Challenging Cases in Allergic and Immunologic Diseases of the Skin offers clinicians a wide range of challenging cases that are certain to provide hours of thoughtful and instructive review. Using a case study format and including excellent quality color images, Challenging Cases in Allergic and Immunologic Diseases of the Skin consists of five parts and 20 chapters. The chapters cover such areas as allergic rhinitis, allergic diseases of the eye, drug-induced urticaria, cosmetic allergy, drug allergy, latex allergy, atopic dermatitis, vasculitis, and a range of other commonly seen disorders of the skin. Each chapter comprises at least two cases that are followed by a differential diagnosis, discussion, and five multiple choice questions for thoughtful stimulation and excellent value as a teaching tool. Comprehensive, concise, and well-designed in presentation, Challenging Cases in Allergic and Immunologic Diseases of the Skin is a one-of-a-kind resource that will become a standard resource for all clinicians who care for patients with allergic and immunologic diseases of the skin.

and the development of resistance such recommenda The aim of this atlas is to provide clear guidance and a source of quick and easy reference for all physicians tions can, of course, only be of a general nature in an dealing with patients suffering from exotic skin diseases atlas such as this. The practising physician is therefore and for medical staff working in tropical and sub recommended to consult pertinent standard texts and guidelines on the respective diseases. Synonyms do tropical regions. It is not designed to replace the numerous excellent textbooks on tropical diseases and not change as rapidly as recommended treatments, and dermatology, but rather to supplement and com in an atlas of tropical dermatology and venerology are plement them in a practical way. indispensable to those readers whose first language is not the same as that used in the text: Thus, in addition The text and illustrations are the result of the per sonal experience gained from around the world in the to the English names, Spanish, French, German, Latin last forty years, and thus provide the reader with easy and local names as far as they are known are quoted to understand practical information on tropical and for each condition. Finally, for some infectious skin diseases, the distribution and life cycles of the parasites venereal diseases and ubiquitous dermatoses of the tropics and subtropics. are shown in maps and diagrams.

Case Studies in Systemic Sclerosis deals specifically with Systemic Sclerosis in a case study format. Each case presentation includes illustrative figures, a discussion of the pathophysiology relevant to the case, a discussion of management that is both evidence-based and expert opinion-based and several key references for further reading. With its easy-to-use format, this book presents multiple different manifestations of Systemic Sclerosis to a wide range of readers. Because this disease has a broad range of systemic features, Case Studies in Systemic Sclerosis is a valuable reference tool not only to the community of rheumatologists (trainees, academic and private practice rheumatologists) and dermatologists, but also potentially to internists, gastroenterologists, pulmonologists, cardiologists and nephrologists.

Measurement of Wound Healing will update the knowledge base and promote the use of measurements in order to improve both understanding of wounds and their management. This book will feature well used vascular measurements, pathological measurements, imaging measurements and so on. There will be chapters on techniques/measurements that have much promise. This book is led by 3 experienced clinician scientists from different backgrounds who have successfully worked together on projects.

Das Buch beinhaltet in praxisgerechter Form die Darstellung der aktuellen und gAngigen Methoden der phlebologischen Diagnostik und Therapie inklusive der bildgebenden Verfahren i. S. der immer wichtiger werdenden Duplexsonographie und Phlebographie. Es wird umfassend auf die konservative Therapie eingegangen, insbesondere die Kompressionstherapie, aber auch auf die Pharmakotherapie bei der chronisch-venAsen Insuffizienz. Aktuelle Aspekte der Thromboseprophylaxe und -therapie werden berA1/4cksichtigt. Das Buch enthAlt zahlreiche Tabellen und Abbildungen in Form von Zeichnungen und Fotodokumentationen. Der besondere Nutzen besteht in der AktualitAt der BeitrAge und der MAglichkeit, in vergleichsweise kurzer Zeit einen Aoeberblick A1/4ber phlebologische Fragestellungen zu bekommen.

Leprosy (Hansen's disease) is an infectious disease caused by Mycobacterium leprae. It is one of the most disabling disorders in developing countries, with a peak incidence in the tropics and subtropics. With globalization, leprosy is now increasingly spreading to the western world. The impact of this infectious disorder is relevant for the human community due to its transmissible nature, and also important for the individual because of its debilitating consequences. Leprosy is a multifaceted systemic disease with variable presentation and clinical picture. Its identification may therefore not be straightforward, especially outside endemic areas. During its chronic course, leprosy is characterized by acute phases during which there may be exacerbation of symptoms and rapid progression of damage. When leprosy affects the eyes, nerves, and kidneys, it can represent a true medical emergency. The aim of this book is to make the reader familiar with the characteristic signs of disease, including abnormalities of the skin, nerves, eyes, hands, feet, testes, and bone. Early identification of the disease is critical to prevent patient disability and establish appropriate therapy. Emphasis will be given to the current diagnostic tools to identify and quantify the organ damage, including electrophysiology, ultrasonography, magnetic resonance imaging, laboratory tests, and histopathology. Specific topics such as leprosy and pregnancy, leprosy and HIV infection, epidemiology, and leprosy control will also be covered.

With chapters from experienced and internationally renowned contributors holding positions in research, industry, and clinical practice, this is the fifth edition of what has become the standard reference for cosmetic scientists and dermatologists seeking the latest innovations and technology for the formulation, design, testing, use, and production of cosmetic products for the skin. *Offers in-depth analysis of specific topics in cosmetic science and research *Presents the latest in international research and its translation to practice *Gives an indispensable guide to a hotly competitive area for research and practice

Understanding Skin Cancer Anatomical Chart, Third Edition, is a highly illustrated chart providing clear, easy-to-understand information on skin cancer, now fully up to date with treatment information for each type of condition/cancer discussed and updated drawings and photographs. It defines and depicts precancerous growths, atypical moles, and malignant melanoma and nonmelanoma, as well as skin cancer prevention and self-examination. This edition includes updated drawings with inclusive representation and condition photos shown on various skin tones. Featured sections: Risk Factors Precancerous Growths Atypical Moles Types of Skin Cancer (Nonmelanoma) Malignant Melanoma Skin Cancer Prevention Self-Examination Self-examination illustrations Illustrations and photographs included: Anatomical illustration of skin layers Self-examination illustrations Actinic keratoses, atypical nevus, basal cell carcinoma, and squamous cell carcinoma Malignant melanoma with examples of "ABCDE" features (asymmetry, border, color, diameter, evolving) 20" x 26" heavy paper laminated with grommets at top corners

Since the industrialization and urbanization of the Western workforce, tanned skin has been perceived increasingly as attractive and fashionable for naturally light-skinned individuals. However, in addition to causing tanning, photo-aging, and other health effects, ultraviolet radiation (UV) is a well-known carcinogen. Despite wide-spread awareness of UV risks, tanning has become increasingly popular in several Western countries including the USA. While millions of individuals tan indoors each day, relatively little is known about this phenomenon. This book fills that gap by providing an overview of indoor tanning, reasons for its popularity, its risks including skin cancers, and the public health context surrounding the behavior. We have invited some of the preeminent experts in the field to summarize the existing scientific literature for each of the chapters. Shedding Light on Indoor Tanning is an up-to-date and comprehensive book that provides a unique and essential overview of the most significant current issues related to indoor tanning for scientists, educators, students, clinicians, and the general public interested in dermatology, aesthetic trends, skin care, and skin cancer.

It has been known for many years that the Malassezia yeasts are associated with a n- ber of different human diseases ranging from pityriasis versicolor to seborrhoeic d- matitis. However the evolving history of their taxonomy and pathogenicity, and the management of the diseases that they cause has been a long, and often diffcult, jou- ney. Their fastidious growth requirements defed the initial attempts to culture these organisms on laboratory media and their true identifcation and the relationship between different species only became apparent with the application of modern molecular techniques. Likewise although recognised in the 19th century as potential causes of human infection, piecing together the complex and, in certain cases, still uncertain relationships to different human diseases has taken many years. Recognised initially as causes of infection of the skin, they are now known to be superfcial c- mensals as well as potential causes of infections in domestic animals and more serious human conditions such as fungemia. They have also been implicated in the pathog- esis of allergic and other infammatory diseases. Given this complex, yet fascinating, history it seems appropriate to bring together current thought on these yeasts, their structure and function and their association with both human and animal disease states. This book provides such a view of the genus Malassezia and the diseases caused by its members.

Cytokines and cytokine receptors remain an area of great interest for the development of targeted therapies for cutaneous inflammatory diseases. Anti-TNF therapeutics have proven to be effective in the treatment of psoriasis, and clinical investigations have now begun for other cytokine-directed therapies, such as those targeting IFN-g, IL-12p40, and IL-18. In addition to therapeutics that target cytokines directly, strategies that target cytokine signaling pathways are in development. This book summarizes the findings of the 56th International Workshop of the Ernst Schering Research Foundation that focused on "Cytokines as Potential Therapeutic Targets for Inflammatory Skin Diseases".

The integument plays an important role in the survival of meta zoans by separating and protecting them from a hostile environ ment. Its function ranges from protection against injury and in fection, participation in the regulation of body temperature and water balance, to respiratory activity, monitoring of the environ ment and production of signals related to behaviour. All these result from specific structural, biochemical and physiological properties of intra-and extracellular components of the integu ment. Thus its characterization can be best accomplished by a multidisciplinary approach with authors specialized in different fields of science. This multi-author book, in two volumes, provides an up-to date survey of the literature. The first volume deals with the integument of invertebrates, the second with that of vertebrates, both organized primarily on a phylum basis. As the level of knowledge on the integument of phyla differs considerably, the information provided is correspondingly either limited or con densed. For some of the smaller groups of invertebrates little information is available, as often only a few electron micrographs are to be found in the literature ; on the other hand, from the large body of knowledge existing for vertebrates, particularly for mammals, no complete overview can be provided, but publica tions giving access to further information have been reviewed critically.

Pharmaceutical companies are spending increasing amounts of money on drug discovery and development. Nevertheless, attrition rates in clinical development are still very high, and up to 90% of new compounds fail in clinical phase I - III trials, which is partially due to lack of clinical efficacy. This indicates a strong need for highly predictive in vitro and in vivo models. The "50th International Workshop of the Ernst Schering Research Foundation" focussed on "Animal Models of T Cell-Mediated Skin Diseases". Such animal models should have impact not only on inflammatory dermatoses but also on other inflammatory disorders due to their model character. The current volume summarises recent advances in animal research that are important for anti-inflammatory drug discovery.

In the last decade there has been no major clinical mono- graph on this increasingly common and difficult malignancy which is a killer of young people. The gap in the literature is now filled by this authoritative volumewhich will be essential reading for any body involved in the study or management of melanoma.

Strong body odor is a condition for which, until now, there have been few treatment methods. The Japanese authors, encouraged by the willingness of Oriental patients to undergo radical treatment, have developed the subcutaneous tissue shaving method, which eliminates the condition in a very short period of time without ugly scarring. The book Human Body Odor not only introduces the completely new subcutaneous tissue shaving method, it also questions conventional theories on the hair cycle itself and throws a new hypothesis about the process of hair generation and regeneration into the scientific arena. This could even lead in the future to a formula for retarding hair loss! Developed over the past twenty years, the authors' new surgical method for the radical treatment of bromidrosis represents a landmark in cosmetic surgery and dermatology!

The term "lymphoma" was originally used by Billroth in 1871 [55], and by Virehow [763] some years before that, for the designation of swelling of lymph nodes that was not due to "eareinoma, sareoma, ehondroma, myxoma, ete. " In his paper, Billroth reeounted sueeessful treatment with arsenie (" Fowler's solution") of multiple "lymphomas" that had developed in a 40-year-old woman during a 10-month period. From this report it is not entirely clear if the multiple" lymphomas" deseribed were infeetious or if they were eonsis- te nt with what we now mean by "malignant lymphoma. " Today, the term "malignant lymphoma" is generally used eolleetively for malignant lymphoproliferative neoplasms that tend to arise in lymph nodes and also eneompasses Hodgkin's disease and non-Hodgkin's lymphomas. The adjeetive "malignant" seems somewhat superfluous sinee, in addition to Bill- roth's original eonnotation, the sense of malignaney is nowadays read into the word "lymphoma. " To be sure, true, i. e. , malignant, lymphomas have to be differentiated from "pseudolymphomas," or to put it more exaetly, "pseudomalignant lymphomas. " In this book, "lymphoma" and "malignant lymphoma" are used interehan- geably for malignant neoplastie lymphoproliferative disorders, and "pseudo- lymphoma" is used for benign lymphomatous proeesses. Our editorial eonsultant, Dr. M. Leider, disagrees with all of this. In his Dictionary of Dermatological Words, Terms, and Phrases [421] and other works, he maintains that there is no etymologieal basis for words bearing the eontrived suffix" -oma" or the true Greek suffix" -ma" to denote malignaney.

Despite the impressive success of current vaccine programs, there remains a need to improve the effectiveness of current vaccines. A more powerful and longer lasting immune response induced by smaller and fewer doses of vaccine is an exciting challenge and necessary to reduce costs and to avoid vaccine shortages during pandemic epidemics. Improvement of effectiveness also enables induction of protective immunity in populations that respond poorly to vaccination, for example elderly or immunocompromised individuals. Furthermore, for some devastating infectious diseases (such as AIDS and malaria) effective vaccines have not been successfully developed.

The reviews in this volume of" Current Topics in Microbiology and Immunology" cover diverse topics related to intradermal immunization. The volume starts with a basic overview of murine and human skin dendritic cell network, respectively, and their role in immunity, as well as an extensive description of the immunobiology of the skin. The next chapter describes the state-of-the-art on delivery systems especially designed for intradermal vaccination. The remaining chapters highlight the effectiveness of intradermal immunization in experimental animal models or in clinical practice, all supporting the view that intradermal immunization is at least as good as other immunization routes.

Many women have to spend one third of their lives in a postmenopausal state and they should have a good quality of life during this period. Althoug HRT is well accepted as the logical treatment of climacteric problems, the prevalence rate is very low in some countries. The reasons for not accepting HRT are manifold and complex. The objective of this book is to describe the essential advances in basic and clinical research that forms the basis of current HRT and to give an overview of the efficacy and safety of HRT.

Features a wealth of clinical illustration Features anatomical correlation for the points being made Features many clinical tips and tricks to enhance results

Sunscreens are universally recommended by dermatologists not only to prevent the immediate effects of overexposure to sunlight but also to prevent skin cancer. While the former goal is immediately evident, the latter remains an unproven hypothesis and is a topic of some controversy. Recent epidemiological studies suggesting a correlation between increased use of sunscreens over the past two decades and the rise in skin cancer have led to the question whether sunscreens applied to skin may be undergoing photoreactions, the effects of which are elaborated many years later. By addressing the key questions, this book advances the field of sunscreen photobiology and provides the reader with an unbiased perspective on this important field.

There are many human cancers which actively synthesize specific characteristic proteins such as melanomas, thyroid cancer and squamous cell carcinoma. Many cancer researchers have of course tried to utilize this specific activity as a key for the selective treatment of cancers. In the past for example, the molecular hybrid compound of DOPA, a substrate of melanin, and nitrogen mustard N-oxide hydrochloride, a ctyotoxic anti-tumor drug, was synthesized as Melphalan and used to treat malignant melanoma. A major problem arose though in that it was soon found to be highly suppressive toward bone marrow and quite toxic while not being remarkably effective. Thus, malignant melanoma could not be cured by it. Such failure led us to develop a novel bimodal therapeutic system which includes the use of non-toxic potentially cytocidal chemicals which selectively accumulate within the cancer cells and which are converted by a controllable modality into an actively cytocidal element in situ. We can now non-surgically cure malignant melanoma and glioblastoma with our selective cancer treatment, neutron capture therapy (NCT); as can be found in this volume. Included are 124 papers on the latest breaking developments discussed at the Sixth International Symposium on NCT for Cancer held in Kobe during the late autumn of 1994.

Melanocytic neoplasms are of capital importance for all surgical pathologists and dermatopathologists. These tumors span a huge range of morphologic expression and biologic behavior, are potentially of the highest medical significance and are often fraught with diagnostic pitfalls and high litigation risk.

"Pathology of Challenging Melanocytic Neoplasms "offers a dynamic text where readers will encounter a broad spectrum of challenging melanocytic lesions, both benign and malignant and will thereby acquire a solid, working knowledge that they can immediately apply to daily diagnosis. The authors aim to clarify this often thorny field, keeping a steady focus on patient-related issues. The volume emphasizes the practical application of basic morphologic principles, immunohistochemistry and molecular methods in order to secure a confident diagnosis. Abundant illustrations display the characteristic features of the most important disease entities.

Rather than being yet another encyclopedic work of reference, this volume takes a fresh approach as it resembles a series of stimulating seminars employing exemplary case material to highlight, illustrate, and succinctly discuss the key points. To this end, the reader will be guided through a series of paired cases that pose a significant diagnostic challenge. By comprehensively comparing and contrasting two related entities, each such chapter will illuminate an intellectual pathway through which an important diagnostic puzzle can be solved. To broaden the differential diagnosis even further, additional illustrative cases are added to each discussion. Algorithms and tables summarize key points. Clinically relevant, up-to-date references will be provided to guide further study. Written by experts in the field, this novel text will be of great value to surgical pathologists in practice and dermatologists as well as residents and fellows training in these specialties.

Over the past 30 years, there has been increasing recognition of psoriatic arthritis as a distinct clinical entity. Psoriatic arthritis occurs mostly in patients with psoriasis and may affect up to 1% of the general population. It has many similarities to other forms of spondyloarthritis, and must be differentiated from related conditions. Given that most patients with psoriatic arthritis have skin and musculoskeletal diseases that significantly affect their quality of life and function, patients are ideally managed in a multidisciplinary clinic with rheumatologists, dermatologists and a nurse specialist, physical therapist and occupational therapist. Psoriatic Arthritis covers the epidemiology and diagnostic and classification criteria, describing the clinical features of the disease, including skin and nail involvement, articular, and other extra-articular manifestations. Laboratory features and imaging characteristics are covered in detail, along with co-morbidities and their impact. A comprehensive review of skin disease therapy is also provided, along with the various treatment options for joint disease, including traditional disease modifying therapy and newer biologic agents . This comprehensive yet concise and practical volume is the perfect guide to psoriatic arthritis for the busy practitioner, and will be of interest to trainees and specialists in rheumatology and dermatology.

DIFFERENTIAL DIAGNOSIS IN DERMATOLOGY Fifth Edition RICHARD ASHTON, MA, MD, FRCP, Consultant Dermatologist, Lighthouse Clinic, Isle of Wight, UK, formerly Consultant Dermatologist to the Royal Navy BARBARA LEPPARD, DM, FRCP, Retired Consultant Dermatologist, Southampton University NHS Trust, UK The ethos of this bestselling text is that however much or little you know about skin disease you can always arrive at the right diagnosis. The secret is to examine the surface of the rash or skin lesion which will help you classify the clinical features correctly - colour, surface features, type of lesion, border and how long it has been present. Algorithms throughout each chapter give the differential diagnosis for the features you have elicited. Accompanying clinical photographs and clear descriptions of the conditions will enable you to check whether you are right or not. If your choice seems unlikely, any conditions that could be confused with the one you selected are listed along the base of the algorithm to help you compare diagnoses so that you can get to the right answer. We hope this new edition - enhanced with specific instructions on treatment - will be the only quick clinical reference you will ever need for dermatology diagnoses. With over 1000 illustrations.

Taking advantage of the accessibility of the skin "in vivo," non-invasive methods were developed about 40 years ago, which have now developed as accurate sources to measure skin properties and structures at the microscopic and macroscopic levels. However, even at the dawn of the twenty-first century, the mechanisms involved in these properties are still only partly understood. As in many domains, including biomedical engineering, numerical modeling has appeared as a complementary key actor for improving our knowledge on skin physiology.

This book gathers, for the first time, chapters describing scientific computing and numerical modeling for a deeper understanding of mechanisms involved in skin physiology. The book is structured around some skin properties and functions, including optical and biomechanical properties, skin barrier function, and homeostasis, covered through several chapters describing either biological or physical models at different scales.