Controlled Release Fertilizers for Sustainable Agriculture provides a comprehensive examination of precision fertilizer applications using the 4-R approach-the right amount of fertilizer at the right time to the right plant at the correct stage of plant growth. This volume consolidates detailed information on each aspect of controlled release fertilizers, including up-to-date literature citations, the current market for controlled release fertilizers and patents. Presenting the tremendous advances in experimental and theoretical studies on sustainable agriculture and related areas, this book provides in-depth insight into state-of-the-art controlled release mechanisms of fertilizers, techniques, and their use in sustainable agriculture. Conventional release mechanisms have historically meant waste of fertilizers and the adverse effects of that waste on the environment. Controlled release delivery makes significant strides in enhancing fertilizer benefit to the target plant, while protecting the surrounding environment and increasing sustainability.

Advances in Clinical Chemistry, Volume 99, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry, with this release including chapters on Extracellular vesicle associated proteins as potential biomarkers, Molecular and non-molecular approaches to etiologic diagnosis of gastroenteritis, Circular RNAs and cancer: Opportunities and challenges, Mass spectrometry-based metabolomics for an in-depth questioning of human health, Application of microfluidic technology in cancer research and therapy, Advances in aptasensor technology, and much more.

Biomaterials for 3D Tumor Modeling reviews the fundamentals and most relevant areas of the latest advances of research of 3D cancer models, focusing on biomaterials science, tissue engineering, drug delivery and screening aspects. The book reviews advanced fundamental topics, including the causes of cancer, existing cancer models, angiogenesis and inflammation during cancer progression, and metastasis in 3D biomaterials. Then, the most relevant biomaterials are reviewed, including methods for engineering and fabrication of biomaterials. 3D models for key biological systems and types of cancer are also discussed, including lung, liver, oral, prostate, pancreatic, ovarian, bone and pediatric cancer. This book is suitable for those working in the disciplines of materials science, biochemistry, genetics, molecular biology, drug delivery and regenerative medicine.

This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field.

Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B, represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and their partners, as well as proteins from muscle sarcomere; representation of intrinsic disorder-related concept of protein structure-function continuum; discussion of the role of intrinsic disorder in phenotypic switching; consideration of the role of intrinsically disordered proteins in the pathogenesis of neurodegenerative diseases and cancer; discussion of the roles of intrinsic disorder in functional amyloids; demonstration of the usefulness of the analysis of translational diffusion of unfolded and intrinsically disordered proteins; consideration of various computational tools for evaluation of functions of intrinsically disordered regions; and discussion of the role of shear stress in the amyloid formation of intrinsically disordered regions in the brain.

Hormones and Synapse, Volume 114 in the Vitamins and Hormones series, highlights advances in the field, with this new volume presenting timely topics, including how growth hormone promotes synaptogenesis, sex hormones and proteins involved in brain plasticity, corticotropin releasing factor modulates excitatory synaptic transmission, bisphenol a and memory: a role for dendritic spines, brain insulin resistance impairs hippocampal synaptic plasticity, estradiol induces synaptic rearrangements, stress and remodeling of hippocampal spine synapses, neurotrophin-3 modulates synaptic transmission, nongenomic neurosteroid modulation of hippocampal dendritic spines, neural sex steroids and hippocampal synaptic plasticity, origin of chemical synapses, neural sex steroids and hippocampal synaptic plasticity, and much more.

Chemical Tools for Imaging, Manipulating, and Tracking Biological Systems: Diverse Chemical, Optical and Bioorthogonal Methods, Volume 641 in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Chapters in this new release include caged cyclopropanes with improved tetrazine ligation kinetics, an analysis of metabolically labeled inositol phosphate messengers by NMR, cell-permeant caged inositol pyrophosphates for probing ss-cells, imaging phospholipase D activity with clickable alcohols via transphosphatidylation, fluorescent biorthogonal labeling of class B GPCRs in live cells, near-infrared photoactivatable nitric oxide donors with integrated photoacoustic monitoring, and much more.

Autism, Volume 173 in the Progress in Molecular Biology and Translational Science series, provides the most topical, informative and exciting monographs available on a wide variety of research topics. Chapters in this new release include updates on atypical brain development in autism spectrum disorder, predicting early diagnosis of autism spectrum disorder using neural and behavioral measures, the roles of the endocannabinoid system in autism spectrum disorder, the neurobiology of sensory processing in autism spectrum disorder, the effects of oxytocin administration on individuals with ASD, resting-state abnormalities of posterior cingulate in autism spectrum disorder, and more.

Advances in Clinical Chemistry, Volume 98, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry. It is the benchmark publication for novel analytical approaches in the clinical laboratory.

Autophagy in Health and Disease, Volume 175, presents the latest insights from renowned experts in the field who discuss the key role of autophagic responses in the preservation of cellular and organismal homeostasis and how defects in the molecular apparatus for autophagy drive or accompany disease. Specific chapters in this new release include Crosstalk between autophagy and cell death signaling: mechanisms and therapeutic relevance, C. elegans to model autophagy-related human disorders, Autophagy in Kidney Disease: advances and therapeutic potential, Autophagy in Chronic Lung Disease, Autophagy in motoneuronal disorders, Strategies employed by viruses to manipulate autophagy, and much more.

Advances in Clinical Chemistry, Volume 97, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry, with chapters in this new release covering metaproteomic analysis of human gut microbiome in digestive and metabolic diseases, liquid biopsy in ovarian cancer, advances in extracellular vesicles analysis, long non-coding RNA HOTAIR in cervical cancer: molecular marker, mechanistic insight, and therapeutic target, genomics of hypertriglyceridemia, cell free DNA biology and its involvement in breast carcinogenesis, and more.

Biostimulants in Alleviation of Metal Toxicity in Plants: Emerging Trends and Opportunities focuses on the role of substances or micro-organisms whose presence can address issues of metal contamination in soils, seeds and plants. Including a range of biostimulant tools, the book highlights both endogenous and exogenous application. Written and edited by a global team of experts, this book presents an overview on biostimulants in determining metal toxicity. As plants encounter a wide range of environmental challenges during their lifecycle, among which metal toxicity is a common form of abiotic stress, this book thoroughly covers important topics on the subject matter. Once inside a plant system, toxic metals may initiate a variety of physiological alterations in plants, including adversely impacted seed germination, root and shoot growth, chloroplasts ultrastructure and photosynthesis, nutrients assimilation, carbohydrates metabolism, and plant hormonal status which, collectively, results in reduced plants yields. In addition to several naturally occurring physiological and metabolic re-programing responses, plants may also modify their root and shoot systems in order to dilute entered amount of toxic metals. As an additional tool biostimulants have emerged as one of the important plant protectors under adverse conditions.

The Chemical Dialogue Between Plants and Beneficial Microorganisms provides foundational insights on plant beneficial microorganisms and their impact on the health and productivity of plants. Providing in-depth and recent updates about unexplored aspects of plant microbes interactions, the book includes the biological repertoire of arbuscular mycorrhizal association, molecular architecture of Rhizobium-plant symbiosis, and endophytes in transcriptional plasticity during host colonization by endophytes. The book also includes details about the mechanism of different plant beneficial microorganisms, how these differ, and their cross signaling. This book will be an important reference for researchers working on different plant beneficial microorganisms and their molecular arsenal.

Plant Life under Changing Environment: Responses and Management presents the latest insights, reflecting the significant progress that has been made in understanding plant responses to various changing environmental impacts, as well as strategies for alleviating their adverse effects, including abiotic stresses. Growing from a focus on plants and their ability to respond, adapt, and survive, Plant Life under Changing Environment: Responses and Management addresses options for mitigating those responses to ensure maximum health and growth. Researchers and advanced students in environmental sciences, plant ecophysiology, biochemistry, molecular biology, nano-pollution climate change, and soil pollution will find this an important foundational resource.

The volume deals with other aspect (s) of metabolic activities of plants under abiotic stress. This book discusses techniques for improving yield potential and adaptiveness to unfavorable environmental conditions. This book also addresses how knowledge of the changes in physiological mechanisms can contribute in understanding the yield structure under abiotic stress. 1. Abiotic Stress and Metabolic Responses in Plants 2. Abiotic Stress and Secondary Metabolites in Plants 3. Microbes: Support and Protect Plants against Abiotic Stresses 4. Abiotic Stress and Physiological Traits in Plants 5. Abiotic Stress and Heat Shock Proteins (HSPs) in Plants

Abiotic stress factors frequently constrain the growth and productivity of major crop species. The single greatest abiotic stress factor that limits crop growth worldwide is water availability. While genetic increases in yield potential are best expressed in optimum environments, they are also associated with enhanced yields under drought and nitrogen deficiency. These gains are especially relevant given that further large increases in the area under irrigation are not expected, and land deterioration associated with intensive agriculture threatens those areas already irrigated. This book is intended to cover all known factors of abiotic stresses and their respective effects on some of the important aspects of physiological processes in plants.1. Abiotic Stress and Crop Yield 2. Physiology of Grain Legume Yield Under Abiotic Stress 3. Photosynthesis and Physiological Parameters Under Intercropping Condition 4. Role of Growth Regulators Under Abiotic Stress 5. Plant Water Relationship Under Abiotic Stress 6. Dry Matter Partitioning Under AbioticS tress 7. Effect of Pesticides on Physiological Processes in Plants

Mechanobiology: From Molecular Sensing to Disease will provide a review of the current state of understanding of mechanobiology and its role in health and disease. It covers: Current understanding of the main molecular pathways by which cells sense and respond to mechanical stimuli, A review of diseases that with known or purported mechanobiological underpinnings; The role of mechanobiology in tissue engineering and regenerative medicine; Experimental methods to capture mechanobiological phenomena; Computational models in mechanobiology.

Enzymatic Polymerizations, Volume 627 in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field.

DNA Repair, Volume 45 in The Enzymes series highlights new advances in the field, with this new volume presenting interesting chapters on DNA polymerase beta and other gap-filling enzymes in mammalian base excision repair, Translesion polymerases, mechanism and function, The Rev1-Pol? Mutasome: Structure and Interactions in Translesion Synthesis, Challenges for base excision repair enzymes: acquiring access to damaged DNA in chromatin Nucleotide excision repair, DNA damage recognition mechanisms in mammalian nucleotide excision repair, Advances in understanding DNA mismatch repair, and more.