Autoimmune disorders of the skin remain an enigma for many clinicians and scientists not familiar with these mostly severe and chronic diseases. The book provides an overview and the latest information on the broad spectrum of cutaneous autoimmune disorders for clinicians, scientists and practitioners in dermatology, medicine, rheumatology, ENT, pediatrics and ophthalmology. The book is unique since it presents the state-of-the-art knowledge on pathophysiology, clinical diagnosis and management of these disorders provided by the world experts in the field. The primary intention is to broaden the understanding of the pathophysiology of cutaneous autoimmune disorders and to provide a practical guide to how to identify and handle these conditions. The book is illustrated with many tables, illustrative figures and clinical color photographs. The third edition has been thoroughly updated and extended by chapters on paraneoplastic cutaneous syndromes, atopic dermatitis and autoimmunity and Skin manifestations of rheumatic diseases.

This volume compiles the perspectives of a multi-author team examining the entire spectrum of burn reconstruction and long-term treatment. Individual chapters cover basic aspects of wound healing and scarring, and those of plastic surgery relating to tissue rearrangement and the use of flaps, as well as the long-term use of skin and skin substitutes. Furthermore, topics such as rehabilitation and scar management are addressed in detail. This part provides detailed reconstruction guidelines divided by anatomic region (e.g. face, hands,...), as well as aspects of future trends and prospects in burn reconstruction, among which are e.g. allotransplantation and bionics.

Of all the techniques used to treat non melanoma skin cancer, the highest cure rates belong to the Mohs surgical procedure. Critical to this technique is optimal preparation and interpretation of frozen sections. With more than 400 high resolution figures, the Atlas of Mohs and Frozen Section Cutaneous Pathology is the premier textbook on the topic, serving as a highly practical guide to microscopic analysis, diagnosis, and discrimination of common and problematic cutaneous neoplasms. Highlights of the Atlas include diagnosis of basic and routine dermatologic entities, diagnosis and distinction of rare and/or deadly neoplasms such as dermatofibrosarcoma protuberans and merkel cell carcinoma, a troubleshooting guide dealing with quality control of the frozen section technique, and discussion of new techniques including immunohistochemistry. Comprehensive and presented in full color, the Atlas of Mohs and Frozen Section Cutaneous Pathology is an indispensable reference for anyone involved with the Mohs procedure, including dermatologic surgeons, Mohs cutaneous surgeons, as well as pathologists and dermatopathologists who perform frozen section analysis of cutaneous specimens.

Over the decades, research has demonstrated that in categories of life deemed to be important, beautiful people achieve more desirable outcomes, are judged more favorably, and receive preferential treatment. An understanding of the historical aspects, science, and implications of what the human mind finds aesthetically pleasing is quintessential for dermatologists, plastic surgeons, and others who practice aesthetic medicine as the importance of beauty in today's society is what brings patients into clinics. While an element of dissatisfaction with one's appearance is commonplace, clinicians should remain vigilant for individuals who seek cosmetic procedures to quell excessive body image concerns that are out of proportion to objective physical findings. Body dysmorphic disorder (BDD) is a disorder of self-perception; it is the impairing preoccupation with a nonexistent or minimal flaw in appearance. According to recent statistics, BDD occurs in 0.7-2.4% of the general population; however, multiple studies have suggested an incidence of 6-16% in patients seeking aesthetic medical treatments. Moreover, a vast majority will at some point seek dermatologic treatment and cosmetic surgery. Such patients are unlikely to be satisfied with corrective procedures, and only 15% of dermatologists surveyed thought that they could successfully treat BDD. Therefore, Beauty and Body Dysmor phic Disorder aims to assist dermatologists, plastic surgeons, and other aesthetic providers in recognizing key characteristics as well as providing treatment strategies to help in caring for those with BDD.

Written by a leading dermatologist, The Blue Man and Other Stories of the Skin provides a compelling and accessible introduction to the life of our largest organ, while also recounting the author's experiences with memorable patients he has treated who suffer from mysterious skin conditions. Robert Norman begins by highlighting the qualities of the skin, tracing the history of its conditions and diseases, then examining the cultural, social and psychological impact of both color and irregularity. The book also features an absorbing collection of stories about some of his most intriguing patients: from a man whose skin mysteriously turned blue, to a hypochondriacal woman who begins to show signs of a life-threatening disease. This is a fascinating account of the dynamic nature of the skin, and the people who inhabit it.

This classic text sets a standard in this subject by outlining the scientific aspects that underlie pathological processes, relating these to specific organ systems and placing all in a context that the student of medicine or pathology can appreciate, understand and enjoy. The clearly defined and easy-to-follow structure, enhanced by numerous photographs and explanatory line diagrams, focuses on core material without neglecting novel concepts and up-to-the minute detail. A one-stop-shop in pathology, it reflects fully the integration of pathology into clinical teaching whether system or problem-based, and will take the student right through medical school and beyond to postgraduate training.

Histamine is an important mediator of allergic diseases, but knowledge of histamine as a cause of numerous non-allergic symptoms and signs is limited. This book offers wide-ranging coverage of histamine intolerance. There is extensive background discussion of the origin of histamine, its content in food and alcoholic beverages and intolerance to red wine. Diagnosis of histamine intolerance is explained and the various symptoms of histamine intolerance are clearly described. Subsequent chapters cover the relation of histamine to a wide variety of conditions, including drug intolerance, atopic dermatitis, seasickness and osteoporosis. This book will prove of value in clinical practice by facilitating differential diagnosis, which is by no means straightforward given the multiplicity of symptoms of histamine intolerance and by assisting in the selection of therapeutic measures.

As a result to the recent significant developments, both in the field of cutaneous pathology and clinical dermatology, many cutaneous neural tumors are now being diagnosed by specialists like dermatopathologists, and treated by dermatologists or dermatologic surgeons. Cutaneous Neural Neoplasms: A Practical Guide provides an essential aid in diagnosis by discussing the cardinal clinico-pathologic features of cutaneous tumors relevant to these specialists. It covers detailed pathologic features, and their differential diagnosis. Applicable special diagnostic techniques are extensively illustrated. Whenever relevant, key therapeutic recommendations are provided. The authors approach each entity by presenting clinical and/or gross photographs when relevant with discussion of the clinical features, followed by the tabulated list of key pathologic features with corresponding histopathologic illustrations. Therapeutic recommendations are summarized. Cutaneous Neural Neoplasms: A Practical Guide is an important new volume that fills a major gap in the currently available resources for practicing physicians, and provides them with an appropriate knowledge base to handle these challenging tumors in the most up-to-date fashion.

Mohs surgery is microscopically controlled surgery used to treat common types of skin cancer and allows for the removal of a skin cancer with a very narrow surgical margin and a high cure rate. However, for those involved with the Mohs procedure, it is critical to understand the optimal preparation and interpretation of frozen sections. Complete with hundreds of high resolution figures, Atlas of Practical Mohs Histopathology is written by leading experts in the field and discusses everything from normal skin histology and rare tumors to pitfalls and incidental findings. Dermatologic surgeons, Mohs cutaneous surgeons, dermatopathologists and pathologists alike will find this book to be a comprehensive and indispensable reference.

This is the first and only book on the diagnosis and treatment of cicatricial alopecia, written by leading experts in the field. This highly illustrated and practical text helps residents and practicing dermatologists to accurately diagnose and treat the scarring alopecias.

This book focuses on the use and significance of in vivo reflectance confocal microscopy (RCM) for non-invasive high-resolution imaging of the skin. All of the chapters in this hands-on guide are generously illustrated with numerous confocal images and structured in a reader-friendly way. The contents include detailed information on the most relevant and up-to-date aspects of RCM, schematic drawings summarizing and explaining the most important RCM criteria, and a chapter specifically devoted to bridging the gap between dermoscopy, RCM, and histopathology. At the end of each chapter, core messages recapitulate the most pertinent aspects. Reflectance Confocal Microscopy for Skin Diseases will be a valuable resource for all physicians involved in the diagnosis and treatment of neoplastic and inflammatory skin diseases.

This volume covers the entire spectrum of acute burn treatment. Individual chapters deal with basic aspects of different burn mechanisms as well as the acute care of burn patients. Pre-hospital management, critical care and basic concepts of burn surgery related to the acute phase, as well as the use of skin and skin substitutes in early stages of therapy are addressed in this volume. Chapters on supportive therapies such as optimizing nutrition and fluid homeostasis, infection control and treatment, respiratory support and pain management complete the comprehensive approach to the patient in this early stage of treatment, while chapters on epidemiology, prevention and disaster management enable the reader to evaluate the given information in a broader context.

Inflammatory Dermatopathology: A Pathologist's Survival Guide provides expert guidance for the reader to develop a systematic approach to the diagnosis of inflammatory disorders of the skin. It covers the most common and clinically important inflammatory disorders of the skin through an image-rich easy to read format. Each section includes practical tips to help navigate the differential diagnosis. Microscopic features are listed as bullet points to enhance readability. Examples of diagnostic comments that practicing pathologists can utilize in their own reports are also provided. Demonstrating a global understanding of inflammatory dermatoses in a quick and efficient manner, Inflammatory Dermatopathology: A Pathologist's Survival Guide will both guide the reader in how to approach inflammatory dermatoses, as well as provide a tool that will help with the writing of surgical pathology reports.

This reader-friendly and unique compendium on all aspects of non-invasive facial rejuvenation shows the current approach to the issue. It describes when and how to use laser and laser-like technology, the variety of superficial and deep peels which can be used by themselves or in conjunction with lasers. Last but not least, it also covers the variety of dermal fillers and skin volume enhancement agents and the increasing cosmetic uses of botulinum toxin. Novices as well as experts will benefit from the wealth of experience and expert practical information of the authors who are world-renowned experts in their field.

Melanoma is one of the most types of cancer. When melanoma is detected at an early stage, treatment is highly successful, but outcomes can be poor when the disease is advanced. There has been significant progress in our understanding of the molecular biology, genetics, and immunology of melanoma over the past decade. This has been accompanied by rapid advances in therapeutic strategies for patients with melanoma. This book provides the clinician and the researcher with a broad understanding of the molecular and cellular pathogenesis of melanoma, explores the clinical characteristics and criteria for clinical and pathological staging of the disease, and provides an overview of current and evolving treatment strategies in the adjuvant, metastatic, and preventive settings. The treatment of special populations and rare variants of melanoma that often present particular clinical challenges is also covered. Authored by international experts in melanoma biology and clinical management, this volume concisely explains how to diagnose, treat, and prevent melanoma while reviewing advances in basic science and providing an overview of innovative approaches still under development.

Human hair is the subject of a remarkably wide range of scientific investigations. Its chemical and physical properties are of importance to the cosmetics industry, forensic scientists and to biomedical researchers. The fifth edition of this book confirms its position as the definitive monograph on the subject. Previous editions were recognized as "concise and thorough" (Journal of the American Chemical Society), "an invaluable resource" (Canadian Forensic Science Society Journal), and "highly recommended" (Textile Research Journal). Chemical and Physical Behavior of Human Hair is a teaching guide and reference volume for cosmetic chemists and other scientists in the hair products industry, academic researchers studying hair and hair growth, textile scientists and forensic specialists. Features of the Fifth Edition: Recent advances in the classification and characterization of the different proteins and genes in IF and keratin associated proteins in human hair are described. The mechanism and incidence of hair growth and loss and hair density vs. age of males & females are described for Asians, Caucasians and Africans in different scalp regions. Details of hair surface lipids and cuticle membranes provide a better understanding of the surface and organization of the CMC and its involvement in stress strain is presented. Recent evidence demonstrates a more bilateral structure in curly hair and a more concentric arrangement of different cortical proteins in straighter hair. SNPs involved in hair form (curl and coarseness) and pigmentation and genes in alopecia and hair abnormalities are described. The latest biosynthetic scheme for hair pigments and structures for these and the different response of red versus brown-black pigments to photodegradation is described. A new method for curvature on 2,400 persons from different countries and groups is used to assign curvature throughout this book. Additional data for age and effects on diameter, ellipticity, elastic modulus, break stress and other parameters are presented with much larger data sets featuring statistical analyses. Hair conditioning, strength, breakage, split ends, flyaway, shine, combing ease, body, style retention, manageability and feel parameters are defined and described. A new section of different life stages by age groups considering collective and individual changes in hair fiber properties with age and how these affect assembly properties.

This fully revised and updated second edition of Sexual Health and Genital Medicine in Clinical Practice covers the range of conditions seen in genitourinary medicine, sexual health and sexually transmitted infection clinics, making it a useful and practical guide to all health practitioners in this area. This book is aimed at medical practitioners who require a quick reference guide to help with diagnosis and management of genital problems. In addition, it provides essential guidance on what to do next when faced with a patient presenting with a genital complaint, whether the patient can be successfully treated with a drug regimen or needs to be referred up to the Sexual Health and Genital Medicine specialist. Sexual Health and Genital Medicine in Clinical Practice will be of particular interest to residents on their rotations through this field of medicine, doctors in training, specialist nurses, and primary care practitioners.

This user-friendly reference tool presents clinical scenarios and discusses some practical complementary and alternative therapies available in dermatology. It focuses on peer-reviewed data that are suitable for use in a conventional dermatology practice and helps dermatologists guide their patients when faced with questions regarding integrative dermatology using an evidence-based, reader-friendly, and case-focused approach. Within the field of dermatology, there is a marked void in the understanding of complementary and alternative approaches, though dermatologists frequently use off-label therapies to manage chronic conditions. They do so, however, with a range of success and potentially considerable side effect profiles. Handbook of Integrative Dermatology is a must-have tool for any practicing dermatologist.

Infertility is defned as the inability to conceive after having unprotected intercourse for a year. Infertility is increasing worldwide and has various causes both in the male and the female partner. Immune reactions to sperm can contribute up to 2-30% of infertility. The sperm has both autoantigenic as well as isoantigenic potential, and is thus capable of p- ducing antisperm antibodies (ASAs) and sperm-reactive T cells in both infertile men and women. Also, over 75% vasectomized men produce autoantibodies to sperm that can cause a problem in regaining fertility even after successful re-anastomosis in vasovasostomy. Early claims regarding the incidence and involvement of ASAs in involuntary human infertility were probably overemphasized because of unreliable techniques and naivety concerning the complexity of the immune response and antigenic nature of the sperm cell. These factors, the lack of well-designed and controlled experimental studies, and the dearth of effective therapeutic modalities resulted in the confusion of the occurrence and importance of ASAs in human infertility. Consequently, evaluation of infertile couples for ASAs and their possible role in infertility was not considered a signifcant proposition. The development of more accurate assays and the discovery of mucosal immunity capable of responses independent of systemic immunity have caused inclusion of sperm cells and genital tract secretions in the analysis of ASAs.

This book is dedicated to our readers with the intention of providing an informative exposition of the myositis syndromes. It is also presented in the hope that perhaps it may serve to inspire and stimulate discussion and research into these disabling disorders. Included are descriptions of clinical features, differential diagnosis, pathogenetic mechanisms, and approaches to therapy. Current concepts of classi- cation and diagnostic techniques are also presented. The production staff at Humana Springer, especially Ms. F. Louie and Ms. C. Walsh, have been instrumental and invaluable in allowing this work to see the light of day. Above all, the scholarly essays of the contributing authors are acknowledged with gratitude. They have given this volume its character and existence. New York, NY Lawrence J. Kagen v Contents Preface ...v Contributors ...ix 1 Evaluation of the Patient ...1 Lawrence J. Kagen 2 Classification of Idiopathic Inflammatory Myopathies ...15 Frederick W. Miller 3 The Inflammatory Milieu: Cells and Cytokines...29 Ann M. Reed and Thomas A. Griffin 4 Juvenile Dermatomyositis: An Update on Clinical and Laboratory Findings ...55 Lauren M. Pachman 5 Inclusion Body Myositis ...87 Lawrence J. Kagen 6 The Role of Muscle Biopsy in the Diagnosis of Inflammatory Myopathy ...95 Sakir Humayun Gultekin 7 Electromyography ...1 1 1 Hans L. Carlson 8 Magnetic Resonance Imaging of Myopathies and Myositis ...127 Carolyn M. Sofka 9 Ultrasound in the Evaluation of the Inflammatory Myopathies ...147 Ronald S. Adler and Giovanna Garofalo vii viii Contents 10 Serological Findings ...165 Ira N.

In this updated third edition, expert physicians assemble user-friendly, clinically-oriented guides to aid in the day-to-day management of the allergic patient. With an emphasis on common allergic diseases and the pharmacological tools to control them, this book disseminates the practical knowledge that practitioners have accumulated through practice and teaching. Three new chapters focus on antihistamines, antileukotrienes, and children experiencing recurrent respiratory tract infections. This book is intended for the front-line physician who cares for allergic patients. It will help any physician improve the care offered to those patients.

Clinical cases are a key component in modern medical education, assisting the trainee or recertifying clinician to work through unusual cases using best practice techniques. Integrative Dermatology is an important discipline in this regard since it is a highly visual subject requiring the reader to describe often very subtle differences in the presentation of patients and define accurately the diagnostic and management criteria to base their clinical decision-making on. In 1992 the National Institutes of Health established the National Center for Complementary and Alternative Medicine (now also called Integrative Medicine), which has led to increased evidence-based research. The objective of this book is to provide readers with an overview of traditional and complementary treatment options for the most common skin problems encountered in clinical practice.

This book discusses lasers and light technologies in dermatology. The innovation is due to the book format: a handbook. It is the first handbook of lasers in dermatology, facilitating access to information to all individuals interested in lasers in this specific medical field . The most recent lasers devices and its applications will be discussed. Illustrations and tables will make the book didactic and comprehensive. Lasers in dermatology are a constantly evolving field. Over the past few decades, novel devices have been developed and new indications for their use have emerged. A broad understanding of the relationship between science and laser principles is the foundation of a solid dermatologic practice. The Lasers in Dermatology Handbook is a tool to understand the use of lasers in clinical practice. Important topics such as vascular lesions, warts, acne, scars, and pigmented lesions are presented and discussed in all aspects. The wide spectrum of laser and light technologies available for skin resurfacing and rejuvenation will be covered as well. Written by internationally renowned authors, this handbook serves as a cornerstone for laser applications and provides updated information for all physicians, particularly dermatologists, interested in implementing lasers in their practice.

Therapeutic breakthroughs in medicine are usually accompanied by a wealth of data. Often they result in a change of disease treatment paradigms. Tacrolimus ointment is the first in the new class of steroid-free Topical Immunomodulators (TIMs), and as such represents the first true breakthrough since the introduction of topical steroids more than 50 years ago for the treatment of T-cell mediated inflammatory skin diseases such as atopic dermatitis. This book gives an easy-to-read overview of the discovery and the development of Tacrolimus ointment for the treatment of atopic dermatitis. Summarising the largest clinical trial program ever conducted in dermatology for a new treatment with more than 13000 patients, it offers a detailed insight into the efficacy and safety profile of Tacrolimus ointment. Based on this large body of data and extensive personal experience, the authors offer practical and hands-on guidance for the physician as to when and how to use Tacrolimus ointment in daily practice.

The book will educate and decode the role of vitamins, essential fatty acids and other nutraceuticals on skin health and their tremendous impact to the current needs of the skin care industry. Focus on conditions, as acne, dermatitis, dry scaly skin or alopecia will provide a comprehensive knowledge of the relationship of nutrition and skin as well as the current attempts in nutritional or dermatological research. It will stimulate food professionals to brainstorm for new products and opportunities that will target the emerging antiaging and wellness trends and modern consumer needs.