Annual Reports in Medicinal Chemistry, Volume 57 in this long-running series, highlights new advances in the field with this new volume presenting interesting chapters on the Mechanism of action of the broadly acting antiviral drug remdesivir, Improving properties of the nucleobase analogue T-706 as a potential anti-SARS-CoV-2 and anti-influenza compound, Antivirals for RNA virus infections Anno 2020-2021, Broad spectrum antiviral fleximer nucleosides, SARS-CoV-2 main protease inhibitors, The search for antivirals to treat alphavirus infections, Inhibitors of Ebola Virus targeting Innate immune evasion, Uracil derivatives as non-nucleoside inhibitors of viral infections, and more.

Advances in Remediation Techniques for Polluted Soils and Groundwater focuses on the thematic areas for assessment, mitigation, and management of polluted sites. This book covers advances in modelling approaches, including Machine Learning (ML)/ Artificial Intelligence (AI) applications; GIS and remote sensing; sensors; impacts of climate change on geogenic contaminants; and socio-economic impacts in the poor rural and urban areas, which are lacking in a more comprehensive manner in the previous titles. This book encompasses updated information as well as future directions for researchers working in the field of management and remediation of polluted sites.

Environmental Systems Science: Theory and Practical Applications looks at pollution and environmental quality from a systems perspective. Credible human and ecological risk estimation and prediction methods are described, including life cycle assessment, feasibility studies, pollution control decision tools, and approaches to determine adverse outcome pathways, fate and transport, sampling and analysis, and cost-effectiveness. The book brings translational science to environmental quality, applying groundbreaking methodologies like informatics, data mining, and applications of secondary data systems. Multiple human and ecological variables are introduced and integrated to support calculations that aid environmental and public health decision making. The book bridges the perspectives of scientists, engineers, and other professionals working in numerous environmental and public health fields addressing problems like toxic substances, deforestation, climate change, and loss of biological diversity, recommending sustainable solutions to these and other seemingly intractable environmental problems. The causal agents discussed include physical, chemical, and biological agents, such as per- and polyfluoroalkyl substances (PFAS), SARS-CoV-2 (the COVID-19 virus), and other emerging contaminants.

Annual Report on Medicinal Chemistry series, highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

Sample Return Missions: The Last Frontier of Solar System Exploration examines the discoveries and results obtained from sample return missions of the past, present, and future. It analyses the results in the context of the current state of knowledge and their relation to the formation and evolution of planetary bodies, as well as to the available technologies and techniques. It provides detailed descriptions of experimental procedures applied to returned samples. Beginning with an overview of previous missions, Sample Return Missions then goes on to provide an overview of facilities throughout the world used to analyze the returned samples. Finally, it addresses techniques for collection, transport, and analysis of the samples, with an additional focus on lessons learned and future perspectives. Providing an in-depth examination of a variety of missions, with both scientific and engineering implications, this book is an important resource for the planetary science community, as well as the experimentalist and engineering communities.