It is with great pleasure that I write this Foreword to the Proceedings of the International Conference on Behcet's Disease which was held in Berlin in June 2002. This was the first International Conference held under the auspices of the International Society for Behcet's Disease which was founded in 2000 in Seoul. First, I congratulate our colleagues in Berlin, led by Professor Christos Zouboulis of the Department of Dermatology at the Free University of Berlin, for having organised a most successful conference and for having compiled these proceedings so rapidly. It will be realised immediately on scanning the contents of this book that the conference was truly international with 210 participants from 26 countries, as Professor Zouboulis has noted in his preface. These included basic scientists, epidemiologists, pathologists, clinicians and, importantly, representatives from patient organisations. The latter held their own conference alongside the scientific-medical conference to mutual benefit. The combined session of patients and doctors (abstracts on pp 601 - 626) gave the opportunity for an exchange of information and fruitful discussion. The wide ranging scope of the communications is evident from the index and it was most encouraging to see their origin - from all parts of the world, from senior and junior colleagues and, from many different disciplines. Many communications may be regarded as preliminary reports of research in progress and we look forward to seeing the definitive publications in appropriate journals in due course."

It is now thirty years since William Montagna and Richard Ellis edited 'The Biology of Hair Growth". In his introduction, Stephen Rothman, of the University of Chicago, USA and one of the driving forces behind research on skin at the time, wrote: 'The pilary system is a perfect micr9cosmic structure. In this microcos- mos we find birth, development, ageing and death, activity and rest, color for- mation and decolorification, greasiness and dryness, infection and sterilization, hypertrophy and atrophy, Qenign tumours and malignant ones. " He foresaw the human pilary system as a model for the study of a multitude of human diseases including ageing and cancer. It was not, how- ever, until the seventies that the development of micro-biochemical tech- niques indeed allowed the use of the human hair follicle as a convenient biopsy tissue for Biomedical Research in general. Measurement of enzyme activities, and important co-factors, and culturing of cells from single follicles all became possible. In the eighties dermal papilla cells were grown in cul- ture and this opened the way to study hair differentiation in vitro. Studying hair differentiation is, in fact, studying growth regulation and it is this aspect that by far transcends the importance of studying hair growth itself. Let us not forget that metastatic prostate cancer is treated with the same drug -cyproterone acetate -that is used for the treatment of alopecia and hirsutism in women.

Physical and chemical agents in the environment damage the DNA of humans, and pose a major threat to human health today, and to the genetic integrity of human populations. Although studies on isolated DNA in vitro, on prokaryotes, on mammalian cells in culture, and on laboratory animals have provided essential background information, it is now possible to study DNA damage and repair in human tissues directly. New techniques of high sensitivity, especially those not requiring radioactive labeling have made possible quantitation of DNA damage and repair, as well as detection of residual, unrepaired DNA lesions . In recent years, several investigators have taken up the challenge of studying damage and repair responses in humans, and we have chosen that work as the special focus of this Symposium. Major advances in under standing damage and responses in human skin, in blood cells and in human internal organs indicate three major themes. First, DNA damage levels in human tissues depend not only on the initial exposures, but also on the capapacity of that tissue for repair of the specific lesion type. Second, repair in human tissues may differ quantitatively and qualitatively from that in human cells in culture.

Dermatology is a specialty in the field of medicine which constantly changes at a vast rate. Alongside technology, new drugs, methods and treatments are continuously developed for the treatment of all common skin diseases. The first edition of the European Handbook of Dermatological Treatments received an overwhelming response from dermatovenereologists all over Europe. Its easy-to-read format, which is also used for this 2nd edition, is aimed at helping the physician to obtain comprehensive information at a glance. The three main sections listed alphabetically define the different diseases, the drugs available and the various methods of treatment used in dermatological practice. Each chapter begins with a brief section of the aetiology and pathogenesis of the skin disease, and leads into the description of the clinical characteristics, the diagnosis and the differential diagnosis. Followed by a detailed discussion on treatment methods, alternative methods are covered as well. Each section ends with a reference list for further reading. This new edition provides an excellent update including the newest developments of drugs, methods and treatments in dermatological practice, maintaining the clear structure and well-proven format. It is a very comprehensive and practical guide and should not be missed by those treating patients with skin diseases.

A fully-illustrated, note-packed volume of information, "Dermatology: Illustrated Study Guide and Comprehensive Board Review" fulfills a real need for a single study guide for the Dermatology Board Exam. Written by a previous Chief Resident of Dermatology at the University of Illinois at Chicago Medical Center, the text focuses on presenting comprehensive information in an easy-to-understand, easy-to-remember format. Tips, tricks, short lists, and tables fill every inch of this book a must-have for any dermatology resident.

Features:

Acts as a concise go-to review book for the Dermatology Board Exam

Hundreds of author notes pinpointing important information

Information presented in an easy-to-read format

Scores of mnemonics and memory tricks to mentally organize information

Over 500 high-quality images placed parallel to the represented skin disorder

Life after Boards essential tips on coding and documentation

Knowledge about diagnostic procedures in melanoma has in creased rapidly within the past few years. Single tumor cells have been identified in normal tissue such as sentinel lymph nodes, as well as in bone marrow, peripheral blood, and other bodily fluids and cells, by molecular technologies. The introduction of polymerase chain reaction-based methods can be regarded as a prototype of this dramatic development towards molecular approaches in new diagnostic procedures. This fact opens up the possibility of clinical use in patients and of influencing treatment strategies. Considerable discrepancies have been described, how ever, in the success rates of these new techniques for the detec tion of minimal residual disease in cancer patients. Despite fav orable results reported by different groups of investigators, it will take several years to define the clinical and pathophysiological relevance of new diagnostic procedures. The 1st International Symposium "Minimal Residual Disease in Melanoma: Biology, Detection and Clinical Relevance of Microme tastases", held in September 1999 in Homburg/Saar, Germany, fo cused on recent developments in this particular area of cancer re search. The purpose of the meeting was to stimulate discussion and exchange of new data and ideas by renowned international scientists. The aim of this volume is to summarize major topics of basic research and clinical investigations presented by invited experts in this fascinating but still. controversial field of melanoma re search.

Although dermatomyositis is a rare connective tissue disease, many physicians are confronted with the diagnosis and treatment of patients affected by this condition. Based on the vast personal experience of the authors, who have diagnosed, treated, and managed many dermatomyositis patients, this clinical guide provides dermatologists, rheumatologists, pediatricians, neurologists, and general practitioners with the keys to interpreting the clinical symptoms of dermatomyositis. Also included are algorithms to help the reader to make the correct diagnosis, as well as guidance on new diagnostic methods and treatment schemes.

The most effective way to heal your skin-from the featured dermatologist on ABC's "Extreme Makeover"

Stress, pregnancy, menopause, and other health concerns can take a heavy toll on your skin. Now respected dermatologist Dr. Ava Shamban shows you how to look your best no matter how you feel, even when you feel your worst. Dr. Shamban's signature approach ranges from at-home simple organic skin care recipes to state of the art dermatologic techniques. From skin cleansing and topical products to eating and exercise, her program is based on the best cutting-edge science and is just what you need to achieve and maintain the healthy glow and feel of great skin.Complete skin-healing program combining skin care, nutrition and fitnessSpecific skin care regimens tailored to age, skin type, and internal conditionHelp for trouble skin resulting from acne, stress, pregnancy, menopause, chemotherapy, and more

In addition to being featured on "Extreme Makeover, " Shamban has been on "Good Morning America," "The Tyra Show," "The View," "Fox News, Extra " and many other shows. She has also been featured in "The New York Times," the "Los Angeles Times, ""Vogue," "Allure," "Marie""Claire" and many other publications.

Start this complete skin recovery program today and discover the optimal way to care for your skin, inside and out.

This volume discusses the background and various clinical applications of radiation therapy in the treatment of non-malignant diseases. It documents the radiobiological and physical principles of treatment and the rationale underlying the use of radiotherapy for various disorders of the CNS, head and neck, eye, skin and soft tissues, bone and joints, and vascular system. In so doing, it draws attention to and elucidates the scope for application of radiotherapy beyond the treatment of malignancies. Both the risks and the benefits of such treatment are fully considered, the former ranging from minor clinical problems to life-threatening diseases.

There are many changes in the skin, hair, and nails during and after pregnancy. Patients are certainly aware that those changes are occurring, but few physicians and even fewer patients know how to predict the course of those changes. Pigmentary changes occur, but are they permanent? Can they be prevented or reversed? Hair may become thicker during pregnancy, only to fall out in the postpartum period. When will hair stop falling out? Will it grow back? What hormonal changes are occurring to produce these effects on the skin, hair, and nails? Will those hormonal changes affect other organs? Some cutaneous manifestations of pregnancy are common and recognized by most physicians. Abdominal striae, for example, are easily identified, but physicians have many questions about them. Why do they develop? Can they be prevented or treated? Other cutaneous manifestations of pregnancy are less common and recognized by few. For example, pruritic urticarial papules and plaques of pregnancy is a debilitating condition that is treatable once diagnosed. Even more important than the treatment, the knowledge imparted to a worried mother that her child will be fine and that the condition is se- limited is priceless; but the condition must first be recognized by the patient's physician. All of these questions and conditions are addressed in this extraordinary book. Pigm- tary disorders are addressed in detail in Chap. 2.

Skin lesions are often the first sign for an endocrine disease. Their description is thus of relevance for early diagnosis and treatment of endocrine disease for specialists in endocrinology as well as in dermatology.

Lavishly illustrated, this book describes the clinical and histological features of skin lesions observed in endocrine diseases. All features are reader-friendly structured and written in the language of dermatologists in order to enable a simple association between the features observed and the endocrine etiology.

Only comprehensive reference book on pressure ulcers and their management

Only book in its field endorsed by the European Pressure Ulcer Advisory Panel, the leading European authority on pressure ulcers

Presents both current and future aspects of diagnosis and treatment.

Presents evidence-based knowledge of pressure ulcer aetiology.

Contains over 90 illustrations.

Explores the possiblities of tissue repair using new tissue engineering strategies.

Allergy is one of the major health problems of most modern societies. Although allergic diseases are well-known for almost two hundred years, their prevalence has increased dramatically over the last decades. Allergic reactions manifest in various organs, most commonly in the skin and mucous membranes, the frontier surfaces where the contact between the individual and the environment takes place. In a very concise and practical way this book covers all aspects of allergic reactions from pathophysiology to diagnosis, therapy and prevention with a strong focus on relevant aspects for the everyday work of the practising dermatologist and allergist in the hospital or office. This book reflects the rich personal experience of a German allergist with international training and reputation, who is active in immunology and allergy research and practice for almost 30 years. In this book, not only IgE-mediated allergic reactions are covered but all other kinds of allergies such as atopic eczema, contact dermatitis, drug eruptions, anaphylaxis and food allergies are equally represented as well as psychosomatic aspects and problems of environmental intolerances.

Epidermolysis bullosa (EB) is a heterogenous group of genodermatoses characterized by the formation of blisters and erosions on skin and mucous membrans from birth on. The cause are mutations in the genes of structural proteins of the junction between epidermis and dermis. This book deals with the treatment of this skin disease itself and its many extracutaneous complications. There is no previous book which has been focused on the therapy and it will be based on evidence-based data derived from the world?'s largest cohort of inherited EB-patients, the American EB Registry. An important chapter will discuss gene therapy in hereditary EB which has been recently successfully performed within a localized skin site on a single EB patient as a proof-of-principle test. Given its unique collective contents, the monograph will provide the primary source for clinical informations of this oftentimes severe multiorgan disease.

This is the first book to specifically deal with hidradenitis suppurativa, a common but overlooked disease that regularly causes significant problems for both patients and doctors. The first section of this book presents the best current knowledge about diagnosis, pathogenesis and complications. The second section offers comprehensive guidelines on diagnosis and therapy. The book will assist doctors in providing a broader range of treatments for their patients. To increase the practical usefulness of the book, a description of the patients' perspective and patient information is included.

New developments in the field of the commonly used photodiagnostic and phototherapeutic methods help to continuously improve the results in the daily practise. Edited by internationally renowned experts, the new edition offers up-to-date, comprehensive and clinically relevant information on every aspect of photodiagnostic and phototherapy. The book is structured in following parts: Photochemotherapy in daily practice, special phototherapeutic modalities and photoprotection in daily practice. Due to the detailed structure this new edition is even more reader-friendly and has a strong focus on clinical aspects. It includes: Guidelines for the treatment selections of specific diseases, practical guidelines for phototherapy with information about basic principles of photobiology, standardized test protocols for photodermatoses and diagnosis for skin tumors.

Simplified Facial Rejuvenation is divided into sections that include anatomy and anesthesia, classifications, dermatologic procedures, suture lifts, surgical variations of the face, surgical variations of the eyes, brow, neck, lips, nose ear, and scalp, and medical legal aspects. The book presents multiple variations of suture lift procedures to allow the physician to decide which is best. Unique surgical procedures of the face are presented, many of which are techniques of minimal incision facelift. The book brings together the more popular procedures for patients that include simpler methods of facial rejuvenation with less pain, shorter recovery time, lower cost, and fewer complications.

Over the past ten years, carbon dioxide laser surgery has made impressive strides and is now applied to every field of surgery without exception. It is the intention of this book to record the work done in this field in the Department of Plastic and Maxillofacial Surgery of the Beilinson Medical Center and Tel Aviv University Medical School, Israel, as well as that performed in association with other depart ments. In this context, one feels that it is incumbent upon one to acknowledge the cooperation of the medical and paramedical staff of the Department of Plastic and Maxillofacial Surgery of the Beilinson Medical Center, as well as that of Prof. Yehuda Shindel and Dr. Daniel Katenelson of the Department of Ear, Nose and Throat, Dr. Y ona Tadir of the Department of Obstetrics and Gynecology and Dr. Itamar Kott of the Department of General Surgery. I should like to make special mention of Dr. Ralph Ger of New York, who worked with me on the original clinical trials, and the engineer Uzi Sharon, who developed the Sharplan Laser with me. The progress of Laser Surgery is well demonstrated by the participation in the four meetings of the International Society for Laser Surgery, the first of which was held in Tel Aviv in 1975 with an attendance of 65 and the last in Tokyo in 1981 with an attendance of 1200.

The scope of dermatologic surgery is so wide that inevitably a large number and variety of complications arise. Of course the majority of complications can be prevented by careful preoperative preparation, meticulous surgical technique, and proper postoperative care, but when they do occur, they can be recognized and managed with skill and competence. This book provides a valuable source of reference for the prevention, recogni tion, and management of complications in dermatologic surgery. Avoiding pro blems is at least as important as dealing with them, and so all the chapters in this book deal with both prevention and management. This book addresses dermatologic surgeons in practice or in training and to surgeons in other specialties who may be required to undertake repair of skin defects. Many ofthe authors accepted the responsibility of contributing to this work in addition to their many other obligations. For this, I am extremely grateful to them. MARwALI HARAHAP Contents Local Anesthesia and Regional Anesthesia George B. Winton ...................................................... 1 Electrodesiccation and Curettage Harvey Finkelstein and Robert Jackson. . . . . . . . . . . . . . . . . . . . . .. . . . 16 . . . . . . . ."

In this handbook the opportunity has been taken firstly to present the waterbalance in the horny layer and the sweat secretion process with particular emphasis on their relationship to the pharmacodynamical aspects of the micro circulation and permeability of the skin. F. A. 1. THIELE was unable to witness the printing of his life-work concerning the water balance of skin, which he had compiled at the university in Nijmegen with J. W. H. MALI and G. 1. DE JONGH and D. A. REAY from Great Britain. Their contribution concentrates on evaluating the cooling function of the sweat glands with their heat-pipe system and on the physico-chemical effects of dermatological therapy and topically applied cosmetics. A certain amount of overlapping with Volume I/4A (E. SCHWARZ) could not be avoided, and yet the presentation by THIELE and co-workers considers different aspects. The pharmacodynamics of externally applied substances involved in microcirculation are related thematically also to percutaneous resorption. Function and morphology of pharmacodynamics in microcirculation are inseparable. Therefore the structural alterations of the blood vessels in reaction to foreign agents or as an adaptation to endogenous tissue hormone release have been examined electronmicroscopically by W. G. FORSSMANN and his team, and relay a distinct picture of the microcirculation in the area of skin reactiveness. The direct pharmacological aspects of the skin and the systemic effects on blood vessels and their permeability have been listed according to the latest research material."

With patients now surviving trauma, neurological diseases, and the geriatric state for longer periods, dermatologists are increasingly being called on to manage these often devastating cutaneous defects. Unrealistic goals regarding prevention and wound healing have compounded the problem, while patient awareness, government intervention, and legal entanglements make an understanding of the diagnosis and management of this dermatologic entity mandatory.
This volume addresses how to both recognise and manage the condition. Beginning with the background of the disease, the book goes on to discuss the clinical features and provides a comprehensive overview of general and specific therapeutic strategies.

Both the major and minor salivary glands can be the site of a wide variety of diseases and functional disturbances. This monograph covers both the common lesions and conditions of the salivary glands as well as the rare ones. Much attention is given to the problematic complaint of dry mouth and the even more cumbersome diagnostic aspects of Sjogren's syndrome. Emphasis is on the clinical aspects and the management of the various disorders. The vast experience of the authors is reflected in their clear and concise style. The illustrations are well chosen and updated references are provided, where appropriate."

This book provides the dermatologist with the essential information needed to properly treat all skin types cosmetically.

All chapters have been written by female dermatologists with many years of personal experience in the field.

The volume includes an overview of the systemic, intrinsic and extrinsic aging process, essential information on anti-aging skin care product ingredients, detailed discussions of patient selection and indications, and a wide range of cosmetic procedures.

This concise book allows you - through its well-organized use of sidebars, photographs and illustrations - to extract any information you may need quickly and easily.

This book offers a broad-ranging assessment of current efforts of the molecular, cellular, hormonal, nutritional and lifestyle strategies being tested and applied by biogerontologists in the search for effective means of intervention, prevention and treatment of age-related diseases, and for achieving healthy old age. Employing a semi-academic style, the book presents data from experimental systems, while focusing primarily on their applications to humans in the prevention and treatment of age-related impairments.