Focusing on the roles of different segments of DNA, Statistics in Human Genetics and Molecular Biology provides a basic understanding of problems arising in the analysis of genetics and genomics. It presents statistical applications in genetic mapping, DNA/protein sequence alignment, and analyses of gene expression data from microarray experiments.

The text introduces a diverse set of problems and a number of approaches that have been used to address these problems. It discusses basic molecular biology and likelihood-based statistics, along with physical mapping, markers, linkage analysis, parametric and nonparametric linkage, sequence alignment, and feature recognition. The text illustrates the use of methods that are widespread among researchers who analyze genomic data, such as hidden Markov models and the extreme value distribution. It also covers differential gene expression detection as well as classification and cluster analysis using gene expression data sets.

Ideal for graduate students in statistics, biostatistics, computer science, and related fields in applied mathematics, this text presents various approaches to help students solve problems at the interface of these areas.

Very Short Introductions: Brilliant, Sharp, Inspiring Physiology is the science of life, and sets out to understand how living things work and what makes them distinct from the non-living. It considers how our bodies are supplied with energy, how they maintain their internal parameters, the ways in which we gather and process information, the ways we take action, and the creation of new generations. This Very Short Introduction explores the field of human physiology, considering how the body works, senses, reacts, and defends itself. As Jamie A. Davies shows, human life (and indeed, all life) is sustained by the interplay of a wide variety of physiological mechanisms and principles. He discusses the physiological experiments and research undertaken to understand these processes, and analyses the ethical issues involved. He also considers the evolution of the scientific field itself, showing how enhanced understandings of physiological knowledge can help inform medical research and care. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.

The latest edition of Robert Arking's seminal text on the biology of aging takes on an extended title, since the field of gerontology has advanced to a point at which it is possible to separate the topic into two implicit subsets, longevity and aging. This multi-faceted description of the biology of aging guides the reader through increasingly interesting answers to seven fundamental questions: What is aging? Why do we age? What mechanisms support extended longevity? What determines the onset of senescence? What is the mechanistic basis of senescence? Why do humans live so long? And lastly, what pro-longevity societal interventions are needed? Inevitably, humans will age but there is no reason why we must suffer from age-related diseases. Aging and longevity are dependent on both genes and social environment. Our biology does not forbid the modulation of aging. What we really want to know is not so much about the biology of aging - which is basically a degenerative process - but rather about biological processes underlying the long term maintenance of our health. New chapters incorporate the latest developments in the field of gerontology. Research done since the previous edition was published has given us insight into how we may stay healthier longer.

Of recent, the structure of the complement system has received considerable attention, including the publication of several three-dimensional structures of complement proteins. This has led to the need for an authoritative resource to provide a complete overview of the basics, as well as an explanation of the cutting-edge work being accomplished in this emerging science. Structural Biology of the Complement System is devoted to the full exploration of structural aspects of the complement system, with special consideration of the links between molecular structure and function. Containing the work of leading authorities across the disciplines of immunology and structural biology, the book serves both as an introductory volume for newcomers to the field and as a comprehensive reference for established researchers, in particular those whose goal is the discovery of anticomplement drugs. Written in a didactic style, this volume is an appropriate resource for students in the fields of immunology and structural biology. Structural Biology of the Complement System comes with downloadable resources containing color figures, a molecular structure visualization program, and files with three-dimensional coordinates of the structures described in the book. These tools allow readers to perform tailored structural manipulation and analysis, while also serving as a starting point for further research.

Scientific developments have increasingly been transforming our understanding of the place of human beings in nature. The study of humanity, carried out in a variety of disciplines from anthropology and paleontology to genetics and neurosciences, is shedding new light on the origins and biological bases of human nature and culture. The findings of these relatively new hyphenated sciences have profound implications for the interpretation of human behavior within spiritual life no less than the material culture. This fine compendium serves as a splendid introduction to sociobiology. Sociobiology, now frequently being referred to by many as evolutionary psychology and evolutionary anthropology, first offered a radically selfish and individualist account of human nature. However, later researchers have moved away from such reductionisms, and into a sense of the common good that characterizes many species, and human brings as well. The emergence of discourses on the role of religion in understanding behavior in terms of moral considerations that permit people to live in community contexts has generated a lively examination within the new social sciences on the source of instinct, impulse, intelligence and interest. This compendium is clearly etched in a new and generous vision of human behavior that is at the same time rooted in the best of the current social sciences. "The Origins and Nature of" Sociality comes out of a symposium sponsored by the Program for Dialogue on Science, Ethics, and Religion of the American Association for the Advancement of Science, and co-chaired by the editors. The contributors focus on the current status of research on sociality and the evolution of cooperative and altruistic behavior in nonhuman and human primates. They examine questions related to the evolution, cultural viability, and hormonal underpinnings of human sociality in specific detail, and describe patterns of sociality among nonhuman primates that many shed light on human social behavior. "Robert W. Sussman" is professor of anthropology, at Washington University in St. Louis. His work has appeared, among other places, in "The American Journal of Physical Anthropology, Folia Primatology," and Zygon. "Audrey R. Chapman" serves as director of the Science and Human Rights program of the American Association for the Advancement of Science, in Washington D.C.

Bio-Architecture studies the natural principles of animal and human constructions from several different perspectives, and presents a great part of the knowledge that gives origin and shape to built form.
Organic architecture offers a design approach arising from natural principles, bringing us back to local history, tradition, and cultural roots to give us built forms which are in harmony with nature. It also shows how architects can take advantage of the resources that contemporary technology has placed within our grasp.
Bio-Architecture is a unique book that studies the natural principles of animal and human constructions from several different perspectives and looks at what gives origin and shape to built form. The text gives an informative, inspiring overview of the drive toward organically informed design both intrinsically and aesthetically using a wide variety of international examples.
Javier Senosiain is an architect and an historian. He has pursued his interest in Organic Architecture across the globe drawing parallels between Buckminster Fuller's Geodesic dome and the spider's web; between Santiago Calatrava's Cathedral of St John in NY and the roots of a tree. Where nature has inspired form, Senosiain has made a career of analyzing and applying the principles he sees in some very creative writing and architecture.
* Beautiful book inspires readers to design with the environment in mind
* Comparative study of the engineering principles in nature and built structures outlines the fundamentals of architectural design
* International examples show how architects use different locations and climates to inform specific biological forms and techniques

With 2003 being the 100th anniversary of modern aviation, Passenger Behaviour was published at a milestone for the aviation industry. Remarkable achievements in engineering have made air travel highly accessible within the span of a single lifetime. However, when evolutionary barriers are exceeded various penalties are exacted. The most common experienced by air passengers include motion sickness, jetlag and increased arousal and stress at different stages of flight. Air travel also brings us into closer contact with strangers, making our examination and understanding of the social psychology of behaviour within groups (among passengers) especially relevant. This book examines a wide range of topics that help the reader to acquire a psychological understanding of how air travel impacts on human relationships; behaviour as well as physiological functions. Written by leading authorities in their areas, it is intended primarily for those with an interest in passenger behaviour and those who work professionally in commercial aviation. This includes pilots, cabin crew, ground staff, airline and airport managers, aviation psychologists, human factors specialists, aerospace medical/nursing personnel and aircraft designers and manufacturers. As air travel being an integral part of most people's lives, this book will also be of interest to anyone who travels either on a frequent or infrequent basis.

This book bridges the gap between a clinician's and material scientists' knowledge by elucidating upon the different biomaterials used in anatomical systems and how those materials react to the human body. It explores both established and future prospective of biomaterial types/designs, and considerations in material selection and synthesis, to guide students from non-clinical background in understanding the relations of material science and the human body.

The health of a population is most accurately reflected in the rate of growth of its children. It is this theme which underlies the analysis and presentation of what is by far the largest compilation of growth data ever assembled. The first edition, published in 1976, included all known reliable recent results on height, weight, skinfolds and other body measurements from all parts of the globe. In this edition, the very numerous measurements taken between 1976 and 1988 have been included as well as the results of the large number of new studies made on rate of maturation as evinced by bone age and pubertal development stages. Many sections of the book dwell on disentangling the effects of the environment and heredity on growth, and thus answer the question of whether one universal standard suffices for all peoples of the world, or whether different populations (such as races or nations) should each have their own optimal growth standards. Written by practical people with experience of the problems in developing countries, this book explains in simple terms the different sorts of growth surveys, how to set about making them, and which sort to choose. All who are professionally concerned with child health should read it.

Everyone has questions about death. In Will My Cat Eat My Eyeballs?, best-selling author and mortician Caitlin Doughty answers the most intriguing questions she's ever received about what happens to our bodies when we die. In a brisk, informative, and morbidly funny style, Doughty explores everything from ancient Egyptian death rituals and the science of skeletons to flesh-eating insects and the proper depth at which to bury your pet if you want Fluffy to become a mummy. Now featuring an interview with a clinical expert on discussing these issues with young people-the source of some of our most revealing questions about death-Will My Cat Eat My Eyeballs? confronts our common fear of dying with candid, honest, and hilarious facts about what awaits the body we leave behind.

This fascinating, multi-disciplinary volume weaves together the fields of biology, archaeology, anthropology and history to produce a stimulating and wide-ranging analysis of the biological history of past human populations. Research methods, theoretical approaches and the outcomes of research are all fully explored, and contributions to the book are made by an eminent mix of experts in the afore-mentioned fields.
Comprehensive in its coverage of the subject, chapters include discussions on adaptation and the English demographic regime; British polygyny, warfare and population structure; and a human ecological approach to the interface of history and biology.
A unique interlacing of human biology and history, this book will encourage further reflection and debate and presents a fresh perspective to the subject for students and professionals across all levels in biology, archaeology, anthroplogy and social history.

eBook available with sample pages: 0203217594

A provocative and timely case for how the science of genetics can help create a more just and equal society In recent years, scientists like Kathryn Paige Harden have shown that DNA makes us different, in our personalities and in our health-and in ways that matter for educational and economic success in our current society. In The Genetic Lottery, Harden introduces readers to the latest genetic science, dismantling dangerous ideas about racial superiority and challenging us to grapple with what equality really means in a world where people are born different. Weaving together personal stories with scientific evidence, Harden shows why our refusal to recognize the power of DNA perpetuates the myth of meritocracy, and argues that we must acknowledge the role of genetic luck if we are ever to create a fair society. Reclaiming genetic science from the legacy of eugenics, this groundbreaking book offers a bold new vision of society where everyone thrives, regardless of how one fares in the genetic lottery.

The diversity of contemporary investigative approaches included in this volume provides an exciting account of our current understanding of brain mechanisms responsible for sensory and perceptual experience in the areas of touch, kinesthesia, and pain.
Postgraduate research students in sensory physiology, neurology, psychology and anatomy, and researchers themselves will find that this volume addresses many of the key issues in our attempts to understand the neural mechanisms that mediate sensory experience arising from the body as a whole, the so-called somatic senses, in particular for touch and pain. The volume provides a record of the occasion of the St Petersburg IUPS symposium, chaired by the editors of this volume, and includes some added recent contributions from other leading international figures in the field. Brought together under the sponsoring banner of the IUPS Commission for Somatosensory Physiology and Pain, these scientists with their different experimental approaches seek collectively to understand the brain mechanisms that underlie our own nature and experience.

Misanthropology: Science, Pseudoscience, and the Study of Humanity introduces students to key concepts in critical thinking across the four core branches of anthropology: cultural, linguistic, biological, and archaeological. It combines a critical analysis of anthropology as a field with current concepts in scientific skepticism. By deconstructing a range of global case studies in which anthropological research runs aground, the book teaches students to distinguish between legitimate science and pseudoscience. It covers key concepts in critical thinking and rigorous research, such as cognitive biases and logical fallacies, data collection and consensus, probabilistic thinking, as well as political, nationalist, racist biases. Students learn not only how to apply these concepts to anthropological research and fieldwork, but also to their consumption of everyday information. This book will appeal to anthropology students and will be particularly useful for instructors of introductory anthropology courses, as well as instructors of courses across the humanities and social sciences focused on inculcating critical thinking skills.

This volume dealing with the male body in the iconography of fascism reflects an ambition rather than an achievement. The supremacy of the global fascist superman never became a reality but was certainly an intention. This work explores the use of the image of the male body for this purpose in European, American and Asian fascism of varying degrees and various interpretations, and the differences and similarities involved. Among the similarities isthe fact that sport in all the cases in this volume was at the centre of the induction of the male body (and mind) into martial self-sacrifice. Sport was an important part of fascist socialization. The reasons are not hard to find. Sport develops muscle and muscle is equated with power - literally and metaphorically. War, the essence of fascism, demands physical fitness and sport helps promote this fitness. Competitive sport can help develop attitudes of aggression and aggression is essential in war.

This volume dealing with the male body in the iconography of fascism reflects an ambition rather than an achievement. The supremacy of the global fascist superman never became a reality but was certainly an intention. This work explores the use of the image of the male body for this purpose in European, American and Asian fascism of varying degrees and various interpretations, and the differences and similarities involved. Among the similarities isthe fact that sport in all the cases in this volume was at the centre of the induction of the male body (and mind) into martial self-sacrifice. Sport was an important part of fascist socialization. The reasons are not hard to find. Sport develops muscle and muscle is equated with power - literally and metaphorically. War, the essence of fascism, demands physical fitness and sport helps promote this fitness. Competitive sport can help develop attitudes of aggression and aggression is essential in war.

This text begins with an in-depth overview into the human organism at the molecular, cellular, tissue and organ levels, and develops into a discussion of the objectives and features of organ systems of the evolved human. The book also covers the relationship between the human body and the environment in which it exists including other organisms that co-habitate the environment. Discussions of the nature of other organisms such as various animals, plants, and micro-organisms makes later information about food science, nutrient density in various food sources, and nutraceuticals easier to comprehend.
Advanced Human Nutrition examines human nutrient requirements, the basis for RDA and other recommendations; human nutrition, digestion, and absorption with relation to organs, exocrine and endocrine functions, histology, and absorptive activities; macronutrients and micronutrients; eicosanoid chemistry and function, and more.
The present and future of nutrition research is examined, including everything from the HANES studies to electron microscopy and molecular biology.

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Jerry Stannard assembled a legendary collection of materials on the history of botany from Homer to Linnaeus, and his mastery of the field was acknowledged as incomparable. However, his work was sadly cut short by his death, and so did not result in the ultimate synthesis he envisioned; the present volume, and its companion, Herbs and Herbalism in the Middle Ages and the Renaissance, bring together his important output in articles and studies. In this selection of papers on pharmacy and medical botany, from the classical period to 1500, Stannard combined philological expertise with the scientific perspective of modern pharmacology to measure the descriptive accuracy and therapeutic efficacy of Materia Medica from Hippocrates to the Renaissance. His sources included not only the obvious technical treatises but also works of literature and the traditions of folklore especially in Italy. Three studies of the scholastic botany of Albertus Magnus form the centrepiece of the collection, and the detailed indexes cover both common and scientific names of plants.

"Fascinating and exhilarating-Sean B. Carroll at his very best."-Bill Bryson, author of The Body: A Guide for Occupants From acclaimed writer and biologist Sean B. Carroll, a rollicking, awe-inspiring story of the surprising power of chance in our lives and the world Why is the world the way it is? How did we get here? Does everything happen for a reason or are some things left to chance? Philosophers and theologians have pondered these questions for millennia, but startling scientific discoveries over the past half century are revealing that we live in a world driven by chance. A Series of Fortunate Events tells the story of the awesome power of chance and how it is the surprising source of all the beauty and diversity in the living world. Like every other species, we humans are here by accident. But it is shocking just how many things-any of which might never have occurred-had to happen in certain ways for any of us to exist. From an extremely improbable asteroid impact, to the wild gyrations of the Ice Age, to invisible accidents in our parents' gonads, we are all here through an astonishing series of fortunate events. And chance continues to reign every day over the razor-thin line between our life and death. This is a relatively small book about a really big idea. It is also a spirited tale. Drawing inspiration from Monty Python, Kurt Vonnegut, and other great thinkers, and crafted by one of today's most accomplished science storytellers, A Series of Fortunate Events is an irresistibly entertaining and thought-provoking account of one of the most important but least appreciated facts of life.

"When you first view Rose-Lynn Fisher's photographs, you might think you're looking down at the world from an airplane, at dunes, skyscrapers or shorelines. In fact, you're looking at her tears. . . . [There's] poetry in the idea that our emotional terrain bears visual resemblance to the physical world; that our tears can look like the vistas we see out an airplane window. Fisher's images are the only remaining trace of these places, which exist during a moment of intense feeling-and then vanish." -NPR "[A] delicate, intimate book. . . . In The Topography of Tears photographer Rose-Lynn Fisher shows us a place where language strains to express grief, longing, pride, frustration, joy, the confrontation with something beautiful, the confrontation with an onion." -Boston Globe Does a tear shed while chopping onions look different from a tear of happiness? In this powerful collection of images, an award-winning photographer trains her optical microscope and camera on her own tears and those of men, women, and children, released in moments of grief, pain, gratitude, and joy, and captured upon glass slides. These duotone photographs reveal the beauty of recurring patterns in nature and present evocative, crystalline imagery for contemplation. Underscored by poetic captions, they translate the mysterious act of crying into an atlas mapping the structure and magnificence of our interior lives. Rose-Lynn Fisher is an artist and author of the International Photography Award-winning studies Bee and The Topography of Tears. Her photographs are exhibited in galleries, festivals, and museums across the world and have been featured by the Dr. Oz Show, NPR, Smithsonian, Harper's, New Yorker, Time, Wired, Reader's Digest, Discover, Brain Pickings, and elsewhere. She received her BFA from Otis Art Institute and lives in Los Angeles.

This handbook presents the most current information on the effects of ionizing radiation on mammalian cells, with emphasis on human tissues. The dose-effect relationship is emphasized in a quantitative manner. The book contains up-to-date data on the late effects of low levels of radiation on humans. It also provides some of the late consequences of radiation therapy detected among cancer survivors.

'Spellbinding . . . More than any other book, [Sentient] has made me think differently about the world this year.' - Financial Times Best Books of the Year The peacock mantis shrimp can throw a punch that can fracture aquarium walls. The great grey owl can hear many decibels lower than the human ear. The star-nosed mole's miraculous nose allows it to catch worms in as little as 120 milliseconds. In Sentient, Jackie Higgins assembles a menagerie of zoological creatures - from land, air, sea and all four corners of the globe - to understand what it means to be human. In it, we also meet the four-eyed spookfish and its dark vision, the vampire bat and its remarkable powers of touch, as well as the common octopus, the Goliath catfish and the duck-billed platypus. Each zoological marvel illustrates the surprising sensory powers that lie within us and enables us to engage with the world in ways we never knew possible. 'Lyrical and lucid . . . Higgins makes popular science accessible.' - Observer

"Why We Sleep is an important and fascinating book...Walker taught me a lot about this basic activity that every person on Earth needs. I suspect his book will do the same for you." --Bill Gates A New York Times bestseller and international sensation, this "stimulating and important book" (Financial Times) is a fascinating dive into the purpose and power of slumber. Sleep is one of the most important but least understood aspects of our life, wellness, and longevity. Until very recently, science had no answer to the question of why we sleep, or what good it served, or why we suffer such devastating health consequences when we don't sleep. Compared to the other basic drives in life--eating, drinking, and reproducing--the purpose of sleep remained elusive. An explosion of scientific discoveries in the last twenty years has shed new light on this fundamental aspect of our lives. Now, preeminent neuroscientist and sleep expert Matthew Walker gives us a new understanding of the vital importance of sleep and dreaming. Within the brain, sleep enriches our ability to learn, memorize, and make logical decisions. It recalibrates our emotions, restocks our immune system, fine-tunes our metabolism, and regulates our appetite. Dreaming mollifies painful memories and creates a virtual reality space in which the brain melds past and present knowledge to inspire creativity. Walker answers important questions about sleep: how do caffeine and alcohol affect sleep? What really happens during REM sleep? Why do our sleep patterns change across a lifetime? How do common sleep aids affect us and can they do long-term damage? Charting cutting-edge scientific breakthroughs, and synthesizing decades of research and clinical practice, Walker explains how we can harness sleep to improve learning, mood, and energy levels; regulate hormones; prevent cancer, Alzheimer's, and diabetes; slow the effects of aging; increase longevity; enhance the education and lifespan of our children, and boost the efficiency, success, and productivity of our businesses. Clear-eyed, fascinating, and accessible, Why We Sleep is a crucial and illuminating book.

Controversy over human evolution remains widespread. However, the human genome project and genetic sequencing of many other species have provided myriad precise and unambiguous genetic markers that establish our evolutionary relationships with other mammals. Human Evolution: Genes, Genealogies and Phylogenies identifies and explains these identifiable, rare and complex markers including endogenous retroviruses, genome-modifying transposable elements, gene-disabling mutations, segmental duplications and gene-enabling mutations. The new genetic tools also provide fascinating insights into when and how many features of human biology arose: from aspects of placental structure, vitamin C dependence and trichromatic vision, to tendencies to gout, cardiovascular disease and cancer. Bringing together a decade's worth of research and tying it together to provide an overwhelming argument for the mammalian ancestry of the human species, the book will be of interest to professional scientists and students in both the biological and biomedical sciences.