In this volume the impact of cell culture models on dermatological research is discussed by scientists from medicine, physiology, biology, pharmacology, and pharmacy. The book includes the following topics: orthology and pathology of the skin, differentiation of keratinocytes and fibroblasts, problems of the cultivation of melanocytes, biochemistry of pigment metabolism, models for wound healing and tissue renewal, fibroblast function and metabolism of collagen, models for the investigation of ageing as well as models for pharmacological and toxicologial tests. Thus, a wide arch is spanned, from basic problems with cultivation and characterization of cell cultures to examples of application. Dermatologists as well as cell biologists will benefit from this publication.

In the past 10 years hirsutism has been the object of a considerable number of fundamental studies. It provides endocrinologists with an experimental model for the investigation of androgen secretion, metabolism and mechanism of action. Plasma androgen assay, free testosterone measurement, hepatic and extrahepatic androgen metabolic clearance and androgen metabolism in the skin are the different steps which were studied by many groups and represent valuable parameters of the mechanisms of hirsutism. Determination of the origin of androgen oversecretion has become easier by technical progress in differential effiuent venous catheterism, which makes it possible to compare androgens in adrenal or ovarian effiuent veins to their peripheral levels, and to determine the ovarian or adrenal source of the androgen oversecretion as well as the side responsible, essential in the case of tumors. The study of androgen metabolism and the discovery of androgen receptors in the skin confIrm the latter as an actual target cell for androgens. This target cell uses the circulating active androgen, i. e., testosterone and can also metabolize local inactive androgens into active ones. This is the case of androstenedione and dehy droepiandrosterone which are the two main androgens secreted in women, since women secrete very little testosterone. The capacity of the skin to transform inactive androgens into active ones varies from one individual to another. That would support the concept of variable skin receptivity from one woman to another and from one ethnic group to another."

Infectious diseases remain a major problem for physicians and other health professionals dealing with problems of the reproductive system. Accordingly, this two-volume comprehensive presentation of infectious diseases involving the male and female reproductive systems promises to be a major contribution in this field and to fill a much-needed vacuum. During the past three decades, the introduction of antimicrobial therapy has dramatically altered both the clinical presentation and the therapeutic approaches employed in dealing with the traditional infections of the repro ductive system. In addition, the changing demographics of infectious problems in the industrial countries and the developing world have been a source of concern. A good deal of important information on this topic is included in this series. In recent years, considerable attention has been given to the role of Myco plasma and Chlamydia in both male and female infertility and the problems related to genital herpes and human papilloma virus infections. Current clinical information is included on these infections as well as on newer aspects of diagnosis, such as the use of laparoscopy in the diagnosis and treatment of pelvic inflammatory disease. Also addressed is new information regarding the role of actinomycosis in pelvic infections; current problems such as toxic shock syndrome and acquired immune deficiency syndrome (AIDS) are reviewed as well. New concepts are included in these vohimes to complement the clinical information. The attachment of microbial organisms to sperm may help to explain access of these and other organisms to the upper female genital tract."

Wounds have existed since the beginning of time, and records of their nature and treatment are found in the earliest documents. Interestingly, many of these treat ments are now being rediscovered or re-used in modern-day clinical practice. In addition to the diverse nature of treatments that have been suggested as being beneficial for wounds, over many centuries there has been a range of clinicians who have cared for patients with wounds, and in many parts of the world today it is not doctors but other professional colleagues - e. g. nurses or podiatrists - who are the most knowledgeable persons on wounds and wound treatments. Finally, the nature of wounds seen in clinical practice is changing. Increasing destructive power is resulting in more severe injuries occurring in patients involved in conflict. Developments in surgical techniques have enabled new surgical procedures to be offered to patients, but novel and more severe complications can result from such technical advances. In addition, many societies around the world are having to deal with an increasing ageing population, and huge increases in the number of patients suffering from chronic wounds are being seen. In summary, expanding treatment options, diverse groups of clinicians caring for patients and changes in the nature of wounds seen in clinical practice are real issues that have to be faced, and solutions have to be found if patients are to receive optional care for their wounds."

A brilliant collection of colour pictures, augmented by appropriate discussion, describing both common and unusual afflictions. Sections on clinical manifestations, histologic findings, differential diagnosis, and treatment, complemented by significant references, have been written by selected authorities in the field. Dermatologists, dentists, and even primary care physicians will find this an indispensable volume in their practices.

Skin cancer is the most frequent malignancy in humans and its incidence is still increasing. This situation calls for major efforts to manage the disease. Preventive measures must include reduced UV exposure and an enhanced common awareness of skin lesions. Advanced surgical techniques allow safe removal with excellent cosmetic results. In many cases alternative treatment modalities such as radiotherapy, cryosurgery and photodynamic therapy are applicable. The development of optimal sun screens and UV-protective clothes, new tools for early diagnosis of malignant lesions including videomicroscopy, improved evaluation of biopsy material and new treatment schemes will contribute to better patient care. New developments in therapy including pegylated interferons, cytokine-inducing molecules, monoclonal antibodies and vaccination approaches using peptides, dendritic cells, viruses or nDNA give hope for well-tolerated and efficient treatments.

This is the eighth volume in the New Clinical Applications Dermatology Series. Awareness of relationships is of prime importance in der matology. Professor Scully and Dr Porter cover the skin and mouth in a comprehensive and informative manner. Mr Peter Wright effortlessly and concisely brings the eye and the skin together. Dr C. Rowland Payne both relates and speculates on the enigma of sarcoidosis. Pro fessor Elder concludes the book with a scholarly update on porphyria and the skin. I thank all the above for their fine contributions. This volume should have widespread appeal. JULIAN VERBOV ABOUT THE EDITOR Dr Julian Verbov is Consultant Dermatologist to Liverpool Health Authority and Honorary Clinical Lecturer in Dermatology at the University of Liverpool. He is a member of the British Association of Dermatologists, repre senting the British Society for Paediatric Dermatology on its Executive Committee. He is Editor of the Proceedings of the North of England Dermatological Society. He is a Fellow of the Zoological Society of London and a Member of the Society of Authors. He is a popular national and international speaker and author of more than 200 publications."

The industrialized world has witnessed a steady increase in diseases of the arteries, veins, and lymph vessels in recent years. The prevalence and incidence of arteriosclerotic vascular disease has taken on the character of an epidemic. Diseases of the superficial and deep veins are widespread. Everypracticing physician is confronted daily by arterial circulatory disorders of the supra-aortic vessels, the thoracic and abdominal aorta, and the pelvic and leg arteries as well as by venous and lymphatic diseases.Todayvascular disease isbest managed in an interdisciplinary way; interventional radiologists and neurologists should be part of the team at any established vascular center. Many older colleagues were forced to acquire their knowledge of vascular diseases on their own. There are still many medical schools and hospitals that lack vascular specialists who are capable of passing on their expertise to students. For manyyears there was no expertise in medical angiology in countries such as Great Britain or the United States. All of vascular medicine resided in the hands of vascular surgeons. It is only in the last few years that vascular internists have appeared in these countries as well

G. Piekarski appears not to have been brought home to at Forty years have passed since Trussent pub- least some clinicians. Of special importance in lished an important book in the English lan- this connection are T. vaginalis and Pentatri- guage on Trichomonas vaginalis Donne and uro- chomonas hominis (Davaine), the intestinal tri- genital trichomoniasis. During the intervening chomonads of many mammalian species, in- four decades, much information has been accu- cluding humans. Some practitioners still tell mulated on trichomonads parasitic in humans their patients about the possibility of an intesti- and on the diseases they cause. In light of this, nal origin of trichomonal infection of the uro- many parasitologists and clinicians believe that the time has come for a complete review, in genital tract. book form, of various aspects of these parasites Trichomonas vaginalis infection of new- and of the trichomonad parasitemias. This need borns, infants, and young children constitutes has been further reinforced by the finding that, an interesting, although not extensively pur- despite the use of effective anti trichomonal sued, area of investigation. For hitherto incom- drugs during the past years, the prevalence of pletely understood reasons, the period of preg- human urogenital trichomoniasis, the world's nancy appears to favor the increase of most common sexually transmitted disease, has symptomatic trichomoniasis; there is, there- been increasing significantly. As might have fore, little doubt that infants can be infected been expected, therefore, discussion of various during birth.

Sarcoidosis is a complex multisystem disease. Shortness of breath (dyspnea) and a cough that won't go away can be among the first symptoms of sarcoidosis, but sarcoidosis can also show up suddenly with the appearance of skin rashes and other dermatoses.

An Atlas of Sarcoidosis: Pathogenesis, Diagnosis and Clinical Features combines illustrations and clinical images of the authors' extensive practices, so that readers have unparalleled access to a comprehensive collection of sarcoidosis images. The atlas is designed to complement and provide a visual supplement to already existing texts on sarcoidosis. Each organ involvement is dealt in a brief and easy to comprehend manner. Various radiographic and laboratory abnormalities are then linked to the clinical features in order to encourage a smooth and easy practical integration at the bedside and to help practising pulmonologists, dermatologists and other clinicians who require a comprehensive visual encyclopedia of sarcoidosis images.

"Ehlers-Dan... Was?" Das hoeren Betroffene der seltenen Ehlers-Danlos-Syndrome (EDS) fast taglich. Die meisten Menschen in ihrem Umfeld haben nie von der Gruppe von angeborenen Bindegewebserkrankungen gehoert oder verbinden damit nur dehnbare Haut und flexible Gelenke. Doch die EDS sind viel mehr als das! Zusatzlich zu den Symptomen der EDS, die den ganzen Koerper betreffen koennen, treten diverse andere Erkrankungen zusammen mit den Ehlers-Danlos-Syndromen auf, wie z. B. Dysautonomie, Mastzellaktivierungssyndrom und viele mehr. Die EDS stellen sowohl Betroffene als auch deren AErzt*innen vor grosse Herausforderungen. Oft sind die Betroffenen daher auf sich alleine gestellt. Sie mussen selbst Expert*innen fur ihre Erkrankung werden, wenn sie eine optimale Versorgung erwarten. Durch eine Mischung aus fachlichen Informationen, Expert*innenmeinungen und Tipps zum praktischen Umgang mit der Gruppe von komplexen Bindegewebserkrankungen bietet dieses Buch vor allem Neueinsteiger*innen - Betroffenen, Angehoerigen, Interessierten sowie Hausarzt*innen und anderem medizinischen Personal - einen kompakten UEberblick uber alle Facetten der Ehlers-Danlos-Syndrome. 18 interessante Videos mit Interviews mit deutschsprachigen und internationalen Expert*innen bereichern das Buch und machen es zu einem multimedialen Erlebnis.

Irritant dermatitis is a common condition, accounting for a significant proportion of occupational skin disease. The recent advent of non-invasive skin bioengineering technology has accelerated dermatology research in this field. This book comprises an exhaustive reference text on irritant contact dermatitis, covering all aspects of the condition: clinical features, epidemiology, prevention and therapy, prognosis, mechanisms, pathology and regulatory issues. The book also presents novel in vitro and in vivo research techniques and findings. As irritant dermatitis affects multiple specialties, the audience for this book is wide, including clinical and investigative dermatologists, allergists, toxicologists, pharmaceutical scientists, occupational and environmental physicians, public health physicians, cosmetologists and skin bioengineers.

"Essentials in Ophthalmology" is a new review series covering all of ophthalmology categorized in eight subspecialties. It will be published quarterly, thus each subspecialty will be reviewed biannually.
Given the multiplicity of medical publications already available, why is a new series needed? Consider that the half-life of medical knowledge is estimated to be around 5 years. Moreover, it can be as long as 8 years between the first description of a medical innovation in a peer-reviewed scientific journal and publication in a medical textbook. A series that narrows this time span between journal and textbook would provide a more rapid and efficient transfer of medical knowledge into clinical practice, and enhance care of our patients.

Andrology for the Clinician consists of two parts: In Part One, the busy clinician can easily find the problem-orientated information he or she needs on such issues as male factor fertility problems, male contraception, and male genital tract infection and tumours. Part Two contains in-depth subject-orientated information and adds important scientific background information to the recommendations received in Part One. Several leading experts have contributed to this work, which has been extensively subedited by world-renowned editors to ensure a well-structured didactic design and homogeneous content. This outstanding book is of great value for all Urologists, Andrologists, Dermatologists, Endocrinologists, Gynaecologists, Reproductive Biologists, GPs, Gerontologists, Psychologists, Psychiatrists, Paediatricians and anyone else interested in the problems of male sex and constitution.

The ability of an epithelial cell to adhere to its neighbor and to the extracellular environment is an essential process that defines in part a normal multicellular organism. In the post-genomic era of cancer biology, it is known that epithelial tumors are multi-clonal and are genetically unstable. In contrast, during the process of tumor metastasis, which is the major cause of death from cancer, a restricted set of adhesion molecules are displayed on the tumor cell surface. The adhesion molecules provide a selective advantage for migration of the tumor cell to a distant site. In this volume, the expression of specific adhesion molecules within human cancer tissues are highlighted. The expression signatures from published DNA microarray and immunohistochemistry studies are detailed. The concept that the alteration of specific adhesion molecules influence the cancer migration ability and cancer damage responses is detailed in this volume; both features are essential for the survival of an invading tumor cell. Defining the minimal adhesion receptors preserved on cancer cells during tumor progression will define the metastatic adhesion signature. Understanding the metastatic adhesion signature will reveal vulnerabilities that could be exploited for the prevention and/or eradication of the invading cancer cell.

In preparation for the quadrennial international IPRAS conference, leading plastic surgeons worldwide have been asked by the International Confederation for Plastic, Reconstructive and Aesthetic Surgery to contribute their most up-to-date findings, research results, and experiences in their area of expertise. The book is structured according to the major fields of plastic surgery, and the reader is thus offered insight into the most significant contributions to the international community, as well as into new developments, tricks, and refinements in the field.

This book is about visions and pioneers in the field share their innovations with the reader.

Innovations in Plastic and Aesthetic Surgery will not only give plastic surgeons up-to-date knowledge of new developments, but will inspire with its innovations, many of which have not been published before."

As essential a text for GPs as for dermatologists, this book is an atlas-like representation of the various forms of melanocytic skin lesions associated with cutaneous melanomas and other pigmented skin tumors. It is a comprehensive and up-to-date text on the practical issues surrounding the management of individuals with these lesions. It encompasses the classical methods of morphology such as the clinical and dermoscopic examination and dermatopathology. The book also deals with the most up-to-date diagnostic approaches such as laser scanning in-vivo microscopy and automated diagnosis. The visual atlas includes superb clinical, dermoscopic and histopathologic images.

Psychocutaneous Medicine offers an overview of diseases in psychosomatic dermatology and creates a bridge between cutaneous and emotional disorders using extraordinary illustrations and clinical images of psychosomatic dermatology. It covers both common and rare diseases and helps doctors and psychologists recognize and deal with psychosocial features in dermatology and venerology. This superbly illustrated clinical atlas with concise text passages follows the American diagnosis classification DSM-V and current evidence-based guidelines. It allows rapid recognition of masked emotional disorders and thus administration of the most effective and efficient treatment as early as possible.

Hone your diagnostic vision for psychosomatic disorders. Treat your patients efficiently and effectively. Psychocutaneous Medicine is a picture atlas and textbook that is indispensable for dermatologists, psychologists, pediatricians and general practitioners.

Hair Transplantation in Cosmetic Dermatology is a fully illustrated reference book that provides a state-of-the-art overview to all aspects of hair transplantation. Using a combination of written text, color photographs, and tables, eleven leading physicians and practitioners in the field discuss the latest surgical procedures to restore a natural-looking frame of hair to the face. This volume is an indispensable reference for dermatologists, practitioners, and residents, providing an extensive coverage of the latest procedures and instruments in hair restoration surgery, techniques for follicular unit extraction, Cicatricial alopecia, and eyelash transplantation.

Presents authoritative state-of-the-art discussions of the key issues pertinent to transdermal drug delivery, examining those topics necessary to enable a critical evaluation of a drug candidate's potential to be delivered across the skin; from physical chemistry and assessment of drug permeability to available enhancement technolgies, to regulatory approval.

Achieving the best aesthetic results in Mohs and other cutaneous surgery requires proper patient selection, careful surgical technique, and meticulous postoperative care. Yet despite the best efforts of both surgeon and patient, complications may develop, sometimes resulting in suboptimal or objectionable scarring. Mohs and Cutaneous Surgery: Maximizing Aesthetic Outcomes describes in detail the techniques and procedures that help achieve the most aesthetic results in cutaneous surgery. The book covers wound healing, surgical planning, intraoperative techniques, and complications. Also covered are surgical scar revision, dermabrasion, laser scar revision, neuromodulators and fillers, as well as topical and intralesional therapies for the improvement of scars.

Expertly distinguish viral diseases from other infectious or noninfectious diseases and choose the most effective treatment with this definitive Second Edition. The only existing text to address issues of skin manifestations of viral disease, Mucocutaneous Manifestations of Viral Diseases explores the diagnosis, treatment, and pathogenesis of viral diseases that infiltrate the skin and affiliated mucous membranes. Readers will find new information on: the new controversial HPV vaccines the latest laboratory finding diseases previously known only in developing countrie ocular and oral manifestations of viral diseas manifestations of prion infection common diseases (all variations of human herpes, hepatitis, pox, etc. rare diseases (Crimean-Congo virus, Junin, Dengue fever, etc.) Organized by specific disease, each chapter in this user-friendly text includes: a timeline of infection and pathogenesis of the diseas a brief taxonomy and history of the diseas tabular information to be used for quick reference by the physician color illustrations of epidermal and cellular manifestation methods of differential diagnosi disease incidence among gender and age groups by geographical regio specific antiviral and prophylaxis recommendations laboratory findings and lab tests used to confirm diagnosis and specific antiviral drugs and vaccines treatment/prophylaxis methods

This comprehensive, definitive, and long overdue reference deals specifically with all the manifestations of latex intolerance including irritation, allergic contact dermatitis, and contact urticaria. Each chapter presents the latest research in skin irritation, contact dermatitis, and contact urticaria. The well-illustrated textbook also covers in-depth basic science and clinically relevant practical issues such as the management of latex intolerance and hand dermatitis. Experts with a special interest in this area from the UK, Europe, and the US provide a balanced international perspective to this first major book dedicated to latex intolerance.

The manifestations of dermatologic disease in the geriatric population are often subtly different to those in the younger age groups and there is a need to produce a practical and clinical reference for dermatology fellows and residents, geriatricians and related clinicians to identify dermatoses and their differential diagnosis specific to the aging population. Diagnosis of Aging Skin Diseases will provide the clinician with a visual encyclopedia of geriatric dermatoses that can be used on rounds or in a reference environment. It also provides a structured review of the differential diagnosis of the lesions illustrated within the book, which will make this a priceless reference resource for all physicians dealing with older skin.

A must-have reference for any researcher or scientist interested in cutaneous protective mechanisms, this guide provides expertly researched chapters on every aspect of stratum corneum structure, function, and development, as well as detailed sections on barrier-repair strategies and the role of barrier function in diseases such as atopic dermatitis, psoriasis, and ichthyosis.