Lipids and Skin Health is the first effort to summarize and review the studies, ideas, and research that link lipid metabolism to the largest organ of our body, the skin.  The book covers the fundamental biology of the skin, and the major involvement of the transcriptional factors that govern lipid synthesis and the bioactive lipids in this intriguing organ. All layers of skin are presented, as well as their relevant lipids from the epidermis to dermis and even to the hypodermis. The important and unique-to-skin biological pathways are laid out, with a special focus on the various models that demonstrate the essential role of lipid synthesis in skin pathophysiology. The use of lipids in the cosmetic industry is emphasized, and last but not least the involvement of lipids in the clinical setting is also discussed.  This book will appeal to healthcare professionals, researchers and dermatology professionals, and will help them to brainstorm new products and opportunities that will target the emerging importance of lipid metabolism in skin for acne, aging, and healthy skin. Apostolos Pappas, Ph.D., is a professional member of the Institute of Food Technology. He started his professional career as a research biochemist in the Skin Research Center of Johnson & Johnson and later served as a group leader at Munich Biotech, where he worked on cancer research. Thereafter he returned to Johnson & Johnson, where he is currently a Research Manager and Fellow focusing on lipid metabolism research. He has authored numerous scientific publications, patent applications, and books.

An understanding of virus infection and the underlying role of the immune system in protection against these diseases is vital in today's medical climate. Previously, only symptoms could be treated, as there were no antiviral therapies. The increasing amounts of research and the huge number of discoveries of immunologic agents and pathways has led to the opportunity to look to the basic physiology of the various disease process as never before. This book is designed to provide the clinician with a thorough and yet approachable textbook describing the relationships between immunology, virology and the disease process.

Mohs surgery is microscopically controlled surgery used to treat common types of skin cancer and allows for the removal of a skin cancer with a very narrow surgical margin and a high cure rate. However, for those involved with the Mohs procedure, it is critical to understand the optimal preparation and interpretation of frozen sections. Complete with hundreds of high resolution figures, Atlas of Practical Mohs Histopathology is written by leading experts in the field and discusses everything from normal skin histology and rare tumors to pitfalls and incidental findings. Dermatologic surgeons, Mohs cutaneous surgeons, dermatopathologists and pathologists alike will find this book to be a comprehensive and indispensable reference.

Melanoma is one of the most types of cancer. When melanoma is detected at an early stage, treatment is highly successful, but outcomes can be poor when the disease is advanced. There has been significant progress in our understanding of the molecular biology, genetics, and immunology of melanoma over the past decade. This has been accompanied by rapid advances in therapeutic strategies for patients with melanoma. This book provides the clinician and the researcher with a broad understanding of the molecular and cellular pathogenesis of melanoma, explores the clinical characteristics and criteria for clinical and pathological staging of the disease, and provides an overview of current and evolving treatment strategies in the adjuvant, metastatic, and preventive settings. The treatment of special populations and rare variants of melanoma that often present particular clinical challenges is also covered. Authored by international experts in melanoma biology and clinical management, this volume concisely explains how to diagnose, treat, and prevent melanoma while reviewing advances in basic science and providing an overview of innovative approaches still under development.

This textbook describes the basic principles of induced organ regeneration in skin and peripheral nerves and extends the original successful paradigm to other organs. A set of trans-organ rules is established and its use in regeneration of several organs is illustrated from the works of several independent investigators who worked with a variety of organs, such as the lung, the bladder, and the Achilles tendon, using collagen-based scaffolds somewhat similar to the original one. These critical medical treatments fill the clinical need that is not met by organ transplantation. New to this second edition: New information extending the paradigm of tissue regeneration from organ regeneration in skin and peripheral nerves to other organs Guidelines, known as trans-organ rules, are described for the first time for extending this unique medical treatment to organs of several medical specialties The work serves as a comprehensive text and reference for students and practitioners of tissue engineering

The sustained skin research efforts over the past decades has led to the accumulation of a significant collection of information on skin structure and physiology as well as on the pathogenesis of cutaneous diseases. In Molecular Dermatology: Methods and Protocols, leading experts in the field provide a collection of state-of-the-art reliable protocols covering a wide spectrum of techniques and experimental models, specific molecular assays and disease models, as well as overviews of diagnostic and research areas relevant to molecular dermatology. As a volume in the highly successful Methods in Molecular Biology (TM) series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and authoritative, Molecular Dermatology: Methods and Protocols emphasizes the vital importance of skin research and collects the methodologies necessary to aid scientists in moving forward in this valuable field.

Male genital disorders represent a common issue in medical practice, especially in the dermatological setting. Correct clinical evaluation of these disorders is essential when addressing the diagnosis, which in some cases may require histopathological confirmation. Depending on the disease, early diagnosis may be not only lifesaving, but also of fundamental importance to the planning of successful treatment. This atlas introduces the most common penile diseases, along with more rarely encountered ones. It provides invaluable guidance on clinical diagnosis by highlighting prominent clinical features and presenting particular videodermatoscopy findings when these are indicative of the diagnosis. In addition, for each condition the most appropriate treatment is proposed, taking into account recent therapeutic advances of proven benefit.

Skin disease can be more than skin deep Our skin is one of the first things people notice about us. Blemishes, rashes, dry, flaky skin all these can breed insecurity, even suicidality, even though the basic skin condition is relatively benign. Skin disease can lead to psychiatric disturbance. But symptoms of skin disease can also indicate psychological disturbance. Scratching, scarring, bleeding, rashes. These skin disturbances can be the result of psychiatric disease. How do you help a dermatological patient with a psychological reaction? How do you differentiate psychological causes from true skin disease? These are challenges that ask dermatologists, psychiatrists, psychologists and other health care specialists to collaborate. Practical Psychodermatology provides a simple, comprehensive, practical and up-to-date guide for the management of patients with psychocutaneous disease. Edited by dermatologists and psychiatrists to ensure it as relevant to both specialties it covers: * History and examination * Assessment and risk management * Psychiatric aspects of dermatological disease * Dermatological aspects of psychiatric disease * Management and treatment The international and multi-specialty approach of Practical Psychodermatology provides a unique toolkit for dermatologists, psychiatrists, psychologists and other health care specialists needing to care for patients whose suffering is more than skin deep.

Human hair is the subject of a remarkably wide range of scientific investigations. Its chemical and physical properties are of importance to the cosmetics industry, forensic scientists and to biomedical researchers. The fifth edition of this book confirms its position as the definitive monograph on the subject. Previous editions were recognized as "concise and thorough" (Journal of the American Chemical Society), "an invaluable resource" (Canadian Forensic Science Society Journal), and "highly recommended" (Textile Research Journal). Chemical and Physical Behavior of Human Hair is a teaching guide and reference volume for cosmetic chemists and other scientists in the hair products industry, academic researchers studying hair and hair growth, textile scientists and forensic specialists. Features of the Fifth Edition: Recent advances in the classification and characterization of the different proteins and genes in IF and keratin associated proteins in human hair are described. The mechanism and incidence of hair growth and loss and hair density vs. age of males & females are described for Asians, Caucasians and Africans in different scalp regions. Details of hair surface lipids and cuticle membranes provide a better understanding of the surface and organization of the CMC and its involvement in stress strain is presented. Recent evidence demonstrates a more bilateral structure in curly hair and a more concentric arrangement of different cortical proteins in straighter hair. SNPs involved in hair form (curl and coarseness) and pigmentation and genes in alopecia and hair abnormalities are described. The latest biosynthetic scheme for hair pigments and structures for these and the different response of red versus brown-black pigments to photodegradation is described. A new method for curvature on 2,400 persons from different countries and groups is used to assign curvature throughout this book. Additional data for age and effects on diameter, ellipticity, elastic modulus, break stress and other parameters are presented with much larger data sets featuring statistical analyses. Hair conditioning, strength, breakage, split ends, flyaway, shine, combing ease, body, style retention, manageability and feel parameters are defined and described. A new section of different life stages by age groups considering collective and individual changes in hair fiber properties with age and how these affect assembly properties.

Inflammatory Dermatopathology: A Pathologist's Survival Guide provides expert guidance for the reader to develop a systematic approach to the diagnosis of inflammatory disorders of the skin. It covers the most common and clinically important inflammatory disorders of the skin through an image-rich easy to read format. Each section includes practical tips to help navigate the differential diagnosis. Microscopic features are listed as bullet points to enhance readability. Examples of diagnostic comments that practicing pathologists can utilize in their own reports are also provided. Demonstrating a global understanding of inflammatory dermatoses in a quick and efficient manner, Inflammatory Dermatopathology: A Pathologist's Survival Guide will both guide the reader in how to approach inflammatory dermatoses, as well as provide a tool that will help with the writing of surgical pathology reports.

This user-friendly reference tool presents clinical scenarios and discusses some practical complementary and alternative therapies available in dermatology. It focuses on peer-reviewed data that are suitable for use in a conventional dermatology practice and helps dermatologists guide their patients when faced with questions regarding integrative dermatology using an evidence-based, reader-friendly, and case-focused approach. Within the field of dermatology, there is a marked void in the understanding of complementary and alternative approaches, though dermatologists frequently use off-label therapies to manage chronic conditions. They do so, however, with a range of success and potentially considerable side effect profiles. Handbook of Integrative Dermatology is a must-have tool for any practicing dermatologist.

Infertility is defned as the inability to conceive after having unprotected intercourse for a year. Infertility is increasing worldwide and has various causes both in the male and the female partner. Immune reactions to sperm can contribute up to 2-30% of infertility. The sperm has both autoantigenic as well as isoantigenic potential, and is thus capable of p- ducing antisperm antibodies (ASAs) and sperm-reactive T cells in both infertile men and women. Also, over 75% vasectomized men produce autoantibodies to sperm that can cause a problem in regaining fertility even after successful re-anastomosis in vasovasostomy. Early claims regarding the incidence and involvement of ASAs in involuntary human infertility were probably overemphasized because of unreliable techniques and naivety concerning the complexity of the immune response and antigenic nature of the sperm cell. These factors, the lack of well-designed and controlled experimental studies, and the dearth of effective therapeutic modalities resulted in the confusion of the occurrence and importance of ASAs in human infertility. Consequently, evaluation of infertile couples for ASAs and their possible role in infertility was not considered a signifcant proposition. The development of more accurate assays and the discovery of mucosal immunity capable of responses independent of systemic immunity have caused inclusion of sperm cells and genital tract secretions in the analysis of ASAs.

This book is dedicated to our readers with the intention of providing an informative exposition of the myositis syndromes. It is also presented in the hope that perhaps it may serve to inspire and stimulate discussion and research into these disabling disorders. Included are descriptions of clinical features, differential diagnosis, pathogenetic mechanisms, and approaches to therapy. Current concepts of classi- cation and diagnostic techniques are also presented. The production staff at Humana Springer, especially Ms. F. Louie and Ms. C. Walsh, have been instrumental and invaluable in allowing this work to see the light of day. Above all, the scholarly essays of the contributing authors are acknowledged with gratitude. They have given this volume its character and existence. New York, NY Lawrence J. Kagen v Contents Preface ...v Contributors ...ix 1 Evaluation of the Patient ...1 Lawrence J. Kagen 2 Classification of Idiopathic Inflammatory Myopathies ...15 Frederick W. Miller 3 The Inflammatory Milieu: Cells and Cytokines...29 Ann M. Reed and Thomas A. Griffin 4 Juvenile Dermatomyositis: An Update on Clinical and Laboratory Findings ...55 Lauren M. Pachman 5 Inclusion Body Myositis ...87 Lawrence J. Kagen 6 The Role of Muscle Biopsy in the Diagnosis of Inflammatory Myopathy ...95 Sakir Humayun Gultekin 7 Electromyography ...1 1 1 Hans L. Carlson 8 Magnetic Resonance Imaging of Myopathies and Myositis ...127 Carolyn M. Sofka 9 Ultrasound in the Evaluation of the Inflammatory Myopathies ...147 Ronald S. Adler and Giovanna Garofalo vii viii Contents 10 Serological Findings ...165 Ira N.

This fully revised and updated second edition of Sexual Health and Genital Medicine in Clinical Practice covers the range of conditions seen in genitourinary medicine, sexual health and sexually transmitted infection clinics, making it a useful and practical guide to all health practitioners in this area. This book is aimed at medical practitioners who require a quick reference guide to help with diagnosis and management of genital problems. In addition, it provides essential guidance on what to do next when faced with a patient presenting with a genital complaint, whether the patient can be successfully treated with a drug regimen or needs to be referred up to the Sexual Health and Genital Medicine specialist. Sexual Health and Genital Medicine in Clinical Practice will be of particular interest to residents on their rotations through this field of medicine, doctors in training, specialist nurses, and primary care practitioners.

Das Buch beinhaltet in praxisgerechter Form die Darstellung der aktuellen und gAngigen Methoden der phlebologischen Diagnostik und Therapie inklusive der bildgebenden Verfahren i. S. der immer wichtiger werdenden Duplexsonographie und Phlebographie. Es wird umfassend auf die konservative Therapie eingegangen, insbesondere die Kompressionstherapie, aber auch auf die Pharmakotherapie bei der chronisch-venAsen Insuffizienz. Aktuelle Aspekte der Thromboseprophylaxe und -therapie werden berA1/4cksichtigt. Das Buch enthAlt zahlreiche Tabellen und Abbildungen in Form von Zeichnungen und Fotodokumentationen. Der besondere Nutzen besteht in der AktualitAt der BeitrAge und der MAglichkeit, in vergleichsweise kurzer Zeit einen Aoeberblick A1/4ber phlebologische Fragestellungen zu bekommen.

The book will educate and decode the role of vitamins, essential fatty acids and other nutraceuticals on skin health and their tremendous impact to the current needs of the skin care industry. Focus on conditions, as acne, dermatitis, dry scaly skin or alopecia will provide a comprehensive knowledge of the relationship of nutrition and skin as well as the current attempts in nutritional or dermatological research. It will stimulate food professionals to brainstorm for new products and opportunities that will target the emerging antiaging and wellness trends and modern consumer needs.

Clinical cases are a key component in modern medical education, assisting the trainee or recertifying clinician to work through unusual cases using best practice techniques. Integrative Dermatology is an important discipline in this regard since it is a highly visual subject requiring the reader to describe often very subtle differences in the presentation of patients and define accurately the diagnostic and management criteria to base their clinical decision-making on. In 1992 the National Institutes of Health established the National Center for Complementary and Alternative Medicine (now also called Integrative Medicine), which has led to increased evidence-based research. The objective of this book is to provide readers with an overview of traditional and complementary treatment options for the most common skin problems encountered in clinical practice.

In this updated third edition, expert physicians assemble user-friendly, clinically-oriented guides to aid in the day-to-day management of the allergic patient. With an emphasis on common allergic diseases and the pharmacological tools to control them, this book disseminates the practical knowledge that practitioners have accumulated through practice and teaching. Three new chapters focus on antihistamines, antileukotrienes, and children experiencing recurrent respiratory tract infections. This book is intended for the front-line physician who cares for allergic patients. It will help any physician improve the care offered to those patients.

This book discusses lasers and light technologies in dermatology. The innovation is due to the book format: a handbook. It is the first handbook of lasers in dermatology, facilitating access to information to all individuals interested in lasers in this specific medical field . The most recent lasers devices and its applications will be discussed. Illustrations and tables will make the book didactic and comprehensive. Lasers in dermatology are a constantly evolving field. Over the past few decades, novel devices have been developed and new indications for their use have emerged. A broad understanding of the relationship between science and laser principles is the foundation of a solid dermatologic practice. The Lasers in Dermatology Handbook is a tool to understand the use of lasers in clinical practice. Important topics such as vascular lesions, warts, acne, scars, and pigmented lesions are presented and discussed in all aspects. The wide spectrum of laser and light technologies available for skin resurfacing and rejuvenation will be covered as well. Written by internationally renowned authors, this handbook serves as a cornerstone for laser applications and provides updated information for all physicians, particularly dermatologists, interested in implementing lasers in their practice.

Dermatopathology is both exciting and exasperating. tum corneum cells. This occurs in disorders of keratiniza Skin has an elegant simplicity in its functions yet a tion because the process of desquamation is disturbed (Figure 1. 1). ferocious complexity in its structure. This is one of the paradoxes that underly the pathology of skin disease Parakeratosis. The presence of nucleated horn cells in and may go some way in explaining the multitudinous the stratum corneum. Normally the horn cells (corneocy disorders to which the skin is subject. The ready visibility tes) are thin lamellae of less than 1 f. lm thickness. They of the skin may also help explain why straightforward contain no detectable cytoplasmic contents as these are histological examination cannot always provide an lost in the granular cell layer. Parakeratosis occurs when answer to a clinicians's question. Quite dramatic appear the process of keratinization is disturbed such as when ances may be due to alterations of the relative rates of the rate of epidermal cell production is increased (as in blood flow, with or without oedema, in the different psoriasis) so that nuclei are not broken down before the vascular plexuses or around different structures in the stratum corneum is reached and when damage occurs horizontal dimension, neither of which may result in to the upper epidermis (Figure 1. 2). 'much to see' histologically. The inherent sampling error Porokeratosis.

Amid today's growing demand for cosmetic medicine, Guide to Minimally Invasive Aesthetic Procedures provides a reliable, up-to-date, and highly illustrated guide to the wide variety of aesthetic procedures commonly requested and performed in this fast-changing field. This easy-to-follow manual offers a quick, practical introduction to the optimal use of everything from botulinum toxin and deoxycholic acid to injectable fillers and laser and light devices.

Therapeutic breakthroughs in medicine are usually accompanied by a wealth of data. Often they result in a change of disease treatment paradigms. Tacrolimus ointment is the first in the new class of steroid-free Topical Immunomodulators (TIMs), and as such represents the first true breakthrough since the introduction of topical steroids more than 50 years ago for the treatment of T-cell mediated inflammatory skin diseases such as atopic dermatitis. This book gives an easy-to-read overview of the discovery and the development of Tacrolimus ointment for the treatment of atopic dermatitis. Summarising the largest clinical trial program ever conducted in dermatology for a new treatment with more than 13000 patients, it offers a detailed insight into the efficacy and safety profile of Tacrolimus ointment. Based on this large body of data and extensive personal experience, the authors offer practical and hands-on guidance for the physician as to when and how to use Tacrolimus ointment in daily practice.

Rheumatologic diseases are highly associated with clinical symptoms of the skin, nails, and mucosal membranes. This book provides the practicing rheumatologist with a rapid, easy to consult reference to help interpret the nature of these cutaneous lesions and then quickly decide upon the appropriate follow-up tests. Utilizing an abundance of informative photographs, it contains all of the essential information needed for early diagnosis and treatment. This comprehensive guide properly orients the practitioner within the challenging world of rheumatologic disorders of the skin and gives insight into when consultation with a dermatologist is advisable.

"The Handbook of Dermatologic Surgery"incorporatesthe most cutting edge technology applicable to dermatologists and dermatologic surgeons today. Designed as a reference guide for dermatologic surgery and aesthetic procedures, it disseminates key scientific information in an easy-to-use pocket book.

This handbook is designed to be readily transportable for dermatologists and dermatologic surgeons, as well as those in training, dermatology residents and fellows, and medical students rotating through dermatology. "