Some of the more recent efforts in tuberculosis (TB) and trypanosomiasis drug discovery from both Product Development Partnerships (PDPs) and academia are highlighted in this this volume. Drug discovery approaches include both target- and phenotypic whole cell screening- approaches. Regarding the latter, mechanism of action studies through target identification are also illustrated.

Genomic and Epigenomic Biomarkers of Toxicology and Disease The latest developments in biomarker research applicable to toxicology and medicine Research on genomic and epigenomic biomarkers is developing rapidly with cutting-edge studies scattered throughout the academic literature, making the status of ongoing scientific activity in this area difficult to ascertain. Genomic and Epigenomic Biomarkers of Toxicology and Disease: Clinical and Therapeutic Actions delivers a comprehensive and authoritative compilation of up-to-date developments in the application of genomic and epigenomic biomarkers to toxicology, disease prevention, cancer detection, therapeutics, gene therapy, and other areas. With contributions from a collection of internationally recognized investigators, this edited volume offers unique insights into current trends and future directions of research in the discussed areas. Combining state-of-the-art information on genomic and epigenomic biomarkers from a range of specialists from around the world, this monograph includes: A thorough introduction to microRNAs as non-invasive biomarkers of toxicity and chemical hazard Comprehensive explorations of extracellular vesicle-associated miRNAs as toxic biomarkers, as well as transcriptomic applications in toxicology and medicine Practical discussions of circulating miRNAs as biomarkers of metal exposure, as well as microRNAs biomarkers of malignant mesothelioma In-depth examinations of the role of noncoding RNAs in innate immune responses perturbed by environmental arsenic with a focus on microRNAs Perfect for researchers, toxicologists, risk assessors, and regulators, Genomic and Epigenomic Biomarkers of Toxicology and Disease: Clinical and Therapeutic Actions will also earn a place in the libraries of graduate students with an interest in biomarkers, toxicology, agriculture, or the environment.

Dynamic Response of Advanced Ceramics Discover fundamental concepts and recent advances in experimental, analytical, and computational research into the dynamic behavior of ceramics In Dynamic Response of Advanced Ceramics, an accomplished team of internationally renowned researchers delivers a comprehensive exploration of foundational and advanced concepts in experimental, analytical, and computational aspects of the dynamic behavior of advanced structural ceramics and transparent materials. The book discusses new techniques used for determination of dynamic hardness and dynamic fracture toughness, as well as edge-on-impact experiments for imaging evolving damage patterns at high impact velocities. The authors also include descriptions of the dynamic deformation behavior of icosahedral ceramics and the dynamic behavior of several transparent materials, like chemically strengthened glass and glass ceramics. The developments discussed within the book have applications in everything from high-speed machining to cutting, grinding, and blast protection. Readers will also benefit from a presentation of emerging trends and directions in research on this subject as well as current challenges in experimental and computational domains, including: An introduction to the history of ceramic materials and their dynamic behavior, including examples of material response to high-strain-rate loading An exploration of high-strain-rate experimental techniques, like 1D elastic stress-wave propagation techniques, shock waves, and impact testing Discussions of the static and dynamic responses of ceramics and the shock response of brittle solids An overview of deformation mechanisms during projectile impact on a confined ceramic, including damage evolution during the nonpenetration and penetration phases. Perfect for researchers, scientists, and engineers working on ballistic impact and shock response of brittle materials, Dynamic Response of Advanced Ceramics will also earn a place in the libraries of industry personnel studying impact-resistant solutions for a variety of applications.

This book is a collection of essays, written by an international group of historians of chemistry, about some of the most interesting chemists dating back into the 18th century. The contributing authors are well-established biographers, and their subjects make a diverse cast of chemistry characters. Among the chemists covered are Robert Bunsen, Joseph Black, John Dalton, Lucretia Borgia, William Crookes, and Humphry Davy. These chemists come from all over the world, and from different eras. Together, this collection truly is a celebration of the wide range of personalities and characters that have worked in chemistry over the centuries.

In diesem Werk werden Moeglichkeiten der Wirkstoffverabreichung dargestellt, wobei physikalische und pharmakokinetische Modelle zur Erzielung der gewunschten Profile und Ansatze herangezogen werden. Nach einem UEberblick uber die Wirkstoffaufnahme und die physiologischen Modelle werden in den Kapiteln uber die oralen Verabreichungswege (die haufigste Form der Verabreichung) die PBPK und verschiedene moegliche Darreichungsformen beschrieben. Bei der systemischen transdermalen Verabreichung ist es notwendig, die Pharmakokinetik der Formulierung und des Wirkstoffs zu verstehen, um die Formulierung von der ersten Konzeption uber die gesamte Entwicklung darauf auszurichten. In weiteren Kapiteln werden die biologischen und praktischen Ansatze bei der pulmonalen und mukosalen Verabreichung besprochen. Fur den Fall der Notfallversorgung betrachten die Autoren die Beziehung zwischen parenteralen Infusionsprofilen und PK/PD. In den letzten Kapiteln werden aktuelle Trends dargestellt, darunter virtuelle Experimente zur Verdeutlichung von Mechanismen sowie moderne Ansatze in der Wirkstoffverabreichung und personalisierten Medizin. Das Werk Drug Delivery Approaches: Perspectives from Pharmacokinetics and Pharmacodynamics eignet sich nicht nur perfekt fur Wissenschaftler, Forscher in der Industrie, Doktoranden und Postdoktoranden in den Bereichen der Pharmawissenschaft und Pharmatechnik, sondern verdient auch einen Platz in den Bucherregalen von Experten, die sich mit Formulierungen, Pharmakokinetik und klinischer Pharmakologie beschaftigen.