Targeted cancer therapies have revolutionised the therapeutic management of many neoplasms, modifying patients' prognosis and overall survival. These drugs block the cancer's growth and spread by interfering with specific molecules which play a crucial role in the proliferation, differentiation and survival of cancer cells. Targeted therapies act selectively on specific molecular targets related to cancers, whereas most of the conventional chemotherapies act on all rapidly dividing normal and neoplastic cells. Moreover, targeted therapies are often cytostatic and non-cytotoxic as standard chemotherapies. Taken together, these aspects appear important in reducing systemic toxicity and ensuring an improved safety profile. The inhibition of epidermal growth factor receptor (EGFR), vascular growth factor (VEGF) and BRAF represents major achievements in research and development of solid tumour's epithelial therapy. This class of biologics is currently widely used in the treatment of metastatic and unresponsive neoplasms of the colon, pancreas, lung, (NSCLC), breast, head and neck and melanoma. This book aims to emphasize skin toxicity associated with EGFR-, VEGF- and BRAF- inhibitors, focusing particularly on their clinical presentation, histopathological findings, and specific therapeutic options.

Advances in Dermatology Research presents original research results on the leading edge of dermatology. Each chapter has been carefully selected in an attempt to present substantial advances across a broad spectrum. Some topics discusses in this book include pemphigoid; cyanosis, and acne.

The book is an extensive overview in the topic of superficial mycoses. The book deliberates on human fungi kingdom, pathogenesis of different superficial mycological diseases, its classical clinical manifestations and the variants clinical forms, with an emphasis on the relevant differential diagnosis, which sometimes might be confused with superficial mycoses. The book is written in a very practical approach accompanied with images and relevant explanations. The book has two main goals. First, to provide broad information regarding superficial dermatomycological diseases. In addition, it gives emphasis on correct diagnosis, focusing on precise and relevant interpretation of mycological laboratory analysis in order to prevent over-diagnosis and misinterpretation of the disease. The clinical approach -- practically -- is necessary for having correct diagnosis. The final diagnosis will be supported by using the standard laboratory analysis. A unique chapter elaborates widely on laboratory analysis, combined with relevant interpretation of the mycological results. This is due to many different saprophytes fungi which are irrelevant to skin diseases and might be interpreted as relevant, by mistake. Other laboratories techniques are discussed widely as well. The different approaches for mycological analysis are elaborated including the interpretation of false positive and false negative results. Other skin disorders such as psoriasis, atopic dermatitis and/or many other nails disorders which could be accompanied with relevant or irrelevant different fungi are discussed widely accompanied with very impressive clinical pictures and explanations of how and when to suspect combined disorders. Topical and systemic anti fungi treatment is listed clearly, focusing on the different antifungal mechanisms of each antifungal family. Drug interactions/contra-indications between the antifungal drug/s and other common drugs are presented in detail as well as the possible side effects of the antifungal drugs. New different drugs and devices such as lasers, photo dynamic therapy (PDT), and drilling of the nails also are examined.

Adverse drug reactions commonly affect the skin. In rare instances, they cause severe morbidity and possibly lead to drug-induced mortality. Toxic epidermal necrolysis (TEN) represents the archetype of such conditions. This book summarises the recent advances in the field of TEN as a major life-threatening adverse drug reaction. Indeed, this dramatic condition remains a puzzling topic for both the clinician at the bedside and in the laboratory. This book is fully updated about the putative biomechanisms, the clinico-pathological correlations and recent treatment advances. The most damaging effects of TEN reside in the skin, eyes and oral mucosa. Physicians keen in intensive care medicine, dermatology and ophthalmology should find here stimulating concepts applicable to the patient with the hope of reducing the TEN fatalities.

The skin is composed of three layers of differentiated tissues. The most external layer is the epidermis, followed by the dermis and the hypodermis, which is the most internal layer of the skin. The increasing incidence of skin cancer has led international health authorities to recommend protection measures to prevent the harmful effects of skin exposure to UV-radiation. Such measures include avoidance of sun exposure, especially at times when disease-inducing wavelengths are more intense, wearing protective clothing and use of topical sunscreens. This book discusses the various properties of sunscreens, the role sunscreens play in skin cancer, and other health effects for individuals using sunscreens.

Pemphigus vulgaris (PV) is the most frequent condition inside the pemphigus group, especially in Europe and North America. It is the prototype of a genetically mediated disease. The HLA alleles associated with PV are well-known. Recent studies found an association between disease severity and some HLA DRB1 and DQB1 alleles. The author of this book discusses the management of PV that should be started with an evaluation of disease severity.

Even those clinicians who feel themselves far from aesthetic dermatology now recognise that BoNT-A is an extraordinary tool in their therapeutic armamentarium for treating complex disorders such as focal idiopathic hyperhidrosis. This has opened a therapeutic scenario for a group of patients very difficult to treat previously. Since the introduction of BoNT-A in the dermatological therapeutic armamentarium, in 1990, things have changed to the point that any dermatologist should now have knowledge of BoNT-A basics, and the practicalities of BoNT-A vial reconstitution and injection. Moreover, in the last years, a widespread availability of multiple different commercially available forms of BoNT-A has been for sale, thus the clinicians must now really know and consider the advantages and disadvantages of the different available products. These would include dosing/duration, immunogenicity, and spread of effect. What has not changed over the years is the safety profile of BoNT-A. The knowledge regarding its side effects and complications have greatly increased, confirming that, despite the attempts of some individuals to assert otherwise, BoNT-A remains one of the safest forms of treatment available to us as physicians. This edited collection provides a comprehensive practical guide on the use of botulinum toxin in several dermatological disorders, including focal idiopathic, axillary, palmar and plantar, craniofacial or segmental hyperhidrosis, chrono-aging, hidradenitis, and gives some suggestion on the use of BoNT-A for the treatment of several orphan skin diseases, not responding to conventional treatments like benign Hailey-Hiley disease, lichen simplex, osmidrosis. Using clear explanations, simple line drawings, diagrams and clinical pictures, it provides suggestions to improve practical knowledge on the use of BTX-A in dermatology. Hot topics include practical information for clinicians regarding the correct counselling of the patients to be treated; methods and ready to use tests to select patients to be treated; the optimal dosage and dilution according to the site of injection and the indication of use; the relevant injection sites for each condition; the correct technique of injection in the different areas of body surface; comparative dosage tables for the various formulations of toxin used; how to manage and prevent side effects related to the use of BoNT-A; common pitfalls and how to optimize outcomes; timing for the follow-up of treated patients. The authors hope that this book may be a starting point for the use of a drug that is still growing, and a useful tool for those clinicians who want to improve their knowledge about the use of BoNT-A in dermatology.

Following the popular success of the first volume published by Dr Azizzadeh and Dr Massry among cosmetic surgeons and physicians, the Editors present a second Multispecialty volume, this one dedicated to Midface and Lower face rejuvenation. The Editors have once again selected an expert team of Editors spanning the practices of Plastic Surgery, Oculoplastic Surgery, Facial Plastic Surgery, and Dermatology, with expert Authors presenting anatomy, techniques, procedure planning, complications, and outcomes in each specialty field. Topics are planned on: Complications of Lower Blepharoplasty and Midface lifting; Deep Plane Face Lifting for Midface Rejuvenation; The Transeyelid Midface Lift; Management of Post-blepharoplasty Lower Eyelid Retraction; Contemporary Thoughts on Lower Eyelid/Midface Aging; Aesthetic Canthal Suspension; Dark Circles: Etiology and Management Options; Laser Resurfacing Applications for Periocular Rejuvenation; Non-Resurfacing Approaches for Lower Eyelid Rejuvenation; Skin Care For The Lower Lids: "Bags," "Dark Circles," and "Wrinkles;" Volumetric Strategies for the Lower Lid and Midface; Transcutaneous Lower Lid Blepharoplasty With and Without Fat Repositioning; Fat Grafting of the Lower Lid and Midface; Transtemporal Midface Lifting to Blend the Lower Eyelid Cheek Junction; Utilizing a New Classification of Midfacial Aging to Customize Multimodality Midface Rejuvenation Surgery; Transconjunctival Lower Lid Blepharoplasty with and without Fat Repositioning, among others. Any practitioner of cosmetic facial procedures, invasive, minimally invasive, or non-invasive, will receive a wealth of information from expert practitioners who obtain excellent results.

In the 21st century, there has been a vast explosion in new information relating to the art and science of dermatology, as well as fundamental cutaneous biology. Furthermore, this information is no longer exclusive to the interests of the small, but growing specialty of dermatology. Clinicians and scientists from a wide variety of disciplines have recognised the broad implications of cutanous lesions in systemic diseases. At present, there is a multidisciplinary and worldwide interest in the progress of dermatology. It is difficult for most fully-booked physicians to spend too much time on searching secondary data for the textbook mentioned; this kind of literature-searching job is very time-consuming and remains somewhat incomplete. It should be very helpful to have textbook-matched handbooks with expanded information from topic-oriented experts. With these factors in mind, we have undertaken this series of books which are specifically oriented toward the advances of dermatology. The scope of the series is purposely broad, with books ranging from pure basic science to practical, applied and clinical dermatology. Thus, while there is something for everyone, all volumes in the series will ultimately prove to be valuable additions to a dermatologist's library. The book consists of 18 chapters prepared by authors from nine countries between five continents. The organisation of this international editorial group has ensured global opinions, avoided regional bias and racial preferences. The topics covered in this book are the core of dermatology: from the fundamental changes of skin biology to newly developed technologies and treatments. What makes this book quite unique is the inclusion of Chinese medicine, telemedicine, biologics, and skin disorders newly categorized as auto-inflammatory, such as Still's Disease and Sweet's syndrome.

Knowledge of cutaneous lymphomas has been growing significantly as a result of important discoveries in immunology, molecular biology, and immunohistochemistry. Improved clinical pathologic correlation and follow-up data, as well as the synergistic collaboration among different lymphoma registries and specialists from several academic medical centers have greatly contributed to the understanding of the difficult field of cutaneous lymphoproliferative disorders. While these advances have increased understanding of skin lymphomas, they have also produced an extensive and sometimes confusing litany of articles, studies, and classification schemes. This issue on Cutaneous Lymphomas in Surgical Pathology Clinics provides an organized and updated review of this challenging topic by leading experts. It bridges critical knowledge gaps in the diagnosis of cutaneous lymphomas. Sezary Syndrome, Mycosis Fungoides and variants are presented along with B-cell, CD30, lymphoproliferative disorders among others. In addition to multiple clinical and microscopic images, tables and algorithms are presented to aid in diagnosis and staging. Beyond its usefulness to general pathologists, dermatopathologists, and hematopathologists, this information is intended to be helpful for dermatologists, hematologists/oncologists, fellows, and residents.

This full-colour handbook is divided into four sections. The first two sections represent the two main approaches to identifying skin diseases: morphological patterns and regional diagnosis. Symptoms are listed in bullet-point format alongside the colour photograph of the disease and the diagnosis includes a cross reference to the full description in the third section. This added user-friendliness is a new feature of the second edition and is clearly explained in the Introduction. All information, as well as the formulary and reading list section, has been updated with the latest in diagnosis and treatment included. The text has been better organised, with certain sections (e.g. the eczemas) grouped together.

In this issue of Dermatologic Clinics, guest editor and Vice Chair for Diversity, Equity and Inclusion, Department of Dermatology at the University of Pennsylvania, Dr. Susan C. Taylor brings her considerable expertise to the topic of Diversity, Equity, and Inclusion in Dermatology. Top experts in the field cover key topics such as social identity; unconscious bias; race, racism and structural racism in medicine; understanding and addressing microaggressions in medicine; gender equity in medicine and dermatology; equity for sexual and gender minority persons in medicine and dermatology; and more. Contains 16 relevant, practice-oriented topics including cultural competence or humility; diversity, equity and inclusion in dermatology workforce and academic medicine; racial disparities in research and clinical trials; diversity, equity and inclusion initiatives in dermatology organizations; steps leaders can take to increase diversity, enhance inclusion and achieve equity; and more. Provides in-depth clinical reviews on diversity, equity, and inclusion in dermatology, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Designed for everyday use in the clinic, Bernard A. Cohen's Pediatric Dermatology, 5th Edition, is a visually stunning, practical reference for anyone who treats children with skin disorders. Diagnostic algorithms, high-quality illustrations, and concise, easy-to-navigate text written by a leading authority in the field set this text/atlas apart, making it ideal for clinical use as well as board exam preparation. Contains nearly 1,000 superb photographs (100 are new or updated) balanced by clear and succinct text. Keeps you up to date with the most current knowledge and latest advancements in the field, including new variants of conditions for infantile hemangiomas and vascular malformations and approaches and findings for treating pigmented lesions in infants and children. Features numerous summary tables and differential diagnosis algorithms to help simplify diagnosis. Offers a comprehensive bibliography at the end of each chapter for further study. Includes European drug names when appropriate. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Physikalische Therapieverfahren spielen in der Behandlung vieler Hauterkrankungen eine entscheidende Rolle. Das gesamte Spektrum der zur Verf gung stehenden M glichkeiten stellt diese 2. bearbeitete und erweiterte Auflage praxisnah dar: Photobiologie, Phototherapie, Lichtdermatosen, Lasertherapie, Ionisierende Strahlen und Kryo- und Elektrochirurgie.

"A concise, well-written, and well-illustrated overview of the topic of cosmetic dermatology that will prove useful to all physicians who care for cosmetic patients."-Archives of Facial Plastic Surgery reviewing the First Edition The bestselling dermatology resource-updated to reflect the latest skin care procedures and treatments Baumann's Cosmetic Dermatology covers the entire gamut of dermatology-with essential information about the anatomy and physiology of skin and skin conditions. Comprehensive and engagingly written, this updated text addresses the latest medications, cosmeceuticals, and procedures. Grounded in an evidence-based, clinically-relevant approach and featuring 400+ full-color images, this is an indispensable resource for everyday practice. Features: Guidance on the efficacy of over-the-counter and prescription skin care products Step-by-step review of must-know procedures NEW: The latest drugs and topical agents, including retinoids, moisturizing agents, antioxidants, depigmenting agents, vitamins, and herbals NEW: The newest laser treatments, pulsed light techniques, varicose veins, and cosmeceuticals 400+ full-color photos and illustrations

This issue of Dermatologic Clinics is the first of a two-part series examining Epidermolysis Bullosa. Guest Editor Dedee Murrell has assembled a panel of experts to pen articles on topics covering pathogenesis, clinical features, diagnosis, treatment, and international perspectives on EB.

The atlas that helps you differentiate visually similar diseases Written with the dermatology trainee in mind, Dermatopathology: Diagnosis by First Impression uses more than 800 high resolution color images to introduce a simple and effective way to defuse the confusion caused by dermatopathology slides. Focused on commonly tested entities, and using low- to high-power views, this atlas emphasizes the key differences between visually similar diseases by using appearance as the starting point for diagnosis. The Third Edition provides: *800 high resolution and annotated photographs, now all fully downloadable *'Key Differences' to train the eye on distinctive diagnostic features * Disease-based as well as alphabetical indexes *75 new interactive self-assessment questions to perfect your diagnostic skills * Brand new algorithms for pattern analysis Dermatopathology: Diagnosis by First Impression, Third Edition, once again provides simple and effective guidance to help you approach dermatopathology and accurate diagnosis of skin disease.

Melanoma is an increasingly important public health problem. Although the cause of most malignant melanomas - over-exposure to ultraviolet light - is well known, effective treatment has remained challenging. The past several years have been marked by extraordinary developments in melanoma treatment in the arena of targeted therapeutics. This book describes these ground-breaking discoveries and their implications for clinical use. As melanoma biology is increasingly understood, so the development of targeted therapies for this disease is spurred ahead. This book covers both established signal transduction inhibitors and the fascinating emerging realm of molecularly-guided immunotherapies. This benchmark book provides the most up-to-date information on the new breed of melanoma therapies. Composed of the works of major researchers and clinicians, this book offers new insights, novel approaches, and promising data for effective treatment planning. Illuminating the latest advances in the field, it is a solid resource for clinical oncologists, translational scientists, and basic cancer researchers.

Dermatology is the science responsible for the study of the skin, mucous membranes (oral and genital) and cutaneous appendages, while dermatopathology focuses on its microscopic study. Although the two fields are closely related, in many cases the identification of dermatological diseases is mainly clinical and depends on the physician's ability and experience. The purpose of this atlas, which collects over 900 clinical and histological photographs in high resolution, is to illustrate and describe the most frequent skin diseases on the basis of clinical cases. Offering a complete guide to the etiology, epidemiology, clinical features, histologic findings and diagnosis of the main skin diseases divided into three subgroups (inflammatory, infectious, or tumoral), it represents an invaluable resource for all medical students, residents, clinicians, and investigators learning dermatology.

Il fuoco di Sant Antonio e una malattia, certo Ma quale? Per noi Italiani e sicuramente l Herpes zoster; ma e sempre stato cosi? Ebbene, no

Sant Antonio Abate aveva la fama di taumaturgo e guaritore gia in vita, nonostante si fosse ritirato in un remoto deserto. Cosi, quando le sue spoglie arrivarono in Europa dopo l anno Mille, tutti coloro che soffrivano di malattie dolorose e urenti, imploravano Sant Antonio che li guarisse da quel "fuoco" che li tormentava.

Ma quali erano queste malattie cosi dolorose? Le antiche cronache sono spesso troppo succinte o troppo romanzate per orientarci nella diagnosi ma erisipela, sifilide, ergotismo hanno fatto certamente buona compagnia allo zoster.

L ergotismo, soprattutto, era una malattia terrorizzante perche compariva ad ondate imprevedibili e, come la peste, colpiva i virtuosi come i viziosi, scardinando l interpretazione allora dominante, del dolore come conseguenza del peccato. Come se non bastasse, l ergotismo non solo provocava terribili sofferenze ma spesso anche stati di confusione mentale e di delirio che erano (questi si ) sicuramente attribuiti al demonio.

Bisogna aspettare il XVIII secolo e l eta dei Lumi per mandare in soffitta le superstizioni che infestavano la medicina ed allora l ergotismo si rivela essere non piu una maledizione ma una solo una malattia, un effetto del consumo di pane nero alloiato

Lo studio degli allucinogeni e la scoperta dell LSD nel XX secolo, mettono la parola fine all interpretazione mistico-religiosa di alcune patologie e gettano inaspettatamente nuova luce su quello che fu il segreto meglio custodito dell Antichita: il culto dei Misteri Eleusini.

In questo libro, la storia del fuoco di Sant Antonio di dipana dai racconti medioevali sino all odierna virologia e suggerisce che la curiosita e la scienza sono l unico antidoto contro la superstizione e il mistero.

Un filo rosso unisce i Misteri Eleusini al Fuoco di Sant Antonio: questo filo e l LSD. La molecola e la stessa ma il contorno e molto diverso e, di sicuro, molto appassionante.

Drugs produced by molecular biological techniques, called the 'biologics', differ from the usual chemical medications. Their optimum use, and the detection and managemenet of adverse events, pose a significant challenge to the clinician. Licences for new biologics continue to be granted for the likes of rituximab, abatacept and certocizumals pegol. Intensive research is also defining new areas in which these drugs will be used in the future, increasing the number of practitioners using biologics. As the use of these drugs increases around the world, so the level of information needed by primary care practitioners and specialist prescribers needs to be expanded The Handbook of Biological Therapy provides the practising clinician with a practica guide to the use of Tumour Necrosis Factor Blocking Therapy (TNF-blockers), and important new class of biologic therapy for rheumatoid arthritis, ankylosing spondylitis, Crohn's disease, ulcerative colitis, psoriasis, and psoriatic arthritis. It is a comprehensive distillation of the authors' clinical experience with these drugs, combined with data from diverse databases offering practical advice on their uses, specific indications, supporting clinical trial data and safety issues, with the aim of making the use of these drugs easier for the busy clinician. All of the authors have been involved from the beginnings of the clinical trial programmes with these drugs and continue to use them in daily practice.

This classic text sets a standard in this subject by outlining the scientific aspects that underlie pathological processes, relating these to specific organ systems and placing all in a context that the student of medicine or pathology can appreciate, understand and enjoy. The clearly defined and easy-to-follow structure, enhanced by numerous photographs and explanatory line diagrams, focuses on core material without neglecting novel concepts and up-to-the minute detail. A one-stop-shop in pathology, it reflects fully the integration of pathology into clinical teaching whether system or problem-based, and will take the student right through medical school and beyond to postgraduate training.

This book provides the description of the granulomatous diseases of otorhinolaryngology, head and neck with their characteristic features, investigations and management. It includes wide variety of infective, idiopathic, neoplastic, hereditary, reactive and various other types of chronic granulomatous reaction in the ear, nose, throat and head neck region. Further, the description is supported with various illustrations including clinical photographs, radiological pictures of CT scan, MRI scan etc. Histopathological and microbiological images which show characteristics and differentiating features are also included to aid in the diagnosis of the diseases. Histopathological colored images with high magnification and immunohistochemistry images are provided for better illustrations. This book also elaborates the important medical and surgical management of the granulomatous diseases. Every chapter ends with the 'Essential features' of that particular granulomatous disease, and this will certainly help the post-grad students and clinicians to differentiate the diseases, early diagnosis and management of the patients with chronic granulomatous diseases.

This book represents the state-of-the-art in the field of skin and autoimmune rheumatic diseases. It covers systematically a growing and multifaceted topic which is of great importance in the clinical practice. It also serves as a sharp educational tool as each chapter provides summaries and specific highlights to key references cited into the text. The pathophysiological link between skin involvement and autoimmunity has been explained in detail, as well as diagnostic and therapeutic aspects.
This book yields an impressive body of well ordered information which summarizes the experience of a selected panel of distinguished physicians and scientists actively involved in the field of skin immunology and systemic autoimmunity.
* Written by a respected panel of distinguished physician-scientists actively involved in the field of skin immunology and systemic autoimmunity
* Box summaries at the end of each chapter highlight important topics
* Up-to-date basic knowledge as well as modern approach to diagnosis and therapy

The aim of this open access book is to provide a unique, timely, critical and comprehensive compilation of more than 30 years of robust international experimental and clinical research related to the basic science and therapeutic application of water-filtered infrared-A (wIRA) and hyperthermia in oncology, psychiatry (depression), musculoskeletal disorders, dermatology, infectiology, and surgery. This is an internationally absolutely unique attempt which publication is timely and of great interest in medical as well as in natural sciences. The aim is to enhance communication and advance the use of heat therapy for patient benefit, and to generate an environment in which anyone with an interest in hyperthermia can discuss, collaborate, network, and share events and resources. Productive dialogue and discussion among scientists and practitioners on issues relating to hyperthermia therapy is essential, especially relating to thermal transmission by water-filtered infrared-A (wIRA). The specificity and advantage of this technology is its tolerance by tissue, and its penetration of up to 3 cm allows the delivery of high heat dosages that are relevant across multiple clinical indications. Currently, wIRA is being applied in Austria, Germany, Portugal, Switzerland, The Netherlands, UK and the USA. The authors' hope is that its use will increase in these countries, and also expand into others. This book will be an invaluable tool for oncologists, surgeons, dermatologists as well as physiotherapists.