Deep Plane Face Lifting for Midface Rejuvenation; The Transeyelid Midface Lift; Management of Post-blepharoplasty Lower Eyelid Retraction; Contemporary Thoughts on Lower Eyelid/Midface Aging; Aesthetic Canthal Suspension; Dark Circles: Etiology and Management Options; Laser Resurfacing Applications for Periocular Rejuvenation; Non-Resurfacing Approaches for Lower Eyelid Rejuvenation; Skin Care For The Lower Lids: "Bags," "Dark Circles," and "Wrinkles;" Volumetric Strategies for the Lower Lid and Midface; Transcutaneous Lower Lid Blepharoplasty With and Without Fat Repositioning; Fat Grafting of the Lower Lid and Midface; Transtemporal Midface Lifting to Blend the Lower Eyelid Cheek Junction; Utilizing a New Classification of Midfacial Aging to Customize Multimodality Midface Rejuvenation Surgery; Transconjunctival Lower Lid Blepharoplasty with and without Fat Repositioning, among others. Any practitioner of cosmetic facial procedures, invasive, minimally invasive, or non-invasive, will receive a wealth of information from expert practitioners who obtain excellent results.

Psoriasis is the most prevalent autoimmune disease in the U.S. . ~125 million people worldwide have psoriasis. Commonly misunderstood and interpreted as a "cosmetic" problem, psoriasis is a complex and potentially debilitating disease; nearly 60% of people with psoriasis reported their disease to be a large problem in their everyday life. This issue of Dermatologic Clinics devoted exclusively to psoriasis is edited by two leaders of the International Psoriasis Council, Dr Alan Menter and Dr Chris Griffiths. Topics include: Genetics of psoriasis; Immunopathogenesis of psoriasis; Phenotypical expressions of psoriasis; Psoriasis as a systemic disease with multiple comorbidities; Outcomes measures in the assessment of psoriasis in clinical practice and trials; Update on topical therapies for mild to moderate psoriasis; Phototherapy and photochemotherapy (PUVA) for psoriasis; Current and future oral systemic therapies for psoriasis; Current biological therapies for psoriasis; Future biological therapies for psoriasis; Psoriatic arthritis for the dermatologist; Pharmacogenomics and the future of psoriasis therapies. This information that goes to the heart of clinical practice is equally appropriate, beyond dermatologists, for internal medicine clinicians, primary care physicians, bone & joint specialists; hematologists/oncologists, and researchers in genetic targeted therapy development.

Malpractice settlements are large for undetected hydroxychloroquine and chloroquine toxicity which, if untreated, can lead to permanent loss of central vision. Knowledge of the ocular toxicity of these drugs has increased during the past fifty years as their use has expanded. Hydroxychloroquine and Chloroquine Retinopathy is the first single-source book on the subject and is essential for the practicing ophthalmologists, rheumatologists, dermatologists, and internists who prescribe these drugs. It covers clinical topics such as signs and symptoms of toxicity, toxicity screening, ancillary testing, to whom and why the drugs are prescribed and dosing considerations. Additionally, the book addresses practice management considerations, including coding, reimbursement and equipment costs, and the medico-legal responsibilities of the rheumatologist and of the ophthalmologist. Guidelines for the management of hydroxychloroquine and chloroquine vary around the world and differences between the guidelines of the United Kingdom, the United States, and other countries are identified. The book concludes with a collection of case examples illustrating common clinical scenarios and their management. This book is a "must-have" resource for physicians who use these drugs.

Topics in this issue of Dermatologic Clinics include: Incidence and prevalence; Impact on quality of life; Special considerations of hyperhidrosis in children; Topical therapies; Iontophoresis; Botox for axillary hyperhidrosis; Botox for palmar/plantar hyperhidrosis; Botox for other hyperhidrosis; Systemic therapies for hyperhidrosis; Procedural approaches; Endoscopic thoracic sympathectomy; Emerging and investigative treatments; Resources for patients and physicians; Incorporating diagnosis and treatment into clinical practice. Dr David Pariser is Editor of this publication; a founding member of the International Hyperhidrosis Society and renown researcher and lecturer on mechanism, diagnosis, and treatment of hyperhidrosis, Dr Pariser continues to investigate therapies that are effective for patients.

Editors Kimberly Brown and Celia Chao and authors review the latest in Melanoma. Articles will include Epidemiology, Risk Factors, Prevention, and Early Detection; Work-up and Staging of Malignant Melanoma; Principles of Surgical Treatment of Malignant Melanoma; Surviving Cutaneous Melanoma; Locoregional Therapies; Melanoma Vaccines; The Role of Radiation Therapy in Melanoma; Systemic Therapy in Melanoma; Unusual Presentations of Melanoma; Surgical Treatment Options for Stage IV Melanoma; Head and Neck Melanoma; Melanoma in Non-Caucasian Populations and more!

Dermoscopy is a non-invasive, widely used diagnostic tool that aids the diagnosis of skin lesions and is proven to increase the accuracy of melanoma diagnosis. This atlas is a comprehensive guide to dermoscopy for practising dermatologists and trainees. Beginning with an introduction to the principles of dermoscopy and an explanation of the parts and types of dermoscope, the next chapter covers dermoscopic histopathological correlation. The following sections cover common dermatological conditions, including hair and nail disorders. Numerous dermoscopic images with markings showing key features clearly illustrate each disorder. Differences in dermoscopic characteristics of fair skin and darker skin types are highlighted.

Dr Henry Lim, renown for expertise and research in photodermatology leads this issue of Dermatologic Clinics. Photodermatology in this issue addresses dermatoses brought on or accelerated by light as well as light forms for dermatology therapies. Photodermatology is used to diagnosis and treat many common conditions that bring patients to the dermatologist. Topics include: Introduction to photobiology; Evaluation of patients with photodermatologic conditions; Photoimmunology; Photoaging; Photocarcinogenesis; Polymorphous Light Eruption (PMLE); Actinic Prurigo; Hydroa vacciniforme and solar urticaria; Chronic actinic dermatitis; drug-induced photosensitivity; Cutaneous porphyrias; Photoaggravated dermatoses; Ultraviolet (UV) based therapy; Photodynamic therapy; Photoprotection. Dr Lim works with one his residents, So Yeon Paek, as his co-Editor on this issue. "On the whole, the book is very informative and nice to read. It is highly recommended to both clinicians and researchers who are interested in the field of photodermatology." Reviewed by: Department of Dermatology, Uppsala University Hospital on behalf of the Acta Dermato-Venereologica journal, Nov 2014

People of African ancestry have sensitive skin and may suffer from a wide variety of skin disorders. Hair disorders are also common and differ from those suffered by Caucasians. This issue of the Dermatologic Clinics focuses on the most common skin and hair disorders seen in black skin, with articles focusing on acne scarring, alopecia, keloids, and skin pigmentation. There are also articles addressing moisturizers for the skin and the effect of hair treatments on the hair and scalp. Also discussed is the sociohistoric issues that can cloud the scientific understanding of clinical entities. Emphasis is often put on race and yet a very clear distinction should be made between race and quantifiable entities such as pigment and hair curl as determinants for skin/hair disease predilection; this is quite distinct from race as a surrogate for social class and a disease determinant for most medical conditions and malignancies.

The main goal of the present book is to deal with the role of nanobiotechnology in skin, soft tissue and bone infections since it is difficult to treat the infections due to the development of resistance in them against existing antibiotics. The present interdisciplinary book is very useful for a diverse group of readers including nanotechnologists, medical microbiologists, dermatologists, osteologists, biotechnologists, bioengineers. Nanotechnology in Skin, Soft-Tissue, and Bone Infections is divided into four sections: Section I- includes role of nanotechnology in skin infections such as atopic dermatitis, and nanomaterials for combating infections caused by bacteria and fungi. Section II- incorporates how nanotechnology can be used for soft-tissue infections such as diabetic foot ulcer and other wound infections; Section III- discusses about the nanomaterials in artificial scaffolds bone engineering and bone infections caused by bacteria and fungi; and also about the toxicity issues generated by the nanomaterials in general and nanoparticles in particular. The readers will be immensely enriched by the knowledge of new and emerging nanobiotechnologies in a variety of platforms.

CONTENTS - PART ONE: THE SKIN AND SKIN PRODUCTS - 1 The Skin - 2 Irritation and Sensitization of the Skin - 3 Nutrition and Hormonal Control of the Skin - 4 Skin Creams - 5 Astringents and Skin Tonics - 6 Protective Creams and Hand Cleansers - 7 Bath Preparations - 8 Skin Products for Babies - 9 Skin Products for Young People - 10 Antiperspirants and Deodorants - 11 Depilatories - 12 Shaving Preparations - 13 Foot Preparations - 14 Insect Repellents - 15 Sunscreen, Suntan and Anti-sunburn Preparations - 16 Skin Lighteners or Bleaches - 17 Face Packs and Masks - 18 Face Powders and Make-up - 19 Coloured Make-up Preparations - 20 The Application of Cosmetics - PART TWO: THE NAILS AND NAIL PRODUCTS - 21 The Nails - 22 Manicure Preparations - PART THREE: THE HAIR AND HAIR PRODUCTS - 23 The Hair - 24 Shampoos - 25 Hair Setting Lotions, Sprays and Dressings - 26 Hair Tonics and Conditioners - 27 Hair Colorants - 28 Permanent Waving and Hair Strengtheners - 29 Hair Straighteners - PART FOUR: THE TEETH AND DENTAL PRODUCTS - 30 The Tooth and Oral Health - 31 Dentifrices - 32 Mouthwashes -

Educational opportunities for pediatric residents and primary care providers that contribute to increased competence in pediatric dermatology are an important component of improving the quality and efficiency of dermatologic care provided to children and adolescents. The 13 articles that comprise this issue have been selected to capture a significant proportion of the most common skin diseases that are seen in children and adolescents. They are intended to provide practical information on diagnosis and initial management that can be performed by the primary care provider and to provide a framework for allowing for more active involvement by the primary care provider with regards to ongoing management of these conditions. From atopic dermatitis to vitiligo, the pediatric primary care provider is guaranteed to see these conditions in their practice. "..covers a wide variety of topics relevant for all pediatricians." Reviewed by BACCH Newsletter, Apr 2015

As baby boomers continue to age, demand for cosmetic procedures continues to rise. New techniques and products are constantly entering the growing market of cosmetic procedures, particularly lasers and fillers. Advances in the use of lasers, fillers, and botox are allowing dermatologist to better refine and customize treatments based on each patient's cosmetic needs. This issue of ther Dermatology Clinics covers all of the latest information on cosmetic dermatology, including articles on fillers, lasers and cosmeceuticals.

Skin immune system (SIS).- Immunological aspects of allergic inflammation: IgE regulation.- The role of T cells in the pathogenesis of atopic dermatitis.- Immunological aspects of allergic inflammation: eosinophils.- Mast cells.- Cell-to-cell interactions.- Atopic dermatitis.- Allergic contact dermatitis: cosmetics.- Clinical aspects of occupational contact dermatitis.- Clinical aspects: urticaria.- Clinical aspects: drug allergy.- Future developments in treatment of atopic dermatitis.

Viewing lesions using a dermatoscope helps the dermatologist distinguish between benign and malignant lesions. It is particularly useful in the early diagnosis of melanoma, which is the fastest growing cancer in the US and worldwide. This issue of the Dermatologic Clinics issue all of the important topics in dermoscopy, including differentiation of lesions, lesions in the young and older populations, and dermoscopy in general dermatology.