This issue of Dermatologic Clinics, guest edited by Drs. Shari Lipner will cover a number of important topics related to Nail Disorders. This issue is one of four each year selected by longtime series Consulting Editor, Dr. Bruce Thiers. Topics discussion include, but are not limited to: Nails and Systemic Disease, Pediatric Nail Disorders, Bacterial and Viral Infections of the Nail Unit, Nail Psoriasis, Lichen Planus, Diagnosis of Melanonychia, Management of Nail Unit Melanoma, Nail Tumors, Dermoscopy of the Nail Unit, Nail Surgery, Pathology of the Nail Unit, Nail Imaging, Nail Cosmetics, and Nail psoriasis in the elderly, among others.

Basic research on the pharmacology of itch has exploded in the wake of two very influential papers that were published in Nature (2007) and Science (2009). Long overlooked as a milder form of pain, itching has rapidly gained a new appreciation in both research and clinical communities because of its complexity and its negative effects on the quality of life of the distressed patients. Like pain, not all itches are the same. Unlike pain, there are no standard drugs equivalent to aspirin and morphine. Epidemiological studies emphasize the high incidence and economic costs of itch (pruritus). It is the most prevalent symptom of a wide variety of allergic and inflammatory skin conditions (e.g., psoriasis, atopic dermatitis), is associated with several systemic diseases (e.g., chronic kidney and liver disease), and occurs in patients undergoing hemodialysis, spinal administration of opioids, and in those suffering from AIDS. The reader will learn about the multiple pathways for itch and their interactions with pain. The relationship between these closely related, yet distinct sensory phenomena, will be emphasized. Both itch and pain use several common molecules to send signals to the brain. Thus, drugs that have been, and are being, developed as analgesics may also attenuate intractable itch. This has been an exciting and very necessary turn of events since traditional H-1 receptor antagonists are ineffective in blocking the pruritus associated with kidney failure and cholestasis. The clinical chapters will provide insights into contemporary treatment regimens for pruritus in different human scenarios.

This book focuses on neglected skin diseases and conditions in resource-poor countries through the lens of livelihoods. These diseases, when neglected, not only affect the skin, but also joint movement and physical appearance, severely influencing the lives and livelihoods of individuals and families in vulnerable communities. The book explores why neglected skin diseases thrive in resource-poor countries, and considers how this cycle might be broken by looking at the impact on livelihoods and access to healthcare in affected communities. The research is shaped by three guiding questions: Firstly, why have some measures been successful in one part of a population and not the other? Secondly, what is unique about vulnerable populations in various parts of the world? And thirdly, can the cycle of debilitating skin diseases and conditions in resource-poor countries be broken? In addressing these concerns, the book excavates past and present efforts in public health measures to combat these diseases, considers the impact of culture and livelihoods, and reviews some of the milestones in disease elimination and eradication. This book will be an indispensable source for health service planners, administrators and practitioners working with vulnerable populations, as well as graduate students and researchers in public health.

This is the second edition of a well-received book that has been revised and updated to reflect the state of the art in laser and light source technology. After an initial chapter describing the latest understanding of laser physics and safety, subsequent chapters consider laser treatment of vascular lesions, laser treatment of pigmented lesions and tattoos, laser removal of unwanted hair, ablative and non-ablative fractional resurfacing, and use of laser treatment for medical purposes. The book is extremely practical and reader friendly. All chapters are very well illustrated, include quick and clear bullet points, and feature a homogeneous structure covering core concepts, currently available technologies, indications and contraindications, an example of a consent form, and the author's personal treatment approaches. The authors are without exception world experts in the field from North America or Europe.

This authoritative, highly illustrated text and color atlas provides a systematic guide to commonly performed minor surgical and dermatology procedures. Accompanied by video clips, this critical resource on skin and minor surgery is designed for all trainees and practitioners, including experienced surgeons, dermatologists, family doctors, nurses, and the supporting healthcare team. Divided into four main color-coded sections, the book covers essential background information including postoperative management and aftercare, the key knowledge required for diagnosis and management, and the skills necessary to perform procedures step by step. Comprehensive coverage-Learn to perform a whole range of procedures from small skin surgical procedures to vasectomy Step-by-step techniques-See how to perform each technique with numerous color illustrations, animations and video clips Practical advice, boxes, tables, warnings, and indications of difficulty level-Achieve success and avoid common pitfalls Authoritative yet contemporary-Gain wisdom from this long-established, trusted book brought completely up to date by today's practitioners

Drugs produced by molecular biological techniques, called the 'biologics', differ from the usual chemical medications. Their optimum use, and the detection and managemenet of adverse events, pose a significant challenge to the clinician. Licences for new biologics continue to be granted for the likes of rituximab, abatacept and certocizumals pegol. Intensive research is also defining new areas in which these drugs will be used in the future, increasing the number of practitioners using biologics. As the use of these drugs increases around the world, so the level of information needed by primary care practitioners and specialist prescribers needs to be expanded The Handbook of Biological Therapy provides the practising clinician with a practica guide to the use of Tumour Necrosis Factor Blocking Therapy (TNF-blockers), and important new class of biologic therapy for rheumatoid arthritis, ankylosing spondylitis, Crohn's disease, ulcerative colitis, psoriasis, and psoriatic arthritis. It is a comprehensive distillation of the authors' clinical experience with these drugs, combined with data from diverse databases offering practical advice on their uses, specific indications, supporting clinical trial data and safety issues, with the aim of making the use of these drugs easier for the busy clinician. All of the authors have been involved from the beginnings of the clinical trial programmes with these drugs and continue to use them in daily practice.

The field of vascular anomalies has grown rapidly in last 25 years. Molecular genetics has led to discovery of genes that cause vascular anomalies. Interventional radiology has become a major contributor to accurate diagnosis and management of previously untreatable disorders. New pharmacologic therapies are under investigation and surgical protocols have been established. Vascular Anomalies: Hemangiomas and Malformations is a comprehensive and interdisciplinary textbook ideal for dermatologists, interventional radiologists, surgical specialists, ophthalmologists, pathologists, geneticists, paediatricians, hematologic-oncologists, and vascular biologists. With a central motif of the biologic dichotomy of vascular tumors and vascular malformations, this book is organized into chapters which address clinical presentation, diagnostic imaging, molecular genetics, pathogenesis, histopathology, and management of vascular anomalies. Generous, full-colour images compliment this extensive volume written by three colleagues and their teammates from Children's Hospital Boston and Harvard Medical School, with leading specialists from other centers.

This book presents state-of-the-art experimental and modelling techniques for skin biophysics that are currently used in academic and industrial research. It also identifies current and future challenges, as well as a growing number of opportunities in this exciting research field. The book covers the basics of skin physiology, biology, microstructural and material properties, and progressively introduces the reader to established experimental characterisation protocols and modelling approaches. Advanced topics in modelling theories and numerical implementation are also presented. The book focusses especially on: 1. Basic physiology, molecular biology, microstructural and material properties of the skin. 2. Experimental characterisation techniques for the skin (including imaging): in vivo and in vitro techniques and combination of those with in silico approaches. 3. State-of-the-art constitutive models of the skin: elastic, anelastic and mechanobiological formulations (e.g. growth, ageing, healing). 4. Applications: mechanics, damage, biological growth, healing, ageing and skin tribology. This book is addressed to postgraduate students in biomedical/mechanical/civil engineering, (bio)physics and applied mathematics, postdoctoral researchers, as well as scientists and engineers working in academia and industry engaged in skin research, particularly, if at the cross-roads of physical experiments, imaging and modelling. The book is also be of interest to clinicians/biologists who wish to learn about the possibilities offered by modern engineering techniques for skin science research and, by so doing, provide them with an incentive to broaden their outlook, engage more widely with the non-clinical research communities and, ultimately, help cross-fertilising new ideas that will lead to better treatment plans and engineering solutions.

R. MARKS Biology has become a 'numbers game'. The advantages of being able to grade changes in tissue, submit results to statistical analysis and accurately record biological phenomena make measurement essential. This is as true for the various disciplines in applied biology as it is for the more esoteric aspects ofthe subject. Regrettably, sk in biologists until recently had not seized the opportunities that the availability of their tissue of interest afforded and fell behind in the exploration of measurement techniques. Probably this resulted in part from the mistaken sentiment that 'to see is to know'. It also originated from the complexity ofthe skin which. as a closely interwoven mixture oftissue types. makes assessments technically difficult. However, we are optimistic about the future. The International Society for Bioengineering and the Skin was formed in Cardiff in ] uly 1979 in response to the wishes of the delegates who had attended the first International Symposium on the subject in Miami in 1976 and the second in Cardiff 3 years later. This volume is the proceedings of the Cardiff meeting. We believe that it demonstrates the brave efforts and variety of new ideas that characterise the studies of scientists who realise the importance of blending the phYSICal sciences with skin biology.

This book provides a concise yet comprehensive source of information on the classification, evaluation, diagnosis, and management of vascular lesions of the orbit and face. It highlights recent technological innovations and new treatments that have significantly improved the ability to accurately evaluate and successfully treat these lesions with reduced complications. Some of these advances include new imaging modalities, intravascular and intralesional treatment approaches, photodynamic therapy, and additional medical therapies. Many of these advances have led to paradigm shifts in the understanding and management of vascular lesions of the orbit and face. This book, written by experts in the fields of ophthalmology, dermatology, diagnostic and interventional radiology, and oculoplastic surgery, features structured, in-depth chapters that can also be quickly consulted as a reference guide. It is an excellent resource for those in training as well as seasoned practitioners wishing to acquaint themselves with the newest diagnostic and treatment techniques for orbital vascular lesions.

Pruritus is a prevalent symptom in many skin conditions. However, much less is known about pruritus without primary skin disease. This problem affects most medical specialties, notably palliative care, haematology, oncology, internal medicine, hepatology, nephrology, anaesthesiology,
immunology and psychiatry. Specialists from these disciplines each see few patients with severe pruritus and therefore have only limited possibility to learn from their experience. In response, this book aims to build a bridge of knowledge and evidence between the various different specialties.
Pruritus can cause extreme discomfort in chronic cancer patients or in people who are receiving cancer treatment, as well as patients with non-malignant terminal illnesses. Knowledge about the pathophysiology of pruritus is scattered through many clinical specialties and this book brings this
information together in a readily accessible compendium of knowledge which will be of value to physicians of any specialty. An international group of contributors cover the neurophysiology, clinical assessment, and measurement of scratching activity as well as opiod-induced pruritus, pruritus in
haematological disorders, neuropathic pruritus, psychogenic pruritus and therapies and treatment.
Aimed primarily at palliative care physicians, oncologists and nurses, the book will also prove valuable to all health care professionals who require guidelines to assist with effective symptom control thereby ensuring best quality of life for their patients.

This book provides the description of the granulomatous diseases of otorhinolaryngology, head and neck with their characteristic features, investigations and management. It includes wide variety of infective, idiopathic, neoplastic, hereditary, reactive and various other types of chronic granulomatous reaction in the ear, nose, throat and head neck region. Further, the description is supported with various illustrations including clinical photographs, radiological pictures of CT scan, MRI scan etc. Histopathological and microbiological images which show characteristics and differentiating features are also included to aid in the diagnosis of the diseases. Histopathological colored images with high magnification and immunohistochemistry images are provided for better illustrations. This book also elaborates the important medical and surgical management of the granulomatous diseases. Every chapter ends with the 'Essential features' of that particular granulomatous disease, and this will certainly help the post-grad students and clinicians to differentiate the diseases, early diagnosis and management of the patients with chronic granulomatous diseases.

This revised text discusses key aspects for protective gloves, including glove materials, the manufacture of gloves, how to perform testing of gloves, and glove performance. The book provides guidance on how to select gloves to prevent skin contamination from chemical and microbial exposure in the occupational environment and presents hard-to-find information in one easy-to-use resource. It covers important concepts, including prevention of contact dermatitis, clinical testing of occupation-related glove sensitivity, and infection control and preventative measures for pandemics. The book: Provides update state-of-the-art information, practices, standards, and guidelines Covers information on protective glove material technology, protective effects, and adverse medical effects Explores ways to select gloves to prevent skin contamination from chemical and microbial exposure in the occupational environment Discusses concepts, including glove materials, the manufacture of gloves, how to perform testing of gloves, and glove performance according to standardized technical methods in vivo. The text will be useful for professionals in the fields of occupational and industrial hygiene, health care, and public health. It will also help graduate students in the fields of chemistry, chemical engineering, mechanical engineering, biology, pharmacy, and environmental health. This book offers a wealth of information on protective glove material technology, protective effects, and adverse medical effects. It gives detailed discussion of parameters, including the selection and use of gloves for industrial chemicals, acrylates, and pesticides, and gloves as protection against microbial contamination. It will be a valuable resource for professionals and graduate students in the fields of occupational and industrial hygiene, healthcare, public health, chemistry, chemical engineering, mechanical engineering, biology, pharmacy, and environmental health.

This title introduces readers to the use of lasers in dermatology/aesthetic practice and focuses on the fundamentals of lasers and light-based devices and their clinical application. Each chapter addresses the use of lasers in the treatment of a variety of skin conditions, detailing mechanisms of action, pre-treatment preparation, post-treatment advice, follow-up, and potential complications and pitfalls. Besides discussing ablative, vascular, pigment-specific and epilation lasers, and intense pulsed light, the book also reviews the use of light-emitting diodes, low-level laser therapy and radio frequency devices. In addition, cosmeceuticals complementing laser treatments are also discussed. Readers will also find the chapter on self-assessment questionnaires especially useful. Practical Introduction to Laser Dermatology provides detailed explanation of the topics, while the chapters are supported by illustrative case studies that will enable readers to develop a deeper understanding of the subject of lasers in dermatology. Using clinically relevant Illustrations, it provides a comprehensive resource on a variety of laser technologies for novice readers and trained laser clinicians.

In this issue of Dermatologic Clinics, guest editor and Vice Chair for Diversity, Equity and Inclusion, Department of Dermatology at the University of Pennsylvania, Dr. Susan C. Taylor brings her considerable expertise to the topic of Diversity, Equity, and Inclusion in Dermatology. Top experts in the field cover key topics such as social identity; unconscious bias; race, racism and structural racism in medicine; understanding and addressing microaggressions in medicine; gender equity in medicine and dermatology; equity for sexual and gender minority persons in medicine and dermatology; and more. Contains 16 relevant, practice-oriented topics including cultural competence or humility; diversity, equity and inclusion in dermatology workforce and academic medicine; racial disparities in research and clinical trials; diversity, equity and inclusion initiatives in dermatology organizations; steps leaders can take to increase diversity, enhance inclusion and achieve equity; and more. Provides in-depth clinical reviews on diversity, equity, and inclusion in dermatology, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

*Provides an accessible and concise aid to prescribing and monitoring systemic dermatologic therapy for all medical professionals involved in patient care *Enables dermatologists, family practitioners, pharmacists, and specialist nurses to make rational decisions about drug treatment while considering known risks and potential unwanted effects *Allows quick and easy access to reliable information with an international perspective

Recent advances in research have resulted in tremendous changes in burn management. Stay fully up to date with the new edition of Total Burn Care, by leading authority Dr. David N. Herndon. Detailed procedural guidelines and video clips walk you through every step of the process, from resuscitation through reconstruction and rehabilitation. Everyone on the burn care team, including general and plastic surgeons, intensivists, anesthestists, and nurses, will benefit from this integrated, multidisciplinary guide to safe and effective burn management. Discusses infection control, early burn coverage, occupational physical exercise, respiratory therapy, and ventilator management. Summarizes key points at the beginning of each chapter for quick reference. Uses an integrated, team approach to help you meet the clinical, physical, psychological, and social needs of every patient. Offers expert guidance on early reconstructive surgery and rehabilitation, with new content on improved surgical techniques. Provides access to 15+ procedural operative videos and PowerPoint presentations on topics ranging from alopecia and anesthesia to radiation and treatment of infection - ideal for teaching and presenting. Covers special populations such as elderly and pediatric patients, and includes a new chapter on burns in pregnancy. Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

Covering all major arthropods of medical importance worldwide, this award-winning resource has established itself as a standard reference for almost 25 years. With the globilization of commerce and the world becoming more intimately connected through the everyday ease of travel, unknown arthropod species are being increasingly encountered. This means access to up-to-date, authoritative information in medical entomology has never been more important. Now in its seventh edition, this book maintains its well-acclaimed status as the ultimate easy-to-use guide to identify disease-carrying arthropods, the common signs and symptoms of vector-borne diseases, and the current recommended procedures for treatment. Includes an in-depth chapter with diagnostic aids to help physicians to recognize and accurately diagnose arthropod-related diseases and conditions more easily Updates all chapters with the latest medical and scientific findings, including Zika virus, red meat allergy, new viruses found in ticks, and vaccine development for malaria and dengue fever Presents a greater medical parasitology emphasis throughout Offers electronic downloads containing additional photographs of arthropod-caused diseases and lesions, as well as instructional videos with pest identification aids, basic entomology, and insect and pest ecology. Illustrated throughout with detailed color images to aid identification, The Goddard Guide to Arthropods of Medical Importance, Seventh Edition will remain an essential guide for physicians, public health officials, and pest control professionals.

Skin cancer is the most frequent malignancy in humans and its incidence is still increasing. This situation calls for major efforts to manage the disease. Preventive measures must include reduced UV exposure and an enhanced common awareness of skin lesions. Advanced surgical techniques allow safe removal with excellent cosmetic results. In many cases alternative treatment modalities such as radiotherapy, cryosurgery and photodynamic therapy are applicable. The development of optimal sun screens and UV-protective clothes, new tools for early diagnosis of malignant lesions including videomicroscopy, improved evaluation of biopsy material and new treatment schemes will contribute to better patient care. New developments in therapy including pegylated interferons, cytokine-inducing molecules, monoclonal antibodies and vaccination approaches using peptides, dendritic cells, viruses or nDNA give hope for well-tolerated and efficient treatments.

Master the latest medical and cosmetic procedures with Surgery of the Skin, the most comprehensive dermatological surgery resource available. Written from the surgeon s perspective, this medical reference book features step-by-step guidance on performing the most updated developments and cutting edge approaches across the entire spectrum of dermatologic surgery.Surgery of the Skin was awarded the prize. "Major Contribution - Book" Reviewed by the Romanian Medical Association, 2015 "Dermatologists, both experienced and inexperienced, along with residents and other doctors interested in cutaneous and aesthetic surgery will greatly benefit from referring to this book." Reviewed by Lisa Naysmith, Section Editor on behalf of Acta Dermato-Venereologica, March 2015 Improve surgical results and avoid pitfalls with expert, evidence-based guidance. Stay on the cutting edge with in-depth step-by-step descriptions of tumescent vertical vector facelifts, blepharoplasty, composite grafts, Botox treatments, soft tissue augmentation, management of dysplastic nevi and melanoma, and more. View immersive videos from an expanded library with more than 130 clips totaling over six hour's footage. Explore brand-new chapters on rejuvenation of the female external genitalia; hidradenitis suppurativa; and photoaging-related mottled pigmentation. Improve treatment outcomes for patients with skin of color and gain a truly global perspective of dermatologic surgery through an expanded contributor group of leading international experts. Master how to perform cutting-edge techniques across the entire spectrum of dermatologic surgery, including botulinum toxins; fillers; cryosurgery; flaps; grafting; scar revisions; lasers; face-lift techniques; blepharoplasty techniques; Mohs surgery; and more. Effectively manage a full range of complex disorders, such as vitiligo surgery, keloids, and leg ulcers, with a unique section devoted to these special procedures. Easily visualize complex procedures and concepts with more than 1,000 illustrations, photos, and graphics. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, references, and videos from the book on a variety of devices. Master basic and highly advanced aesthetic and reconstructive techniques into your practice with comprehensive visual guidance

Melanocytic Lesions: A Case Based Approach provides a concise yet comprehensive guideline on how to diagnose common as well as problematic and challenging melanocytic lesions. In the first 11 chapters, each entity is illustrated by an actual case; followed by discussion of how the diagnosis is reached, of the histologic differential diagnoses and of diagnostic pitfalls and ends with bulleted teaching points. Pertinent and up to date references are included at the end of each chapter. The latter chapters cover current microstaging and classification of melanoma, ancillary techniques including immunohistochemistry as well as available molecular assays and molecular targeted therapy. All figures and glass slides of the discussed cases are hosted online for easy viewing and access. Melanocytic Lesions: A Case Based Approach will serves as a useful resource for pathologists, dermatologists and researchers dealing with melanocytic lesions.

Nanoscience in Dermatology covers one of the two fastest growing areas within dermatological science, nanoscience and nanotechnology in dermatology. Recently, great progress has been made in the research and development of nanotechnologies and nanomaterials related to various applications in medicine and, in general, the life sciences. There is increasing enthusiasm for nanotechnology applications in dermatology (drug delivery, diagnostics, therapeutics, imaging, sensors, etc.) for understanding skin biology, improving early detection and treatment of skin diseases, and in the design and optimization of cosmetics. Light sensitive nanoparticles have recently been explored, opening a new era for the combined applications of light with nanotechnology, also called photonanodermatology. However, concerns have been raised regarding the adverse effects of intentional and unintentional nanoparticle exposure and their toxicity. Written by experts working in these exciting fields, this book extensively covers nanotechnology applications, together with the fundamentals and toxicity aspects. It not only addresses current applications of nanotechnology, but also discusses future trends of these ever-growing and rapidly changing fields, providing scientists and dermatologists with a clear understanding of the advantages and challenges of nanotechnology in skin medicine.

* This book is the first to establish the theory and practice of an integrative psychodynamic approach to treating body-focused repetitive behaviors. * This book will help therapists working with people who struggle with body-focused repetitive behaviors enhance their capacity to understand and treat the relational roots of the behaviors. * This book provides a template for therapists to avoid the pitfalls of relapse and cross-addiction endemic to the typical cognitive-behavioral approach.

Few dermatologic problems carry as many emotional overtones as hair loss in women, which is by far the most common hair problem encountered in daily clinical practice. Fortunately, a specific diagnosis can usually be established through the application of appropriate examinations and tests, and treatment suited to the diagnosis is likely to control the problem. This comprehensively illustrated monograph provides both specialists and primary care physicians with the practical know-how required for successful management of hair loss in female patients of all ages. The book opens by critically examining various myths about hair loss. The different examination techniques are then described, and the various forms of hair loss and their treatment are discussed in detail. Approaches to follow-up are outlined, and the management of patient expectations is carefully considered. The potential role of hair care and cosmetics is also explored in some depth. "

This atlas is a comprehensive guide to the treatment and correction of scars. It is divided into four sections covering the different types of scar: atrophic and stretch marks, keloid and hypertrophic, normotrophic, and mixed. For each scar type, the various invasive and minimally invasive procedures and their results are documented with the aid of numerous high-quality photographs. In the section on keloid and hypertrophic scars, treatment is presented according to scar localization. In addition, the influence of etiology on treatment is considered, with distinction between scars due to injuries, animal bites, inflammatory diseases (including acne and varicella), and burns. Care is taken to distinguish between approaches suitable for fresh scars (in the inflammation, proliferation, and maturation phases) and those appropriate for scars present for more than one year. Potential adverse effects and complications of treatment are also explored. "