Annual Reports in Medicinal Chemistry, Volume 57 in this long-running series, highlights new advances in the field with this new volume presenting interesting chapters on the Mechanism of action of the broadly acting antiviral drug remdesivir, Improving properties of the nucleobase analogue T-706 as a potential anti-SARS-CoV-2 and anti-influenza compound, Antivirals for RNA virus infections Anno 2020-2021, Broad spectrum antiviral fleximer nucleosides, SARS-CoV-2 main protease inhibitors, The search for antivirals to treat alphavirus infections, Inhibitors of Ebola Virus targeting Innate immune evasion, Uracil derivatives as non-nucleoside inhibitors of viral infections, and more.

Advances in Remediation Techniques for Polluted Soils and Groundwater focuses on the thematic areas for assessment, mitigation, and management of polluted sites. This book covers advances in modelling approaches, including Machine Learning (ML)/ Artificial Intelligence (AI) applications; GIS and remote sensing; sensors; impacts of climate change on geogenic contaminants; and socio-economic impacts in the poor rural and urban areas, which are lacking in a more comprehensive manner in the previous titles. This book encompasses updated information as well as future directions for researchers working in the field of management and remediation of polluted sites.

Environmental Systems Science: Theory and Practical Applications looks at pollution and environmental quality from a systems perspective. Credible human and ecological risk estimation and prediction methods are described, including life cycle assessment, feasibility studies, pollution control decision tools, and approaches to determine adverse outcome pathways, fate and transport, sampling and analysis, and cost-effectiveness. The book brings translational science to environmental quality, applying groundbreaking methodologies like informatics, data mining, and applications of secondary data systems. Multiple human and ecological variables are introduced and integrated to support calculations that aid environmental and public health decision making. The book bridges the perspectives of scientists, engineers, and other professionals working in numerous environmental and public health fields addressing problems like toxic substances, deforestation, climate change, and loss of biological diversity, recommending sustainable solutions to these and other seemingly intractable environmental problems. The causal agents discussed include physical, chemical, and biological agents, such as per- and polyfluoroalkyl substances (PFAS), SARS-CoV-2 (the COVID-19 virus), and other emerging contaminants.

Annual Report on Medicinal Chemistry series, highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

Organic Reaction Mechanisms 2018, the 54th annual volume in this highly successful and unique series, surveys research on organic reaction mechanisms described in the available literature dated 2018. The following classes of organic reaction mechanisms are comprehensively reviewed: Reaction of Aldehydes and Ketones and their Derivatives Reactions of Carboxylic, Phosphoric, and Sulfonic Acids and their Derivatives Oxidation and Reduction Carbenes and Nitrenes Nucleophilic Aromatic Substitution Electrophilic Aromatic Substitution Carbocations Nucleophilic Aliphatic Substitution Carbanions and Electrophilic Aliphatic Substitution Elimination Reactions Polar Addition Reactions Cycloaddition Reactions Molecular Rearrangements Transition Metal Coupling Radical Reactions An experienced team of authors compile these reviews every year, so that the reader can rely on a continuing quality of selection and presentation.

Sample Return Missions: The Last Frontier of Solar System Exploration examines the discoveries and results obtained from sample return missions of the past, present, and future. It analyses the results in the context of the current state of knowledge and their relation to the formation and evolution of planetary bodies, as well as to the available technologies and techniques. It provides detailed descriptions of experimental procedures applied to returned samples. Beginning with an overview of previous missions, Sample Return Missions then goes on to provide an overview of facilities throughout the world used to analyze the returned samples. Finally, it addresses techniques for collection, transport, and analysis of the samples, with an additional focus on lessons learned and future perspectives. Providing an in-depth examination of a variety of missions, with both scientific and engineering implications, this book is an important resource for the planetary science community, as well as the experimentalist and engineering communities.

Developed for the new International A Level specification, these new resources are specifically designed for international students, with a strong focus on progression, recognition and transferable skills, allowing learning in a local context to a global standard. Recognised by universities worldwide and fully comparable to UK reformed GCE A levels. Supports a modular approach, in line with the specification. Appropriate international content puts learning in a real-world context, to a global standard, making it engaging and relevant for all learners. Reviewed by a language specialist to ensure materials are written in a clear and accessible style. The embedded transferable skills, needed for progression to higher education and employment, are signposted so students understand what skills they are developing and therefore go on to use these skills more effectively in the future. Exam practice provides opportunities to assess understanding and progress, so students can make the best progress they can.

The Microbiology of Nuclear Waste Disposal is a state-of-the-art reference featuring contributions focusing on the impact of microbes on the safe long-term disposal of nuclear waste. This book is the first to cover this important emerging topic, and is written for a wide audience encompassing regulators, implementers, academics, and other stakeholders. The book is also of interest to those working on the wider exploitation of the subsurface, such as bioremediation, carbon capture and storage, geothermal energy, and water quality. Planning for suitable facilities in the U.S., Europe, and Asia has been based mainly on knowledge from the geological and physical sciences. However, recent studies have shown that microbial life can proliferate in the inhospitable environments associated with radioactive waste disposal, and can control the long-term fate of nuclear materials. This can have beneficial and damaging impacts, which need to be quantified.