The so-called 'connective tissue disorders' hold a particular fascination to both the rheumatologist and the dermatologist, and the diagnosis of, sometimes subtle, changes in the skin can often be difficult. This book aims to give a succinctaccount ofcutaneous manifestations of the major connective tissue diseases, including the cutaneous side effects of anti-rheumatic therapy, and the main diagnostic and prognostic features and guides to their management. Although the book is intended primarily for dermatologists and rheumatologists, it will also be of value to general physicians and general practitioners. We would like to express our thanks to our colleagues in the Medical Photography Department at the Royal United Hospital, Bath, especially Tim Browne and AnnabelHancock, and to Hilary Woolf for painstakingly typing the manuscript. We would like also to thank the following who have generously allowed us to reproduce their clinical and pathological photographs. Dr T. I. MacLeod (Figs. 2.2, 2.6, 3.1, 5.7, 7.2, 9.20, 11.6(b)); Dr S. O'Loughlin (Figs 3.2(b) and (e)); Dr R. S-H. Tan (Figs 3.4, 11.6(a)); Dr C. T. C. Kennedy (Figs 3.6, 4.1, 6.14); Dr T. Provost (Fig. 3.12(a)); Dr R.

The blistering diseases, although relatively uncommon, are of major clinical and scientific importance. Patients with these diseases can present great difficulties in diagnosis and management. The bullous diseases are life-threatening and many patients perish either from their disease or from complications of therapy. They may present to dermatologists, general physicians, paeditricians, oral surgeons, dentists, otolaryngologists and ophthalmologists. All of these specialities may be involved in their management.;This book places emphasis both on the practical management and on the major advances of the past decade.

Die klassische Magistralrezeptur hat eine lange Tradition und stutzt sich vorwiegend auf Empirie. In der Praxis sind nahezu 50% der durch Dermatologen verordneten Externa Magistralrezepturen. Es ist unumganglich, dass die Magistralrezeptur dem gegenwartigen Stand des wissenschaftlichen Fortschrittes angepasst wird. Obsolete Wirkstoffe mussen vermieden werden. Die Galenik soll optimalisiert werden. Ahnlich wie bei Spezialitaten soll sich der verordnende Arzt darauf verlassen konnen, dass bei empfohlenen Magistralrezepturen die pharmakologische Wirkung des Wirkstoffes in der Grundlage gesichert oder zumindest sehr wahrscheinlich ist. Externagrundlagen fur bestimmte Indikationen sollen gezielt unter wissenschaftlichen Gesichtspunkten zusammengestellt werden. Hauptanliegen des Buches sind gezielte therapeutische Empfehlungen unter diesen Gesichtspunkten."

The field of dermatology has very much changed during the last decades. An ever-increasing knowledge about the pathogenesis of diseases of the skin has made it possible to not only better classify but also to make dermatoses better explainable and understandable. The present book exemplifies this with a very common disease, the dyshidrotic eczema of the hands. Most current textbooks still describe "dyshidrosis" as a disease of the eccrine sweat glands, as was first postulated in 1873 by T. Fox. In 1962, R. D. G. P. Simons challenged this concept and since then, it has not been possible to establish a uniform pathogenetic concept regarding "dyshidrosis". The only generally accepted view is that the dermatosis has multiple etiologies. This monograph is intended to be a follow-up to Simons' book published in 1966, entitled Eczema of the Hands. Investigations into Dyshidrosiform Eruptions. It repre sents an attempt to view the clinical and experimental aspects of atopic palmoplantar eczema as a basis for an understanding of the entire entity of dyshidrosis. My special thanks go to Prof. Dr. E. Macher, Miinster, who made it possible for me to complete this work, to Prof. Dr. S. Nolting, Miinster, who aroused my interest in the subject, and to Prof. Dr. P. Frosch, Heidelberg, who generously provided the necessary technical equipment for investiga tional use. Clinical examinations are impossible without patients and control per sons. I would like to thank all the people who took part in this project.

"Conclusions are usually considered guesses" Henry S. Haskins, American writer in Meditations in Wall Street Students' minds, whether undergraduate or postgraduate, soon become stale when faced with lectures or even not so large textbooks. Supplementing lecture notes and textbooks with multiple-choice questions, therefore, attunes the mind to this style of examination which the student will certainly meet and yet also relieves the tedium and monotony of the conventional learning route. This multiple-choice textbook, therefore, should be used side by side with lecture notes, textbooks and clinical teaching material. The book covers a wide field of genitourinary medicine. This necessarily overlaps with general medicine, urology, bacteriology, virology, psychiatry, sexual medicine, im munology and proctology. With regard to immunology, a basic set of teaching questions are included so that HIV disease may be more easily understood without recourse to immunology textbooks. The answers to the questions are not given in a uniform style. This is partly to relieve monotony, and partly because some questions need no explanation, others need a prose answer and yet others are best answered by a point-by-point explanation. We also provide references for those interested. There is some overlap between questions but only enough, we hope, to facilitate learning but not produce somnolence."

1 2 Peter Reeve and Lavelle Hanna lSmith Kline & French Laboratories, Research and Development, 709 Swedeland Road, Swedeland, PA 19479, USA 2Department of Microbiology, S-412, University of California, San Francisco, San Francisco, CA 94143, USA Trachoma, an infectious keratoconjunctivitis due to chlamydial infection, was one of the earliest recognized clinical entities. References to it have been noted in Egyp- tian papyri and in Greco-Roman medical treatises. Since those times it has remained a most important eye infection, and indeed trachoma is still a major cause of blindness in rural communities, affecting probably 6 million people (Dawson). The causal agent of trachoma was identified by Halberstaeter and von Provazek in a much-quoted but little-read paper published over 75 years ago. It was after the isolation and demonstration of the growth of the causal agent of trachoma, Chlamy- dia trachomatis, by Tang and his colleagues in China in the late 1950s that there was an enormous increase in our knowledge of these agents. The real explosion of knowledge and interest in Chlamydia, however, has been in the last decade. With the growing awareness of the extraordinary commonness of chlamydial infections, not only in developing countries but also in the highly developed countries, has come a considerable interest from all areas concerned with medical science, from clinicians to molecular biologists.

This is a highly illustrated guide to the diagnosis and management of nail conditions in children. With new material on genetics and on developments such as dermoscopy, it will be invaluable as a reliable clinical reference for both dermatologists and pediatricians, as well as those in family practice.

F. H. Comhaire Many diseases were, at the beginning, merely defined by the description of their clinical appearance. Next, the pathogenic mechanisms underlying the diseases were recognized. Since then, the proof of presence of the pathogenic agent or agents has been required to confirm the diagnosis. However, it sometimes happens that the pathogenic agent can be demonstrated without the disease being clinically evident. Confusion arising from this observation may cause endless, often purely emotional discussions between "believers" and "non-believers." Moreover, if the disease involves potential disturbance of male fertility, the problem is further obscured by the difficulty of defining man's fertility. Indeed, during the short history of andrology, the criteria for judging a man and his ejaculate as potentially fertile or infertile have repeatedly changed. Andrological "landmarks" in general do not hold up for long, and some scientists continue to set themselves the task of proving the "old" definitions invalid. Certainly, such developments are necessary to make science more exact and to improve medical care. However, while this research is being done, the male partners of barren marriages continue to seek advice and treatment. Common sense and an empirical approach in the handling of these cases may result in obviously encouraging results, which non-believers will ascribe to "witchcraft" and believers will see as confirmation of their opinions.

Why another dermatology text? In 1973, when Drs. Nasemann and Sauerbrey wrote the introduction to the first edition of Haut krankheiten und venerische Infektionen. they addressed this question. They promised their book would be concise and profusely illustrated to best teach the fundamentals of dermatology. The German text, now in its fourth edition, has been widely successful. In undertaking an American revised translation of their work, it was my hope to meet a need in the English-language literature similar to that met by the German text. I believe that both students and non dermatologic physicians will find this volume a useful introduction to the art and science of treating skin disorders. The practice of dermatology differs from country to country. This text is therefore not simply a translation, but an adaptation that incorporates much new material. In the pages that follow, I have built on the successful framework of the German text, incorporating its excellent photographs and other teaching aids. Discussion of therapy has been extensively revised to reflect current practice in the United States. Original chapters on male infertility and proctology (two dermatologic domains in Germany) are not included in this book. They have been replaced by wholly new chapters on cutaneous surgery and tropical dermatology. We are grateful to Ronald G. Wheeland, M.D., for contributing the surgical chapter.

The stratum corneum is a magnificent example of the successful adaptation of a tissue. Its efficient function is a prerequisite for life itself. We depend on its control of the movement of water through the skin and on its protective role in the prevention of penetration by pathogens or harmful substances. Apart from its functional importance, there is no escaping the fact that the most common skin disorders (psoriasis, eczema, inherited disorders of keratinization, acne) are 'characterised by abnormal keratinization and or scaliness. Despite all this, understanding of its chemistry, structure, physiology and involvement in disease has been sadly deficient; however, there are signs of enlightenment. This symposium is evidence of changed atti. tudes. Leading researchers from many countries have applied modem biomedical techniques and the methods of molecular biology to the many problems and questions posed by the stratum corneum. Although there have been several symposia and publications on the process of keratinization, few have been broadly based on the stratum corneum. For this reason we believe that the proceedings of this symposium will be invaluable for all who are profeSSionally concerned with skin biology. Cardiff/Diisseldorf, November 1982 R. Marks G. Plewig v Acknowledgements Alcon Labs. Limited Brocades G. B. Limited Cardiff City Council Cassella-Riedel Pharma GmbH. Cilag-Chemie Dermal Laboratories Limited Dista Products Limited Dome Div. Miles Laboratories Limited Hoechst AG. Imperial Chemical Industries Limited Janssen Pharmaceuticals Limited Johnson & Johnson Limited L'Oreal E."

In recent years immunobiology has witness- aspects on the background of various meth- ed most remarkable achievements and the ods applied, as well as clinicopathologic im- understanding of lymphomas and leukemias plications. A special chapter is addressed to is greatly increased. Knowing that these "Pagetoid Reticulosis" elucidating the neoplasms are essentially immunoprolif- various views on the cytogenesis of this neo- plasm. For the same reason, a contribution erative diseases extended the dermatological views of the corresponding skin tumors. on "Merkel Cell Neoplasms of the Skin" has Sophisticated techniques and new im- been included because these tumors have munological methods now enable us to been mistaken for pagetoid reticulosis. analyze and classify cutaneous malignant The last chapter on "Cooperative Study lymphomas far better than before. As a Groups, Staging and Treatment" leads off consequence this has produced a vast lit- with the signmcant contribution from the erature on this subject in the last few years. Kiel Lymphoma Study Group (G. Brit- For those who are not so familiar with mod- tinger}. 1t deals with the results of a prospec- em immunological thinking, it has become tive study of nodal lymphomas which were increasingly difficult to keep abreast with classilled according to the Kiel Classmca- these developments, and a comprehensive tion. Treatment protocols applied to skin review of this subject appeared to be needed. lymphomas are reported from Cooperative This is the purpose of the present book.

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. The complete guide to skin surgery and cosmetic procedures, from surgery fundamentals to surgical and cosmetic procedures An invaluable new guide for family and emergency physicians, PAs, and nurse practitioners, Dermatologic Surgery and Cosmetic Procedures in Primary Care Practice provides state-of-the-art dermatologic procedures used in virtually every clinical practice. With practical tips and tricks used by dermatologic surgeons, it covers excisional surgery, neurotoxin injections, surgical instrument selection, wound dressing, local anesthesia, incision and drainage, nail surgery, and more.

Get practical guidance from renowned dermatologist Dr. Thomas Habif and his expert team of co-authors in this user-friendly, focused text. Written specifically for the non-specialist, this easy-to-follow reference offers precisely the diagnostic and treatment information you need to quickly identify the 250 skin disorders you're most likely to see. It's an ideal resource for any medical practitioner who'd rather treat than refer patients with skin disease, as well as an excellent review for board preparation. Comprehensive yet concise, bullet-point format provides classification of primary, secondary, and special lesions, pediatric considerations, clinical pearls to guide decision making, and more. Disorders Index at the front of the book speeds you quickly to a desired topic, and the dermatologic drug formulary and "differential diagnosis by anatomical region and lesion" guide provide rapid access to essential clinical information. Easy-to-understand schematics indicate disease distribution across the body (from rare to common) for each key disorder. Updated with the latest therapy options and expanded coverage of key topics, including drug reactions and tropical disease. Hundreds of new and never-before-published images (more than 1,000 photographs in all) clearly depict how skin disorders present at different stages. Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

The patch test (epicutaneous test) and photo patch test are used to clarify the etiology and diagnosis of allergic as well as light-potentiated contact der matitis. The patch test must be correlated with historic data and physical ex amination. Contact dermatitis constitutes a significant proportion (5%-15%) of the dis eases at dermatologic clinics. If the results are to be reliable, patch tests should be performed properly and the technique should not be varied in an arbitrary manner. The examiner should adhere strictly to the standard procedure so as to understand its possibilities and its limitations. Interpretation of the actual patch test reactions places high demands on the experience and skill of the examiner and on his knowledge of chemistry and pharmacology. This monograph is concerned only with the patch test method used to demonstrate the existence of contact allergy and light-potentiated contact allergy. It does not describe the "prophetic patch test" ("predictive patch test"), which is used to demonstrate the sensitizing capacity of a substance. The terminology in the text is that recommended by the International Con tact Dermatitis Research Group. (In this book dermatitis = eczema.) 1.2 Historic Development Joseph Jadassohn devised the epicutaneous test. In 1895 he tested a syphilitic patient who developed a cutaneous eruption after treatment with mercury ointment.

The sixth edition of Lockey and Ledford's Allergens and Allergen Immunotherapy continues to provide comprehensive coverage of all types of allergens and allergen vaccines, providing clinicians the essential information they need to accurately diagnose and manage all allergic conditions. With new and updated chapters, the sixth edition is the most up-to-date, single resource on allergy and immunotherapy. Key Features Completely revised and updated Detailed single source reference on allergy and immunotherapy Reorganized to provide clinicians with essential information to make diagnoses and offer the best treatments

Richly pigmented skin is the most common skin type internationally

Historically, dermatology has focused on white skin. But rich pigmentation can lead to differences in presentation, disease course and outcome, and reaction to treatment. Some dermatologic conditions are seen predominantly or only in richly pigmented skin.

"Ethnic Dermatology: Principles and Practice" provides a practical approach to the dermatology of non-white skin. Written from a global perspective to include Asian, African-Caribbean and North African skin types, it covers all the bases of dermatology including: Grading scales in dermatologic diseasePediatric dermatologyDermatology and systemic diseaseDrug eruptionsHair and scalp disordersCosmetic dermatology

With a central focus on practical action from an international cast of authors, "Ethnic Dermatology: Principles and Practice" gives you the clinical tools you need when skin colour matters.

Covering many aspects of dermatology, this handy and comprehensive reference aid is packed with key information on common skin problems including quick reference treatment guidelines. Topics include: *The integumentary system *Anatomy and physiology *How skin is affected by infection, ageing and ethnicity *Skin healing and wound management *Describing skin conditions *Pharmacology *Eczema and dermatitis *Fungal infections *Acne vulgaris *Evaluation of melanoma and pigmented lesions *Common skin conditions in primary care

This highly successful guide, now in its firth edition with sales in excess of 26,000, is essential reading for all those requiring a basic understanding of epidemiology-the study of how often and why diseases occur in different groups of people.

Assuming no prior knowledge of the subject, it guides the novice through both the theory and practical pitfalls with the aid of familiar examples.

Subjects covered include:
What is Epidemiology?
Quantifiying Disease in Populations
Comparing Disease Rates
Measurement Error and Bias
Planning and Conducting a Survey
Ecological Studies
Longitudinal Studies
Case-control and Cross Sectional Studies
Experimental Studies
Screening
Outbreaks of Disease
Reading Epidemiolgical Reports

This concise and readable book, now revised and updated, is an invaluable tool for all health care professionals and medical students whether they are getting to grips with epidemiology for the first time or as a practical revision aid for those needing to refresh or update their knowledge.

DIFFERENTIAL DIAGNOSIS IN DERMATOLOGY Fifth Edition RICHARD ASHTON, MA, MD, FRCP, Consultant Dermatologist, Lighthouse Clinic, Isle of Wight, UK, formerly Consultant Dermatologist to the Royal Navy BARBARA LEPPARD, DM, FRCP, Retired Consultant Dermatologist, Southampton University NHS Trust, UK The ethos of this bestselling text is that however much or little you know about skin disease you can always arrive at the right diagnosis. The secret is to examine the surface of the rash or skin lesion which will help you classify the clinical features correctly - colour, surface features, type of lesion, border and how long it has been present. Algorithms throughout each chapter give the differential diagnosis for the features you have elicited. Accompanying clinical photographs and clear descriptions of the conditions will enable you to check whether you are right or not. If your choice seems unlikely, any conditions that could be confused with the one you selected are listed along the base of the algorithm to help you compare diagnoses so that you can get to the right answer. We hope this new edition - enhanced with specific instructions on treatment - will be the only quick clinical reference you will ever need for dermatology diagnoses. With over 1000 illustrations.

Recognizing the enormous variety of skin diseases in lightly pigmented skin depends on the development of a number of visual skills that have to be developed still further to recognize skin diseases in deeply pigmented skin from different ethnic groups. The comparison of skin disorders in white and deeply pigmented skin is in itself an important way of learning; by using this book regularly, the reader will become familiar with the appearance of common and uncommon skin diseases in people with varying degrees of skin pigmentation. This beautifully illustrated text on ethnic dermatology provides a systematic approach to the diagnosis and management of a wide variety of skin diseases; the second edition has been reorganized and updated to enforce its usefulness for the busy practitioner needing to compare important differences in the way skin diseases manifest themselves.

This second volume in an exciting and detailed series on contact allergens provides monographs of all 181 fragrances and 79 essential oils which have caused contact allergy / allergic contact dermatitis, including the indicators for fragrance allergy (fragrance mixes I and II and Myroxylon pereirae resin [Balsam of Peru]) and non-fragrance allergens in botanical products used in the perfume industry. The monographs present: Identification section; Contact allergy (general population, patients with dermatitis, case reports and case series); Cross-reactions; Patch test sensitization; Presence in products and chemical analyses; Other side effects (irritant contact dermatitis, photosensitivity, immediate-type reactions, systemic side effects) and more. Key Features: Presents monographs of all known fragrance chemicals and essential oils which have caused contact allergy / allergic contact dermatitis Provides a full literature review of relevant topics of allergenic fragrances and essential oils Identifies INCI and IUPAC names, synonyms, CAS and EC numbers, structural formulas, RIFM and Merck Index monographs, SCCS opinions, IFRA and EU restrictions and advises on patch testing Presents an alphabetical list of all synonyms indicating their INCI names Covers an extensive amount of information to benefit dermatologists, allergists, and non-medical professionals involved with the research, development and marketing of fragrances and essential oils

Caterina Longo, MD, PhD Associate Professor, Dermatology and Venereology, at Universita degli Studi di Modena e Reggio Emilia (UNIMO); Azienda Unita Sanitaria Locale - IRCCS di Reggio Emilia, Centro Oncologico ad Alta Tecnologia Diagnostica, Modena, Italy; President of AIDNID; Executive Board Member of the International Dermoscopy Society Many texts deal with how to diagnose the straightforward melanomas of the skin, but there are many less common skin tumors that a clinician needs to be aware of because these are still likely to be encountered at some point in a clinical setting and many of them have serious implications. This highly illustrated text from an internationally acclaimed researcher provides a reliable guide to how to proceed with diagnosis of these more challenging entities. Contents: Tumors of the Epidermis: Nevoid basal cell carcinoma syndrome * Fibroepithelioma of Pinkus * Basosquamous carcinoma * Verrucous carcinoma * Sarcomatoid squamous cell carcinoma * Lentigines, Nevi, and Melanoma: Atypical Spitz nevus (tumor) * Halo Spitz nevus * Desmoplastic nevus * Pigmented epithelioid melanocytoma * Animal-type melanoma * Nevoid melanoma * Balloon cell melanoma * Desmoplastic melanoma * Special site melanoma (mucosal, acral) * Tumors of Cutaneous Appendages: Trichoadenoma * Trichoepithelioma and Brooke-Spiegler syndrome * Desmoplastic trichoepithelioma * Trichoblastoma * Tumors of the follicular infundibulum * Tricholemmoma and tricholemmal carcinoma and Cowden syndrome * Pilomatrixoma * Fibrofolliculoma/trichodiscoma and Birt-Hogg-Dube syndrome * Sebaceous tumors *Syringocystadenoma papilliferum * Hidradenoma * Cylindroma and familial cylindromatosis and Brooke-Spiegler syndrome * Spiradenoma * Mammary and extramammary Paget's disease * Syringoma * Eccrine poroma and eccrine porocarcinoma * Mesenchymal Tumors: Dermatofibrosarcoma protuberans * Atypical fibroxanthoma * Malignant fibrous histiocytoma (pleomorphic undifferentiated sarcoma) * Other Uncommon Tumors: Merkel cell carcinoma * Kaposi's sarcoma * Angiosarcoma * Retiform hemangioendothelioma With contributions from: Alessandro Annetta * Giuseppe Argenziano * Elisa Benati * Caterina Bombonato * Stefania Borsari * Eugenia Veronica Di Brizzi * , Gerardo Ferrara * Giorgio La Viola * Mara Lombardi * Elvira Moscarella * Riccardo Pampena * Giovanni Paolino * Simonetta Piana