Drugs produced by molecular biological techniques, called the 'biologics', differ from the usual chemical medications. Their optimum use, and the detection and managemenet of adverse events, pose a significant challenge to the clinician. Licences for new biologics continue to be granted for the likes of rituximab, abatacept and certocizumals pegol. Intensive research is also defining new areas in which these drugs will be used in the future, increasing the number of practitioners using biologics. As the use of these drugs increases around the world, so the level of information needed by primary care practitioners and specialist prescribers needs to be expanded The Handbook of Biological Therapy provides the practising clinician with a practica guide to the use of Tumour Necrosis Factor Blocking Therapy (TNF-blockers), and important new class of biologic therapy for rheumatoid arthritis, ankylosing spondylitis, Crohn's disease, ulcerative colitis, psoriasis, and psoriatic arthritis. It is a comprehensive distillation of the authors' clinical experience with these drugs, combined with data from diverse databases offering practical advice on their uses, specific indications, supporting clinical trial data and safety issues, with the aim of making the use of these drugs easier for the busy clinician. All of the authors have been involved from the beginnings of the clinical trial programmes with these drugs and continue to use them in daily practice.

Understanding Skin Cancer Anatomical Chart, Third Edition, is a highly illustrated chart providing clear, easy-to-understand information on skin cancer, now fully up to date with treatment information for each type of condition/cancer discussed and updated drawings and photographs. It defines and depicts precancerous growths, atypical moles, and malignant melanoma and nonmelanoma, as well as skin cancer prevention and self-examination. This edition includes updated drawings with inclusive representation and condition photos shown on various skin tones. Featured sections: Risk Factors Precancerous Growths Atypical Moles Types of Skin Cancer (Nonmelanoma) Malignant Melanoma Skin Cancer Prevention Self-Examination Self-examination illustrations Illustrations and photographs included: Anatomical illustration of skin layers Self-examination illustrations Actinic keratoses, atypical nevus, basal cell carcinoma, and squamous cell carcinoma Malignant melanoma with examples of "ABCDE" features (asymmetry, border, color, diameter, evolving) 20" x 26" heavy paper laminated with grommets at top corners

Dermatology is the science responsible for the study of the skin, mucous membranes (oral and genital) and cutaneous appendages, while dermatopathology focuses on its microscopic study. Although the two fields are closely related, in many cases the identification of dermatological diseases is mainly clinical and depends on the physician's ability and experience. The purpose of this atlas, which collects over 900 clinical and histological photographs in high resolution, is to illustrate and describe the most frequent skin diseases on the basis of clinical cases. Offering a complete guide to the etiology, epidemiology, clinical features, histologic findings and diagnosis of the main skin diseases divided into three subgroups (inflammatory, infectious, or tumoral), it represents an invaluable resource for all medical students, residents, clinicians, and investigators learning dermatology.

Dermoscopy: The Essentials presents the practical guidance you need to master this highly effective, more economical, and less invasive alternative to biopsy. Drs. Peter Soyer, Giuseppe Argenziano, Rainer Hofmann-Wellenhof, and Iris Zalaudek explain all aspects of performing dermoscopy and interpreting results. With approximately 30% new clinical and dermoscopic images, valuable pearls and checklists, and online access to the fully searchable and downloadable text, you'll have everything you need to diagnose earlier and more accurately. Avoid diagnostic pitfalls through pearls that explain how to accurately use dermoscopy and highlight common mistakes. Master all aspects of performing dermoscopy and interpreting the results with easy-to-use "traffic light" systems and checklists for quick and effective learning. Gain a better visual understanding with approximately 30% new clinical and dermoscopic images that depict the appearance of benign and malignant lesions and feature arrows and labels to highlight important manifestations. Get better diagnostic results for less by learning how to successfully perform dermoscopy with this portable, to-the-point resource. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

This book provides the description of the granulomatous diseases of otorhinolaryngology, head and neck with their characteristic features, investigations and management. It includes wide variety of infective, idiopathic, neoplastic, hereditary, reactive and various other types of chronic granulomatous reaction in the ear, nose, throat and head neck region. Further, the description is supported with various illustrations including clinical photographs, radiological pictures of CT scan, MRI scan etc. Histopathological and microbiological images which show characteristics and differentiating features are also included to aid in the diagnosis of the diseases. Histopathological colored images with high magnification and immunohistochemistry images are provided for better illustrations. This book also elaborates the important medical and surgical management of the granulomatous diseases. Every chapter ends with the 'Essential features' of that particular granulomatous disease, and this will certainly help the post-grad students and clinicians to differentiate the diseases, early diagnosis and management of the patients with chronic granulomatous diseases.

This book is a thorough, practical review of the challenges facing clinicians treating skin microbes and how to combat these therapeutic dilemmas. It expresses the critical public health concern of antimicrobial resistance and shows how microorganisms are developing the ability to halt the progress of antimicrobials like antibiotics, antivirals, and antifungals. Chapters are grouped together in five sections for ease of use. The first three sections of the book convey foundational information on the mechanisms of antibiotics, antivirals, and antifungals resistance, as well as the implications of lack of vaccination. The fourth section then turns to the specifics of drug resistance for protozoan and helminth infections focusing primarily on initial and subsequent resistance to treatment. The book closes with a discussion on the potential solutions of innovative therapy including new delivery mechanisms, broad-spectrum antibiotics, phytocompounds, and biofilms. Chapters feature magnified, microscopic photos for identifying structures as they appear on the skin. Part of the Updates in Clinical Dermatology series, Overcoming Antimicrobial Resistance of the Skin is an important resource relevant during the COVID-19 pandemic, and is written for all medical healthcare professionals.

Dermatology: Diseases and Treatment is designed to provide the busy clinician with an organized, condensed and practical approach to the patient with a skin problem. It includes the elements of diagnosis for hundreds of the most common cutaneous problems and provides recommendations for the management of these conditions. Also included are detailed descriptions of the most commonly used medications in dermatology today.

This book is a comprehensive, practical guide to the latest developments in the understanding and management of atopic dermatitis. Detailed information is provided on age-specific clinical symptoms, features, and diagnostic methods. Current theories on the pathogenesis of atopic dermatitis are closely examined, with attention to the roles played by genetic, allergic, immunologic, and skin barrier dysfunctions. In the second half of the book, the scientific background to and the practical use of the full range of treatment methods are described, covering topical agents, systemic agents, phototherapy, allergen-specific immunotherapy, and the most recently developed biologics and small molecules. This textbook will be an excellent guide to diagnosis and treatment for not only dermatologists but also practitioners in allergy and general medicine, including pediatricians, allergists, and primary care physicians. In addition, it will be of value for all scientists interested in developing new drugs for atopic dermatitis.

This book addresses the importance of the physicians' understanding on how varying ethnic and cultural identities can affect dermatological disease presentation in patients. It bridges the gap in knowledge for practicing dermatologists, especially those not studying or practicing in a highly multi-ethnic center who may not be exposed to patients from a variety of cultures. Concise and cohesive, the book examines how dermatoses can manifest due to cosmetic practices, therapeutics, religious practices, cultural hair-related practices, and environmental variables. These elements underscore that without exposure to patients of varying backgrounds, it can be nearly impossible to learn about practices that may influence a patient's health. There are many examples of cultural practices causing dermatologic lesions, and it is becoming increasingly more likely that practicing dermatologists will encounter patients with these findings as migration, tourism, and public interest continue to rise. Socially conscientious and relevant, Cultural Practices and Dermatoses covers everything from more common cultural practices, such as acupuncture and threading, to lesser known ones, like pew blisters and turban ear, as there is limited medical literature describing their cutaneous effects and complications.

This book discusses recent advances in theoretical-computational studies on the biosynthesis of melanin pigment (melanogenesis). These advances are being driven by the development of high-performance computers, new experimental findings, and extensive work on medical applications involving the control of pigmentation and the treatment of challenging dermatological diseases. Understanding the elementary processes involved in chemical reactions at the atomic scale is important in biochemical reaction design for effective control of the pigmentary system. Accordingly, the book focuses on the elementary steps involved in melanogenesis, which crucially affect the composition of the resulting melanin pigment by means of competitive reactions. The book also addresses reactions analogous to melanogenesis, with a focus on o-quinone reactions, which are especially important for understanding melanogenesis-associated cytotoxicity.

In this book, detailed information on the nosology, pathology, pathogenesis, clinical presentation, diagnosis and treatment of large- and medium-sized vessel and single-organ vasculitis is provided and critically discussed by the most expert physicians and researchers in the field. Among the conditions considered are giant cell arteritis, Takayasu arteritis, polyarteritis nodosa, primary central nervous system vasculitis, isolated aortitis, isolated gastrointestinal vasculitis, cutaneous vasculitis and isolated genitourinary vasculitis. The role of histopathology in the diagnosis and prognosis of these vasculitis is evaluated, along with the part played by imaging studies in diagnosing and monitoring these diseases, while indications and limitations of the available imaging modalities are discussed as well. The expanding role of biological agents for the treatment of the large vessel vasculitis is addressed, as well as the current approaches to these diseases. This book will be a valuable companion in decision-making for medical practitioners, internists, specialists, researchers and postgraduate students interested in the intriguing fields of vasculitis and rare diseases.

This book provides a current experience in the diagnostic techniques and treatment approaches available for unusual cutaneous lymphomas. It features concise case-based chapters with a particular emphasis on instances of mature T-cell and NK-cell neoplasms, mature B-cell neoplasms, immature hematopoietic malignancies, and other lymphoproliferative disorders. Clinically-oriented cases emphasize the importance of physical examination along with modern tests of laboratory diagnostics and clinico-pathological correlations. Cutaneous Lymphomas: Unusual Cases 3 presents a range of difficult and rare cases, which would be uncommon even to the specialists in this field. Therefore, it is a vital reference source for dermatologists, dermatophatologists, cutaneous oncologists, hematooncologists, pathologists, oncologists, and other medical professionals who treat these patients.

The aim of this open access book is to provide a unique, timely, critical and comprehensive compilation of more than 30 years of robust international experimental and clinical research related to the basic science and therapeutic application of water-filtered infrared-A (wIRA) and hyperthermia in oncology, psychiatry (depression), musculoskeletal disorders, dermatology, infectiology, and surgery. This is an internationally absolutely unique attempt which publication is timely and of great interest in medical as well as in natural sciences. The aim is to enhance communication and advance the use of heat therapy for patient benefit, and to generate an environment in which anyone with an interest in hyperthermia can discuss, collaborate, network, and share events and resources. Productive dialogue and discussion among scientists and practitioners on issues relating to hyperthermia therapy is essential, especially relating to thermal transmission by water-filtered infrared-A (wIRA). The specificity and advantage of this technology is its tolerance by tissue, and its penetration of up to 3 cm allows the delivery of high heat dosages that are relevant across multiple clinical indications. Currently, wIRA is being applied in Austria, Germany, Portugal, Switzerland, The Netherlands, UK and the USA. The authors' hope is that its use will increase in these countries, and also expand into others. This book will be an invaluable tool for oncologists, surgeons, dermatologists as well as physiotherapists.

This book is written to help educate dermatologists and general physicians of the challenges involved in treating those with darker skin tones in culturally appropriate ways. Distinctly broken up into three sections for ease of use, the reader enters the text through a series of chapters meant to introduce the physician to the anatomical structure and makeup of patient with skin of color as well as the evolution basic concepts for understanding and treatment. The second and longest section looks at diseases and cosmetic concerns covering some of the most common issues for patients with skin of color. The last section offers cultural considerations to treatment and care. Socially conscious and comprehensive, Ethnic Skin and Hair is written by some of the leading names in dermatological treatment of skin of color, and functions as a concise and thorough tool for dermatologists at every stage in their career.

Rhytidoplasty is a palliative procedure in which face wrinkles are surgically removed to promote a more youthful appearance. This book, written by leading specialists for Brazil and abroad, discusses a wide variety of topics related to facial rejuvenation. The first sections focus on the surgical planning, including psychological considerations, preparation of the patient and anatomical and biochemical changes caused by the aging process. It also describes the surgical anatomy of the forehead, face, neck and eyelids. The third section provides a comprehensive overview of the basic techniques of facelift with details of refined surgical approaches for each segment of the face and neck. It highlights liposuction techniques, lipo-injection as well as transference of stem cells, showing their importance in reshaping the facial contours. It addresses both the treatment of soft tissue and craniofacial bone structures to improve the aesthetics of the face. The next sections present the final scars after face-lifting, minimally invasive procedures as complementary approaches during rhytidoplasty and the associated procedures during rhytidoplasty. The last section discusses postoperative care. Aesthetic Facial Surgery consists of 64 chapters focusing on all aspects of face lifting, and meticulously describes surgical details not covered in other medical books. Featuring numerous figures, photographs and videos, it is a valuable resource for young and experience surgeons alike around the world.

This is a handbook on dermatologic differential diagnosis and clinical management, focusing on sixty-two challenging and vexing clinical cases that the Shelleys have encountered in over fifty years of patient practice in dermatology. The management problems of these extremely perplexing cases go far beyond evidence-based medicine. Each case is presented as a well-written vignette, told in a case-study tone. The authors first present the background of each case in a concise, thorough, manner including all the important clinical details, including tests and results. The authors then reveal the process involved in the diagnosis and the therapy involved. Finally, they include a section called 'Questions for the Doctor', which suggests relevant questions that the doctor should be pondering in each case. This is the perfect book for residents preparing for their boards.

This book details the uses of platelet-rich plasma (PRP) techniques for dermatologic purposes and describes the techniques and protocols for its application in clinical practice. Concise and practical, this reference covers not only the procedural steps in collecting PRP from a patient, but also applications in wound healing, hair loss, skin rejuvenation, scarring, and face and body augmentation. It addresses the issues that are caused by fad procedures, such as the "Vampire Facelift," and emphasizes the importance of reliable information in these cases. Chapters are supplemented with multimedia including high-quality images, illustrations, and an instructional video. Platelet-Rich Plasma in Dermatologic Practice is written for clinicians in practice looking to offer alternatives to more invasive aesthetic surgery techniques.

Anti-aging skin care is an important part of dermatologic practice. The science behind the aging process has led to revolutionary changes in the treatment options available. Dermatologists can offer increasing numbers of combinations of pharmaceutical and cosmetic products. As choice increases so the possibility of confusion arises. Cosmeceuticals and Cosmetic Practice offers a no-nonsense guide to defusing this confusion. With an emphasis on practical applications, and with easy-access summary features, you can learn the secrets of successful cosmeceutical practice for your patients.

This book is intended as a manual and offers an essential tool for practicing and occupational dermatologists, for postgraduates training in dermatology and allergo-immunology, and for allergologists and occupational physicians. Moreover, the authors include information from the world literature, addressing the needs of those who work in industrial fields and are concerned about the dermatological safety of products. The book provides a handy update on this complex, rapidly evolving research area, and in particular, an in-depth analysis of its clinical aspects. It will enable dermatologists to recognize the various clinical manifestations of the condition, make a prompt diagnosis and choose the most effective treatment. Contact dermatitis, a vast and fascinating field of study, has a high frequency of occurrence worldwide in both children and adults of both sexes, and during their daily routine, dermatologists invariably encounter many patients with this disease. To ensure the proper management of these patients it is necessary first of all to formulate a clinical diagnosis on accurate morphological grounds, since it is the most clinically polymorphic disease in dermatology and hence very demanding in terms of differential diagnosis. Then, to achieve properly targeted prevention for each patient, it is essential to isolate the causes among the numerous etiological chemical agents present in both working and leisure time activities and environments. The aim of this book is therefore two-fold: firstly to provide information on the various clinical features of contact dermatitis and review their differential diagnosis, and secondly to provide a comprehensive etiological overview. Particular attention has been paid to the methodologies and importance of patch tests and other diagnostic tools, as well as to the principles of prognosis, treatment and rehabilitation, together with considerations on some preventive aspects underlying contact dermatitis. A wealth of color clinical images, as well as tables and explanatory diagrams, round out the book.

This book will be a vital tool for all clinicians in the front line when an ill child presents with an acute illness. Experienced paediatricians, postgraduate doctors, primary care physicians, and paediatric nurses will find this a useful refresher, and it will be an invaluable primer for newly trained doctors and students, or those new to the paediatric wards. Each chapter here provides an overview of each symptom and sign followed by the most likely underlying causes in an easy-to-use tabular format. Investigative techniques and guidelines follow, ranging from the simple and inexpensive to the more complex, as do Top Tips and Red Flag warnings to note; new to this second edition are concluding summaries of Key Points, as well as an entirely new Endocrine chapter.

Psychodermatology covers all aspects of how the mind and body interact in relation to the onset and progression of various skin disorders. This book is the first text written by a multidisciplinary team of psychiatrists, psychologists, child specialists and dermatologists for all the health professionals who treat patients with skin problems. They cover a broad range of issues affecting these patients, including: stigma, coping, relationships, psychological treatments, the impact on children, comorbidities, psychoneuroimmunology, quality of life and psychological treatments.

A fully-illustrated, note-packed volume of information, Dermatology: Illustrated Study Guide and Comprehensive Board Review fulfills a real need for a single study guide for the Dermatology Board Exam. Written by a previous Chief Resident of Dermatology at the University of Illinois at Chicago Medical Center, the text focuses on presenting comprehensive information in an easy-to-understand, easy-to-remember format. The second edition of this incredibly popular book includes: * Close to 800 full-color clinical and histologic images * Over 75 new histopathologic images and over 170 tables * Layout similar to first edition with outline approach * Clinical images parallel to corresponding text for easy reinforcement of text * Updated coverage of new medications, new entities and new mutations * Must-have for any dermatologist or dermatology resident for studying for the in-service training exam and dermatology board exam * Excellent review source for dermatology with easy to read format, numerous mnemonics and high-quality clinical images

This book provides valuable information to increase confidence in proper, effective management of patients with psychodermatolic conditions. Patients with psychocutaneous disease may present to multiple professionals to seek care. The multidimensional nature of the conditions can lead to specialists being fearful of how to properly manage patients. With the information provided in this book, healthcare providers can increase their comfort and become less hesitant when making decisions determining the proper treatment course and assessing the need for referral. Due to the cross-disciplinary nature of this topic, this book will have a large target audience: Healthcare providers from multiple diverse fields such as, but not limited to, family medicine, dermatology, and psychiatry. Dermatologists, Psychiatrists, general practitioners, dermatology and psychiatry residents, physician's assistants, nurses, psychologists, and medical students with exposure to patients with psychocutaneous conditions and/or a special interest in the field may also benefit from the presented material. Professors, educators, and researchers with an interest in psychodermatology or interdisciplinary medicine The Handbook of Psychodermatology will be a powerful resource as an aid in creating coursework material for undergraduate medical students specifically for psychiatry and/or dermatology lectures. In addition, it will be useful to graduate medical education teams creating curriculums for incoming residents in psychiatry, dermatology, family medicine, and pediatrics