Arthur Conan Doyle's enduringly popular Sherlock Holmes has his own undeniable place in the public eye. Holmes is often seen applying concepts of some branch of science in his work, discussing scientific matters with Watson, or is involved in situations where the applicability of the formal sciences is apparent. The Scientific Sherlock Holmes connects Holmes' vegetable poisons with concepts in botany, his use of fingerprinting with forensic science, and carbon monoxide poisoning and hemoglobin tests with concepts in chemistry, thus integrating the Holmes stories with all branches of science.

CARBON MONOXIDE IN DRUG DISCOVERY An insightful reference for the latest physiological and therapeutic studies of carbon monoxide In Carbon Monoxide in Drug Discovery: Basics, Pharmacology, and Therapeutic Potential, a team of distinguished authors delivers foundational knowledge, the latest research, and remaining challenges regarding the physiological roles and therapeutic efficacy of carbon monoxide (CO). The editors have included a broad selection of resources from leading experts in the field that discuss the background and physiological roles of CO, a variety of delivery forms including CO prodrugs using benign carriers, CO sensing, therapeutic applications, and clinical trials. Organized by topic to allow each chapter to be read individually, the book covers a wide range of topics, from physiological and patho-physiological mechanisms at the molecular level to clinical applications for multiple disease processes. The editors of Carbon Monoxide in Drug Discovery have created a compelling argument for shifting the accepted understanding of CO from poison to bioactive molecule with enormous clinical benefits. Readers will also benefit from: A thorough introduction to the background and physiological actions of carbon monoxide, including endogenous CO production in sickness and in health Comprehensive explorations of CO delivery forms, including non-carrier formulations, metal-carbonyl complexes, and organic CO donors Practical discussions of carbon monoxide sensing and scavenging, including fluorescent probes for intracellular carbon monoxide detection In-depth examinations of the therapeutic applications of CO, including CO in solid organ transplantation Perfect for professors, graduate students, and postdocs in the fields of biology, pharmacology, immunology, medicinal chemistry, toxicology, and drug delivery, Carbon Monoxide in Drug Discovery: Basics, Pharmacology, and Therapeutic Potential is also an invaluable resource for industrial scientists in these areas.

"General Chemistry for Engineers" is tailored for a one-semester freshman-level college course for students pursuing engineering degrees. The book offers a balance of conciseness, rigor, and depth needed to prepare students for more advanced coursework and careers in various engineering specialties, such as civil, environmental, electrical, computer, mechanical and industrial engineering, in addition to chemical engineering.
This text leads students through the breadth of a typical two-semester sequence in general chemistry. It elucidates the key concepts and skills important for entering engineering students, including problem solving, qualitative and quantitative thinking, and importance of units. Examples are drawn from problems of interest to modern engineers, including alternative energy, advanced materials, and the environment. The book is the result of the author's unique experiences teaching approximately 2,500 freshman in chemistry and upper-level students in chemical and biological engineering, in addition to leading research and development teaching in the medical device and specialty pharmaceutical industries. The author received a variety of teaching awards at Northeastern honoring his work in making an intense, fast-pace course manageable and exciting.
Paul A. DiMilla is an Associate Academic Specialist in Chemistry & Chemical Biology and Chemical Engineering at Northeastern University. He received his B.S. from the Massachusetts Institute of Technology and his Ph.D. from the University of Pennsylvania, both in Chemical Engineering. He was a Postdoctoral Fellow in Chemistry at Harvard University prior to beginning his faculty career in Chemical and Biomedical Engineering at Carnegie Mellon University, where he co-founded Automated Cell, Inc.
Paul was a Visiting Professor of Bioengineering at the Franklin W. Olin College of Engineering and a Visiting Scholar in Biomedical Engineering at Boston University. Additionally, he led R&D teams in the private sector, developing tissue-engineered medical products and drug- generating biodegradable polymers. He received an Early Career Development Award from the NSF, a Searle Scholar Award, and the first Whitaker Young Investigator Award. He is also the inventor on seven issued US patents.

Annual Reports in Computational Chemistry provides timely and critical reviews of important topics in computational chemistry as applied to all chemical disciplines. Topics covered include quantum chemistry, molecular mechanics, force fields, chemical education, and applications in academic and industrial settings. Focusing on the most recent literature and advances in the field, each article covers a specific topic of importance to computational chemists.
* Broad coverage of computational chemistry and up-to-date information
* Each chapter reviews the most recent literature on a specific topic of interest to computational chemists