Based on the First Biannual Lifespan Development Conference, this volume offers a multidisciplinary and multidimensional approach to the study of lifespan development in the areas of neuropsychology, cognition, behavior genetics, and perception. The objective of the conference was to provide a lively forum for the discussion of issues related to lifespan development and to reflect on important topics challenging the field during the 1990s. The chapters in this book, motivated by the conference presentations, cover:
* the assessment and evaluation of developmental changes in visual perception;
* the contribution of behavioral genetic factors to development;
* the predictability of perinatal risk factors as they relate to cognitive and linguistic outcomes;
* the neuropsychological changes during aging; and
* innovative approaches to the study of cognitive development using neuropsychological testing methods.

Awarded the W. W. Howells Award for the Outstanding Book in Biological Anthropology, this volume presents a comprehensive, integrated, and up-to-date overview of the major physiological and behavioral factors affecting human reproduction. In attempting to identify the most important causes of variation in fertility within and among human populations, Wood summarizes data from a wide range of societies. Trained as an anthropologist as well as a demographer, he devotes special attention to so-called "natural fertility" populations, in which modern contraceptives and induced abortion are not used to limit reproductive output. Such an emphasis enables him to study the interaction of biology and behavior with particular clarity. The volume weaves together the physiological, demographic, and biometric approaches to human fertility in a way that will encourage future interdisciplinary research. Instead of offering a general overview, the focus is to answer one question: Why does fertility and the number of live births vary from couple to couple within any particular population, and from population to population across the human species as a whole? Topics covered include ovarian function, conception and pregnancy, intrauterine mortality, reproductive maturation and senescence, coital frequency and the waiting time to conception, marriage patterns and the initiation of reproduction, the fertility-reducing effects of breastfeeding, the impact of maternal nutrition on reproduction, and reproductive seasonality. This unique combination of comprehensive subject matter and an integrated analytical approach makes the book ideally suited both as a graduate-level textbook and as a reference work.

Awarded the W. W. Howells Award for the Outstanding Book in Biological Anthropology, this volume presents a comprehensive, integrated, and up-to-date overview of the major physiological and behavioral factors affecting human reproduction. In attempting to identify the most important causes of variation in fertility within and among human populations, Wood summarizes data from a wide range of societies. Trained as an anthropologist as well as a demographer, he devotes special attention to so-called "natural fertility" populations, in which modern contraceptives and induced abortion are not used to limit reproductive output. Such an emphasis enables him to study the interaction of biology and behavior with particular clarity. The volume weaves together the physiological, demographic, and biometric approaches to human fertility in a way that will encourage future interdisciplinary research. Instead of offering a general overview, the focus is to answer one question: Why does fertility and the number of live births vary from couple to couple within any particular population, and from population to population across the human species as a whole? Topics covered include ovarian function, conception and pregnancy, intrauterine mortality, reproductive maturation and senescence, coital frequency and the waiting time to conception, marriage patterns and the initiation of reproduction, the fertility-reducing effects of breastfeeding, the impact of maternal nutrition on reproduction, and reproductive seasonality. This unique combination of comprehensive subject matter and an integrated analytical approach makes the book ideally suited both as a graduate-level textbook and as a reference work.

Controversy over human evolution remains widespread. However, the human genome project and genetic sequencing of many other species have provided myriad precise and unambiguous genetic markers that establish our evolutionary relationships with other mammals. Human Evolution: Genes, Genealogies and Phylogenies identifies and explains these identifiable, rare and complex markers including endogenous retroviruses, genome-modifying transposable elements, gene-disabling mutations, segmental duplications and gene-enabling mutations. The new genetic tools also provide fascinating insights into when and how many features of human biology arose: from aspects of placental structure, vitamin C dependence and trichromatic vision, to tendencies to gout, cardiovascular disease and cancer. Bringing together a decade's worth of research and tying it together to provide an overwhelming argument for the mammalian ancestry of the human species, the book will be of interest to professional scientists and students in both the biological and biomedical sciences.

Since its discovery as the cause of infectious mononucleosis in 1964, the Epstein-Barr virus (EBV) has been etiologically implicated in an increasing number of human diseases. Generally considered the first human oncogenic virus because of a number of studies linking it with Burkitt's lymphoma and nasopharyngeal carcinoma (NPC), as well as its documented oncogenicity in nonhuman primates, EBVhas served as a model for identifying subsequent candidate oncogenic viruses and the stimulus for Evans' revision of the Henle-Koch postulates to accommodate the problems in proving viral oncogenicity in humans. Research on the role of EBV in human cancer was particularly en hanced (a) by the pioneering work of Werner and Gertrude Henle, and (b) by the coordinated efforts of the Special Virus Leukemia Program and its successors, the Special Virus Cancer Program and the Virus Cancer Program of the National Cancer Institute (NCI). Initiated by Dr. Frank J. Rauscher, who subsequently became director of the Ncr and is now Vice-President of the American Cancer Society, and expanded by Dr. John B. Moloney, whose contributions to cancer research were honored at this Second International Symposium on EBV and Associated Malignant Diseases, these NCI contract-sup ported programs brought together investigators from all over the world to participate in a joint effort to unravel the mystery of EBV behavior and pathogenicity. It was these programs that gave us the opportunity to work with such outstanding people as Professor Yohei Ito, to whom this book is dedicated."

First published in 1986. Routledge is an imprint of Taylor & Francis, an informa company.

1) Classic anatomical atlases 2) Detailed labeling of the earliest phases of prenatal neorological development 3) Appeals to neuroanatomists, developmental biologists and clinical practioners. 4) Persistent relevance - brain development is not going to change.

Your brain is a collection of maps. That is no metaphor: scrawled across your brain's surfaces are actual schematic images of the sights, sounds, and actions that hold the key to your survival. Scientists first began uncovering these maps over a century ago, but we are only now beginning to unlock their secrets. Our inner cartography distorts and shapes our experience of the world, supporting complex thought, and making technology-enabled mind-reading a reality. The maps in our brain invite us to view ourselves from a startling new perspective. In Brainscapes, Rebecca Schwarzlose combines unforgettable real-life stories, cutting-edge research, and vivid illustrations to reveal brain maps' surprising lessons about our place in the world - and the world's place within us.

Early Life Origins of Health and Disease is a new book which presents and discusses the many factors that may have impact on normal development. In a concise and readable manner, the authors consider both the proven and suggestive evidence that the high prevalence of hypertension, diabetes, obesity and, in some populations, kidney disease, may not be all due to genetics or adult environment alone. There is good evidence that stress and more subtle dietary deficiencies, as well as placental malfunction, may increase the risk that the offspring will develop these problems in later life. Finally, new and emerging evidence for other areas of human health and disease such a motor control and mental health is critically reviewed for the first time. The book is a 'must' for all scientists interested in researching these areas, as there is a critical evaluation of the methodology used and suggestions for the 'optimal' way in which to investigate these phenomena.

There is a perception in the scientific community that the discipline of Physiology is in crisis, or at least, in a phase of profound transition and change. At the root of the problem is confusion between objectives (the biological questions to be solved) and the methods and technologies to be applied. Traditionally, ever since Claude Bernard's concept of the "milieu interieur," Physiology was an integrative science with the prime concern of studying regulatory mechanisms leading to adaptation and homeostasis in the presence of challenges from a dynamic internal and external environment. This study of control mechanisms can be applied on any level of fu- tion whether subcellular, cellular, and organ, but reaches its highest level of complexity with the functioning of the body as a whole and its interaction with the external environment. This involves the determination of the interaction of genetic with environmental factors and the resulting integrated body adaptation. It might seem obvious that in the pursuit of these questions any appropriate combination of techniques on any organizational level could be used. Yet the advent of molecular techniques has resulted in a preoccupation with the problems and challenges inherent in these techniques, sometimes at the expense of the original perspectives and concepts. The many new mechanisms that have been discovered at the molecular level, as well as their economical exploitation, have contributed to a climate of reductionism.

A New York Times bestseller and a Book of the Year for the Evening Standard and The Times.

Is getting a little less comfortable the key to living a happier, healthier life?

When journalist Scott Carney came across a picture of a man in his fifties sitting on a glacier in just his underwear, he assumed it must be a hoax. Dutch guru Wim Hof claimed he could control his body temperature using his mind and teach others to do the same. Sceptical, Carney signed up to Hof’s one-week course, not realising that it would be the start of a four-year journey to unlock his own evolutionary potential.

From hyperventilating in a Polish farmhouse to underwater weight training in California, and eventually climbing Mt Kilimanjaro wearing just shorts and running shoes, Carney travelled the world testing out unorthodox methods of body transformation and discovering the science behind them.

In What Doesn’t Kill Us he explains how getting a little less comfortable can help us to unlock our lost evolutionary strength.

In this book, Ljiljana Progovac proposes a gradualist, adaptationist approach to the evolution of syntax, subject to natural selection. She provides a specific framework for its study, combining the fields of evolutionary biology, theoretical syntax, typology, neuroscience, and genetics. The author pursues an internal reconstruction of the stages of grammar based on the syntactic theory associated with Chomskyan Minimalism and arrives at specific, testable hypotheses, which are then corroborated by an abundance of theoretically analysed 'living fossils' drawn from a variety of languages. Her approach demonstrates that these fossil structures do not just coexist alongside more modern structures, but are in fact built into the very foundation of more complex structures, leading to quirks and complexities that are suggestive of a gradualist evolutionary scenario. By reconstructing a particular path along which syntax evolved, Evolutionary Syntax sheds light on the crucial properties of language design itself, as well as on the major parameters of crosslinguistic variation. As a result, this reconstruction can be meaningfully correlated with both the hominin timeline and the ever-growing body of genetic evidence that is available.

This work is concerned with a group of proteins which were originally consid ered to be an esoteric phenomenon but which have now been shown to play critical roles both in normal and stressed cells as well as being involved in a variety of human diseases. It is the purpose of this work to give a comprehen sive view of these proteins and their various aspects. After an introductory chapter providing an overview of these proteins, the work is divided into four main sections each of which deals with one important aspect of these proteins. Thus, the first section contains a series of chapters which describe individual stress proteins and their roles in particular biological phenomena. Evidently, the induction of these proteins by elevated tempera ture or other stresses is their defining feature and the second section of this book therefore considers the regulation of stress protein gene expression both by stressful stimuli such as elevated temperature or ischaemia and by non stressful stimuli such as cytokines.

In this book, Ljiljana Progovac proposes a gradualist, adaptationist approach to the evolution of syntax, subject to natural selection. She provides a specific framework for its study, combining the fields of evolutionary biology, theoretical syntax, typology, neuroscience, and genetics. The author pursues an internal reconstruction of the stages of grammar based on the syntactic theory associated with Chomskyan Minimalism and arrives at specific, testable hypotheses, which are then corroborated by an abundance of theoretically analysed 'living fossils' drawn from a variety of languages. Her approach demonstrates that these fossil structures do not just coexist alongside more modern structures, but are in fact built into the very foundation of more complex structures, leading to quirks and complexities that are suggestive of a gradualist evolutionary scenario. By reconstructing a particular path along which syntax evolved, Evolutionary Syntax sheds light on the crucial properties of language design itself, as well as on the major parameters of crosslinguistic variation. As a result, this reconstruction can be meaningfully correlated with both the hominin timeline and the ever-growing body of genetic evidence that is available.

Parasitic zoonoses, the parasitic diseases transmitted between humans and other vertebrate animals, are widespread. The increasing pace of internationalization changes in diet and easy movement from one part of the world to another has caused parasitic zoonoses to be more prevalent. Consequently, these diseases have become the focus of recent research by parasitologists and pathologists whose work is presented in this book. Included in addition to the pathology of parasitic zoonoses and recent trends in research of imported parasites are the classification of phenotypes of anisakid nematodes, the immunohistopathological diagnostic method, and molecular technology to detect and diagnose parasites. Also included are papers on parasitology and international health and the pathology of cerebral malaria. With 38 color illustrations, this book is an invaluable resource for parasitologists, pathologists, and clinicians.

The scientific study of networks - computer, social, and biological - has received an enormous amount of interest in recent years. However, the network approach has been applied to the field of animal behaviour relatively late compared to many other biological disciplines. Understanding social network structure is of great importance for biologists since the structural characteristics of any network will affect its constituent members and influence a range of diverse behaviours. These include finding and choosing a sexual partner, developing and maintaining cooperative relationships, and engaging in foraging and anti-predator behavior. This novel text provides an overview of the insights that network analysis has provided into major biological processes, and how it has enhanced our understanding of the social organisation of several important taxonomic groups. It brings together researchers from a wide range of disciplines with the aim of providing both an overview of the power of the network approach for understanding patterns and process in animal populations, as well as outlining how current methodological constraints and challenges can be overcome. Animal Social Networks is principally aimed at graduate level students and researchers in the fields of ecology, zoology, animal behaviour, and evolutionary biology but will also be of interest to social scientists.

The scientific study of networks - computer, social, and biological - has received an enormous amount of interest in recent years. However, the network approach has been applied to the field of animal behaviour relatively late compared to many other biological disciplines. Understanding social network structure is of great importance for biologists since the structural characteristics of any network will affect its constituent members and influence a range of diverse behaviours. These include finding and choosing a sexual partner, developing and maintaining cooperative relationships, and engaging in foraging and anti-predator behavior. This novel text provides an overview of the insights that network analysis has provided into major biological processes, and how it has enhanced our understanding of the social organisation of several important taxonomic groups. It brings together researchers from a wide range of disciplines with the aim of providing both an overview of the power of the network approach for understanding patterns and process in animal populations, as well as outlining how current methodological constraints and challenges can be overcome. Animal Social Networks is principally aimed at graduate level students and researchers in the fields of ecology, zoology, animal behaviour, and evolutionary biology but will also be of interest to social scientists.

Given the very limited capacity of regeneration in the brain, protecting neurons that are on the brink of death is a major challenge for basic and clinical neuroscience, with implications for a broad spectrum of acute and chronic neurological and psychiatric diseases. This book brings together leading experts from neurobiology, neurophysiology, neuropharmacology, neuroimmunology and clinical neuroscience to highlight the most recent milestones in this rapidly evolving field. The book will serve as a reference for both basic neuroscientists and clinicians interested in an authoritative update on the molecular and cellular biology of neuroprotection and its promises for new therapeutic strategies.

This volume is concerned with the enzymes of the nervous system. Cerebral enzymes form the basis of the functional brain. They are needed for the control of the energetics of the nervous system, whether it be their release or their direction; for the elaboration of transmitters and for their destruction; for the synthesis, transport, and breakdown of all metabolites of the nervous system. They are indispensable for the control of the multitude of factors that govern our thinking and our behavior. They make it possible for us to comprehend what is taking place around us and perhaps to understand what may be in store for us. Enzymes are the stuff of life, and no living cell can be without them. They are the results of many millions of years of evolution, from the time when biological membranes first came into being and were folded to produce the first cells within which the earliest enzymes were wrought. Countless changes have taken place within them, so that, now, only those enzymes exist that play specific roles in the functions of the living cells of today. Those in the nervous system possess a mUltiple role: in the creation, maintenance, and ultimate breakdown of the component cells and in enabling consciousness, perception, memory, and thought to become possible. But though life may go on forever, the enzymes that make life possible will undergo the many changes involved in the evolutionary process.

Origins of Language: A Slim Guide offers a concise and accessible overview of what is known about the evolution of the human capacity for language. Non-human animals communicate in simple ways: they may be able to form simple concepts, to feel some limited empathy for others, to cooperate to some extent, and to engage in mind-reading. Human language, however, is characterized by its ability to efficiently express a wide range of subtle and complex meanings. After the first simple beginnings, human language underwent an explosion of complexity, leading to the very complicated systems of grammar and pronunciation found in modern languages. Jim Hurford looks at the very varied aspects of this evolution, covering human prehistory; the relation between instinct and learning; biology and culture; trust, altruism, and cooperation; animal thought; human and non-human vocal anatomy; the meanings and forms of the first words; and the growth of complex systems of grammar and pronunciation. Written by an internationally recognized expert in the field, it draws on a number of disciplines besides linguistics, including philosophy, neuroscience, genetics, and animal behaviour, and will appeal to a wide range of readers interested in language origins and evolution.

Human enhancement has become a major concern in debates about the future of contemporary societies. This interdisciplinary book is devoted to clarifying the underlying ambiguities of these debates, and to proposing novel ways of exploring what human enhancement means and understanding what practices, goals and justifications it entails.

It should not come as too much of a surprise that biological membranes are considerably more complex than lipid bilayers. This has been made quite clear by the fluid-mosaic model which considers the cell membrane as a two-dimensional solution of a mosaic of integral membrane proteins and glycoproteins firmly embedded in a fluid lipid bilayer matrix. Such a model has several virtues, chief among which is that it allows membrane components to diffuse in the plane of the membrane and orient asymmetrically across the membrane. The model is also remarkable since it provokes the right sort of questions. Two such examples are: Does membrane fluidity influence enzyme activity? Does cholesterol regulate fluidity? However, it does not go far enough. As it turns out, there is now another version of this model, the so-called post-fluid mosaic model which incorporates two concepts, namely the existence in the membrane of discrete domains in which specific lipid-lipid, lipid-protein and protein-protein interactions occur and ordered regions that are in motion but remain separate from less ordered regions. We must admit that both are intriguing problems and of importance in guiding our thinking as to what the next model might be.
We have chosen not to include the subject of membrane transport in the present volume. This obviously represents a break with convention. However, the intention is to have the topic covered subsequent volumes relating to organ systems. It would be right to regard this as an attempt to strengthen the integrated approach to the teaching of medicine.

What if there were a pill for love? Or an anti-love drug, designed to help us break up? This controversial and timely new book argues that recent medical advances have brought chemical control of our romantic lives well within our grasp. Substances affecting love and relationships, whether prescribed by doctors or even illicitly administered, are not some far-off speculation - indeed our most intimate connections are already being influenced by pills we take for other purposes, such as antidepressants. Treatments involving certain psychoactive substances, including MDMA-the active ingredient in Ecstasy-might soon exist to encourage feelings of love and help ordinary couples work through relationship difficulties. Others may ease a breakup or soothe feelings of rejection. Such substances could have transformative implications for how we think about and experience love. This brilliant intervention into the debate builds a case for conducting further research into "love drugs" and "anti-love drugs" and explores their ethical implications for individuals and society. Rich in anecdotal evidence and case-studies, the book offers a highly readable insight into a cutting-edge field of medical research that could have profound effects on us all. Will relationships be the same in the future? Will we still marry? It may be up to you to decide whether you want a chemical romance. -- .

This book is the compilation of papers presented at the International Symposium on in vivo Body Composition Studies, held at the University of Toronto, Ontario, Canada, June 20 - 23, 1989. The purpose of this conference was to report on advances in techniques for the in vivo measurement of body composition and to present recent data on normal body composition and changes during disease. This conference was the most recent of several meetings on body composition studies, and follows two successful such meetings, one at Brookhaven National Laboratory in 1986, and at Edinburgh in 1988. The large number of excellent research papers and posters presented at these conferences demonstrates the rapid growth of the field and the broad interest in the subject of in vivo body composition studies. The proceedings of the Brookhaven meeting "In Vivo Body Composition Studies", is published by The Institute of Physical Sciences in Medicine, London. Both the Brookhaven and the current Toronto meeting emphasized the clinical applications, together with the techniques employed. The Edinburgh meeting placed more emphasis on the methodological problems and design of instrumentation. Because of the number of papers presented at the meeting it was necessary to ask the authors from the same institution to combine their presentations into a single paper where appropriate. The editors wish to thank the authors for their cooperation and for graciously accepting the minor revisions made to each manuscript.