Contains current American Association of Pharmaceutical Scientists/Food and Drug Administration (AAPS/FDA) guidelines for the experimentation and analysis of in vivo and in vitro percutaneous absorption This up-to-the-minute reference provides comprehensive coverage of the latest advances in the development, preparation, and application of topical and transdermal therapeutic systems-exploring the biochemistry and treatment of various skin diseases as well as the structure and function of the skin, adverse dermal responses to drug formulations, mechanisms of drug transport through barrier membranes, and methods for measuring and modulating percutaneous permeation. Offers contemporary discussions on the bioequivalence of dermatological and transdermal dosage forms With more than 1800 useful references and 350 illustrations, tables, and equations, Dermatological and Transdermal Formulations is an essential source for cosmetic and pharmaceutical scientists, dermatologists, toxicologists, agrochemists, regulatory agency personnel, and upper-level undergraduate and graduate students in these disciplines.

Since skin forms the interface between the human body and the environment, its mechanical properties are important in health and disease. Bioengineering of the Skin: Skin Biomechanics gives a thorough introduction in the biological basis of skin biomechanics. It explains the non-invasive methods that allow measurement of the mechanical properties of the skin focusing on commercially available instruments.

Written by internationally leading experts in the field of non-invasive measurement technology of the skin, this volume describes the anatomy, biochemistry, physiology, and pathology of skin biomechanics. It explains in detail how to measure skin mechanic properties and how to use these measurements in the development of drugs and cosmetics.

Over 300 kitchen-tested recipes designed for the psoriasis, eczema, and psoriatic-arthritic patient, plus the latest nutritional facts for everyone

Foreword by Annemarie Colbin, C.H.E.S. and Founder of The Natural Gourmet Institute, New York

Statistics show that more than 100 million people worldwide suffer from the chronic skin disease psoriasis. In his first book, "HEALING PSORIASIS: The Natural Alternative, " Dr. Pagano presented a report of his natural, drug-free treatment regimen that has alleviated, controlled, and even healed psoriasis without the use of steroid creams, tar baths, injections, or ultraviolet treatments.

"Dr. John's Healing Psoriasis Cookbook "is the companion book to "Healing Psoriasis." The cookbook consists of three parts:
Part I - Basic Principles - gives technical data which includes the six principles behind the regimen: 1) Detoxification; 2) Diet and Nutrition; 3) Herb Teas; 4) Spinal Adjustments; 5) External Applications; and 6) Right Thinking
Part II - The Recipes - consists of over 300 original recipes specifically designed for the psoriatic patient
Part III - Eye on Nutrition - is loaded with general nutritional information and advice good for all readers.
There is also a helpful Color Photographic Portfolio of case histories which give undeniable proof of the efficacy of the Pagano regimen.

This book is designed to help develop a GPs skill in disease recognition and treatment. For this reason it approaches the subject from a symptoms-specific rather than a disease-specific angle.
It contains approximately 60 high-quality illustrations and explanatory text. It is ideal for use as an instant reference in day-to-day clinical practice or as part of ongoing CME. It would be ideally suited for those studying for the Diploma in Practical Dermatology

Ranging from the Egypt of the Pharaohs to the present day, Historical Atlas of Dermatology and Dermatologists offers a unique insight into the history of dermatology and the influences that led to present practice. It sheds new light on the emergence of dermatology as a separate medical speciality and on some of the key players who have contributed to its development. Arranged as an illustrated time-line this volume features an exceptional range of historical plates such as 'Molluscum contagiosum', from Thomas Bateman's Delineations of Cutaneous Diseases, 1817, an 1869 painting of ichthyosis hystrix by Carl Heitzmann, and early experiments in ultraviolet therapy by Finsen and colleagues in 1903. The authors have selected individuals representative of each era, workers who dealt seriously with the dermatologic concerns of the day, or who through their opinions or behavior project the color and ambience of the period in which they lived. They have included typical examples of the books, journals, instruments, and devices that made up the annals and paraphernalia of the speciality as it evolved. In order to know where you are going, you have to know where you've been. The field of dermatology has been fragmented in the last 30 years. It is becoming increasingly difficult to answer the simple questions: What is dermatology and what is a dermatologist? Research dermatology, dermato-histopathology, pediatric dermatology, and the explosion of surgical techniques have all made their mark on how dermatology is practiced. Historical Atlas of Dermatology and Dermatologists explores the development of this field and where it may be going in the future.

This book makes reference to all the main skin conditions - eczema, acne, vitiligo, psoriasis, dermatitis and alopecia amongst others - and makes extensive use of case studies and vignettes. It is this blend of theory and practical experience that is the hallmark of the book. All those concerned with dermatological problems will find something of value in it and should find it a valuable addition to their resources.

Skin lesions are often the first sign for an endocrine disease. Their description is thus of relevance for early diagnosis and treatment of endocrine disease for specialists in endocrinology as well as in dermatology.

Lavishly illustrated, this book describes the clinical and histological features of skin lesions observed in endocrine diseases. All features are reader-friendly structured and written in the language of dermatologists in order to enable a simple association between the features observed and the endocrine etiology.

This book includes 200 clinical cases which present as emergencies. Congenital and acquired conditions affecting all body systems in infants and children are covered, including allergy, abuse, burns, fractures and other trauma, feeding problems, foreign bodies, genetic disorders, infections, poisoning, haematology, oncology, and much more. Cases appear in random order, reflecting actual practice in emergency medicine, and reinforcing skills in investigation, diagnosis, and treatment. It is superbly illustrated with high-quality radiographic images and photographs and is indispensable for all health professionals dealing with emergencies involving children.

Chemotherapy and radiotherapy for cancer can have devastating side effects on the skin of a patient. This innovative guide for both dermatologists and oncologists gives a good introduction both to therapy regimes and to dermatological management for medical professionals treating their patients.

Principles of Polymer Science and Technology in Cosmetics and Personal Care

This concise, comprehensive guide is divided into two sections; nails and the skin. Each section includes information on the types of infections, aetiology, diagnostic procedures, such as sampling techniques, and therapy, including topical, systemic and adjunctive.

Skin reactions to drugs are a ubiquitous problem-the most commonly observed drug sensitivity observed in a wide range of specialties. Skin Reactions to Drugs emphasizes the mechanisms and clinical and laboratory proof of a cause-and-effect relationship between drugs and adverse reactions. It discusses the technique of drug challenge, which has been extensively developed in Finland, but not commonly practiced in the rest of the world.
In this textbook, 12 of the most common drug eruptions are described both clinically and histologically. It features a chapter on systemic contact dermatitis and also addresses cutaneous adverse drug reactions that appear in HIV-infected patients. 40 full-color photographs provide vivid examples of the reactions being discussed. A highly practical resource for practicing physicians and other health care workers, Skin Reactions to Drugs represents the platinum standard of research conducted on the causation of certain adverse reactions of skin.

There are many changes in the skin, hair, and nails during and after pregnancy. Patients are certainly aware that those changes are occurring, but few physicians and even fewer patients know how to predict the course of those changes. Pigmentary changes occur, but are they permanent? Can they be prevented or reversed? Hair may become thicker during pregnancy, only to fall out in the postpartum period. When will hair stop falling out? Will it grow back? What hormonal changes are occurring to produce these effects on the skin, hair, and nails? Will those hormonal changes affect other organs? Some cutaneous manifestations of pregnancy are common and recognized by most physicians. Abdominal striae, for example, are easily identified, but physicians have many questions about them. Why do they develop? Can they be prevented or treated? Other cutaneous manifestations of pregnancy are less common and recognized by few. For example, pruritic urticarial papules and plaques of pregnancy is a debilitating condition that is treatable once diagnosed. Even more important than the treatment, the knowledge imparted to a worried mother that her child will be fine and that the condition is se- limited is priceless; but the condition must first be recognized by the patient's physician. All of these questions and conditions are addressed in this extraordinary book. Pigm- tary disorders are addressed in detail in Chap. 2.

This unique reference provides concise, single-source coverage of the clinical, research, and therapeutic aspects of dermatological problems associated with bacteria, fungi, and viruses.
Introduces many novel antifungal, antibacterial, and antiviral agents
Highlighting the molecular biology as well as risk - benefit ratios of new diagnostic and treatment modalities, Cutaneous Infection and Therapy
evaluates the role of antimicrobial soaps in personal hygiene and research on preoperative skin preparation and infection rates
discusses reasons for the reduced risk of infection using occlusive wound dressings
explains the epidemiology, presentation, pathophysiology, and treatment of athlete's foot and fungal diseases of the scalp
presents new oral antifungals for the treatment of onychomycosis
examines the advantages and disadvantages of preparations to treat superficial fungal infections
addresses oral candidiasis in HIV infection and the resistance to antifungal therapy in AIDS patients
reviews the patterns of candidiasis in children and current approaches to antifungal therapy
covers the epidemiology, implications, and management of herpes in pregnant women and newborns
and much more

This book demonstrates evidence of a new microorganism infecting a person complaining of a dermopathy and fibers spontaneously exiting the dermis who was diagnosed with delusional parasitosis. The organism is likely a fungus that lives beneath the epidermis with the ability to infect common fibers including cotton, feathers and hair follicles.

Practitioners of aesthetic medicine and surgery already have a series of textbooks instructing on how to treat the standard patient. Unfortunately, they also have patients who do not conform to the average-those who are of a different age, or sex, ethnicity, or medical history, or who have special social requirements. Aesthetic Rejuvenation Challenges and Solutions: A World Perspective pools the expertise of top aesthetic practitioners who look at those complicated areas that tend to be ignored in the more standard textbooks and provides advice on managing these areas of special challenge that arise in clinical practice. The book contains extensive material on "non-standard" and "non-textbook" patients. It discusses how to evaluate these patients, and when to decide that a patient is not suited for a particular procedure. It discusses the treatment of patients of different ethnic groups, and provides guidance on how to manage patient expectations and deal with dissatisfied patients.

Botulinum toxin injections are the most used and best-known aesthetic treatment internationally, but there remain a number of problematic topics and suboptimal results. Here an internationally known expert and his contributors explain the scientific background and aesthetic principles that can help clinicians achieve better results in problem cases.

Handbook of Mouse Mutations with Skin and Hair Abnormalities presents 48 mouse mutations that are all available to the biomedical community. Many of the mouse mutations with dermatological diseases are reviewed and illustrated in detail. This popular reference book gives you a single source to use when determining which mouse mutation will best serve your needs as a biomedical tool for sophisticated research projects.

The book also includes an overview of domestic animal genodermatoses to provide alternatives to mouse models that do not exist or to complement those that do. A detailed section written by renowned experts compares the biology of human and mouse skin and skin diseases in the areas of development and the use of animal models, mammalian genetics, keratin biochemistry, epidermal and hair follicle cycles and kinetics, cytokines and growth factors, keratinocyte culture systems, cutaneous carcinogenesis, cutaneous immune system, and skin changes associated with mutations of the endocrine system.

Novel drug delivery technologies strive to bypass challenging biological layers to elicit desired pharmacological activity. The skin, one of our key defensive barriers, allows certain topically applied substances and toxins to pass. The dermatokinetics of a drug determines the efficacy of treatment of skin disorders. Presenting the first comprehensive reference on this important area of research, Dermatokinetics of Therapeutic Agents includes a general overview of the theoretical as well as practical aspects of dermatokinetics and addresses the impact of a drug delivery system on the dermatokinetics of drugs. Chapters and illustrations cover introductory aspects and the significance, methods, and models used in dermatokinetic studies of therapeutic agents. Topics include: Theoretical Models for Dermatokinetics of Therapeutic Agents Drug Delivery Approaches to Modulate Dermatokinetics of Drugs Conventional Methods of Cutaneous Drug Sampling Cutaneous Microdialysis Sampling Substrates by Skin Permeabilization Spectroscopic Techniques in Dermatokinetics Studies Regulatory Perspective of Dermatokinetic Studies

Atopic dermatitis (eczema) is one of the most common and most challenging skin conditions, for patients and practitioners alike. Uniquely organized by intrinsic and extrinsic etiologies, Atopic Dermatitis: Inside Out or Outside In? examines a myriad of causes that start from both the inside of the body and from the external environment, offering physicians practical ways to design treatments that specifically address these causes. Drs. Lawrence S. Chan and Vivian Y. Shi, along with a team of expert contributing authors, examine the etiology of this complex disorder and provide targeted, comprehensive solutions and the most useful therapeutic plans based on pathophysiology, including evidence-based integrative management. Analyzes the pathophysiology of atopic dermatitis from two distinct fronts: inside out and outside in-an approach that is unique in the field. Begins with an overview of the disease, then delves into both internal and external pathogenic factors, followed by the Clinician's Corner, which offers practical recommendations for treatment. Organizes therapeutic discussions by corresponding pathophysiology rather than a one-size-fits-all approach. Covers recently FDA-approved and emerging medications, as well as atopic comorbidities. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

The new edition of Dermatological Signs of Systemic Disease helps you identify a full range of common and rare systemic diseases early on so they can be managed as effectively as possible. Formerly titled Dermatological Signs of Internal Disease, it takes an evidence-based approach to diagnosis and treatment, offering dependable clinical recommendations that enable you to attain definitive diagnoses of internal diseases that manifest on the skin. Allows you to attain definitive diagnoses of internal diseases that manifest on the skin. Uses a consistent, user-friendly format for easy reference. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, and references from the book on a variety of devices. Covers hot topics such as lupus erythematosus, dermatomyositis, autoinflammatory diseases, eosinophilic and neutrophilic dermatoses, and psoriasis therapies and co-morbidities. Highlights newer therapies and treatment options for most diseases. Includes over 500 full-color illustrations - 200 new to this edition - that provide the best possible representations of diseases as they appear in the clinic. Features more viewpoints from an expanded team of nationally recognized experts in their respective fields.

This paper explains how Iran developed its nuclear programme to the point where it threatens to achieve a weapons capability within a short time frame, and analyses Western policy responses aimed at forestalling that capability. Key questions are addressed: will the world have to accept an Iranian uranium-enrichment programme, and does having a weapons capability mean having the Bomb? For nearly two decades, Western strategy on the Iran nuclear issue emphasised denial of supply. Since 2002, there has also been a demand-side dimension to the strategy, aimed at changing Iran's cost benefit calculations through inducements and pressure. But the failure of these policies to prevent Iran from coming close to achieving a nuclear-weapons capability has promoted suggestions for fallback strategies that would grant legitimacy to uranium enrichment in Iran in exchange for intrusive inspections and constraints on the programme. The paper assesses these 'second-best options in terms of their feasibility and their impact on the proliferation risks of diversion of nuclear material and knowledge, clandestine development and NPT break-out, and the risk of stimulating a proliferation cascade in the Middle East and beyond. It concludes that the risks are still best minimised by reinforcing the binary choice presented to Iran of cooperation or isolation, and strengthening denial of supply.

This is a highly illustrated guide to the diagnosis and management of nail conditions in children. With new material on genetics and on developments such as dermoscopy, it will be invaluable as a reliable clinical reference for both dermatologists and pediatricians, as well as those in family practice.

Offering broad coverage of the basic, clinical and curative aspects of photomedicine, this reference reflects the recent expansion of knowledge on the effects of light on normal skin as well as photosensitivity disorders and the use of light in treating various diseases and conditions.;The book demonstrates how light acts as a therapeutic agent by means such as phototherapy, photochemotherapy, extracorporeal photopheresis, and the use of lasers in photomedicine and photodynamic therapy.;Providing a detailed introduction to the subject, Clinical Photomedicine: discusses the fundamental principles of photomedicine such as skin optics, light sources, and pharmacology; explicates the acute and chronic effects of light on normal skin, including sunburn reaction, photoaging, and skin cancer; considers photoimmunology; examines clinical photosensitivity diseases as well as topical and systemic photoprotection; and much more.;With over 1300 literature citations, Clinical Photomedicine is designed as a resource for dermatologists and photobiologists, as well as residents and fellows in these disciplines.

Darkening patches on the skin can result in great distress for the patient. However, definitive diagnosis between the many possible causes and effective treatment can be very hard for the medical practitioner to achieve. This is the first major professional reference with systematic coverage of diagnosis and the various treatment options, and it will be an indispensable clinical reference.