This book is the most up-to-date publication on fluorescence diagnostic (FDAP) and photodynamic therapy (PDT) methods used in dermatology. Both techniques are presently world wide introduced as standards for the delineation and the treatment of cutaneous precancerous stages and tumors, which show steadily increasing numbers due to e.g. more frequent sun exposure. Summarizing experiences on more than 5.000 treated patients, it offers a comprehensive information on every aspect of skin tumor detection and treatment. The main part of the book focuses on the clinical aspects giving detailed descriptions on skin tumor detection as well as photodynamic treatment of selected diseases (solar keratoses, basal cell carcinomas, squamous cell carcinomas, Bowen's disease, psoriasis lesions, etc.). The clinically oriented chapters are supplemented by practical guidelines for PDT and FDAP. The included atlas is comprised of 270 high quality color figures allowing daily use as a handbook.

Chronic venous insufficiency, manifesting as disabling open leg ulcers, lipodermatosclerosis and severe cutaneous hyperpigmentation is thought to affect five percent of the population over age 80 and a significant proportion, probably greater than one percent, of Western populations under age 65. To date little has been known about how to treat this condition cost-effectively beyond supportive and palliative care. Thus, the most important feature of Chronic Venous Insufficiency is that it describes the interventions which markedly ameliorate, and in some cases cure, the condition. The authoritative text has been skilfully illustrated to show how new methods of endovascular and endoscopic interventions can be integrated with radiologic techniques to correct totally the abnormalities which produce chronic venous insufficiency. Taken as a whole this volume will enable general surgeons, vascular surgeons, dermatologists and interventional radiologists to treat a condition that was, until recently, thought to be untreatable.

"The Handbook of Dermatologic Surgery"incorporatesthe most cutting edge technology applicable to dermatologists and dermatologic surgeons today. Designed as a reference guide for dermatologic surgery and aesthetic procedures, it disseminates key scientific information in an easy-to-use pocket book.

This handbook is designed to be readily transportable for dermatologists and dermatologic surgeons, as well as those in training, dermatology residents and fellows, and medical students rotating through dermatology. "

Dermatopathology is both exciting and exasperating. tum corneum cells. This occurs in disorders of keratiniza Skin has an elegant simplicity in its functions yet a tion because the process of desquamation is disturbed (Figure 1. 1). ferocious complexity in its structure. This is one of the paradoxes that underly the pathology of skin disease Parakeratosis. The presence of nucleated horn cells in and may go some way in explaining the multitudinous the stratum corneum. Normally the horn cells (corneocy disorders to which the skin is subject. The ready visibility tes) are thin lamellae of less than 1 f. lm thickness. They of the skin may also help explain why straightforward contain no detectable cytoplasmic contents as these are histological examination cannot always provide an lost in the granular cell layer. Parakeratosis occurs when answer to a clinicians's question. Quite dramatic appear the process of keratinization is disturbed such as when ances may be due to alterations of the relative rates of the rate of epidermal cell production is increased (as in blood flow, with or without oedema, in the different psoriasis) so that nuclei are not broken down before the vascular plexuses or around different structures in the stratum corneum is reached and when damage occurs horizontal dimension, neither of which may result in to the upper epidermis (Figure 1. 2). 'much to see' histologically. The inherent sampling error Porokeratosis.

Since the incidence of skin neoplasms is constantly increasing as the population ages, there is a need for a monograph about radiation treatment of skin neoplasms and diseases. Excellent cosmetic and functional results can be shown with this treatment modality. This book comprehensively examines the indications for radiation therapy of cutaneous cancers, pre-cancerous lesions and benign dermatological disorders. The monograph provides concise introduction to physical and radiobiological principles, selection of radiation factors, dose definitions, as well as radiation reactions and risk assessments. Specific indications for radiotherapy of cutaneous neoplasms and radiation protection measures are discussed. Topics include radiation therapy of basal cell carcinoma, squamous cell carcinoma, lymphomas, Kaposi's sarcoma, Lentigo maligna melanoma, and Merkel cell tumor. A separate chapter discusses the skin reactions after nuclear accidents. Major scientific publications of the past 10 years are reviewed.

Rheumatologic diseases are highly associated with clinical symptoms of the skin, nails, and mucosal membranes. This book provides the practicing rheumatologist with a rapid, easy to consult reference to help interpret the nature of these cutaneous lesions and then quickly decide upon the appropriate follow-up tests. Utilizing an abundance of informative photographs, it contains all of the essential information needed for early diagnosis and treatment. This comprehensive guide properly orients the practitioner within the challenging world of rheumatologic disorders of the skin and gives insight into when consultation with a dermatologist is advisable.

Gene therapy is a novel concept of treating diseases at the molec- ular level by rescuing genetic defects through the introduction of corrective genes. The knowledge of genetic defects underlying var- ious diseases is being rapidly accumulated, and new genotypic findings are being reported with striking frequency. The elucida- tion of the genetic background of many diseases, including hered- itary blistering and hyperkeratotic skin disorders, has provided the necessary knowledge to correct inborn genetic aberrations in ani- mal models and patient-derived tissue. However,skin is not only a target organ for gene therapy ofcutaneous disorders. Dueto its bio- logical properties, easy accessibility, and convenient, established culture conditions and grafting techniques, skin has rapidly be- come an important target for correcting other diseases as well. Both skin fibroblasts and epidermal keratinocytes have been successfully transfected ex vivo and in vivo using viral and nonvir- al gene transfer methods. Notably,in the first corrective gene ther- apy approach in 1987, fibroblasts from adenosine-deaminase (ADA)-deficienthumans with severe combined immunodeficiency (SCID) syndrome were transduced using retroviral vectors. More- over, skin cells are capable of synthesizing various proteins that are therapeutic, either locally or systemically. Human epidermal grafts expressing human growth hormone after retroviral gene transfer and grafting onto athymic mice released human growth hormone into the bloodstream of the transplanted mice, for a lim- ited time.

The latest techniques in utilising ultrapulsed CO2 lasers in aesthetic plastic surgery. Edited by an expert and pioneer in the field, this handy manual teaches practitioners the clinical applications of lasers in facelifts, blepharoplasty, resurfacing of the skin, pigmented lesions, vascular lesions, and sun damage, etc. - including material on surgical "pearls", complications, patient selection and management, together with the advantages and disadvantages of each technique. With over 200 full-colour illustrations, and chapters by top contributors, plastic surgeons, cosmetic surgeons, and dermatologists will all find this to be a valuable resource in becoming skilled in the use of lasers.

Practical Patch Testing and Chemical Allergens in Contact Dermatitis covers the most relevant allergens in a concise and algorithmic fashion, with practical tips for patch testing. This book assists practitioners and trainees with educating patients on how to avoid their irritants and allergens to effectively manage contact dermatitis. Clinical pearls for patch testing of certain allergens are clearly outlined in this book to help providers avoid common pitfalls and reduce the risk of incorrect diagnoses, making it an essential reference for all involved in the treatment of contact dermatitis.

Lasers in Dermatology: An Introductory Guide provides a comprehensive guide to all aspects of cutaneous laser treatment. Practical aspects of laser selection and treatment are combined with easily understood sections on basic science, laser safety and current regulations. The author is internationally recognised for his research in the laser treatment of skin disease, and has close links with the development of training programmes for the use of lasers in Dermatology.

Children with skin diseases maypresent to family physicians, pediatricians or dermatologists. In book we have tried to provide a concise and under standable source of information about common skin disorders which will be useful to any physician encountering children with cutaneous signsand symptoms. We have concentrated on 26 common skin diseases which account for morethan 90% ofallskin-related doctor visits by children and adolescents, regardless of the orientation of the physician. The format of each chapter is uniform. The clinical description is accompanied by several typical photographs. The differential diagnostic approach withbriefcriteriais pre sentedin a table. Themajoremphasis is on the treatment; wehave tried to combine our long years of experience in pediatricdermatology withthe in ternationalliteratureand especially more recent evidence-based studies. We have tried to present a rangeof therapeutic possibilities, but also give firm recommendations. There have already been two successful German editions of this book. We hopethat this first English editionalsofinds a receptive readership. We are committed to the concept that childhood skin diseases are best treated whenall involved physicians have onlyone goal - the best possible carefor all children. "Turf" battles between various specialties overaspects of care only harm our patients and in the end our own self-respect. The back ground of the three editors reflects this theme; there are two dermatolo gists, one German (DA) and one American (WB), and a pediatrician (He)."

Venous valves rank among the smallest and most delicate organs of the human and animal bodies - so why devote an entire book to them? We were induced to do so by several reasons. First of all we would point out the clinical significance of venous valves. In the pathogenesis of a number of widespread diseases, such as varicose veins or the post-thrombotic syndrome, venous valves are involved as the underlying cause or at least a factor contributory to the symptoms. According to Taheri et al. these venous diseases occur ten times more frequently than arterial obliterations. Incompetence of venous valves also plays a causal role in varicocele, the most frequent cause of male infertility. But not only pathogenetic reasons induced us to write this book. In more recent times there has been a growing tendency to reconstruct functional valve disorders therapeutically; several surgical methods have been developed, which are critically reviewed in this book. It was our aim to sum up existing knowledge with respect to structure and function of venous valves and to expand that knowl edge by findings of our own. Examinations of semi-thin sections and unilayered en-face preparations have hardly been published so far, and systematic studies of the ultrastructure by electron-microscopy were not to be found in the literature. We are very grateful, therefore, to Dr. Silvana Geleff for having undertaken such a study upon our suggestion."

This is the ninth volume in the New Clinical Applications Der- matology Series. Some important topics that merit discussion are included in this book. Dr Messenger discusses clinicopathological aspects of the common disorder, alopecia areata. Dr Mendelsohn gives a straightforward, clear account of pregnancy eruptions. Dr Graham-Brown gives a comprehensive yet concise survey of that strange condition, lichen planus. Dr Graham treats us to a thorough appraisal of the enigmatic juvenile plantar dermatosis. Mr Walton takes an experienced comprehensive look at ectoparasites of import- ance to man and the concluding chapter by Dr Finlay provides a concise, helpful insight into how modern technology can aid der- matology. JULIAN VERBOV VII ABOUT THE EDITOR Dr Julian Verbov is Consultant Dermatologist to Liverpool Health Authority and Honorary Clinical Lecturer in Dermatology at the University of Liverpool. He is a member of the British Association of Dermatologists, repre- senting the British Society for Paediatric Dermatology on its Executive Committee. He is Editor of the Proceedings of the North of England Dermatological Society. He is a Fellow of the Zoological Society of London and a member of the Society of Authors. He is a popular national and international speaker and author of more than 200 publications. His special interests include paediatric dermatology, inherited disorders, dermatoglyphics, pruritus ani, cutaneous poly- arteritis nodosa, therapeutics, drug abuse, and medical humour. He organizes the British Postgraduate Course in Paediatric Dermatology and is a member of the Editorial Board of Clinical and Experimental Dermatology.

"The Manual of Dermatology" was developed by Dr. Cafardi at the University of Alabama at Birmingham, Department of Dermatology, and covers broad dermatological topics necessary for any dermatology resident treating patients. Topics include alopecia, medication dosing and management pearls, fungal disorders, genodermatoses, differential diagnoses of various skin diseases, management of infections, surgical anatomy and tips, HIV dermatology, pediatric dermatology, and skin cancer management and terminology. The practicality of this book is unique and includes key clinical data for residents, making it essential as a reference for quick differential diagnoses, work-up tips, management, and treatment options.

This quick reference offers a more practical approach to dermatology, with drug names and dosing, and more information on mycology/onychomycosis than any other handbook on the market. "The Manual of Dermatology" is portable, comprehensive, easily accessible, and is based upon algorithms, tables, and pearls taught to dermatology medical students, making it a vital resource in all university medical libraries across the country.

"

We have endeavoured in this book to bring the reader up-to-date information, which will contribute to an enhanced ability to diagnose and treat mycobacterial skin diseases. This volume is mainly concerned with conveying to dermatologists, microbiologists, immunologists, dermatologists in training, registrars in other specialties and interested family practitioners, a concise appraisal of some recent developments in the various aspects of myco bacterial skin diseases. The chapters dealing with bacteriology, pathology and immunology have been planned to appear at the beginning of the book to provide the necessary conceptual framework for the section on clinical science, which deals with the variety of clinical states. The value of the clinical descriptions is vastly enhanced by a careful reading of the earlier chapters. The contributing authors have been most cooperative in making this, the tenth volume in the New Clinical Applications in Dermatology series, an excellent treatise. I thank each of them for their superb contributions. If this book stimulates and encourages a greater interest in, and a better understanding of, mycobacterial skin diseases, and enables physicians to serve more effectively those who suffer, the time and effort spent to produce it will be amply rewarded. PROFESSOR MARWALI HARAHAP IX SERIES EDITOR'S FOREWORD It was with great pleasure that I heard of Professor Harahap's wish to produce a volume on mycobacterial skin diseases."

Botulinum toxins now play a very significant role in the management of a wide variety of medical conditions; from headaches to hypersalivation, and from spasticity to sweating. In this book, a strong, international team of experts outline the basic neurochemistry of botulinum toxins and chart the progress of the drug from laboratory to clinic. Then individual chapters summarize their use for the main clinical indications in the context of other available treatments. This book will be of interest to neuroscientists and practising clinicians working in a wide range of specialities, from neurology and dermatology to pediatrics, plastic surgery and rehabilitation medicine.

This, the seventh volume in the New Clinical Applications Series, has an international flavour, with contributions from Australia (Mr N.e. Davis), Great Britain (Drs A.W. Macfarlane, N.C. Smith, M.F. Spittle, J.L.Verbov), and USA (Dr M.e. Finan and Professor R.K. Winkelmann). Dr Smith discusses some common skin tumours with his character istic informative clarity. It is appropriate that an authority such as Mr Davis should discuss a tumour that has a particularly high inci dence in his own country. Dr Spittle is a recognized authority on lymphomas and she writes succinctly on their management. Dr Finan and Professor Winkelmann have extensive experience of the rare condition, necrobiotic xanthogranuloma, and Drs Macfarlane and Verbov have been involved in the management of many patients with scleromyxoedema. I am very pleased to have had the opportunity of working with the contributors and thank them most sincerely for their efforts. I hope that this volume will interest dermatologists, oncologists, pathologists, radiotherapists and surgeons. JULIAN VERBOV ix ABOUT THE EDITOR Dr Julian Verbov is Consultant Dermatologist to Liverpool Health Authority and Clinical Lecturer in Dermatology at the University of Liverpool. He is a member of the British Association of Dermatologists, rep resenting the British Society for Paediatric Dermatology on its Executive Committee. He is a Committee Member of the North of England Dermatological Society, and Editor of its Proceedings."

We live today in a world densely populated by human beings living in close commu nication with one another all over the surface of the planet. Viewed from a certain distance it has the look of a single society, a community, the swarming of an intensely social species trying to figure out ways to become successfully independent. We obvi ously need, at this stage, to begin the construction of some sort of world civilization. The final worst-case for all of us has now become the destruction, by ourselves, of our species. I Although this warning is often repeated, we must not forget its paramount importance and the commitment that each sector of society has to make a world civilization possible. Tropical dermatology is a good example of an important area of our spe cialty that has never caught the proper attention of the leading centers of research in the developed countries, even though it comprehends major infec tious, parasitic, and nutritional problems of one-half of the world's land area and three-quarters of the world's population. The relevance of tropical dermatology in this extensive and overpopulated area of the globe has public health connotations that emphasize its importance. The sheer size of the problem makes it an urgent and outright need to recruit and train adequate personnel to do a proper job, and that includes not only dermatologists but paramedical personnel, nurses, and laboratory technicians.

As patient interest in more youthful, healthy looking skin has increased in recent years so has the physician's interest and demand for new, safe, effective and scientifically based skin rejuvenation programs. Dr. Zein Obagi's new book promises to fill this growing demand. Long famous for his skin classifications systems, Dr. Obagi's Skin Health and Rejuvenation will focus on his skin care regimens and his techniques for revitalizating the human skin. In addition to featuring over 100 photographs and illustrations, this new volume will include sections on Dr. Obagi's skin peels and how to correct sun damage, remove pre-cancerous cells, control the pigmentary system, stimulate skin collagen and help restore skin elasticity. This volume is certain to set the standard in skin care procedures for dermatologists, plastic surgeons and cosmetic facial surgeons alike.

This comprehensive and detailed text deals with the diagnosis and surgery of blepharoptosis and will benefit any practicing physician, fellow or resident dealing with the malady. It includes 200 illustrations, 150 in color.

Dermatopathology is evolving as a significant subspecialty. In most instances, the increasing workload may be readily dealt with by the experienced pathologist. Many dramatic changes, however, have occured in dermatopathology which necessitate a review in a number of areas. This volume provides such a review of selected topics. The contributions by internationally recognized experts deal with the impact of HIV on the skin, the application of molecular techniques in infection, the understanding of fibrohistiocytic tumours, differentiating Spitz from Spitzoid melanomas and toxic epidermal necrolysis from graft-versus-host disease, as well as the recognition and updated classification of primary lymphomas. This text is undoubtedly valuable to histopathologists and dermatologists who, often together, diagnose, manage and provide therapy in this exciting medical field.

- Not only written by experts but the content of each of the chapters has also been peer-reviewed.

- Presents a step-by-step approach to the treatment of chronic wounds.

- For dermatologists, but also many other medical disciplines such as general practitioners and family physicians who also treat chronic wounds.

The quintessential visual guide to facial aesthetic enhancement and dermal filler injection techniques from top experts In-depth and detailed knowledge of anatomy, different facial shapes, and ethnic origins is essential to delivering safe, effective, natural, and harmonious aesthetic facial treatment results. Dermal Fillers: Facial Anatomy and Injection Techniques is the culmination of many years of expertise decrypting facial anatomy as it applies to aesthetic enhancement of the face. This visually rich atlas is authored by internationally renowned Brazilian dermatologists André Braz, an esteemed expert in the use of botulinum toxin, fillers, and lasers; and Thais Sakuma, a distinguished lecturer in the application of botulinum toxin and hyaluronic acid fillers. Nineteen highly practical, concise, and didactic chapters are organized consistently with structured text at the beginning of each chapter. The book encompasses the application of injection techniques for the full spectrum of indications, from softening wrinkles to facial contouring. Important topics include facial assessment, hyaluronic acid science, facial aging, and regional nerve blocks for pain management. Meticulous anatomic descriptions and images depict the relationships between superficial and deeper structures such as vasculature, thereby providing vital knowledge to help clinicians avoid potentially serious complications. Key Features: Systematic organization based on aesthetic zones, from superficial to deep Richly illustrated, with 1664 outstanding drawings, remarkable cadaver dissection images, and patient photos Seventeen concise video sequences elucidate key injection techniques Comprehensive coverage of potential complications, such as unintended injection of filler into vasculature Expert discussion of safety issues, potential pitfalls, and the naturalness of expected outcomes This is the ultimate resource for all dermatologists, plastic surgeons, and non–core practitioners who wish to expand their practices to offer complex facial cosmetic injection techniques and achieve optimal patient outcomes. This book includes complimentary access to a digital copy on https://medone.thieme.com.