This volume provides an overview of the latency strategies developed during the estimated 200 Myears long coevolution of Alpha-, Beta- and Gammaherpesvirinae and their host species. The main emphasis is on herpesviruses infecting humans. However, relevant cases if herpesviruses infecting animals are covered as well. Special emphasis is drawn on results on molecular mechanisms regulating latent promoters of herpesvirus genomes and signals and molecular pathways resulting in reactivation of latent viral genomes. To balance the volume, epigenetic mechanisms (DNA methylation, histone modification, chromatin structure) involved in cell type specific expression of growth-transformation-associated Gammaherpesvirus genes will also be discussed at length)

In recent years nobody could have failed to notice the frequent and often sensati- alist media headlines warning of the latest global disease threat to humankind. But behind all the hyperbole lie real challenges related to dealing with the increasing incidence of emerging zoonotic disease events, the majority of which are thought to originate in wildlife (Jones et al. 2008). There are also many important diseases of domestic livestock which also occur in wildlife (e. g. foot and mouth disease and classical swine fever in wild boar, bovine tuberculosis in deer, badgers or possums), some of which can have a devastating impact on the farming industry, the wider rural economy and ultimately the public purse. But we should also not forget that wildlife diseases may have serious implications for the conservation of biodiversity. For some of the rarest, most endangered species (such as the Ethiopian wolf) d- ease may pose the greatest threat to their survival. If we are to avoid or reduce these impacts then we must improve our ability to detect and manage the risks associated with disease in wildlife populations. This is a challenge that will require expertise from many different disciplines: veterinary, ecological, medical, economic, poli- cal and zoological. In such an interdisciplinary field it is difficult to stay up to date with contemporary ideas and with techniques that may be rapidly evolving.

Safety of Meat and Processed Meat provides the reader with the recent developments in the safety of meat and processed meat, from the abattoir along the processing chain to the final product. To achieve this goal, the editor uses five approaches. The first part deals with the main biological contaminants like pathogen microorganisms, specially E. coli and L. monocytogenes, toxins and biogenic amines that can be present either in meat or its derived products. The second part focuses on main technologies for meat decontamination as well as developments like active packaging or bioprotective cultures to extend the shelf life. The third part presents non-biological contaminants and residues in meat and meat products including nitrosamines, PAH, veterinary drugs and environmental compounds. The fourth part discusses current methodologies for the detection of microorganisms, its toxins, veterinary drugs, environmental contaminants and GMOs, and the final part deals with predictive models, risk assessment, regulations on meat safety, consumer perception, and other recent trends in the field. This book is written by distinguished international contributors with excellent experience and reputation. In addition, brings together advances in different safety approaches.

As aquaculture continues to expand there is a need for greater knowledge of medicinal treatments both for the prevention and treatment of disease and for the economic husbandry of fish. This book, the first of its kind, is written for a worldwide readership. It is a reference manual for anyone involved in the selection of medicines for administration to fish. It will also be useful to administrators concerned with the legal control of aquaculture. The first part covers issues which affect all medicine's methods of administering drugs to fish, the various aspects of safety and the relevant legislation in countries with important aquacultural industries. Subsequent parts review the range of available medicinal substances and present current knowledge of the pharmacology and methods of use for each. Particular attention is given to safety issues - for the fish, for the person administering the medicine, for the consumer of medicated fish and for the environment.

Gonadotropin-releasing hormone (GnRH) cells are the key regulators of reproductive function in all vertebrate organisms. The GnRH molecule is synthesized in a small number of neurons in rostral hypothalamic regions of the brain. In mammals, these neurons release the GnRH decapeptide into the portal capillary system leading to the anterior pituitary gland. There, GnRH causes the release of the gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which in turn act upon the gonads to stimulate their maturation, and to cause synthesis of sex steroid hormones, estrogen, progesterone and testosterone. Although each of the levels of the hypothalamic-pituitary-gonadal axis is critical for reproductive function, GnRH neurons play the primary role in the control of reproductive maturation and adult reproductive function, and may even play a role in reproductive senescence.

Since its discovery in 1970, there has been intense interest in GnRH-producing neurons, with more than 8000 papers and chapters in the last decade alone. Despite this activity of research in basic and clinical science, there has never been a book written specifically on GnRH neurons. GnRH: The Master Molecule of Reproduction aims to bring together the large and diverse literature of both laboratory and applied research that focuses on these unique cells.

This book will provide basic background into reproductive neuroendocrinology, as well as specifics regarding the role of GnRH neurons in the control of reproduction. Students studying endocrinology, reproduction, neuroendocrinology or molecular endocrinology will benefit from this book. In addition, this book will take a multi-species approach which will be useful both to basic researchers as well as clinicians. Whenever possible, species differences and similarities will be presented, and if possible, studies on humans, or the clinical relevance of basic research findings to humans will be discussed (such as the treatment of reproductive disorders such as abnormalities in pubertal development, or infertility).

Animal welfare is attracting increasing interest worldwide, but particularly from those in developed countries, who now have the knowledge and resources to be able to improve the welfare of farm animals. The increased attention given to farm animal welfare in the West derives largely from the fact that the relentless pursuit of ?nancial reward and ef?ciency has led to the development of intensive animal production systems that disturb the conscience of many consumers. In developing countries, human survival is still a daily uncertainty, so that provision for animal welfare has to be balanced against human welfare. Welfare is usually provided for only if it supports the output of the animal, be it food, work, clothing, sport or companionship. In reality there are resources for all if they are properly husbanded in both developing and developed countries. The inequitable division of the world's riches creates physical and psychological poverty for humans and animals alike in many sectors of the world. Livestock are the world's biggest land user (FAO, 2002) and the population is increasing rapidly to meet the need of an expanding human population. Populations of farm animals managed by humans are therefore incre- ing worldwide, and in some regions there is a tendency to allocate fewer resources, such as labour, to each animal with potentially adverse consequences on the a- mals' welfare.

The domestic pig is perceived as an animal with intelligence and character and yet, in the industrialized world, the majority of people have had little or no contact with them. Pigs are subject to a wide range of environments from the tropics to the sub-arctic, ranging from small-scale, extensive systems to large-scale intensive systems. They may spend their whole life on one farm or may be subject to long-distance transport multiple times. Not surprisingly, many aspects of their life experiences can impact their welfare.

This book brings together a team of leading pig welfare research scientists to review the natural history of the pig, the welfare of pigs at different stages of life and to indicate what the future holds in terms of pig welfare. The text is aimed at researchers and teachers working in veterinary and animal science together with those working in the pig industry and for governmental and non-governmental animal welfare organizations.

Man's attempts to learn about aspects of the human body and its functions by observation and study of animals are to be found throughout history, especially at times and in cultures where the human body was considered sacrosanct, even after death. This book describes the origins and later development, especially in the eighteenth and nineteenth centuries, of comparative medicine and its interrelationship with medicine and veterinary medicine and the efforts of its practitioners to understand and control outbreaks of infectious, epidemic diseases in humans and in domestic animals. In the nineteenth century their efforts and increasing professionalism led to the creation of specialised institutes devoted to the study of comparative medicine. Paradoxically the first such institute, the Brown Institution, opened in London in 1871, despite the fact that the study of this branch of medicine in Britain had always lagged behind that in France and Germany. The book discusses the rise and fall of this centre and describes how it was soon overtaken in importance by the great institutes in Paris and Berlin and then, from the turn of the century, by American institutes, funded by private fortunes. This book sheds much new light on the medical and veterinary history of this period and will provide a new perspective on the history of bacteriology.

Veterinarians increasingly encounter wildlife casualties in practice and have a duty of care for the welfare of the animals. This comprehensive and easy-to-use self assessment book contains some 208 clinical cases with 325 illustrations. It has been compiled by authors with a wide range of experience and expertise in this area. Common conditions seen in wildlife species are covered with cases from Europe, North America, the Middle East and Australia. The selection of cases is presented randomly and covers scenarios relevant to most readers. The book is of value to veterinarians in practice and training and to all those working directly with wildlife who wish to expand their knowledge in this field.

Now in its third edition, Veterinary Hematology: Atlas of Common Domestic and Non-Domestic Species continues to offer veterinarians and veterinary technicians an essential guide to veterinary hematology. Comprehensive in scope, the atlas presents the fundamentals of both normal and abnormal blood cell morphologies, with coverage of a wide range of species, including dogs, cats, horses, ruminants, llamas, rats, mice, nonhuman primates, ferrets, rabbits, guinea pigs, birds, amphibians, and reptiles. Designed as a useful and accessible guide, the updated third edition presents more than 300 color images and includes a new chapter that describes the best techniques for using hematology instruments. The authors--noted experts on the topic--clearly show how to identify and interpret the hematological changes that may occur in a variety of species. In addition, a companion website offers a wealth of additional hematological images. This vital atlas: Provides an updated edition of the popular veterinary hematology atlas for veterinarians, veterinary students, and veterinary technicians Contains a new instructive chapter on hematology instrumentation Presents hundreds of high-quality color photographs that help in identification Covers a range of species from dogs and cats to birds and reptiles Features a companion website that provides a wealth of hematological images Written for both novice and experienced veterinarians, Veterinary Hematology provides a complete resource to blood morphologic abnormalities in domestic and non-domestic species.

A unique, case-based guide to diagnosing and treating a wide range of conditions encountered in canine internal medicine Canine Internal Medicine: What's Your Diagnosis? is an ideal guide to how internal medicine cases are handled in the clinical setting. This text is part of an exciting series, which combines problem-based learning, case studies, and questions and answers. Designed for veterinarians in practice and students, the series presents material in a format designed to enhance critical thinking and understanding. Adopting a case-based approach, chapters are built around body systems and are directed by questions to test the reader's ability to interpret clinical history, illustrative images and diagnostic results in order to provide differential diagnoses, diagnostic plans and treatment options. Common pitfalls in diagnosis and management are discussed, and you will benefit from the experience of the author as a busy and experienced clinician. An innovative and interesting way to increase knowledge and skills in canine internal medicine, Canine Internal Medicine: What's Your Diagnosis? is an indispensable resource for veterinary students, veterinarians in small animal practice, and those studying for post-graduate qualification in small animal medicine.

The devastating impacts of natural disasters not only directly affect humans and infrastructure, but also animals, which may be crucial to the livelihoods of many people. This book considers the needs of animals in the aftermath of disasters and explains the importance of looking to their welfare in extreme events. The authors explore how animals are affected by specific disaster types, what their emergency and subsequent welfare needs are and the appropriate interventions. They describe the key benefits of management of animals to populations and discuss preventative measures that can be taken to reduce risk and build resilience. They also include a summary of recent debates and public policy advances on animals in disasters. The book covers livestock, companion and wild animals, with case studies to show how the concepts can be put into practice. It provides a standalone text for students of disaster studies and management as well as professionals and NGOs who require an entry-level introduction to the subject.

This is the first guide to Veterinary Narrative Medicine, a cutting-edge approach in human medicine with multiple applications in veterinary medicine. The text combines the latest research with numerous real-world examples and practical techniques to improve client communication, patient care, and veterinary well-being. Narrative Medicine maintains that a patient should be viewed as an individual rather than an example of a disease process, and that this can be accomplished by using narrative. This book explores methods and theories from leaders in the human Narrative Medicine field while addressing topics unique to veterinary medicine. Readers will gain tools to help navigate difficult conversations and situations in clinical practice, including those involving the end of life. Narrative Medicine in Veterinary Practice also addresses the important issue of veterinary wellness. The ability to view the veterinarian's own stories and those of clients and patients as narratives may help practitioners maintain both emotional and work-place boundaries as well as decrease burnout and compassion fatigue. The book describes basic techniques to promote self-reflection and mindfulness, skills often overlooked in the veterinary profession which can improve resilience and increase the enjoyment of veterinary practice. This is important reading for veterinary practitioners, students, veterinary nurses, technicians, social workers, and all veterinary clinic staff.

Das Tierschutzgesetz vom 24. Juli 1972 war die erste Neufassung des Tierschutzrechts in Deutschland seit dem Reichstierschutzgesetz aus dem Jahre 1933. In chronologischem Ablauf verfolgt der Autor den oft muhevollen Weg zu einem neuen modernen Tierschutzgesetz in der Zeit zwischen 1950 und 1972. Einen Schwerpunkt der Darstellung bildet die Arbeit der Tierschutzvereinigungen, die nicht mude wurden, fur ein reformiertes Tierschutzgesetz zu kampfen. Daneben zeigt der Autor die nach dem Zweiten Weltkrieg veranderten Anforderungen an den Tierschutz - wie die wachsende Massentierhaltung und die zunehmende wissenschaftliche Forschung an Tieren - auf, vergleicht die zahlreichen Gesetzentwurfe und erlautert die entscheidenden Hindernisse und deren UEberwindung. Die Geschichte des Tierschutzrechts von 1950 bis 1972 ist nicht nur ein Stuck deutscher Rechts- und Zeitgeschichte. Immer noch hochaktuell macht sie deutlich, wie schwer es die Politik hat, auf einem moralisch so heiklen Gebiet die verschiedenen Anliegen angemessen zu berucksichtigen - die der Menschen, vor allem aber die der Tiere.

The second edition of Food Safety and Quality Assurance is a basic reference for veterinarians, extension specialists, and others who help food-animal producers throughout the food chain to provide a safe product to consumers. The assurance of safety and quality must start with the producer. Professionals providing specialized expertise to the producer must be familiar with modern production practices in order to identify activities that may have an adverse effect on safety and quality; must be knowledgeable about microbial and nonmicrobial agents that reduce the marketability of the product and produce disease in the consumer; and must be familiar with modern processing techniques for foods of animal origin to understand the scientific basis for the inspection procedures required by regulatory agencies. This greatly expanded edition provides this information and includes a chapter analyzing the social and political context for the development of food safety and quality assurance inspection of foods of animal origin. Also new to this edition is its examination of egg production, in addition to red meat, poultry, milk, and fish, as well as its coverage of risk assessment and safe food handling at home. The second edition goes beyond North America in scope. As economic trade barriers fall and new trading groups are forged by governments, it is becoming increasingly important to understand food issues, both regulatory and biological, from a global perspective.

This comprehensive book is an exploration of the history of veterinary medicine from the ancient world to the present as well as an examination of the development of man's relationship with animals through early domestication, usage as food, fibre and traction to modern therapy animals and companions. The book is organised so that it can be read in a linear way or that researchers interested in a particular aspect can access specific content.

This book covers all details for a successful control and elimination strategy against propagation of deadly liver and intestinal flukes of the genus Schistosoma in China. Cancer due to schistosomiasis is still common in subtropical countries and affords hundred thousands of human and animal deaths per year. Expert authors play close attention to the biology and morphologic aspects of Schistosoma species as well as the history and status quo of schistosomiasis epidemiology. In a unique way, the present work illustrates the need to involve strategic measurements, and to control both adult worms and larval parasite stages. With a special focus on Jiangxi Province, the authors present an effective management plan, ranging from intermediate host snail control to diagnostic tools, medical aid, as well as public health education. This approach from China can be used as blueprint in other countries hit by the same worm infections. The contents of this book will thus be meaningful for academics and practitioners in the fields of parasitology, public health, as well as human and veterinary medicine.

Thorough revision of a comprehensive and highly readable textbook on veterinary anaesthesia A popular book amongst veterinary students and veterinary anaesthesia residents, the new edition of Veterinary Anaesthesia: Principles to Practice continues to be a comprehensive textbook covering the key principles of veterinary anaesthesia, encompassing a wide range of species. Fully revised, the information is summarised in a simple, accessible format to help readers navigate and locate relevant information quickly. Filled with technical and species-based chapters, it offers a quick reference guide to analgesic infusions, as well as emergency drug dose charts for canines, felines, and equines. Provides broad coverage of the basics of veterinary anaesthesia and how it is implemented in clinical practice Includes new information on mechanisms of general anaesthesia Features new and improved photographs and line illustrations, plus end of chapter questions to test your knowledge Covers veterinary anaesthesia for a wide range of species, including dogs, cats, horses, rabbits, donkeys, and pigs Expands example case material to increase relevance to day-to-day clinical practice Updated to contain the latest developments in the field, Veterinary Anaesthesia: Principles to Practice is designed specifically for veterinary students and those preparing to take advanced qualifications in veterinary anaesthesia. It is also a useful reference for veterinarians in practice and advanced veterinary nurses and technicians.

Among unconventional agents and unclassified viruses the contributions to this volume focused on prion-related diseases, with special emphasis on bovine spongiform encephalopathy and human spongiform encephalopathies, and Borna disease virus, an agent known since long time to be pathogenic for horses and sheep, which is now discussed as a potential pathogen for humans. Additionally, the volume contains articles about newly discovered viruses like porcine respiratory and reproductive syndrome virus and viruses that are classified only provisionally like African swine fever virus, hepatitis C and E viruses, or the arteriviruses.

This new edition uniquely integrates text discussions with learning activities, including fill-in-the-blank, puzzle, and matching exercises. Newly updated to reflect the latest terminology, this best-selling text now features numerous new and revised pedagogical features that make it an excellent resource both in the classroom and for self-study. Brand-new additions include several new appendices, new anatomical drawings, and a more extensive index. Many sections have been completely rewritten for consistency and greater reader comprehension, and review sections now include more thought-provoking questions and multiple-choice tests.Logical organization and an extensive illustration program make it an excellent resource both in the classroom and in clinical practice. Integrated review sections, featuring fill-in-the-blank and matching exercises. Glossaries at the end of each chapter. Useful appendices featuring common abbreviations, veterinary specialties, and much more. Several new appendices devoted to terminology specific to various veterinary specialties: pathology, pharmacology, surgery, and more Greater attention paid to writing style throughout, resulting in a more consistent, easier-to-read text Complete rewrite of review sections to include critical thinking questions, as well as more multiple-choice questions Numerous new anatomical drawings place many terms in their proper visual perspective A more extensive index ensures that it can be used with confidence as a comprehensive reference on the job New exotics chapter

Zoonotic diseases pose a serious threat to global health and economy. Domestic and wild birds play crucial roles in transmission and spread of important zoonotic pathogens, with significant implications on human and avian health. Although zoonotic diseases have been extensively studied, information on various aspects of avian zoonotic pathogens have not been revisited or revised to any great extent. This book is a comprehensive and updated compilation of important zoonotic diseases that are transmitted by domestic and wild birds, and consists of 21 chapters that meticulously describe the (i) etiology and evolution, (ii) complex epidemiology, such as migration pathways in context of disease transmission, (iii) pathogenesis, (iv) clinical signs and necropsy findings, (v) diagnostics including latest molecular assays, and (vi) preventative and control strategies, with an emphasis on therapeutics and prophylaxis, of important zoonotic pathogens (bacterial, fungal, parasitic and viral) of avian origin in humans and birds. Each chapter is aptly supported by interactive tables and figures, and features an updated reference section. This book aims to create awareness and enlighten students of veterinary and human medicine on the role of birds in zoonoses, and would serve as a useful reference for working veterinarians, human doctors, and public health experts.

In Praise of A "The Complete Book of Foaling"

"A must read for anybody who has ever thought about breeding a mare." --Judith Forbis, Ansata Arabian Stud

"Brilliantly writtenreads like a novel, yet beautifully organized so that you can flip to a section at a moment's notice if your mare is in trouble." --"Equus"

"This book should be included in every foaling kit. In fact, it should never sit on the bookshelf in the housekeep it in the barn where you can always get to it in a hurry!" --"Modern Horse Breeding"

"Right away the illustrations set this book apart from any other in its class. Dr. Hayes's ability to teach is the other distinctionshe has a knack for explaining things in such a way that you understand and remember, and the learning process is fun. I couldn't put the book down until I had read it cover to cover." --Walter Schimanski, Masada Arabians

The Howell Equestrian Library is a distinguished collection of books on all aspects of horsemanship and horsemastership. The nearly fifty books in print offer readers in all disciplines and at all levels of competition sound instruction and guidance by some of the most celebrated riders, trainers, judges and veterinarians in the horse world today. Whether your interest is dressage, show jumping or Western riding, or whether it's breeding, grooming or health care, Howell has a book to answer your needs. Get to know all the books in the Howell Equestrian Library: many are modern-day classics and have achieved the status of authoritative references in the estimation of those who ride, train and care for horses.
The Howell Equestrian Library

Veterinary Forensics: Investigation, Evidence Collection, and Expert Testimony will provide anyone involved in an investigation of an animal involved crime or civil action with the knowledge and tools that can give guidance for their actions in completing a forensic investigation. All 50 U.S. states, and numerous countries around the world, have laws against animal abuse and cruelty. Law enforcement agents, veterinarians, the judiciary, attorneys and forensic scientists may be involved in cases of animal cruelty, neglect or human crimes that may have an animal element. Additionally, the animal can be the victim, suspect or in some instances the witness of a crime. Given that acquittal or conviction is dependent upon the nature and veracity of the evidence, the quality of the evidence in an animal-related crime investigation must be beyond reproach. The book begins with a discussion of animal abuse and crimes against animals, crime scene investigation, and, from there, discusses various types of forensic examinations of the animal, culminating in a review of the judicial system and testimony in a court of law. All contributing authors are practicing professionals in law, veterinary medicine, and the private sector who provide current, best-practice evidence collection and forensic techniques. Chapters provide in-depth detail about the forensic clinical examination and forensic necropsy of small and large animal species, forensic radiology, forensic toxicology, bitemark analysis and animal behavior. Various, relevant forensic disciplines such as bloodstain pattern analysis, DNA analysis, animal sexual abuse, agroterrorism, animal hoarding, ritual crimes against animals, and animal fighting are discussed. Key Features: Presents established and accepted police techniques in animal crime scene investigation including identification, documentation and packaging of physical evidence and scene photography and videography Includes essential techniques to collect and preserve biological and DNA evidence for animal DNA testing Review of the forensic clinical examination and forensic necropsy of small and large animals Provides methods of evidence presentation in the courtroom, the nature of court room testimony, and the development of an expert report Veterinary Forensics: Investigation, Evidence Collection, and Expert Testimony fills the void of applied, real-world investigative techniques for the collection and presentation of veterinary forensic medical and scientific information. It will be a welcome reference to both the student and professional in the understanding all relevant evidentiary, investigative, and legal elements of the discipline.

This issue of Veterinary Clinics: Exotic Animal Practice, guest edited by Dr. Christal Pollock, focuses on Renal Disease. This is one of three issues each year selected by the series consulting editor, Dr. Jorg Mayer. Articles in this issue include, but are not limited to: Anatomy and physiology of the avian renal system; Diseases of the avian renal system; Laboratory evaluation of renal function; Diagnostic imaging of the avian renal system; Clinical management of avian renal disease; Anatomy and physiology of the reptile renal system; Clinical management of reptile renal disease; Diagnostic imaging of the renal system in exotic companion mammals; Renal disease in amphibians; Renal disease in fish; Diseases of the reptile renal system; Diagnostic imaging of the reptile urinary system; and Renal disease in exotic companion mammals.

4* Doody's Review! Ideal for veterinary students, residents and clinicians, the fourth edition of this bestselling textbook has been fully updated in line with developments in research and teaching. The logical chapter progression reflects the stages in a clinical case work-up and how epidemiological concepts and methods contribute. This new edition provides guidelines for improving patient and population health outcomes, and detecting emerging diseases through systematic evaluation of patient encounters and electronic medical records incorporates new methodologies and concepts drawn from the recent veterinary practice literature updates chapter content including expanded coverage of risk, statistical and economic analyses, and surveillance for emerging diseases more than 60 examples of clinical research drawn from the international veterinary practice literature presented as structured abstracts; follow-up questions invite the reader to participate in the analysis of results online links to full text versions of more than half of structured abstracts and more than 40% of the book's 174 literature citations updates the listing and review of public and private online resources, including guidelines for online literature searching and critical evaluation of clinical reports. Today's veterinary curricula places greater emphasis on experiential/problem-based learning versus discipline-oriented instruction. This fourth edition is ideally suited to introduce epidemiologic concepts and methodologies to veterinary students in the context of the patient encounter, and should be of use at any point in the veterinary curriculum.