The Chemistry of Heterocyclic Compounds, since its inception, has been recognized as a cornerstone of heterocyclic chemistry. Each volume attempts to discuss all aspects - properties, synthesis, reactions, physiological and industrial significance - of a specific ring system. To keep the series up-to-date, supplementary volumes covering the recent literature on each individual ring system have been published. Many ring systems (such as pyridines and oxazoles) are treated in distinct books, each consisting of separate volumes or parts dealing with different individual topics. With all authors are recognized authorities, the Chemistry of Heterocyclic Chemistry is considered worldwide as the indispensable resource for organic, bioorganic, and medicinal chemists.

H4 R is the newest member of the histamine receptor family, which was discovered about twelve years ago. It is considered a very promising drug target. The effort to improve the pharmacokinetic properties of the currently available H4 R ligands is reflected in a steadily growing number of scientific publications and patent applications. Preclinical data strongly confirms the need for novel potent H4 R ligands to explore their therapeutic value in allergy, inflammation, autoimmune disorders, and possibly, cancer. Readers will be provided with extensive knowledge on histamine metabolism, as well as cellular histamine transport, storage and release, effects of histamine and histamine receptor ligands, with particular attention to the H4 R, on inflammatory cells including mast cells, basophils, eosinophils, neutrophils, macrophages, dendritic cells, and T cells. The present knowledge on the regulatory role of histamine and the therapeutic exploitation of histamine receptor ligands in atopic diseases, with emphasis on human and animal models of asthma, allergic dermatitis and pruritus are discussed.

The Chemistry of Heterocyclic Compounds, since its inception, has been recognized as a cornerstone of heterocyclic chemistry. Each volume attempts to discuss all aspects - properties, synthesis, reactions, physiological and industrial significance - of a specific ring system. To keep the series up-to-date, supplementary volumes covering the recent literature on each individual ring system have been published. Many ring systems (such as pyridines and oxazoles) are treated in distinct books, each consisting of separate volumes or parts dealing with different individual topics. With all authors are recognized authorities, the Chemistry of Heterocyclic Chemistry is considered worldwide as the indispensable resource for organic, bioorganic, and medicinal chemists.

The Chemistry of Heterocyclic Compounds, since its inception, has been recognized as a cornerstone of heterocyclic chemistry. Each volume attempts to discuss all aspects - properties, synthesis, reactions, physiological and industrial significance - of a specific ring system. To keep the series up-to-date, supplementary volumes covering the recent literature on each individual ring system have been published. Many ring systems (such as pyridines and oxazoles) are treated in distinct books, each consisting of separate volumes or parts dealing with different individual topics. With all authors are recognized authorities, the Chemistry of Heterocyclic Chemistry is considered worldwide as the indispensable resource for organic, bioorganic, and medicinal chemists.

Chemicals, both helpful and harmful, affect our everyday lives. From cosmetics to medications to cleansers to lighting, automotive, and office products, each is composed of a complex blending of elements to perform a specific task. This book analyzes over 100 groups of products, identifying the specific chemical composition of a product, its historical use, how it functions, and any associated environmental and/or human health issues. Ten laboratory exercises provide students with the opportunity to observe these chemicals in action. Readers will learn which chemical elements are in everyday products and how they may affect health and environment, assisting them in making educated choices as consumers. Chemicals, both helpful and harmful, affect our everyday lives. From cosmetics to medications to cleansers to lighting, automotive, and office products, each is composed of a complex blending of elements to perform a specific task. This book analyzes over 100 groups of products, identifying the specific chemical composition of a product, the historical use of the product, how it functions, and any associated environmental and/or human health issues. Ten laboratory exercises provide students with the opportunity to observe these chemicals in action. Readers will learn which chemical elements are in everyday products and how they may affect health and environment, assisting them in making educated choices as consumers. Products analyzed include: Soaps and laundry products; cosmetics and bathroom products; health and medical products; baby products; cleaning products; lighting; common household and lawn products; automotive and general repair products; common materials [paper, plastic cement, spray paint] and office supply products.

Uniting the key organic topics of total synthesis and efficient synthetic methodologies, this book clearly overviews synthetic strategies and tactics applied in total synthesis, demonstrating how the total synthesis of natural products enables scientific and drug discovery. Focuses on efficiency, a fundamental and important issue in natural products synthesis that makes natural product synthesis a powerful tool in biological and pharmaceutical science Describes new methods like organocatalysis, multicomponent and cascade reactions, and biomimetic synthesis Appeals to graduate students with two sections at the end of each chapter illustrating key reactions, strategies, tactics, and concepts; and good but unfinished total synthesis (synthesis of core structure) before the last section Compiles examples of solid phase synthesis and continuing flow chemistry-based total synthesis which are very relevant and attractive to industry R&D professionals

Cellulose nanocrystals are being used more frequently as processing and nanofabrication techniques have advanced considerably. Cellulose Nanocrystals includes topics including Extraction and Fabrication Methodologies, Scale-Up Strategies and Life Cycle Assessment, Surface Modification Strategies, Nanocomposites, and Characterization and Testing Protocols. This book will appeal to physical, chemical and biological scientists as well as engineers.

This book contains 959 cosmetic and toiletry formulations, based on information received from numerous industrial companies and other organizations. This is Volume 4 of the Second Edition of this work; Volume 1 was published in 1989, Volume 2 in 1992, and Volume 3 in early 1995. There are no duplications in any of these volumes.

The data represent selections from manufacturers' descriptions made at no cost to, nor influence from, the makers or distributors of these materials. Only the most recent formulas have been included. It is believed that all of the trademarked raw materials listed are currently available, which will be of interest to readers concerned with raw material discontinuances.

The cosmetic and toiletry raw materials market is projected to increase to close to $2.0 billion in 1995. The information in this book will be of particular interest to anyone considering new products or process variations. Each formulation in the book is identified by a description of end use. The formulations include the following as available, in the manufacturer's own words: a listing of each raw material contained; the percent by weight of each raw material; suggested formulation procedure; and the formula source, which is the company or organization that supplied the formula.

Each formula is indexed in the section that is most applicable. The reader seeking a formula for a specific end use should check each section, which could possibly apply.

The formulations in the book are divided into twelve categories as shown below. In addition, a valuable section on Trade-Named Raw Materials is included, which lists trade names, a brief chemical description, and the supplier's name. Thefinal section contains Suppliers' Addresses and will no doubt be a useful tool to the reader.

Section titles are listed below. Parenthetic numbers indicate the number of formulations per topic.

Personal protective equipment (PPE) is critical for those dealing with toxic, infectious, and radioactive materials. An easily accessible guide for professionals and researchers in all PPE fields, this book takes a fresh look at how PPE is designed, selected, and used in today's emergency response environment where users may need to be protected against deliberately used chemical, biological, or radiological agents in terrorism or warfare scenarios as well as more traditional hazards. Covering the physics, chemistry, and physiology of these hazards, the book explains how PPE protects from various forms of hazards as well as how to use this information to select PPE against these highly hazardous substances for first responder or military users. The design of PPE and components plus relevant performance and evaluation standards are also discussed.

How can students, teachers, parents, and librarians be certain that the information a Web site provides is accurate and age appropriate? In this unique book, experienced science educator Judith A. Bazler reviews hundreds of the most reliable chemistry-related Web sites. Each review discusses the most appropriate grade level of the site, analyzes its accuracy and usefulness, and provides helpful hints for getting the most out of the resource. The Web is the first place many students look for information. Yet the Web is notoriously unreliable. How can students, teachers, parents, and librarians be certain that the information a Web site provides is accurate and age appropriate? In this unique book, experienced science educator Judith A. Bazler reviews hundreds of the most reliable chemistry-related Web sites. Each review discusses the most appropriate grade level of the site, analyzes its accuracy and usefulness, and provides helpful hints for getting the most out of the resource. Sites are organized by topic, from Acids to Thermodynamics, making it easy to locate the most useful sites. A handy summary presents the best places on the Web to find information on science museums, science centers, careers in chemistry, and chemistry supplies.

Dusty Plasmas Physics, Chemistry and Technological Impacts in Plasma Processing Edited by Andr? Bouchoule Universit? d'Orl?ans, France Dusty Plasmas gives the reader a thorough overview of current knowledge on many aspects of the subject, from the basic science to technological implications. The basic physics and chemistry of dusty plasmas developed in the first two chapters are complemented by the more practical considerations of diagnostics and technological implications in the two final chapters. The book will be of interest to those already involved in or just discovering dusty plasmas in their research and/or industrial activity.
* Physics and Modelling of Dusty Plasmas
* Sources and Growth of Particles
* Diagnostics of a Dusty Plasma
* Technological Impacts of Dusty Plasmas

QUALITY PLANNING AND ASSURANCE Discover the most crucial aspects of quality systems planning critical to manufacturing and service success In Quality Planning and Assurance: Principles, Approaches, and Methods for Product and Service Development, accomplished engineer Dr. Herman Tang delivers an incisive presentation of the principles of quality systems planning. The book begins with an introduction to the meaning of the word "quality" before moving on to review the principles of quality strategy and policy management. The author then offers a detailed discussion of customer needs and the corresponding quality planning tasks in design phases, as well as a treatment of the design processes necessary to ensure product or service quality. Readers will enjoy explorations of advanced topics related to proactive approaches to quality management, like failure modes and effects analysis (FMEA). They ll discover discussions of issues like supplier quality management and the key processes associated with quality planning and execution. The book also includes: A thorough introduction to quality planning, including definitions, discussions of quality system, and an overview of the planning process A comprehensive exploration of strategic planning development, including strategic management, risk management and analysis, and pull and push strategies Practical discussions of customer-centric planning, including customer-oriented design, quality function deployment, and affective engineering In-depth examinations of quality assurance by design, including the design review process, design verification and validation, and concurrent engineering Perfect for senior undergraduate and graduate students in technology and management programs, Quality Planning and Assurance will also earn a place in the libraries of managers and technical specialists in a wide range of fields, including quality management.

Establishes sound safety management principles and focuses on the revised Z10.0 safety standard, the new 45001 safety standard, and serious injury prevention Filled with updated chapters and information throughout, this book covers the provisions of ANSI/ASSP Z10.0-2019, the American standard for Occupational Health and Safety Management Systems. It expands in detail on the principles for advanced safety management, the content of the revised Z10.0 standard, and the newly adopted international standard, ISO 45001. It also emphasizes the need to reduce the occurrence of serious injuries, illnesses, and fatalities. Advanced Safety Management: Focusing on Z10.0, 45001 and Serious Injury Prevention, Third Edition expands on the material in previous editions and includes several new chapters emphasizing culture, systems design, and incident investigations. Beginning with an overview of ANSI/ASSP Z10.0-2019 and ANSI/ASSP/ISO 45001-2018, it goes on to offer chapters on: Essentials for the Practice of Safety; Human Error Avoidance; Hazards Analyses and Risk Assessments; Three- and Four-Dimensional Risk Scoring Systems; Safety Design Reviews; The Procurement Process; Audit Requirements; The Management Oversight and Risk Tree (MORT); and more. Expands in detail on the principles for advanced safety management, the content of the revised ANSI/ASSP Z10.0. standard and the newly adopted international standard, ISO 45001 New chapters cover the Significance of An Organization's Culture; Fundamental Concepts; and Systems/Macro Thinking Places emphasis on the more prominent risk-based approach in the practice of safety Provides methods to align safety, operational, and financial goals, along with quality and environmental standards Explains the concepts of risk reduction, waste reduction, environmental impact deduction, and Prevention through Design (PtD) Advanced Safety Management is an important book for safety professionals, industrial hygienist, plant managers, OSHA and EPA advocates, students majoring in safety or industrial hygiene, and union leaders.

The definitive guide to creating fluorine-based compounds and the materials of tomorrow Discovered as an element by the French chemist Henri Moissan in 1886, through electrolysis of potassium fluoride in anhydrous hydrogen fluoride "le fluor," or fluorine, began its chemical history as a substance both elusive and dangerous. With a slight pale yellow hue, fluorine is at room temperature a poisonous diatomic gas. Resembling a spirit from a chemical netherworld, fluorine is highly reactive, difficult to handle, yet very versatile as a reagent with the power to form compounds with almost any other element. Comprising 20% of pharmaceutical products and 30% of agrochemical compounds, as well as playing a key role in electric cars, electronic devices, and space technology, compounds containing fluorine have grown in importance across the globe. Learning how to safely handle fluorine in the preparation of innovative new materials with valuable new properties is of critical importance to chemists today. Bringing together the research and methods of leading scientists in the fluorine field, Efficient Preparations of Fluorine Compounds is the definitive manual to creating, and understanding the reaction mechanisms integral to a wide variety of fluorine compounds. With sixty-eight contributed chapters, the book's extensive coverage includes: * Preparation of Elemental Fluorine * Synthesis Methods for Exotic Inorganic Fluorides with Varied Applications * Introduction of Fluorine into Compounds via Electrophilic and Nucleophilic Reactions * Direct Fluorination of Organic Compounds with Elemental Fluorine * Efficient Preparations of Bioorganic Fluorine Compounds * Asymmetric Fluorocyclization Reactions * Preparations of Rare Earth Fluorosulfides and Oxyfluorosulfides The book offers methods and results that can be reproduced by students involved in advanced studies, as well as practicing chemists, pharmaceutical scientists, biologists, and environmental researchers. The only chemical resource of its kind, Efficient Preparations of Fluorine Compounds from its first experiment to its last is a unique window into the centuries old science of fluorine and the limitless universe of fluorine-based compounds.

Supercritical fluids behave either like a gas or a liquid, depending on the values of thermodynamic properties. This tuning of properties, and other advantageous properties of supercritical fluids led to innovative technologies. More than 100 plants of production size are now in operation worldwide in the areas of process and production technology, environmental applications, and particle engineering. New processes are under research and development in various fields.

This book provides an overview of the research activities in the field of Supercritical Fluids in Germany. It is based on the research program "Supercritical fluids as solvents and reaction media" on the initiative of the "GVC-Fachausschu Hochdruckverfahrenstechnik" (i.e. the German working party on High Pressure Chemical Engineering of the Society of Chemical Engineers).

This research program provided an immensely valuable platform for exchange of knowledge and experience. More than 50 young researchers were involved contributing with their expertise, their new ideas, and the motivation of youth. The results of this innovative research are described in this book.
- This book provides an overview of the research activities in the field of Supercritical Fluids in Germany
- Contains results of projects within the research program on "Supercritical fluids as solvents and reaction media" on the initiative of the German working party on High Pressure Chemical Engineering of the Society of Chemical Engineers.
- More than 50 young researchers were involved in contributing with their expertise, their new ideas, and the motivation of youth.