This book deals with the application of mathematics in modeling and understanding physiological systems, especially those involving rhythms. It is divided roughly into two sections. In the first part of the book, the authors introduce ideas and techniques from nonlinear dynamics that are relevant to the analysis of biological rhythms. The second part consists of five in-depth case studies in which the authors use the theoretical tools developed earlier to investigate a number of physiological processes: the dynamics of excitable nerve and cardiac tissue, resetting and entrainment of biological oscillators, the effects of noise and time delay on the pupil light reflex, pathologies associated with blood cell replication, and Parkinsonian tremor. One novel feature of the book is the inclusion of classroom-tested computer exercises throughout, designed to form a bridge between the mathematical theory and physiological experiments. This book will be of interest to students and researchers in the natural and physical sciences wanting to learn about the complexities and subtleties of physiological systems from a mathematical perspective. The authors are members of the Centre for Nonlinear Dynamics in Physiology and Medicine. The material in this book was developed for use in courses and was presented in three Summer Schools run by the authors in Montreal.

Traditionally a subject of number theory, continued fractions appear in dynamical systems, algebraic geometry, topology, and even celestial mechanics. The rise of computational geometry has resulted in renewed interest in multidimensional generalizations of continued fractions. Numerous classical theorems have been extended to the multidimensional case, casting light on phenomena in diverse areas of mathematics. This book introduces a new geometric vision of continued fractions. It covers several applications to questions related to such areas as Diophantine approximation, algebraic number theory, and toric geometry. The reader will find an overview of current progress in the geometric theory of multidimensional continued fractions accompanied by currently open problems. Whenever possible, we illustrate geometric constructions with figures and examples. Each chapter has exercises useful for undergraduate or graduate courses.

This book extends classical Hermite-Hadamard type inequalities to the fractional case via establishing fractional integral identities, and discusses Riemann-Liouville and Hadamard integrals, respectively, by various convex functions. Illustrating theoretical results via applications in special means of real numbers, it is an essential reference for applied mathematicians and engineers working with fractional calculus. Contents Introduction Preliminaries Fractional integral identities Hermite-Hadamard inequalities involving Riemann-Liouville fractional integrals Hermite-Hadamard inequalities involving Hadamard fractional integrals

Intended for graduates and researchers in physics, chemistry, biology, and applied mathematics, this book provides an up-to-date introduction to current research in fluctuations in spatially extended systems. It covers the theory of stochastic partial differential equations and gives an overview of the effects of external noise on dynamical systems with spatial degrees of freedom. Starting with a general introduction to noise-induced phenomena in dynamical systems, the text moves on to an extensive discussion of analytical and numerical tools needed to gain information from stochastic partial differential equations. It then turns to particular problems described by stochastic PDEs, covering a wide part of the rich phenomenology of spatially extended systems, such as nonequilibrium phase transitions, domain growth, pattern formation, and front propagation. The only prerequisite is a minimal background knowledge of the Langevin and Fokker-Planck equations.

Thisbook introduces the reader the theory of nonlinear inclusions and hemivariational inequalities with emphasison the study of contact mechanics. The work covers both abstract results in thearea of nonlinear inclusions, hemivariational inequalities as well as the study of specific contact problems, including their modelling and their variational analysis. Provided results are based on original research on the existence, uniqueness, regularity and behavior of the solution for various classes of nonlinear stationary and evolutionary inclusions. In carrying out the variational analysis of various contact models, onesystematically uses results of hemivariational inequalities and, in this way, illustrates the applications of nonlinear analysis in contact mechanics. New mathematical methods are introduced and applied in the study of nonlinear problems, which describe the contact between a deformable body and a foundation. Contact problems arise in industry, engineering and geophysics. Their variational analysis presented in this book lies the background for their numerical analysis. This volume will interest mathematicians, applied mathematicians, engineers, and scientists as well as advanced graduate students."

Fundamentals of Differential Equations presents the basic theory of differential equations and offers a variety of modern applications in science and engineering. Available in two versions, these flexible texts offer the instructor many choices in syllabus design, course emphasis (theory, methodology, applications, and numerical methods), and in using commercially available computer software. Fundamentals of Differential Equations, Eighth Edition is suitable for a one-semester sophomore- or junior-level course. Fundamentals of Differential Equations with Boundary Value Problems, 'Sixth Edition, contains enough material for a two-semester course that covers and builds on boundary value problems. The Boundary Value Problems version consists of the main text plus three additional chapters (Eigenvalue Problems and Sturm-Liouville Equations; Stability of Autonomous Systems; and Existence and Uniqueness Theory)

Bifurcation theory studies how the structure of solutions to equations changes as parameters are varied. The nature of these changes depends both on the number of parameters and on the symmetries of the equations. Volume I discusses how singularity-theoretic techniques aid the understanding of transitions in multiparameter systems. This volume focuses on bifurcation problems with symmetry and shows how group-theoretic techniques aid the understanding of transitions in symmetric systems. Four broad topics are covered: group theory and steady-state bifurcation, equicariant singularity theory, Hopf bifurcation with symmetry, and mode interactions. The opening chapter provides an introduction to these subjects and motivates the study of systems with symmetry. Detailed case studies illustrate how group-theoretic methods can be used to analyze specific problems arising in applications.

This monograph contains an in-depth analysis of the dynamics given by a linear Hamiltonian system of general dimension with nonautonomous bounded and uniformly continuous coefficients, without other initial assumptions on time-recurrence. Particular attention is given to the oscillation properties of the solutions as well as to a spectral theory appropriate for such systems. The book contains extensions of results which are well known when the coefficients are autonomous or periodic, as well as in the nonautonomous two-dimensional case. However, a substantial part of the theory presented here is new even in those much simpler situations. The authors make systematic use of basic facts concerning Lagrange planes and symplectic matrices, and apply some fundamental methods of topological dynamics and ergodic theory. Among the tools used in the analysis, which include Lyapunov exponents, Weyl matrices, exponential dichotomy, and weak disconjugacy, a fundamental role is played by the rotation number for linear Hamiltonian systems of general dimension. The properties of all these objects form the basis for the study of several themes concerning linear-quadratic control problems, including the linear regulator property, the Kalman-Bucy filter, the infinite-horizon optimization problem, the nonautonomous version of the Yakubovich Frequency Theorem, and dissipativity in the Willems sense. The book will be useful for graduate students and researchers interested in nonautonomous differential equations; dynamical systems and ergodic theory; spectral theory of differential operators; and control theory.

In the first part of this EMS volume Yu.V. Egorov gives an account of microlocal analysis as a tool for investigating partial differential equations. This method has become increasingly important in the theory of Hamiltonian systems. Egorov discusses the evolution of singularities of a partial differential equation and covers topics like integral curves of Hamiltonian systems, pseudodifferential equations and canonical transformations, subelliptic operators and Poisson brackets. The second survey written by V.Ya. Ivrii treats linear hyperbolic equations and systems. The author states necessary and sufficient conditions for C?- and L2 -well-posedness and he studies the analogous problem in the context of Gevrey classes. He also gives the latest results in the theory of mixed problems for hyperbolic operators and a list of unsolved problems. Both parts cover recent research in an important field, which before was scattered in numerous journals. The book will hence be of immense value to graduate students and researchers in partial differential equations and theoretical physics.

This book introduces a new, state-of-the-art method for the study of the asymptotic behavior of solutions to evolution partial differential equations; much of the text is dedicated to the application of this method to a wide class of nonlinear diffusion equations. The underlying theory hinges on a new stability result, formulated in the abstract setting of infinite-dimensional dynamical systems, which states that under certain hypotheses, the omega-limit set of a perturbed dynamical system is stable under arbitrary asymptotically small perturbations.The Stability Theorem is examined in detail in the first chapter, followed by a review of basic results and methods---many original to the authors---for the solution of nonlinear diffusion equations. Further chapters provide a self-contained analysis of specific equations, with carefully-constructed theorems, proofs, and references. In addition to the derivation of interesting limiting behaviors, the book features a variety of estimation techniques for solutions of semi- and quasilinear parabolic equations.Written by established mathematicians at the forefront of the field, this work is a blend of delicate analysis and broad application

This self-contained monograph presents matrix algorithms and their analysis. The new technique enables not only the solution of linear systems but also the approximation of matrix functions, e.g., the matrix exponential. Other applications include the solution of matrix equations, e.g., the Lyapunov or Riccati equation. The required mathematical background can be found in the appendix. The numerical treatment of fully populated large-scale matrices is usually rather costly. However, the technique of hierarchical matrices makes it possible to store matrices and to perform matrix operations approximately with almost linear cost and a controllable degree of approximation error. For important classes of matrices, the computational cost increases only logarithmically with the approximation error. The operations provided include the matrix inversion and LU decomposition. Since large-scale linear algebra problems are standard in scientific computing, the subject of hierarchical matrices is of interest to scientists in computational mathematics, physics, chemistry and engineering.

The conference Operator Theory, Analysis and Mathematical Physics - OTAMP is a regular biennial event devoted to mathematical problems on the border between analysis and mathematical physics. The current volume presents articles written by participants, mostly invited speakers, and is devoted to problems at the forefront of modern mathematical physics such as spectral properties of CMV matrices and inverse problems for the non-classical Schroedinger equation. Other contributions deal with equations from mathematical physics and study their properties using methods of spectral analysis. The volume explores several new directions of research and may serve as a source of new ideas and problems for all scientists interested in modern mathematical physics.

This book addresses several mathematical models from the most relevant class of kp-Schroedinger systems. Both mathematical models and state-of-the-art numerical methods for adequately solving the arising systems of differential equations are presented. The operational principle of modern semiconductor nano structures, such as quantum wells, quantum wires or quantum dots, relies on quantum mechanical effects. The goal of numerical simulations using quantum mechanical models in the development of semiconductor nano structures is threefold: First they are needed for a deeper understanding of experimental data and of the operational principle. Secondly, they allow us to predict and optimize in advance the qualitative and quantitative properties of new devices in order to minimize the number of prototypes needed. Semiconductor nano structures are embedded as an active region in semiconductor devices. Thirdly and finally, the results of quantum mechanical simulations of semiconductor nano structures can be used with upscaling methods to deliver parameters needed in semi-classical models for semiconductor devices, such as quantum well lasers. This book covers in detail all these three aspects using a variety of illustrative examples. Readers will gain detailed insights into the status of the multiband effective mass method for semiconductor nano structures. Both users of the kp method as well as advanced researchers who want to advance the kp method further will find helpful information on how to best work with this method and use it as a tool for characterizing the physical properties of semiconductor nano structures. The book is primarily intended for graduate and Ph.D. students in applied mathematics, mathematical physics and theoretical physics, as well as all those working in quantum mechanical research or the semiconductor / opto-electronic industry who are interested in new mathematical aspects.

This book provides an account for the non-specialist of the circle of ideas, results and techniques, which grew out in the study of Brownian motion and random obstacles. It also includes an overview of known results and connections with other areas of random media, taking a highly original and personal approach throughout.

This book is based upon my monograph Index Theory for Hamiltonian Systems with Applications published in 1993 in Chinese, and my notes for lectures and courses given at Nankai University, Brigham Young University, ICTP-Trieste, and the Institute of Mathematics of Academia Sinica during the last ten years. The aim of this book is twofold: (1) to give an introduction to the index theory for symplectic matrix paths and its iteration theory, which form a basis for the Morse theoretical study on Hamilto nian systems, and to give applications of this theory to periodic boundary value problems of nonlinear Hamiltonian systems. Here the iteration theory means the index theory of iterations of periodic solutions and symplectic matrix paths. (2) to serve as a reference book on these topics. There are many different ways to introduce the index theory for symplectic paths in order to establish Morse type index theory of Hamiltonian systems. In this book, I have chosen a relatively elementary way, i.e., the homotopy classification method of symplectic matrix paths. It depends only on linear algebra, point set topology, and certain basic parts of linear functional analysis. I have tried to make this part of the book self-contained and at the same time include all of the major results on these topics so that researchers and students interested in them can read it without substantial difficulties, and can learn the main results in this area for their possible applications."

This volume contains 23 articles on algebraic analysis of differential equations and related topics, most of which were presented as papers at the conference "Algebraic Analysis of Differential Equations - from Microlocal Analysis to Exponential Asymptotics" at Kyoto University in 2005. This volume is dedicated to Professor Takahiro Kawai, who is one of the creators of microlocal analysis and who introduced the technique of microlocal analysis into exponential asymptotics.

This book describes numerical methods for partial differential equations (PDEs) coupling advection, diffusion and reaction terms, encompassing methods for hyperbolic, parabolic and stiff and nonstiff ordinary differential equations (ODEs). The emphasis lies on time-dependent transport-chemistry problems, describing e.g. the evolution of concentrations in environmental and biological applications. Along with the common topics of stability and convergence, much attention is paid on how to prevent spurious, negative concentrations and oscillations, both in space and time. Many of the theoretical aspects are illustrated by numerical experiments on models from biology, chemistry and physics. A unified approach is followed by emphasizing the method of lines or semi-discretization. In this regard this book differs substantially from more specialized textbooks which deal exclusively with either PDEs or ODEs. This book treats integration methods suitable for both classes of problems and thus is of interest to PDE researchers unfamiliar with advanced numerical ODE methods, as well as to ODE researchers unaware of the vast amount of interesting results on numerical PDEs.

Main concepts of quasi-stationary distributions (QSDs) for killed processes are the focus of the present volume. For diffusions, the killing is at the boundary and for dynamical systems there is a trap. The authors present the QSDs as the ones that allow describing the long-term behavior conditioned to not being killed. Studies in this research area started with Kolmogorov and Yaglom and in the last few decades have received a great deal of attention. The authors provide the exponential distribution property of the killing time for QSDs, present the more general result on their existence and study the process of trajectories that survive forever. For birth-and-death chains and diffusions, the existence of a single or a continuum of QSDs is described. They study the convergence to the extremal QSD and give the classification of the survival process. In this monograph, the authors discuss Gibbs QSDs for symbolic systems and absolutely continuous QSDs for repellers. The findings described are relevant to researchers in the fields of Markov chains, diffusions, potential theory, dynamical systems, and in areas where extinction is a central concept. The theory is illustrated with numerous examples. The volume uniquely presents the distribution behavior of individuals who survive in a decaying population for a very long time. It also provides the background for applications in mathematical ecology, statistical physics, computer sciences, and economics.

The first formulations of linear boundary value problems for analytic functions were due to Riemann (1857). In particular, such problems exhibit as boundary conditions relations among values of the unknown analytic functions which have to be evaluated at different points of the boundary. Singular integral equations with a shift are connected with such boundary value problems in a natural way. Subsequent to Riemann's work, D. Hilbert (1905), C. Haseman (1907) and T. Carleman (1932) also considered problems of this type. About 50 years ago, Soviet mathematicians began a systematic study of these topics. The first works were carried out in Tbilisi by D. Kveselava (1946-1948). Afterwards, this theory developed further in Tbilisi as well as in other Soviet scientific centers (Rostov on Don, Ka zan, Minsk, Odessa, Kishinev, Dushanbe, Novosibirsk, Baku and others). Beginning in the 1960s, some works on this subject appeared systematically in other countries, e. g., China, Poland, Germany, Vietnam and Korea. In the last decade the geography of investigations on singular integral operators with shift expanded significantly to include such countries as the USA, Portugal and Mexico. It is no longer easy to enumerate the names of the all mathematicians who made contributions to this theory. Beginning in 1957, the author also took part in these developments. Up to the present, more than 600 publications on these topics have appeared."

Inverse problems have a long history in acoustics, optics, electromagnetics and geophysics, but only recently have the signals provided by ocean acoustic sensors become numerous and sophisticated enough to allow for realistic identification of the ocean parameters. Acoustic signals propagating for long distances in the water column and reflections of underwater sound from the ocean boundaries provide novel problems of interpretation and inversion. The chapters in this volume discuss some of the contemporary aspects of these problems. They provide recent and useful results for bottom recognition, inverse scattering in acoustic wave guides, and ocean acoustic tomography, as well as a discussion of some of the new algorithms, such as those related to matched-field processing, that have recently been used for inverting experimental data. Each chapter is by a noted expert in the field and represents the state of the art. The chapters have all been edited to provide a uniform format and level of presentation.

The theory and applications of infinite dimensional dynamical systems have attracted the attention of scientists for quite some time. Dynamical issues arise in equations which attempt to model phenomena that change with time, and the infinite dimensional aspects occur when forces that describe the motion depend on spatial variables. This book may serve as an entree for scholars beginning their journey into the world of dynamical systems, especially infinite dimensional spaces. The main approach involves the theory of evolutionary equations. It begins with a brief essay on the evolution of evolutionary equations and introduces the origins of the basic elements of dynamical systems, flow and semiflow.

Over the past ten years, the asymptotic theory of one-parameter semigroups of operators has witnessed an explosive development. A number oflong-standing open problems have recently been solved and the theory seems to have obtained a certain degree of maturity. These notes, based on a course delivered at the University of Tiibingen in the academic year 1994-1995, represent a first attempt to organize the available material, most of which exists only in the form of research papers. If A is a bounded linear operator on a complex Banach space X, then it is an easy consequence of the spectral mapping theorem exp(tO"(A)) = O"(exp(tA)), t E JR, and Gelfand's formula for the spectral radius that the uniform growth bound of the wt family {exp(tA)h~o, i. e. the infimum of all wE JR such that II exp(tA)II :::: Me for some constant M and all t 2: 0, is equal to the spectral bound s(A) = sup{Re A : A E O"(A)} of A. This fact is known as Lyapunov's theorem. Its importance resides in the fact that the solutions of the initial value problem du(t) =A () dt u t , u(O) = x, are given by u(t) = exp(tA)x. Thus, Lyapunov's theorem implies that the expo- nential growth of the solutions of the initial value problem associated to a bounded operator A is determined by the location of the spectrum of A.

As far as the number of new results and quoted papers is concerned the present book may be considered a monograph. However, it also has some features of a textbook. Firstly, it proceeds from concrete problems to abstract ones, and secondly, all considerations and procedures are presented in much detail when met for the first time (such very elementary expositions can be found especially at the beginning of Chapters III and V). Finally, the authors focus their attention on elementary problems which can be dealt with by relatively simple methods. The authors hope that all this will make it possible also for an applied or technical research worker with some mathematical training to read this book. Naturally, the reader is supposed to be familiar with some basic notions from mathematical analysis, functional analysis and theory of partial differential equations. Also, the arguments and procedures which are repeated in the book are presented more briefly when met again, the reader being expected to become gradually more thoroughly acquainted with them. The authors have tried to provide a complete bibliography of all relevant publications (their number reaches about 500) from the theory of time-periodic solutions to non-linear partial and abstract differential equations whose origin may be put in the early thirties of this century.

Many physical problems are meaningfully formulated in a cylindrical domain. When the size of the cylinder goes to infinity, the solutions, under certain symmetry conditions, are expected to be identical in every cross-section of the domain. The proof of this, however, is sometimes difficult and almost never given in the literature. The present book partially fills this gap by providing proofs of the asymptotic behaviour of solutions to various important cases of linear and nonlinear problems in the theory of elliptic and parabolic partial differential equations.
The book is a valuable resource for graduates and researchers in applied mathematics and for engineers. Many results presented here are original and have not been published elsewhere. They will motivate and enable the reader to apply the theory to other problems in partial differential equations.

This volume provides a comprehensive review of the developments which have taken place during the last thirty years concerning the asymptotic properties of solutions of nonautonomous ordinary differential equations. The conditions of oscillation of solutions are established, and some general theorems on the classification of equations according to their oscillatory properties are proved. In addition, the conditions are found under which nonlinear equations do not have singular, proper, oscillatory and monotone solutions. The book has five chapters: Chapter I deals with linear differential equations; Chapter II with quasilinear equations; Chapter III with general nonlinear differential equations; and Chapter IV and V deal, respectively, with higher-order and second-order differential equations of the Emden-Fowler type. Each section contains problems, including some which presently remain unsolved. The volume concludes with an extensive list of references. For researchers and graduate students interested in the qualitative theory of differential equations.