This volume of "Progress in Heterocyclic Chemistry" (PHC) is the twelfth annual review of the literature, covering the work published on most of the important heterocyclic ring systems during 1999, with inclusions of earlier material as appropriate. As in PHC-11, there are also three specialized reviews in this year's volume. In the inaugural chapter, Michael Groziak revitalizes the field of boron heterocycles, a relatively obscure class of heterocycles, but with a promising future. Heterocyclic phosphorus ylides are similarly a little known but useful class of compounds and Alan Aitken and Tracy Massil have provided a comprehensive review of them in Chapter 2. In Chapter 3 Jack Li discusses the remarkably versatile palladium chemistry in pyridine alkaloid synthesis.

The subsequent chapters deal with recent advances in the field of heterocyclic chemistry arranged by increasing ring size and with emphasis on synthesis and reactions.

For everybody teaching chemistry or becoming a chemistry teacher, the authors provide a practice-oriented overview with numerous examples from current chemical education, including experiments, models and exercises as well as relevant results from research on learning and teaching. With their proven concept, the authors cover classical topics of chemical education as well as modern topics such as every-day-life chemistry, student's misconceptions, the use of media or the challenges of motivation. This is the completely revised and updated English edition of a highly successful German title.

Understanding the Periodic Table of Chemical Elements is critical for success in the chemistry classroom and laboratory. In today's classroom, students not only need to understand the properties of the chemical elements, but how these elements play such an integral role in industry, the earth and the environment, and in modern life. No resource provides a better introduction than Robert Krebs's The History and Use of Our Earth's Chemical Elements. In this thoroughly revised edition, with extensive new examples on the importance of the chemical elements, the elements are examined within their groups, enabling students to make connections between elements of similar structure. In addition, the discovery and history of each element - from those known from ancient times to those created in the modern laboratory - is explained clearly and concisely. Understanding the Periodic Table of Chemical Elements is critical for success in the chemistry classroom and laboratory. In today's classroom, students not only need to understand the properties of the chemical elements, but how these elements play such an integral role in industry, the earth and the environment, and in modern life. No resource provides a better introduction than Robert Krebs's The History and Use of Our Earth's Chemical Elements. In this thoroughly revised edition, with extensive new and updated examples on the use of the chemical elements, the elements are examined within their groups, enabling students to make connections between elements of similar structure. In addition, the discovery and history of each element - from those known from ancient times to those created in the modern laboratory - is explained clearly and concisely. In addition to the handy Guide to the Chemical Elements that comprises the bulk of the work, The History and Use of Our Earth's Chemical Elements includes other useful features: ; Introductory material on the basics of chemistry and the Periodic Table ; Appendices on the discoverers of the chemical elements ; A glossary of words commonly used in chemistry and chemical engineering ; A complete bibliography of useful resources, including websites All of this information makes The History and Use of Our Earth's Chemical Elements the ideal one-volume resource for understanding the importance of the chemical elements.

A comprehensive analysis of essential new technologies

Adsorption promises to play an integral role in several future energy and environmental technologies, including hydrogen storage, CO removal for fuel cell technology, desulfurization of transportation fuels, and technologies for meeting higher standards on air and water pollutants. Ralph Yang’s Adsorbents provides a single and comprehensive source of knowledge for all commercial and new sorbent materials, presenting the fundamental principles for their syntheses, their adsorption properties, and their present and potential applications for separation and purification. Chapter topics in this authoritative, forward-looking volume include:

• Formulas for calculating the basic forces or potentials for adsorption
• Calculation of pore-size distribution from a single adsorption isotherm
• Rules for sorbent selection
• Fundamental principles for syntheses/preparation, adsorption properties, and applications of commercially available sorbents
• Mesoporous molecular sieves and zeolites
• ¸-complexation sorbents and their applications
• Carbon nanotubes, pillared clays, and polymeric resins

Yang covers the explosion in the development of new nanoporous materials thoroughly, as the adsorption properties of some of these materials have remained largely unexplored. The whole of the text benefits from the new adsorbent designs made possible by the increase in desktop computing and molecular simulation, making Adsorbents useful to both practicing laboratories and graduate programs. Ralph Yang’s comprehensive study contributes significantly to the resolution of separation and purification problems by adsorption technologies.

Sulfur, through its major derivative, sulfuric acid is among the most used and important raw materials in industry today. It is a critical part of every sector of the worlds economies and is regarded as one of the best indices of a nations industrial development. In fact, sulfuric acid is the most produced chemical in the United States. This book is a scientific history of sulfur, tracking the technologies, applications, and the industry itself from ancient markets to the current global economy.

Each chapter is devoted to either a method of production or a set of applications as they intertwined during different stages of industrial and technological developments. Particular attention is given to Herman Frasch, inventor of the "Frasch Process," which enabled America to go from 100% import of sulfur to the worlds largest exporter in less than a decade.

The sulfur industry is also an excellent case study of entrepreneurship and relationship with inventors. It reveals the characteristics of entrepreneurs and inventors and approaches required to formulate goals. Most importantly, it shows how to succeed in new ventures. Rockefeller might have been a failure if Frasch had not rescued him from his bad investment in oil. Since sulfur must be removed from oil and natural gas before they can be used as energy sources, Frasch turned certain failure into wild success through his technological expertise and determination.

Although scientific and technical in nature, this book is written so that anyone without a strong chemistry background will enjoy reading it. The interested audience goes far beyond the boundaries of sulfur applications and the oil industry and should be foundin every technical, university, and public library.

This book contains a comprehensive review of CMP (Chemical-Mechanical Planarization) technology, one of the most exciting areas in the field of semiconductor technology. It contains detailed discussions of all aspects of the technology, for both dielectrics and metals. The state of polishing models and their relation to experimental results are covered. Polishing tools and consumables are also covered. The leading edge issues of damascene and new dielectrics as well as slurryless technology are discussed.

Though the game-theoretic approach has been vastly studied and utilized in relation to economics of industrial organizations, it has hardly been used to tackle safety management in multi-plant chemical industrial settings. Using Game Theory for Improving Safety within Chemical Industrial Parks presents an in-depth discussion of game-theoretic modeling which may be applied to improve cross-company prevention and -safety management in a chemical industrial park. By systematically analyzing game-theoretic models and approaches in relation to managing safety in chemical industrial parks, Using Game Theory for Improving Safety within Chemical Industrial Parks explores the ways game theory can predict the outcome of complex strategic investment decision making processes involving several adjacent chemical plants. A number of game-theoretic decision models are discussed to provide strategic tools for decision-making situations. Offering clear and straightforward explanations of methodologies, Using Game Theory for Improving Safety within Chemical Industrial Parks provides managers and management teams with approaches to asses situations and to improve strategic safety- and prevention arrangements.

Chemistry and Application of H-Phosphonates is an excellent source for those planning the synthesis of new phosphorus-containing compounds and in particular derivatives containing a phosphonate, phosphoramide or phosphonic acid diester group. The rich chemistry, low cost and easy availability of diesters of H-phosphonic acid makes them an excellent choice as synthone in a number of practically important reactions.

Phosphonic acid esters are intermediates in the synthesis of important classes of compounds such as alpha-aminophosphonic acids, bisphosphonates, epoxyalkylphosphonates, alpha-hydroxyalkylphosphonates, phosphoramides, poly(alkylene H-phosphonate)s, poly(alkylene phosphate)s, nucleoside H-phosphonates. The synthesis of each of these compound classes is reviewed in detail.

Alpha-Aminophosphonic acids are an important class of biologically active compounds, which have received an increasing amount of attention because they are considered to be structural analogues of the corresponding Alpha-amino acids. The utilities of alpha-aminophosphonates as peptide mimics, haptens of catalytic antibodies, enzyme inhibitors, inhibitors of cancers, tumours, viruses, antibiotics and pharmacologic agents are well documented. Alpha-Hydroxyalkanephosphonates are compounds of significant biological and medicinal applications. Dialkyl epoxyalkylphosphonates are of interest because of their use as intermediates in the synthesis of bioactive substances, and as modifiers of natural and synthetic polymers. Bisphosphonates are drugs that have been widely used in different bone diseases, and have recently been used successfully against many parasites. Poly(alkylene H-phosphonate)s andpoly(alkylene phosphate)s are promising, biodegradable, water soluble, new polymer-carriers of drugs. Nucleoside H-phosphonates seem to be the most attractive candidates as starting materials in the chemical synthesis of DNA and RNA fragments. The 5'-hydrogen phosphonate-3'-azido-2',3'-dideoxythimidine is one of the most significant anti-HIV prodrug, which is currently in clinical trials.

Chapters review the synthesis; physical and spectral properties (1H, 13C, 31P and 17O NMR data); characteristic reactions; important classes of compounds based on these esters of H-phosphonic acid; their application as physiologically active substances, flame retardants, catalysts, heat and light stabilizers, lubricants, scale inhibitors, polymer-carriers of drugs; preparation of H-phosphonate diesters and general procedures for conducting the most important reactions.
* provides ideas for the synthesis of phosphonates, phosphoramides and diesters of phosphonic acid (new phosphorus-containing compounds)
* reviews structure, spectra and biological activity of H-phosphonates and their derivatives
* examines new areas of application of phosphorus-containing compounds

This book introduces systematically the concept of weakly-bound complexes into the broad field of atmospheric sciences. To fill up the gap between our rapidly expanding knowledge of the individual properties of Van der Waals and hydrogen-bonded molecules, and our understanding of their role in the atmospheric processes, an ensemble of related topics are covered by a team of expert co-authors. The general properties of the weakly bound molecular complexes (or "clusters") are discussed, as well as their distribution in the planetary atmospheres. Collision-induced and dimeric absorption and emission are considered in the context of atmospheric spectroscopy. The advanced experimental techniques which enable us to study the spectroscopic features of molecular complexes in the gas phase, or which are adsorbed, are reviewed. The role of molecular complexes in the cometary atmosphere, the Earth mesosphere, and the atmospheres of the giant planets and some of their satellites are also discussed in detail.

Significant progress has been made in the study of three-dimensional quantitative structure-activity relationships (3D QSAR) since the first publication by Richard Cramer in 1988 and the first volume in the series, 3D QSAR in Drug Design. Theory, Methods and Applications, published in 1993. The aim of that early book was to contribute to the understanding and the further application of CoMFA and related approaches and to facilitate the appropriate use of these methods. Since then, hundreds of papers have appeared using the quickly developing techniques of both 3D QSAR and computational sciences to study a broad variety of biological problems. Again the editor(s) felt that the time had come to solicit reviews on published and new viewpoints to document the state of the art of 3D QSAR in its broadest definition and to provide visions of where new techniques will emerge or new appli- tions may be found. The intention is not only to highlight new ideas but also to show the shortcomings, inaccuracies, and abuses of the methods. We hope this book will enable others to separate trivial from visionary approaches and me-too methodology from in- vative techniques. These concerns guided our choice of contributors. To our delight, our call for papers elicited a great many manuscripts.

Hardbound. Eminent scientists at the cutting edge of pharmacology and medicinal chemistry research provide us with yet another excellent addition to this famous series. The focus on bacterial resistance mechanisms serves to highlight an important area of unmet medical need requiring the attention of medicinal chemists.Five topical subjects are reviewed: the biosynthesis, metabolism and function of Vitamin D3 and the potential application of its analogues in bone disorders and immune-related diseases; the therapeutic potential of neurokinin antagonists; opioid receptor antagonists; the mechanisms of bacterial resistance; and a survey of recent advances in cannabinoid research.This volume will deservedly take its place in clinical and industrial pharmaceutical libraries, and will prove invaluable to medicinal chemists.

Enhanced with new problems and applications, the Fourth Edition of CHEMISTRY FOR ENGINEERING STUDENTS provides a concise, thorough, and relevant introduction to chemistry that prepares you for further study in any engineering field. Updated with new conceptual understanding questions and applications specifically geared toward engineering, the book emphasizes the connection between molecular properties and observable physical properties and the connections between chemistry and other subjects such as mathematics and physics.

The editors wish to thank the European Science Foundation for its support of the programme on the Evolution of Chemistry in Europe, 1789-1939, as well as for sponsoring the publication of this volume. Through the subdivision of this initiative that deals specifically with chemical industry it has been possible for historians of science, technology, business and economics to share often widely differing viewpoints and develop consensus across disciplinary and cultural boundaries. The contents of this volume are based on the third of three workshops that have considered the emergence of the modern European chemical industry prior to 1939, the first held in Liege (1994), the second in Maastricht (1995), and the third in Strasbourg (1996). All contributors and participants are thanked for their participation in often lively and informative debates. The generous hospitality of the European Science Foundation and its staff in Strasbourg is gratefully acknowledged. Introduction Emerging chemical knowledge and the development of chemical industry, and particularly the interaction between them, offer rich fields of study for the historian. This is reflected in the contents of the three workshops dealing with the emergence of chemical industry held under the aegis of the European Science Foundation's Evolution of Chemistry in Europe, 1789-1939, programme. The first workshop focused mainly on science for industry, 1789- 1850, and the second on the two-way traffic between science and industry, 1850-1914. The third workshop, dealing with the period 1900-1939, covers similar issues, but within different, and wider, contexts.

Emerging disciplines in the border zone between physics and chemistry have 1 attracted the attention of historians of science particularly in the last 20 years. 2 Quantum chemistry, as an offshoot of theoretical chemistry, has recently acquired 3 some importance in the history of chemistry. It is the product of close 1 Cf. Hiebert, E. : Discipline Identi cation in Chemistry and Physics, in: Science in Context, 9(2) (1996), 93-119; Nye, M. J. : Physics and Chemistry: Commensurate or Incommensurate Sciences? in: The Invention of Physical Science, Intersections of Mathematics, Theology and Natural Philosophy since the Seventeenth Century - Essays in Honor of Erwin N. Hiebert. Kluwer Academic Publishers, Dordrecht 1992; From Chemical Philosophy to Theoretical Chemistry: Dynamics of Matter and Dynamics of Disciplines, 1800-1950. University of California Press, Berkeley 1994; Servos, J. W. : Physical Chemistry from Ostwald to Pauling, the Making of a Science in America. Princeton University Press, New Jersey 1990; Chemical Sciences in the 20th Century: Bridging Boundaries, edited by Carsten Reinhard. Wiley-VCH, Weinheim 2001 (incl. a comprehensive bibliography). 2 In an earlier article I point out that the term "quantum chemistry" [Quantenchemie] rst appeared in 1929. To my knowledge it was coined by the physicist Arthur Haas. Talks he had del- ered before the Viennese Chemico-Physical Society in the spring of 1929 are assembled in his book: Die Grundlagen der Quantenchemie: Eine Einleitung in vier Vortrage. It was published by the Akademische Verlagsgesellschaft in Leipzig.