In this handbook the opportunity has been taken firstly to present the waterbalance in the horny layer and the sweat secretion process with particular emphasis on their relationship to the pharmacodynamical aspects of the micro circulation and permeability of the skin. F. A. 1. THIELE was unable to witness the printing of his life-work concerning the water balance of skin, which he had compiled at the university in Nijmegen with J. W. H. MALI and G. 1. DE JONGH and D. A. REAY from Great Britain. Their contribution concentrates on evaluating the cooling function of the sweat glands with their heat-pipe system and on the physico-chemical effects of dermatological therapy and topically applied cosmetics. A certain amount of overlapping with Volume I/4A (E. SCHWARZ) could not be avoided, and yet the presentation by THIELE and co-workers considers different aspects. The pharmacodynamics of externally applied substances involved in microcirculation are related thematically also to percutaneous resorption. Function and morphology of pharmacodynamics in microcirculation are inseparable. Therefore the structural alterations of the blood vessels in reaction to foreign agents or as an adaptation to endogenous tissue hormone release have been examined electronmicroscopically by W. G. FORSSMANN and his team, and relay a distinct picture of the microcirculation in the area of skin reactiveness. The direct pharmacological aspects of the skin and the systemic effects on blood vessels and their permeability have been listed according to the latest research material."

With patients now surviving trauma, neurological diseases, and the geriatric state for longer periods, dermatologists are increasingly being called on to manage these often devastating cutaneous defects. Unrealistic goals regarding prevention and wound healing have compounded the problem, while patient awareness, government intervention, and legal entanglements make an understanding of the diagnosis and management of this dermatologic entity mandatory.
This volume addresses how to both recognise and manage the condition. Beginning with the background of the disease, the book goes on to discuss the clinical features and provides a comprehensive overview of general and specific therapeutic strategies.

Epidermolysis bullosa (EB) is a heterogenous group of genodermatoses characterized by the formation of blisters and erosions on skin and mucous membrans from birth on. The cause are mutations in the genes of structural proteins of the junction between epidermis and dermis. This book deals with the treatment of this skin disease itself and its many extracutaneous complications. There is no previous book which has been focused on the therapy and it will be based on evidence-based data derived from the world?'s largest cohort of inherited EB-patients, the American EB Registry. An important chapter will discuss gene therapy in hereditary EB which has been recently successfully performed within a localized skin site on a single EB patient as a proof-of-principle test. Given its unique collective contents, the monograph will provide the primary source for clinical informations of this oftentimes severe multiorgan disease.

Sarcoidosis is a complex multisystem disease. Shortness of breath (dyspnea) and a cough that won't go away can be among the first symptoms of sarcoidosis, but sarcoidosis can also show up suddenly with the appearance of skin rashes and other dermatoses.

An Atlas of Sarcoidosis: Pathogenesis, Diagnosis and Clinical Features combines illustrations and clinical images of the authors' extensive practices, so that readers have unparalleled access to a comprehensive collection of sarcoidosis images. The atlas is designed to complement and provide a visual supplement to already existing texts on sarcoidosis. Each organ involvement is dealt in a brief and easy to comprehend manner. Various radiographic and laboratory abnormalities are then linked to the clinical features in order to encourage a smooth and easy practical integration at the bedside and to help practising pulmonologists, dermatologists and other clinicians who require a comprehensive visual encyclopedia of sarcoidosis images.

Allergy is one of the major health problems of most modern societies. Although allergic diseases are well-known for almost two hundred years, their prevalence has increased dramatically over the last decades. Allergic reactions manifest in various organs, most commonly in the skin and mucous membranes, the frontier surfaces where the contact between the individual and the environment takes place. In a very concise and practical way this book covers all aspects of allergic reactions from pathophysiology to diagnosis, therapy and prevention with a strong focus on relevant aspects for the everyday work of the practising dermatologist and allergist in the hospital or office. This book reflects the rich personal experience of a German allergist with international training and reputation, who is active in immunology and allergy research and practice for almost 30 years. In this book, not only IgE-mediated allergic reactions are covered but all other kinds of allergies such as atopic eczema, contact dermatitis, drug eruptions, anaphylaxis and food allergies are equally represented as well as psychosomatic aspects and problems of environmental intolerances.

As essential a text for GPs as for dermatologists, this book is an atlas-like representation of the various forms of melanocytic skin lesions associated with cutaneous melanomas and other pigmented skin tumors. It is a comprehensive and up-to-date text on the practical issues surrounding the management of individuals with these lesions. It encompasses the classical methods of morphology such as the clinical and dermoscopic examination and dermatopathology. The book also deals with the most up-to-date diagnostic approaches such as laser scanning in-vivo microscopy and automated diagnosis. The visual atlas includes superb clinical, dermoscopic and histopathologic images.

"Ehlers-Dan... Was?" Das hoeren Betroffene der seltenen Ehlers-Danlos-Syndrome (EDS) fast taglich. Die meisten Menschen in ihrem Umfeld haben nie von der Gruppe von angeborenen Bindegewebserkrankungen gehoert oder verbinden damit nur dehnbare Haut und flexible Gelenke. Doch die EDS sind viel mehr als das! Zusatzlich zu den Symptomen der EDS, die den ganzen Koerper betreffen koennen, treten diverse andere Erkrankungen zusammen mit den Ehlers-Danlos-Syndromen auf, wie z. B. Dysautonomie, Mastzellaktivierungssyndrom und viele mehr. Die EDS stellen sowohl Betroffene als auch deren AErzt*innen vor grosse Herausforderungen. Oft sind die Betroffenen daher auf sich alleine gestellt. Sie mussen selbst Expert*innen fur ihre Erkrankung werden, wenn sie eine optimale Versorgung erwarten. Durch eine Mischung aus fachlichen Informationen, Expert*innenmeinungen und Tipps zum praktischen Umgang mit der Gruppe von komplexen Bindegewebserkrankungen bietet dieses Buch vor allem Neueinsteiger*innen - Betroffenen, Angehoerigen, Interessierten sowie Hausarzt*innen und anderem medizinischen Personal - einen kompakten UEberblick uber alle Facetten der Ehlers-Danlos-Syndrome. 18 interessante Videos mit Interviews mit deutschsprachigen und internationalen Expert*innen bereichern das Buch und machen es zu einem multimedialen Erlebnis.

In this volume the impact of cell culture models on dermatological research is discussed by scientists from medicine, physiology, biology, pharmacology, and pharmacy. The book includes the following topics: orthology and pathology of the skin, differentiation of keratinocytes and fibroblasts, problems of the cultivation of melanocytes, biochemistry of pigment metabolism, models for wound healing and tissue renewal, fibroblast function and metabolism of collagen, models for the investigation of ageing as well as models for pharmacological and toxicologial tests. Thus, a wide arch is spanned, from basic problems with cultivation and characterization of cell cultures to examples of application. Dermatologists as well as cell biologists will benefit from this publication.

In the past 10 years hirsutism has been the object of a considerable number of fundamental studies. It provides endocrinologists with an experimental model for the investigation of androgen secretion, metabolism and mechanism of action. Plasma androgen assay, free testosterone measurement, hepatic and extrahepatic androgen metabolic clearance and androgen metabolism in the skin are the different steps which were studied by many groups and represent valuable parameters of the mechanisms of hirsutism. Determination of the origin of androgen oversecretion has become easier by technical progress in differential effiuent venous catheterism, which makes it possible to compare androgens in adrenal or ovarian effiuent veins to their peripheral levels, and to determine the ovarian or adrenal source of the androgen oversecretion as well as the side responsible, essential in the case of tumors. The study of androgen metabolism and the discovery of androgen receptors in the skin confIrm the latter as an actual target cell for androgens. This target cell uses the circulating active androgen, i. e., testosterone and can also metabolize local inactive androgens into active ones. This is the case of androstenedione and dehy droepiandrosterone which are the two main androgens secreted in women, since women secrete very little testosterone. The capacity of the skin to transform inactive androgens into active ones varies from one individual to another. That would support the concept of variable skin receptivity from one woman to another and from one ethnic group to another."

The morphological behaviour of leucocytes* leaving the blood has been studied for more than a hundred years and can be described in some detail, but the mechanisms involved are for the most part still unclear. Following an inflammatory stimulus, dy- namic changes occur in small blood vessels near the inflamed site and are followed by margination of leucocytes and by their adherence to the endovascular surface of endo- out of the vessel in the gaps between endothelial thelial cells. The leucocytes migrate cells and move towards the noxious stimulus, directed presumably by chemotactic gra- dients. Having reached the gradient source, they may engage in phagocytosis, killing and digestion of micro-organisms or of damaged tissue. In this review, we deal with the adhesive properties of leucocytes, which have US1,l;ll- ly been measured in vitro, and with their possible relevance to the leucocyte-endo- We also deal with the locomotion of leucocytes, its machinery thelial cell interaction.

The skin, uniquely positioned at the interface between the human body and the external world, plays a multifaceted role in the expression of cancer. Primary skin cancer is the most common cancer afflicting mankind and is rising in inci dence, despite the fact that it is often preventable. Besides primary cancer, the skin may show direct and indirect evidence of internal cancer, thus serving as a window to the body for both laymen and physicians alike. In addition, the acces sibility of the skin is useful for the study of carcinogenesis as well as cancer treat ment options. lowe much of my interest in skin cancer to Dr. Leon Goldman, the father of dermatologic laser surgery, and to Dr. Edmund Klein, the father of modern immunotherapy. We, at the Roswell Park Memorial Institute, were indeed for tunate to have a wealth of patients available for study. Many of the illustrations used in this book were of my patients at the Institute, and I kindly thank the fol lowing publications and their respective publishers for allowing me to reuse some of my photographs, most notably: Cancer Medicine (2nd edition), Journal of Surgical Oncology, Journal of the American Academy of Dermatology, Archives of Dermatology, Cancer, and Journal of Dermatologic Surgery and Oncology. We are very fortunate in this work to have some of the world's foremost authorities in their areas as contributors, such as Drs. Zackheim, Lambert, J.W. Trimble, J.R. Trimble, Jackson, Crutcher, Mashberg, Wick, Sidell, F. Helm, G.

Wounds have existed since the beginning of time, and records of their nature and treatment are found in the earliest documents. Interestingly, many of these treat ments are now being rediscovered or re-used in modern-day clinical practice. In addition to the diverse nature of treatments that have been suggested as being beneficial for wounds, over many centuries there has been a range of clinicians who have cared for patients with wounds, and in many parts of the world today it is not doctors but other professional colleagues - e. g. nurses or podiatrists - who are the most knowledgeable persons on wounds and wound treatments. Finally, the nature of wounds seen in clinical practice is changing. Increasing destructive power is resulting in more severe injuries occurring in patients involved in conflict. Developments in surgical techniques have enabled new surgical procedures to be offered to patients, but novel and more severe complications can result from such technical advances. In addition, many societies around the world are having to deal with an increasing ageing population, and huge increases in the number of patients suffering from chronic wounds are being seen. In summary, expanding treatment options, diverse groups of clinicians caring for patients and changes in the nature of wounds seen in clinical practice are real issues that have to be faced, and solutions have to be found if patients are to receive optional care for their wounds."

Infectious diseases remain a major problem for physicians and other health professionals dealing with problems of the reproductive system. Accordingly, this two-volume comprehensive presentation of infectious diseases involving the male and female reproductive systems promises to be a major contribution in this field and to fill a much-needed vacuum. During the past three decades, the introduction of antimicrobial therapy has dramatically altered both the clinical presentation and the therapeutic approaches employed in dealing with the traditional infections of the repro ductive system. In addition, the changing demographics of infectious problems in the industrial countries and the developing world have been a source of concern. A good deal of important information on this topic is included in this series. In recent years, considerable attention has been given to the role of Myco plasma and Chlamydia in both male and female infertility and the problems related to genital herpes and human papilloma virus infections. Current clinical information is included on these infections as well as on newer aspects of diagnosis, such as the use of laparoscopy in the diagnosis and treatment of pelvic inflammatory disease. Also addressed is new information regarding the role of actinomycosis in pelvic infections; current problems such as toxic shock syndrome and acquired immune deficiency syndrome (AIDS) are reviewed as well. New concepts are included in these vohimes to complement the clinical information. The attachment of microbial organisms to sperm may help to explain access of these and other organisms to the upper female genital tract."

A brilliant collection of colour pictures, augmented by appropriate discussion, describing both common and unusual afflictions. Sections on clinical manifestations, histologic findings, differential diagnosis, and treatment, complemented by significant references, have been written by selected authorities in the field. Dermatologists, dentists, and even primary care physicians will find this an indispensable volume in their practices.

Skin cancer is the most frequent malignancy in humans and its incidence is still increasing. This situation calls for major efforts to manage the disease. Preventive measures must include reduced UV exposure and an enhanced common awareness of skin lesions. Advanced surgical techniques allow safe removal with excellent cosmetic results. In many cases alternative treatment modalities such as radiotherapy, cryosurgery and photodynamic therapy are applicable. The development of optimal sun screens and UV-protective clothes, new tools for early diagnosis of malignant lesions including videomicroscopy, improved evaluation of biopsy material and new treatment schemes will contribute to better patient care. New developments in therapy including pegylated interferons, cytokine-inducing molecules, monoclonal antibodies and vaccination approaches using peptides, dendritic cells, viruses or nDNA give hope for well-tolerated and efficient treatments.

Irritant dermatitis is a common condition, accounting for a significant proportion of occupational skin disease. The recent advent of non-invasive skin bioengineering technology has accelerated dermatology research in this field. This book comprises an exhaustive reference text on irritant contact dermatitis, covering all aspects of the condition: clinical features, epidemiology, prevention and therapy, prognosis, mechanisms, pathology and regulatory issues. The book also presents novel in vitro and in vivo research techniques and findings. As irritant dermatitis affects multiple specialties, the audience for this book is wide, including clinical and investigative dermatologists, allergists, toxicologists, pharmaceutical scientists, occupational and environmental physicians, public health physicians, cosmetologists and skin bioengineers.

Andrology for the Clinician consists of two parts: In Part One, the busy clinician can easily find the problem-orientated information he or she needs on such issues as male factor fertility problems, male contraception, and male genital tract infection and tumours. Part Two contains in-depth subject-orientated information and adds important scientific background information to the recommendations received in Part One. Several leading experts have contributed to this work, which has been extensively subedited by world-renowned editors to ensure a well-structured didactic design and homogeneous content. This outstanding book is of great value for all Urologists, Andrologists, Dermatologists, Endocrinologists, Gynaecologists, Reproductive Biologists, GPs, Gerontologists, Psychologists, Psychiatrists, Paediatricians and anyone else interested in the problems of male sex and constitution.

"Essentials in Ophthalmology" is a new review series covering all of ophthalmology categorized in eight subspecialties. It will be published quarterly, thus each subspecialty will be reviewed biannually.
Given the multiplicity of medical publications already available, why is a new series needed? Consider that the half-life of medical knowledge is estimated to be around 5 years. Moreover, it can be as long as 8 years between the first description of a medical innovation in a peer-reviewed scientific journal and publication in a medical textbook. A series that narrows this time span between journal and textbook would provide a more rapid and efficient transfer of medical knowledge into clinical practice, and enhance care of our patients.

The ability of an epithelial cell to adhere to its neighbor and to the extracellular environment is an essential process that defines in part a normal multicellular organism. In the post-genomic era of cancer biology, it is known that epithelial tumors are multi-clonal and are genetically unstable. In contrast, during the process of tumor metastasis, which is the major cause of death from cancer, a restricted set of adhesion molecules are displayed on the tumor cell surface. The adhesion molecules provide a selective advantage for migration of the tumor cell to a distant site. In this volume, the expression of specific adhesion molecules within human cancer tissues are highlighted. The expression signatures from published DNA microarray and immunohistochemistry studies are detailed. The concept that the alteration of specific adhesion molecules influence the cancer migration ability and cancer damage responses is detailed in this volume; both features are essential for the survival of an invading tumor cell. Defining the minimal adhesion receptors preserved on cancer cells during tumor progression will define the metastatic adhesion signature. Understanding the metastatic adhesion signature will reveal vulnerabilities that could be exploited for the prevention and/or eradication of the invading cancer cell.

The most effective way to heal your skin-from the featured dermatologist on ABC's "Extreme Makeover"

Stress, pregnancy, menopause, and other health concerns can take a heavy toll on your skin. Now respected dermatologist Dr. Ava Shamban shows you how to look your best no matter how you feel, even when you feel your worst. Dr. Shamban's signature approach ranges from at-home simple organic skin care recipes to state of the art dermatologic techniques. From skin cleansing and topical products to eating and exercise, her program is based on the best cutting-edge science and is just what you need to achieve and maintain the healthy glow and feel of great skin.Complete skin-healing program combining skin care, nutrition and fitnessSpecific skin care regimens tailored to age, skin type, and internal conditionHelp for trouble skin resulting from acne, stress, pregnancy, menopause, chemotherapy, and more

In addition to being featured on "Extreme Makeover, " Shamban has been on "Good Morning America," "The Tyra Show," "The View," "Fox News, Extra " and many other shows. She has also been featured in "The New York Times," the "Los Angeles Times, ""Vogue," "Allure," "Marie""Claire" and many other publications.

Start this complete skin recovery program today and discover the optimal way to care for your skin, inside and out.

Photodynamic therapy is a proven effective treatment of actinically damaged skin cells, nonmelanoma skin cancers, and acne and other pilosebaceous conditions. As an agent for general facial rejuvenatin it has untapped potential. The current state of PDT therapy and future applications are discussed in detail in this exciting new volume. Throughout, the focus is on evidence-based clinical uses of PDT, including pretreatment regimens, avoidance and management of complications, and posttreatment suggestions.

This volume discusses the background and various clinical applications of radiation therapy in the treatment of non-malignant diseases. It documents the radiobiological and physical principles of treatment and the rationale underlying the use of radiotherapy for various disorders of the CNS, head and neck, eye, skin and soft tissues, bone and joints, and vascular system. In so doing, it draws attention to and elucidates the scope for application of radiotherapy beyond the treatment of malignancies. Both the risks and the benefits of such treatment are fully considered, the former ranging from minor clinical problems to life-threatening diseases.

Achieving the best aesthetic results in Mohs and other cutaneous surgery requires proper patient selection, careful surgical technique, and meticulous postoperative care. Yet despite the best efforts of both surgeon and patient, complications may develop, sometimes resulting in suboptimal or objectionable scarring. Mohs and Cutaneous Surgery: Maximizing Aesthetic Outcomes describes in detail the techniques and procedures that help achieve the most aesthetic results in cutaneous surgery. The book covers wound healing, surgical planning, intraoperative techniques, and complications. Also covered are surgical scar revision, dermabrasion, laser scar revision, neuromodulators and fillers, as well as topical and intralesional therapies for the improvement of scars.

This book provides the dermatologist with the essential information needed to properly treat all skin types cosmetically.

All chapters have been written by female dermatologists with many years of personal experience in the field.

The volume includes an overview of the systemic, intrinsic and extrinsic aging process, essential information on anti-aging skin care product ingredients, detailed discussions of patient selection and indications, and a wide range of cosmetic procedures.

This concise book allows you - through its well-organized use of sidebars, photographs and illustrations - to extract any information you may need quickly and easily.

Simplified Facial Rejuvenation is divided into sections that include anatomy and anesthesia, classifications, dermatologic procedures, suture lifts, surgical variations of the face, surgical variations of the eyes, brow, neck, lips, nose ear, and scalp, and medical legal aspects. The book presents multiple variations of suture lift procedures to allow the physician to decide which is best. Unique surgical procedures of the face are presented, many of which are techniques of minimal incision facelift. The book brings together the more popular procedures for patients that include simpler methods of facial rejuvenation with less pain, shorter recovery time, lower cost, and fewer complications.