Frontiers in Molecular Biology is a series of books designed to report on rapidly evolving, key areas of research in molecular biology. Individual chapters are written by leading researchers who are specialists in their fields. Each book is carefully organized to provide an integrated analysis of current progress in the area covered. Parasitic protozoa cause major infectious diseases of humans and domestic animals. In recent years, new techniques in molecular biology have allowed tremendous advances in our understanding of these parasites. Molecular Biology of Parasitic Protozoa covers this fast-moving field at an advanced level for which there is no other up-to-date book. Topics covered include trypanosomatid and Toxoplasma genetics, structure and replication of kinetoplast DNA, regulation of gene expression in trypanosomes, trans-splicing, RNA editing, the three genomes of Plasmodium, mechanisms of drug resistance, biogenesis of glycosomes and hydrogenosomes, glycosylphosphatidylinositols and the surface architecture of parasitic protozoa. Molecular Biology of Parasitic Protozoa is a unique compendium of current research findings in this important area. It contains over 900 references and provides a comprehensive review of the field as well as valuable insights and predictions of future progress by leading researchers.

The increase in environmentally induced diseases and the loosening of regulation and safety measures have inspired a massive challenge to established ways of looking at health and the environment. Communities with disease clusters, women facing a growing breast cancer incidence rate, and people of color concerned about the asthma epidemic have become critical of biomedical models that emphasize the role of genetic makeup and individual lifestyle practices. Likewise, scientists have lost patience with their colleagues' and government's failure to adequately address environmental health issues and to safeguard research from corporate manipulation.

Focusing specifically on breast cancer, asthma, and Gulf War-related health conditions-"contested illnesses" that have generated intense debate in the medical and political communities-Phil Brown shows how these concerns have launched an environmental health movement that has revolutionized scientific thinking and policy. Before the last three decades of widespread activism regarding toxic exposures, people had little opportunity to get information. Few sympathetic professionals were available, the scientific knowledge base was weak, government agencies were largely unprepared, laypeople were not considered bearers of useful knowledge, and ordinary people lacked their own resources for discovery and action.

Brown argues that organized social movements are crucial in recognizing and acting to combat environmental diseases. His book draws on environmental and medical sociology, environmental justice, environmental health science, and social movement studies to show how citizen-science alliances have fought to overturn dominant epidemiological paradigms. His probing look at the ways scientific findings are made available to the public and the changing nature of policy offers a new perspective on health and the environment and the relationship among people, knowledge, power, and authority.

The result of ten years' detailed research, this is a complete and detailed system of trauma methods which the non-specialist general duty doctor can use to treat all human injuries that might benefit from his care. It is designed mainly for medical schools and hospitals in the developing world, but any doctor who is not a trauma specialist will find it useful. A valuable feature is a system of closed methods for all fractures which can be treated this way, and there is an extensive chapter on the treatment of burns. The book is published in collaboration with the Deutsche Gestellschaft fur Technische Zusammenarbeit and the Kenyan Ministry of Health, and is part of a complete series on surgery, anaesthesia and obstetrics for hospitals in the developing world.

The four Primary Surgery volumes are manuals written for the non-specialist doctor and medical students. Two other volumes Trauma and Primary Anaesthesia have already been published and a fourth, Primary Mother Care is in preparation. The manuals describe what a doctor can do if s/he cannot refer a patient, both in emergency and for cold surgery'. Surgery has become fragmented into many specialties, and these manuals select methods of which the generalist can make good use. Although common problems such as Caesarean section, the resection of dead gut, and the release of pus from infected bones are highlighted, it is recognized that rare problems are fairly common, and thus the manuals aim to be comprehensive. The organization and equipment found within an operating theatre is described, and an extensive equipment list is provided. The previous volumes have been well-received, as a reader from Africa testifies: With the volume on Trauma (which never leaves the theatre) open, my colleagues and I have done several operations successfully, which we previously knew nothing about. I was especially impressed with the descriptions of how to make burr holes for intracranial bleeding. Foll

Every person on our home planet is affected by a worldwide deluge of man-made chemicals and pollutants - most of which have never been tested for safety. Our chemical emissions are six times larger than our total greenhouse gas emissions. They are in our food, our water, the air we breathe, our homes and workplaces, the things we use each day. This universal poisoning affects our minds, our bodies, our genes, our grandkids, and all life on Earth. Julian Cribb describes the full scale of the chemical catastrophe we have unleashed. He proposes a new Human Right - not to be poisoned. He maps an empowering and hopeful way forward: to rid our planet of these toxins and return Earth to the clean, healthy condition which our forebears enjoyed, and our grandchildren should too.

Address to the Conference on Employee Mental Wellness by Walter B. Wriston, Chairman, Citicorp The mental well-being of employees is a subject of fundamental importance to each of us, our companies, our professions, and the nation. Both the Washington Business Group on Health and Boston University's Center for Industry and Health Care should be commended for the timely initiative this conference represents. I hope it will be come an ongoing effort to improve the mental health services to the nation's private sector workers and their dependents. I have had a deep interest in the delivery of health care for a long time, both from the perspective of a major employer and from my participation in the governance of New York Hospital-Cornell Medical Center. It has also been my privilege to chair the Business Round table's Task Force on Health and to serve on the President's Labor Management Committee which, among other things, has been working on heaith care problems. This experience obviously does not give me any claim to special expertise on the issue of mental health. It may prove helpful, however, as we work together formulating our thoughts about the nation's health system, the role of industry, and where the mental health issue fits into the picture."

This book serves as a comprehensive introductory guide to the practical aspects of risk assessment. Chapters include clearly defined objectives and summaries. The book includes: hazard identification, dose-response, exposure assessment, risk characterization, chemical mixtures, epidemiology, emerging issues and global perspectives with accessible language. The book concludes with a set of hypothetical case studies. Toxicological Risk Assessment for Beginners aims not to create an expert, but rather to provide readers with their first understanding of the risk assessment topic. This book was designed with the student in mind. We simplify a complex process for beginners and balance theory with practical aspects, but remain fluid enough to increase difficulty with case studies. By incorporating an action based, step by step approach to learning the risk assessment process, this book provides its readers with an elementary understanding of how the risk assessment process is initiated, developed and finished, making it a valuable guide for graduate students, post-doctoral fellows and early career scientists in industry.

It is a pleasure to introduce this special volume of the Industry and Health Care Series. It is special for the best of reasons: it is primarily written by industry representatives. Using the Washing ton Business Group on Health 1978 Annual Meeting as its starting point, this volume captures the feelings, concerns, and experience of many who are leading industry's increasingly significant presence in health policy and economics. While many of the largest companies achieve more sophisticated levels of involvement, the fact remains that most companies of all sizes and especially the smaller businesses either will not or cannot devote the time or resources to become active participants. We hope this volume will help demonstrate the value of even one person's commit ment. Although our organizational focus is Washington, the WBGH rec ognizes that, in the long run, the quality and cost of the health care most Americans receive will be-and should be-determined at the local level. To let this happen without industry involvement would represent an abdication of both responsibility and opportunity. Fortunately, we see a growth of industry involvement, growth not just in terms of numbers but also in terms of the scope of activities. * Recognizing that the key to changing provider behavior is to change the economic incentives, emanating from the major payers, em- vi Preface ployers are subjecting their employee benefit plans to the most com plete scrutiny in many years.

Close followers of the evolution of the Series on Industry and Health Care will recognize in this fourth volume some continuity and some change. The essential concept behind the series remains: here, as before, we are looking to private industry as a potential agent of change in the American health care delivery system. We have made some structural accommodations, however, to comments received from readers in industry and in health services. The original concept of a topical monograph supplemented by a separate hardbound volume of background papers has yielded to the present formula in which each volume is complete in itself. The series continues to draw much of its material from interdisciplinary working conferences convened by the Bos ton University Center for Industry and Health Care. Rather than publish confer ence proceedings, we have again undertaken to analyze the discussions and to integrate with them some timely background materials. Readers have found this format a major improvement over traditional conference reports and sum maries."

This fifth issue in the Industry and Health Care series takes a quick turn through unpredictable and only partially charted waters. The series as a whole has set out to explore the role of industry as a potential agent of change in the health care system, and to map the courses that may lead toward control of costs. One that looks possible is the effort now being made to infuse some competition into the health care industry through organized systems of care, known as HMOs. Health maintenance organizations, especially the fee-for-service variety known as IPAs (individual practice associations), have been a particular inter est of the Center for Industry and Health Care, where a national data base 'on IP A performance is being established with the aid of the Robert Wood Johnson Foundation. The Center's identity with HMOs, combined with its focus on industry and health care, has afforded us unusual access to nascent corporate thinking on the pros and cons of HMO sponsorship. We are grateful for these opportunities, and for the insights industry people have shared with us. This series draws heavily on that experience."

With this first monograph, Springer-Verlag launches an unusual publishing venture. The purpose of the Springer Series on Industry and Health Care is to explore in depth the current and potential future role of industry both management and labor in all private sector enterprises-as a financer of health care benefits, as a provider of health care services, and as an extremely influential "consumer" of health care. The assumption behind the series is that private industry has the capabil ity, as an alternative to increased government intervention, to effect major change in the health care delivery system and is beginning to show evidence of exercising that influence. The subject matter covered by the series crosses boundaries between disciplines and specialities-occupational medicine, medical care, public health, economics, business administration, law, public policy, medical sociology-and arises in disparate arenas-labor-manage ment relations, corporate negotiations with insurance carriers, physician patient interactions, public policy, and politics. The Springer Series will draw much of its material from interdisciplinary working conferences, will analyze and synthesize the discussions, add timely background material, and be published within no more than six months of the conferences on which they build. The series will consist of four monographs a year and two volumes of background papers."

The Springer Series on Industry and Health Care is intended to character ize present and future ways in which industry can influence the nation's health care system in the direction of greater efficiency and effectiveness. Its potential audience includes nearly everyone interested in health care because the sys tem's future configuration is now being influenced by corporate health pro grams and the involvement of individual corporate leaders in health affairs. The first volume of the Springer Series provided a broad background on industry as a payer, provider, and consumer of health services. Unlike volumes planned for the future, it did not single out any particular aspect of corporate activity in health but rather identified and catalogued the many new involve ments of industry, both management and labor, in the health care scene. This, the second volume in the series, is designed to complement the first and to complete the process of laying the groundwork for the series as a whole. Volume two covers the same vista as volume one, but paints with a broader brush. It seemed to us, as editors of the series and authors of volume one, that the academic and somewhat distant overview we provided could be rounded out in a second volume by someone with a more immediate and practical perspective on industry's involvement in health care."

This book's main objective is to decipher for the reader the main processes in the atmosphere and the quantification of air pollution effects on humans and the environment, through first principles of meteorology and modelling/measurement approaches. The understanding of the complex sequence of events, starting from the emission of air pollutants into the atmosphere to the human health effects as the final event, is necessary for the prognosis of potential risk to humans from specific chemical compounds and mixtures of them. It fills a gap in the literature by providing a solid grounding in the first principles of meteorology and air pollution, making it particularly useful for undergraduate students. Its broad scope makes it a valuable text in many related disciplines, containing a comprehensive and integrated methodology to study the first principles of air pollution, meteorology, indoor air pollution, and human exposure. Problem-solving exercises help to reinforce concepts.

The European School of Oncology came into existence to respond to a need for information, education and training in the field of the diagnosis and treatment of cancer. There are two main reasons why such an initiative was considered necessary. Firstly, the teaching of oncology requires a rigorously multidisciplinary approach which is difficult for the Universities to put into practice since their system is mainly disciplinary orientated. Secondly, the rate of technological development that impinges on the diagnosis and treatment of cancer has been so rapid that it is not an easy task for medical faculties to adapt their curricula flexibly. With its residential courses for organ pathologies and the seminars on new techniques (laser, monoclonal antibodies, imaging techniques etc.) or on the principal therapeutic controversies (conservative or mutilating surgery, primary or adjuvant chemotherapy, radiotherapy alone or integrated), it is the ambition of the European School of Oncology to fill a cultural and scientific gap and, thereby, create a bridge between the University and Industry and between these two and daily medical practice. One of the more recent initiatives of ESO has been the institution of permanent study groups, also called task forces, where a limited number of leading experts are invited to meet once a year with the aim of defining the state of the art and possibly reaching a consensus on future developments in specific fields of oncology.

"Networks in Tropical Medicine" explores how European doctors and scientists worked together across borders to establish the new field of tropical medicine in the late nineteenth and early twentieth centuries. The book shows that this transnational collaboration in a context of European colonialism, scientific discovery, and internationalism shaped the character of the new medical specialty. Even in an era of intense competition among European states, practitioners of tropical medicine created a transnational scientific community through which they influenced each other and the health care that was introduced to the tropical world. One of the most important developments in the shaping of tropical medicine as a specialty was the major sleeping sickness epidemic that spread across sub-Saharan Africa at the turn of the century. The book describes how scientists and doctors collaborated across borders to control, contain, and find a treatment for the disease. It demonstrates that these medical specialists' shared notions of "Europeanness," rooted in common beliefs about scientific, technological, and racial superiority, led them to establish a colonial medical practice in Africa that sometimes oppressed the same people it was created to help.

Fully revised for this third edition, the Oxford Handbook of Occupational Health is a concise, practice-based guide to the area. Bringing together the latest legislation and guidance with current practice in the field, this is an authoritative reference to assessing and managing health risks in the workplace. Consisting of twelve sections covering the full breadth of practice, this Handbook covers workplace hazards and diseases, occupational health emergencies, and practical procedures. This third edition also contains new information on ethics, work health and disability, infection control, respiratory disorders, and fitness for work, with updated diagrams, figures and chemical structures to aid reader understanding. Providing a thorough, easy-to-use guide to the whole of occupational health, this Handbook is the essential resource for all occupational physicians, occupational health nurses, and all those dealing with workplace health and fitness, giving you the information you need at your fingertips.

Aquatic Chemistry Concepts, Second Edition, is a fully revised and updated textbook that fills the need for a comprehensive treatment of aquatic chemistry and covers the many complicated equations and principles of aquatic chemistry. It presents the established science of equilibrium water chemistry using the uniquely recognizable, step-by-step Pankow format, which allows a broad and deep understanding of aquatic chemistry. The text is appropriate for a wide audience, including undergraduate and graduate students, industry professionals, consultants, and regulators. Every professional using water chemistry will want this text within close reach, and students and professionals alike will expect to find at least one copy on their library shelves. Key Features Extremely thorough, one-of-a-kind treatment of aquatic chemistry which considers: a) chemical thermodynamics fundamentals; b) acid/base, titration, and buffer calculations; c) CO2 chemistry and alkalinity; d) complexation of metal ions by ligands and chelates; e) mineral solubility processes; f) redox chemistry, including the chemistry of chlorine (as in disinfection), oxygen, CO2 and methane, nitrogen, sulfur, iron, and lead, including the story of lead in the drinking water of Flint, Michigan; and g) electrical effects in aqueous solutions including the Debye-Huckel Law (and related equations for activity corrections), double layers, and colloid stability Discussions of how to carry out complex calculations regarding the chemistry of lakes, rivers, groundwater, and seawater Numerous example problems worked in complete detail Special foreword by Jerry L. Schnoor 'There's a lot to like about a book on water chemistry that lays it out simply. Einstein said that everything should be as simple as it can be, but not simpler. Wise advice. And that is what James F. Pankow has accomplished in the second edition of his textbook, Aquatic Chemistry Concepts. It covers the "waterfront" of essential inorganic chemistry topics, and it supplies enough examples to lead the student toward problem solving.' -From the Foreword, Jerry L. Schnoor

The range of environments in which people can survive is extensive, yet most of the natural world cannot support human life. The Biology of Human Survival identifies the key determinants of life or death in extreme environments from a physiologist's perspective, integrating modern concepts of stress, tolerance, and adaptation into explanations of life under Nature's most austere conditions. The book examines how individuals survive when faced with extremes of immersion, heat, cold or altitude, emphasizing the body's recognition of stress and the brain's role in optimizing physiological function in order to provide time to escape or to adapt. In illustrating how human biology adapts to extremes, the book also explains how we learn to cope by blending behavior and biology, first by trial and error, then by rigorous scientific obsrvation, and finally by technological innovation. The book describes life-supprt technology and how it enables humans to enter once unendurable realms from the depths of the ocean to the upper reaches of the atmosphere and beyond. Finally, it explores the role that advanced technology might play in special enviornments of the future, now in long journeys into space.

Im Zuge der Globalisierung, bei der Container und Menschen von einem Kontinent zum anderen transportiert werden, landen taglich Erreger oder Krankheitsubertrager in Europa an und koennen sich schnell ausbreiten. Daher ist es notwendig, das Wissen um die UEbertragungswege von Parasiten auf den Menschen stets aktuell zu halten und die Gefahren einer Einschleppung und Ausbreitung rechtzeitig einzudammen. Dieses Buch bietet eine aktuelle UEbersicht uber die wichtigsten einheimischen und tropischen Parasiten des Menschen und ihre potenziellen UEbertrager. Es wendet sich an AErzte, Pharmazeuten, Laborpersonal und Studierende der Humanmedizin und Biologie, aber auch an alle, die sich uber Vorbeuge- und Bekampfungsmassnahmen informieren wollen. Informationen zu den einzelnen Parasiten werden jeweils in 11 Abschnitten komprimiert dargestellt: 1. Namensgebung - 2. Weltweite Verbreitung und epidemiologische Daten - 3. Lebenszyklen und Aussehen - 4. Symptome der Erkrankung - 5. Diagnosemoeglichkeiten - 6. Infektionswege - 7. Vorbeugemassnahmen - 8. Inkubationszeiten - 9. Zeiten bis zur Weiterubertragung - 10. Dauer eines Befalls - 11. Therapiemassnahmen In Tabellen, zahlreichen Schemata und auf 200 farbigen Abbildungen werden die wichtigsten Aspekte eines Parasitenbefalls sowie die aktuellen Bekampfungsmassnahmen dargestellt. Fragen helfen zudem bei der UEberprufung des eigenen Wissens. Die Neuauflage wurde um weitere Erreger erganzt und durch AEnderungen bei den Therapien aktualisiert

"Why I Became an Occupational Physician" and Other Occupational Health Stories brings together an edited collection of the short articles published in the journal Occupational Medicine between 2002 and 2018. The articles originally appeared as 'fillers', commissioned to literally 'fill' the blank spaces at the end of the main scientific papers, but they soon became a feature in their own right. Written by doctors working in occupational medicine and health, the fillers began as a series of pieces exploring the varied and often surprising reasons why the individuals chose to pursue this unique speciality, whether it was a natural career move, triggered by a specific event, or stumbled upon by chance. Over time the articles became much broader in their scope and the journal began to attract pieces from some brilliant writers: Mike Gibson, John Challenor, Nerys Williams, and of course the superlative Anthony Seaton, amongst many others. Each article offers something different: a peek into history, a humorous adventure, a quiet musing, or a thought-provoking observation, but all are tied together under the umbrella of occupational medicine, a speciality that is often little known or understood in the wider world of medicine. This book brings together over 15 years' worth of fascinating and diverse articles into one volume for the first time, giving a rare insight into the world of the occupational physician.

Fundamentals of Environmental and Toxicological Chemistry: Sustainable Science, Fourth Edition covers university-level environmental chemistry, with toxicological chemistry integrated throughout the book. This new edition of a bestseller provides an updated text with an increased emphasis on sustainability and green chemistry. It is organized based on the five spheres of Earth's environment: (1) the hydrosphere (water), (2) the atmosphere (air), (3) the geosphere (solid Earth), (4) the biosphere (life), and (5) the anthrosphere (the part of the environment made and used by humans). The first chapter defines environmental chemistry and each of the five environmental spheres. The second chapter presents the basics of toxicological chemistry and its relationship to environmental chemistry. Subsequent chapters are grouped by sphere, beginning with the hydrosphere and its environmental chemistry, water pollution, sustainability, and water as nature's most renewable resource. Chapters then describe the atmosphere, its structure and importance for protecting life on Earth, air pollutants, and the sustainability of atmospheric quality. The author explains the nature of the geosphere and discusses soil for growing food as well as geosphere sustainability. He also describes the biosphere and its sustainability. The final sphere described is the anthrosphere. The text explains human influence on the environment, including climate, pollution in and by the anthrosphere, and means of sustaining this sphere. It also discusses renewable, nonpolluting energy and introduces workplace monitoring. For readers needing additional basic chemistry background, the book includes two chapters on general chemistry and organic chemistry. This updated edition includes three new chapters, new examples and figures, and many new homework problems.

The role natural environments play in human health and wellbeing is attracting increasing attention. There is growing medical evidence that access to the natural environment can prevent disease, aid recovery, tackle obesity and improve mental health. This book examines the history of natural environments being used for stress-reduction, enjoyment, aesthetics and catharsis, and traces the development of the connection between humans and the environment, and how they impact our personal and collective health.

Das Management von Patentauslaufen in pharmazeutischen Unternehmen erfahrt in Zeiten von stetig zunehmender Regulierung und geringer gefullten Produktpipelines erneut grosse Aufmerksamkeit. Im Mittelpunkt dieses Bandes steht die Frage, welche der in der Literatur diskutierten Patentauslaufstrategien unter Berucksichtigung der aktuellen Rechtslage und Weiterentwicklung der pharmazeutischen Branche noch anwendbar sind. Dabei erfasst die Autorin sowohl branchenspezifische Besonderheiten als auch konzeptionelle Grundlagen der Marketingforschung. Basierend auf diesen Erkenntnissen erstellt die Autorin ein neues Klassifikationsschema an Patentauslaufstrategien fur die pharmazeutische Branche und gibt Handlungsempfehlungen fur das Management des Patentauslaufs.

Documents both environmental and work-related causes of lung disease

Unlike other books on the subject, this new volume approaches occupational and environmental lung disease from the starting point of the patient who comes to the physician with respiratory symptoms. The authors recognize that potentially harmful exposures occur not only in the work environment, but also as a result of hobbies or other leisure activities, or from outdoor air pollution, and it is up the physician to identify whether a particular job or hobby is the cause of the patient's respiratory symptoms.
To help you arrive at a differential diagnosis, chapters in the book are arranged by job or exposure, and are divided into 5 sections: Personal environmentHome environmentOther indoor environmentsWork environmentGeneral environment

Each is written by an expert in the specific topic and provides pragmatic information for the practicing physician. This practical book is an invaluable resource that belongs close at hand for all physicians dealing with patients experiencing respiratory symptoms.

Das Leben in der Stadt kann zu physischen und psychischen Erkrankungen fuhren. Dabei spielen Umweltfaktoren, wie z.B. Extremwetterereignisse, Luftverunreinigung, Larmbelastung oder veranderte Stadtklimatologie durch Versiegelung eine entscheidende Rolle.Ein grunes Stadtbild kann durch die Schaffung gesundheits- und bewegungsfoerdernder Strukturen die Gesundheit und das Wohlbefinden der Burger positiv beeinflussen und damit Krankheiten, die durch das Stadtleben begunstigt werden, abmildern.