Therapeutic breakthroughs in medicine are usually accompanied by a wealth of data. Often they result in a change of disease treatment paradigms. Tacrolimus ointment is the first in the new class of steroid-free Topical Immunomodulators (TIMs), and as such represents the first true breakthrough since the introduction of topical steroids more than 50 years ago for the treatment of T-cell mediated inflammatory skin diseases such as atopic dermatitis. This book gives an easy-to-read overview of the discovery and the development of Tacrolimus ointment for the treatment of atopic dermatitis. Summarising the largest clinical trial program ever conducted in dermatology for a new treatment with more than 13000 patients, it offers a detailed insight into the efficacy and safety profile of Tacrolimus ointment. Based on this large body of data and extensive personal experience, the authors offer practical and hands-on guidance for the physician as to when and how to use Tacrolimus ointment in daily practice.

Melanocytic Lesions: A Case Based Approach provides a concise yet comprehensive guideline on how to diagnose common as well as problematic and challenging melanocytic lesions. In the first 11 chapters, each entity is illustrated by an actual case; followed by discussion of how the diagnosis is reached, of the histologic differential diagnoses and of diagnostic pitfalls and ends with bulleted teaching points. Pertinent and up to date references are included at the end of each chapter. The latter chapters cover current microstaging and classification of melanoma, ancillary techniques including immunohistochemistry as well as available molecular assays and molecular targeted therapy. All figures and glass slides of the discussed cases are hosted online for easy viewing and access. Melanocytic Lesions: A Case Based Approach will serves as a useful resource for pathologists, dermatologists and researchers dealing with melanocytic lesions.

A beautifully illustrated, multimedia guide to facial soft-tissue reconstruction from leading clinicians Principles of Facial Reconstruction: A Subunit Approach to Cutaneous Repair, Third Edition by distinguished clinicians Wayne F. Larrabee Jr., David A. Sherris, Jeffrey C. Teixeira, and esteemed contributors presents evidence-based facial reconstruction techniques that simplify flap design based on location and defect. The book's primary focus is soft-tissue defects of moderate size rather than larger flap reconstructions. Building on the acclaimed prior editions, the third edition features new content and images. Key surgical principles are detailed graphically in an easy-to-navigate, concise layout. The two opening chapters cover a review of soft-tissue biomechanics and physiology, followed by fundamentals of wound closure, wound healing, grafts, and flaps. The seven consistently organized anatomic chapters present a brief overview of the anatomy of the region, followed by succinct descriptions of surgical approaches for relevant subunits in that region. The final two chapters provide details on free flaps and graft harvesting techniques. The reader-friendly format enables quick determination of the most reliable reconstruction options for repair of the scalp, forehead, eyes, nose, cheek, ears, and lips and chin. Key Features Firsthand experience from renowned experts on the most reliable defect reconstructions Full-color clinical photographs, around 500 high-quality illustrations, and diagrams provide precise insights on key surgical concepts Following a facial unit principle, decision-making algorithms guide readers on selection of the most effective flap or graft for each case This is a must-have resource for plastic surgeons, otolaryngologists, and oral-maxillofacial surgeons, and dermatology residents and fellows, as well as surgeons specializing in the field of facial plastic surgery. This book includes complimentary access to a digital copy on https://medone.thieme.com.

This textbook presents the current (and near-future) state of affairs of molecular testing as it pertains to the dermatology patient. It focuses on practical applications of molecular diagnostics over a cross-section of dermatologic disease, including melanoma, lymphoma, soft tissue tumors, genodermatoses, and infectious disease. It includes practical advice to those ordering molecular tests as well as to those considering performing such tests, providing a potential template for a comprehensive dermatologic molecular diagnostics test menu. Pitfalls of interpretation and algorithmic approaches to testing are included. The textbook is directed towards all readers - clinicians, pathologists, laboratorians, and other inquisitive minds - independent of their level of molecular expertise, to provoke thought or perhaps even change practice. The context for the book is the rapid evolution of the field of molecular diagnostics, which is becoming more pervasive in all disciplines of medicine, including dermatology. This is indeed an exciting time in dermatology. Molecular testing is now incorporated into all aspects of patient management, including diagnostics (identifying and classifying disease), prognostics (predicting disease course), and theranostics (predicting response to therapy). For example, molecular tests are now used to detect germline mutations that result in genodermatoses, somatic genetic events that characterize tumors such as melanoma and sarcomas, and genetic material of otherwise undetectable infectious organisms. For melanoma and lymphoma, testing can potentially predict tumor behavior and modify patient staging. Regarding theranostics, molecular tests that identify specific mutations in proto- oncogenes, such as BRAF and others, are now used to predict which patients will respond to designer targeted therapies. Molecular theranostics has revolutionized the entire treatment paradigm for patients with advanced melanoma, repla

Dermatopathology is both exciting and exasperating. tum corneum cells. This occurs in disorders of keratiniza Skin has an elegant simplicity in its functions yet a tion because the process of desquamation is disturbed (Figure 1. 1). ferocious complexity in its structure. This is one of the paradoxes that underly the pathology of skin disease Parakeratosis. The presence of nucleated horn cells in and may go some way in explaining the multitudinous the stratum corneum. Normally the horn cells (corneocy disorders to which the skin is subject. The ready visibility tes) are thin lamellae of less than 1 f. lm thickness. They of the skin may also help explain why straightforward contain no detectable cytoplasmic contents as these are histological examination cannot always provide an lost in the granular cell layer. Parakeratosis occurs when answer to a clinicians's question. Quite dramatic appear the process of keratinization is disturbed such as when ances may be due to alterations of the relative rates of the rate of epidermal cell production is increased (as in blood flow, with or without oedema, in the different psoriasis) so that nuclei are not broken down before the vascular plexuses or around different structures in the stratum corneum is reached and when damage occurs horizontal dimension, neither of which may result in to the upper epidermis (Figure 1. 2). 'much to see' histologically. The inherent sampling error Porokeratosis.

The interpretation of melanocytic tumors represents probably the most difficult task in the field of dermatopathology. The second edition of this text and atlas depicts a broad range of the most important and most challenging melanocytic lesions. Each individual case is illustrated with at least three high-quality color photographs and is commented on at length, highlighting the diagnostic clues. The goal of the authors is to assist the ordinary pathologist in making a precise workable diagnosis in their daily practice. They achieve this by providing simple criteria that will serve as a sound basis for an unequivocal diagnosis of either a benign or a malignant melanocytic neoplasm. The reader will find Histological Diagnosis of Nevi and Melanoma to be an invaluable guide to correct diagnosis even in difficult or rare cases.

"The Handbook of Dermatologic Surgery"incorporatesthe most cutting edge technology applicable to dermatologists and dermatologic surgeons today. Designed as a reference guide for dermatologic surgery and aesthetic procedures, it disseminates key scientific information in an easy-to-use pocket book.

This handbook is designed to be readily transportable for dermatologists and dermatologic surgeons, as well as those in training, dermatology residents and fellows, and medical students rotating through dermatology. "

This book is the most up-to-date publication on fluorescence diagnostic (FDAP) and photodynamic therapy (PDT) methods used in dermatology. Both techniques are presently world wide introduced as standards for the delineation and the treatment of cutaneous precancerous stages and tumors, which show steadily increasing numbers due to e.g. more frequent sun exposure. Summarizing experiences on more than 5.000 treated patients, it offers a comprehensive information on every aspect of skin tumor detection and treatment. The main part of the book focuses on the clinical aspects giving detailed descriptions on skin tumor detection as well as photodynamic treatment of selected diseases (solar keratoses, basal cell carcinomas, squamous cell carcinomas, Bowen's disease, psoriasis lesions, etc.). The clinically oriented chapters are supplemented by practical guidelines for PDT and FDAP. The included atlas is comprised of 270 high quality color figures allowing daily use as a handbook.

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. 200 full-color photographs and concise text offer a thorough overview of occupational and contact dermatology This atlas provides visual descriptions with synopsis for all dermatologists who see and treat cases of contact or occupational dermatoses. This book deals in detail with footwear dermatitis, airborne contact dermatitis, cosmetic and medicament dermatitis, regional contact dermatitis, occupational dermatoses, non-eczematos contact dermatitis, contact urticaria, etc.

Chronic venous insufficiency, manifesting as disabling open leg ulcers, lipodermatosclerosis and severe cutaneous hyperpigmentation is thought to affect five percent of the population over age 80 and a significant proportion, probably greater than one percent, of Western populations under age 65. To date little has been known about how to treat this condition cost-effectively beyond supportive and palliative care. Thus, the most important feature of Chronic Venous Insufficiency is that it describes the interventions which markedly ameliorate, and in some cases cure, the condition. The authoritative text has been skilfully illustrated to show how new methods of endovascular and endoscopic interventions can be integrated with radiologic techniques to correct totally the abnormalities which produce chronic venous insufficiency. Taken as a whole this volume will enable general surgeons, vascular surgeons, dermatologists and interventional radiologists to treat a condition that was, until recently, thought to be untreatable.

The gold-standard text in dermatology - completely updated for today's practice by an all-new editorial board Encyclopedic in scope, yet skillfully edited to make it easy to read and understand, this trusted classic delivers everything clinicians need to know about skin, skin symptoms, and skin diseases. Presented in full color, Fitzpatrick's covers all the essentials, from the basic science of skin to the day-to-day clinical issues of managing common skin disorders such as acne, skin cancer, and psoriasis. Backed by the expertise of more than 500 world-renowned contributors, and the reference of choice for clinicians, students, and educators, Fitzpatrick's is enhanced by thousands of full-color photographs and a wealth of newly enhanced tables and diagrams. The Ninth Edition is bolstered by a new global editorial team; a reorganized table of contents; a more simple, readable, and direct writing style, the incorporation of more genetic, syndromic, and treatment information into each chapter; the addition of first, second, and third line treatment options; and improved table presentation. The reorganized table of contents reflects how disease presents rather than its cause.

Rheumatologic diseases are highly associated with clinical symptoms of the skin, nails, and mucosal membranes. This book provides the practicing rheumatologist with a rapid, easy to consult reference to help interpret the nature of these cutaneous lesions and then quickly decide upon the appropriate follow-up tests. Utilizing an abundance of informative photographs, it contains all of the essential information needed for early diagnosis and treatment. This comprehensive guide properly orients the practitioner within the challenging world of rheumatologic disorders of the skin and gives insight into when consultation with a dermatologist is advisable.

The skin is the largest human organ system. Loss of skin integrity due to injury or illness results in a substantial physiologic imbalance and ultimately in severe disability or death. The most common cause of significant skin loss is thermal injury, followed by trauma and chronic ulcerations.

Over the past decades extraordinary advances have been made in the understanding of cellular and molecular processes of wound healing and the pathobiology of chronic wounds. This knowledge has led to wound care innovations that facilitate more rapid closure of wounds with better functional and aesthetic outcome. A sensible and resource-saving utilization of these innovative technologies requires a broad knowledge of these processes and innovations.

This book intends to give an overview about today's wound care developments in tissue engineering and skin replacement. It presents a variety of indications and diversities of clinical applications to help the surgeon select a specific procedure for each clinical situation.

This book is devoted exclusively to differential diagnosis in pediatric dermatology. It covers the full range of relevant conditions: inherited skin disorders; nevi; viral, bacterial, fungal, and parasitic infections; acne; allergic diseases; autoimmune skin disorders; connective tissue diseases; tumors; and miscellaneous conditions. Each comparison addresses the differential diagnosis between two (or occasionally three or four) dermatological conditions, containing between two and six images and a short text emphasizing the clinical differences between the diseases in question. At the end of each chapter, a summary highlights one or two characteristics essential for the differential diagnosis. The author is an expert who, since 1982, has been responsible for a column devoted to the differential diagnosis of pediatric dermatology in the European Journal of Pediatric Dermatology. The volume will represent an ideal tool for pediatric dermatologists, pediatricians, and GPs, and will help them in the diagnostic process.

Practical Patch Testing and Chemical Allergens in Contact Dermatitis covers the most relevant allergens in a concise and algorithmic fashion, with practical tips for patch testing. This book assists practitioners and trainees with educating patients on how to avoid their irritants and allergens to effectively manage contact dermatitis. Clinical pearls for patch testing of certain allergens are clearly outlined in this book to help providers avoid common pitfalls and reduce the risk of incorrect diagnoses, making it an essential reference for all involved in the treatment of contact dermatitis.

This book offers thorough coverage of emergencies in dermatology, from the basics of critical care for dermatologic emergencies, to neonatal and pediatric emergencies, infectious emergencies, drug eruptions and HIV-AIDS-related emergencies, among many others.

Children with skin diseases maypresent to family physicians, pediatricians or dermatologists. In book we have tried to provide a concise and under standable source of information about common skin disorders which will be useful to any physician encountering children with cutaneous signsand symptoms. We have concentrated on 26 common skin diseases which account for morethan 90% ofallskin-related doctor visits by children and adolescents, regardless of the orientation of the physician. The format of each chapter is uniform. The clinical description is accompanied by several typical photographs. The differential diagnostic approach withbriefcriteriais pre sentedin a table. Themajoremphasis is on the treatment; wehave tried to combine our long years of experience in pediatricdermatology withthe in ternationalliteratureand especially more recent evidence-based studies. We have tried to present a rangeof therapeutic possibilities, but also give firm recommendations. There have already been two successful German editions of this book. We hopethat this first English editionalsofinds a receptive readership. We are committed to the concept that childhood skin diseases are best treated whenall involved physicians have onlyone goal - the best possible carefor all children. "Turf" battles between various specialties overaspects of care only harm our patients and in the end our own self-respect. The back ground of the three editors reflects this theme; there are two dermatolo gists, one German (DA) and one American (WB), and a pediatrician (He)."

Since the incidence of skin neoplasms is constantly increasing as the population ages, there is a need for a monograph about radiation treatment of skin neoplasms and diseases. Excellent cosmetic and functional results can be shown with this treatment modality. This book comprehensively examines the indications for radiation therapy of cutaneous cancers, pre-cancerous lesions and benign dermatological disorders. The monograph provides concise introduction to physical and radiobiological principles, selection of radiation factors, dose definitions, as well as radiation reactions and risk assessments. Specific indications for radiotherapy of cutaneous neoplasms and radiation protection measures are discussed. Topics include radiation therapy of basal cell carcinoma, squamous cell carcinoma, lymphomas, Kaposi's sarcoma, Lentigo maligna melanoma, and Merkel cell tumor. A separate chapter discusses the skin reactions after nuclear accidents. Major scientific publications of the past 10 years are reviewed.

Gene therapy is a novel concept of treating diseases at the molec- ular level by rescuing genetic defects through the introduction of corrective genes. The knowledge of genetic defects underlying var- ious diseases is being rapidly accumulated, and new genotypic findings are being reported with striking frequency. The elucida- tion of the genetic background of many diseases, including hered- itary blistering and hyperkeratotic skin disorders, has provided the necessary knowledge to correct inborn genetic aberrations in ani- mal models and patient-derived tissue. However,skin is not only a target organ for gene therapy ofcutaneous disorders. Dueto its bio- logical properties, easy accessibility, and convenient, established culture conditions and grafting techniques, skin has rapidly be- come an important target for correcting other diseases as well. Both skin fibroblasts and epidermal keratinocytes have been successfully transfected ex vivo and in vivo using viral and nonvir- al gene transfer methods. Notably,in the first corrective gene ther- apy approach in 1987, fibroblasts from adenosine-deaminase (ADA)-deficienthumans with severe combined immunodeficiency (SCID) syndrome were transduced using retroviral vectors. More- over, skin cells are capable of synthesizing various proteins that are therapeutic, either locally or systemically. Human epidermal grafts expressing human growth hormone after retroviral gene transfer and grafting onto athymic mice released human growth hormone into the bloodstream of the transplanted mice, for a lim- ited time.

Lasers in Dermatology: An Introductory Guide provides a comprehensive guide to all aspects of cutaneous laser treatment. Practical aspects of laser selection and treatment are combined with easily understood sections on basic science, laser safety and current regulations. The author is internationally recognised for his research in the laser treatment of skin disease, and has close links with the development of training programmes for the use of lasers in Dermatology.

Doctors and the general public are increasingly recognising diseases of the vulva and vagina as a cause of sexual dysfunction, morbidity and death, yet the wide but sometimes rare range of conditions involving this area are poorly represented in most textbooks of pathology. As the first volume in the Essentials of Diagnostic Gynecological Pathology series sponsored by the British Association of Gynecological Pathologists, Pathology of the Vulva and Vagina is one of the very few dealing wholly with this subject. Pathology of the Vulva and Vagina introduces the topic with a stylishly illustrated description of the embryology and development which is fundamental to understanding the pathogenesis and symptomatology. Subsequent chapters cover infections and non- infectious dermatoses, specifying those that can predispose to cancer. The precancerous conditions of vulval intraepithelial neoplasia, melanocytic proliferations and extra-mammary Paget's disease are integrated respectively with accounts of human papilloma virus, malignant melanoma and recent awareness of ano- genital mammary-like glands. Advances in the recognition of potentially confusing benign conditions, prognosis and staging update the pathology of squamous and adenocarcinoma in these organs. The difficulties of sentinel node biopsy are explored and a comprehensive chapter clearly highlights the difficult differential diagnosis of mesenchymal lesions. As most histopathology departments receive many gynecological specimens, Pathology of the Vulva and Vagina has been written to be useful diagnostically to general as well as specialist gynecological histopathologists and pathologists in training. Gynecologists, oncologists, dermatologists, genitourinary physicians and cancer nurse specialists will find expert insights here that will help in treatment and counselling of their patients.

"The Manual of Dermatology" was developed by Dr. Cafardi at the University of Alabama at Birmingham, Department of Dermatology, and covers broad dermatological topics necessary for any dermatology resident treating patients. Topics include alopecia, medication dosing and management pearls, fungal disorders, genodermatoses, differential diagnoses of various skin diseases, management of infections, surgical anatomy and tips, HIV dermatology, pediatric dermatology, and skin cancer management and terminology. The practicality of this book is unique and includes key clinical data for residents, making it essential as a reference for quick differential diagnoses, work-up tips, management, and treatment options.

This quick reference offers a more practical approach to dermatology, with drug names and dosing, and more information on mycology/onychomycosis than any other handbook on the market. "The Manual of Dermatology" is portable, comprehensive, easily accessible, and is based upon algorithms, tables, and pearls taught to dermatology medical students, making it a vital resource in all university medical libraries across the country.

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Venous valves rank among the smallest and most delicate organs of the human and animal bodies - so why devote an entire book to them? We were induced to do so by several reasons. First of all we would point out the clinical significance of venous valves. In the pathogenesis of a number of widespread diseases, such as varicose veins or the post-thrombotic syndrome, venous valves are involved as the underlying cause or at least a factor contributory to the symptoms. According to Taheri et al. these venous diseases occur ten times more frequently than arterial obliterations. Incompetence of venous valves also plays a causal role in varicocele, the most frequent cause of male infertility. But not only pathogenetic reasons induced us to write this book. In more recent times there has been a growing tendency to reconstruct functional valve disorders therapeutically; several surgical methods have been developed, which are critically reviewed in this book. It was our aim to sum up existing knowledge with respect to structure and function of venous valves and to expand that knowl edge by findings of our own. Examinations of semi-thin sections and unilayered en-face preparations have hardly been published so far, and systematic studies of the ultrastructure by electron-microscopy were not to be found in the literature. We are very grateful, therefore, to Dr. Silvana Geleff for having undertaken such a study upon our suggestion."

We live today in a world densely populated by human beings living in close commu nication with one another all over the surface of the planet. Viewed from a certain distance it has the look of a single society, a community, the swarming of an intensely social species trying to figure out ways to become successfully independent. We obvi ously need, at this stage, to begin the construction of some sort of world civilization. The final worst-case for all of us has now become the destruction, by ourselves, of our species. I Although this warning is often repeated, we must not forget its paramount importance and the commitment that each sector of society has to make a world civilization possible. Tropical dermatology is a good example of an important area of our spe cialty that has never caught the proper attention of the leading centers of research in the developed countries, even though it comprehends major infec tious, parasitic, and nutritional problems of one-half of the world's land area and three-quarters of the world's population. The relevance of tropical dermatology in this extensive and overpopulated area of the globe has public health connotations that emphasize its importance. The sheer size of the problem makes it an urgent and outright need to recruit and train adequate personnel to do a proper job, and that includes not only dermatologists but paramedical personnel, nurses, and laboratory technicians.