The study of self-consciousness helps humans understand themselves and restores their identities. But self-consciousness has been a mystery since the beginning of history, and this mystery cannot be resolved by conventional natural science. In Self-Consciousness, author Masakazu Shoji takes the mystery out of self-consciousness by proposing the idea that the human brain and body are a biological machine. A former VLSI microprocessor designer and semiconductor physicist, Shoji was guided by the ideas of ancient sages to create a conceptual design of a human machine brain model. He explains how it works, how it senses itself and the outside world, and how the machine creates the sense of existence of the subject SELF to itself, just as a living human brain does. A follow-up to Shoji's previous book, Neuron Circuits, Electronic Circuits, and Self-Consciousness, this new volume examines self-consciousness from three unconventional viewpoints to present a complex theory of the mind and how self-consciousness develops.

**NEW YORK TIMES BESTSELLER** Why do human beings behave as they do? 'Awe-inspiring... You will learn more about human nature than in any other book I can think of' Henry Marsh, bestselling author of And Finally. We are capable of savage acts of violence but also spectacular feats of kindness: is one side of our nature destined to win out over the other? Every act of human behaviour has multiple layers of causation, spiralling back seconds, minutes, hours, days, months, years, even centuries, right back to the dawn of time and the origins of our species. In the epic sweep of history, how does our biology affect the arc of war and peace, justice and persecution? How have our brains evolved alongside our cultures? This is the exhilarating story of human morality and the science underpinning the biggest question of all: what makes us human? 'One of the best scientist-writers of our time' Oliver Sacks

Richard D. Alexander is an accomplished entomologist who turned his attention to solving some of the most perplexing problems associated with the evolution of human social systems. Using impeccable Darwinian logic and elaborating, extending and adding to the classic theoretical contributions of pioneers of behavioral and evolutionary ecology like George Williams, William Hamilton and Robert Trivers, Alexander developed the most detailed and comprehensive vision of human social evolution of his era. His ideas and hypotheses have inspired countless biologists, anthropologists, psychologists and other social scientists to explore the evolution of human social behavior in ever greater detail, and many of his seminal ideas have stood the test of time and come to be pillars of our understanding of human social evolution. This volume presents classic papers or chapters by Dr. Alexander, each focused on an important theme from his work. Introductions by Dr. Alexander's former students and colleagues highlight the importance of his work to the field, describe more recent work on the topic, and discuss current issues of contention and interest.

This book looks at how the human brain got the capacity for language and how language then evolved. Its four parts are concerned with different views on the emergence of language, with what language is, how it evolved in the human brain, and finally how this process led to the properties of language. Part I considers the main approaches to the subject and how far language evolved culturally or genetically. Part II argues that language is a system of signs and considers how these elements first came together in the brain. Part III examines the evidence for brain mechanisms to allow the formation of signs. Part IV shows how the book's explanation of language origins and evolution is not only consistent with the complex properties of languages but provides the basis for a theory of syntax that offers insights into the learnability of language and to the nature of constructions that have defied decades of linguistic analysis, including including subject-verb inversion in questions, existential constructions, and long-distance dependencies. Denis Bouchard's outstandingly original account will interest linguists of all persuasions as well as cognitive scientists and others interested in the evolution of language.

Collectively, the chapters in this work will provide the reader with novel insight into the inter-relationships of the function of different organelles in the sequences of events that lead to cellular dysfunction and degeneration in the aging human population. The chapters are rich in information for cell and molecular biologists pursuing studies of the different diseases covered. In addition, the clinician will find value in understanding mechanisms underlying age-related disease as such an understanding will lead to novel therapeutic approaches for an array of age-related diseases.

This volume of "Advances in Cell Aging and Gerontology" critically reviews the rapidly advancing area of telomerase research with a focus at the molecular and cellular levels. The clearly established function of telomerase is to maintain chromosome ends during successive rounds of cell division by adding a six base DNA repeat on to the telomeric ends of chromosomes. As presented in the chapters of this volume, the mechanisms that regulate telomerase expression and activity are complex. Moreover, emerging data suggest additional roles for telomerase in the regulation of cell differentiation and survival.

It is expected that this quite comprehensive volume will provide a valuable resource for graduate students and postdocs in the telomerase field and for established investigators in other fields who are beginning to study telomerase in their particular research program. With an increasing number of proteins being brought into the fold of telomerase research (e.g., DNA damage and repair response proteins, heat-shock proteins, and proteins in various signal transduction cascades) many new scientists are beginning to study this enzyme from novel vantage points.

This book reconstructs what the earliest grammars might have been and shows how they could have led to the languages of modern humankind.
Like other biological phenomena, language cannot be fully understood without reference to its evolution, whether proven or hypothesized," wrote Talmy Givon in 2002. As the languages spoken 8,000 years ago were typologically much the same as they are today and as no direct evidence exists for languages before then, evolutionary linguists are at a disadvantage compared to their counterparts in biology. Bernd Heine and Tania Kuteva seek to overcome this obstacle by combining grammaticalization theory, one of the main methods of historical linguistics, with work in animal communication and human evolution. The questions they address include: do the modern languages derive from one ancestral language or from more than one? What was the structure of language like when it first evolved? And how did the properties associated with modern human languages arise, in particular syntax and the recursive use of language structures? The authors proceed on the assumption that if language evolution is the result of language change then the reconstruction of the former can be explored by deploying the processes involved in the latter. Their measured arguments and crystal-clear exposition will appeal to all those interested in the evolution of language, from advanced undergraduates to linguists, cognitive scientists, human biologists, and archaeologists.

During the past several years there has been a shortage of flight opportunities for biological and medical projects. And those that were available usually had severe restrictions on instrumentation, number of subjects, duration, time allotted for performing the experiments, a possibility for repetition of experiments. It is our hope and expectation that this will change once the international Space Station is in full operation. The advantages of a permanent space station, already demonstrated by the Russian Mir station, are continuous availability of expert crew and a wide range of equipment, possibility of long-term experiments where this is waranted, increased numbers of subjects through larger laboratory space, proper controls in the large 1-G centrifuge, easier repeatability of experiments when needed.
The limited number of flight opportunities during recent years probably explains why it has taken so long to acquire a sufficient number of high quality contributions for this seventh volume of Advances in Space Biology and Medicine. While initially the series wassailed at annually appearing volumes, we are now down to a biannual appearance. Hopefully, it will be possible to return to annual volumes in the future when results from space station experimentation at beginning to pour in.
The first three chapters of this volume deal with muscle. Fejtek and Wassersug provide a survey of all studies on muscle of rodents flown in space, and include an interesting demography of this aspect of space research. Riley reviews our current knowledge of the effects of long-term spaceflight and re-entry on skeletal muscle, and considers the questions still to be answered before we can be satisfied that long-term space missions, such as on the space station, can be safely undertaken. Stein reviews our understanding of the nutritional and hormonal aspects of muscle loss in spaceflight, and concludes that the protein loss in space could be deleterious to health during flight and after return. Strollo summarizes our understanding of the major endocrine systems on the ground, then considers what we know about their functioning in space, concluding that there is much to be learned about the changes taking place during spaceflight. The many problems of providing life support (oxygen regeneration and food supply) during extended stay on the Moon, on Mars, or in space by means of plant cultivation are discussed by Salisbury. The challenges of utilizing electrophoresis in microgravity for the separation of cells and proteins are illustrated and explained by Bauer and colleagues. Finally, the chapter on teaching of space life sciences by Schmitt shows that this field of science has come of age, but also that its multidisciplinary character poses interesting challenges to teaching it.

Gray's Anatomy, published in the UK in 1858 under the original title Anatomy: Descriptive and Surgical, is a detailed English textbook on human anatomy, focused on teaching medical students human anatomy for practical knowledge during surgery. This unique first edition includes more than 300 pages of illustrations by H.V. Carter, M.D. Each image is labeled with the corresponding bones, muscles, nerves, and organs. In addition, the book is separated into chapters based on the systems of the body for easy use. While Gray's Anatomy may no longer be a suitable study guide for modern physicians, it is considered a classic work on the subject and is a great reference for those interested in the origins of the study of human anatomy. HENRY GRAY (1827-1861) was a renowned British anatomist who studied at St George's Hospital Medical School in London. His focus was on the endocrine glands and spleen until he approached fellow colleague Henry Vandyke Carter to help him write a comprehensive and accessible anatomy textbook. The team worked for more than a year studying unclaimed cadavers to help write the text. It was published in England in 1858 and in America only one year later. Gray published the first two editions before it was acquired by Longman's in 1863, shortly after Gray's early death from smallpox.

The leading scholars in the rapidly-growing field of language evolution give readable accounts of their theories on the origins of language and reflect on the most important current issues and debates. As well as providing a guide to their own published research in this area they highlight what they see as the most relevant research of others. The authors come from a wide range of disciplines involved in language evolution including linguistics, cognitive science, computational science, primatology, and archaeology.

Living organisms exhibit specific responses when confronted with sudden changes in their environmental conditions. The ability of the cells to acclimate to their new environment is the integral driving force for adaptive modification of the cells. Such adaptation involves a number of cellular and biochemical alteration including metabolic homeostasis and reprogramming of gene expression. Changes in metabolic pathways are generally short-lived and reversible, while the consequences of gene expression are a long-term process and may lead to permanent alternation in the pattern of adaptive responses.
The heart possesses remarkable ability to adapt itself against any stressful situation by increasing resistance to the adverse consequences. Stress composes the foundation of many degenerative heart diseases including atherosclerosis, spasm, thrombosis, cardiomyopathy, and congestive heart failure. Based on the concept that excessive stress may play a crucial role in the pathogenesis of ischemic heart disease, attempts were made to design methods for preventing of myocardial injury. Creation of stress reactions by repeated ischemia and reperfusion or subjecting the hearts to heat or oxidative stress enables them to meet the future stress challenge. Repeated stress exposures adapt the heart to withstand more severe stress reactions probably by upregulating the cellular defense and direct accumulation of intracellular mediators, which presumably constitute the material basis of increased adaptation to stress. Thus, the powerful cardioprotective effect of adaptation is likely to originate at the cellular and molecular levels that compose fundamental processes in the prophylaxis of such diseases.
Volume six of the Advances in Organ Biology series contains state-of-the-art reviews on myocardial preservation and cellular adaptation from the leading authorities in this subject.

This set includes Volumes 1-7 of 15 short atlases reimagining the classic 5 volume Atlas of Human Central Nervous System Development. A handy paperback edition completes the coverage of the first trimester of human brain development. Serial sections from specimens between 4mm and 60mm are illustrated and annotated in great detail, together with 3D reconstructions. An introduction and glossary summarize these earliest stages of human Central Nervous System development. Key Features 1) Classic anatomical atlases 2) Detailed labeling of the earliest phases of prenatal neurological development 3) Appeals to neuroanatomists, developmental biologists and clinical practitioners. 4) Persistent relevance - brain development is not going to change.

Breast cancer research has never been in such an exciting and hopeful phase as today. From a clinical perspective, the discovery of genetic markers of risk in a proportion of familial breast cancer cases has opened up new vistas for understanding and ultimately preventing this disease. On the other hand, aggressive - even daring - therapies are being proven to be effective against advanced breast cancer. For the breast cancer experimentalist, this is also a time of great advance. Although animal and cell culture breast cancer models have proven to be of great use, there are now increasing opportunities to test the concepts developed in these models in actual clinical samples and cases. It is gratifying to see how well these concepts "translate" into the clinical setting. A very active area of research that is linking the laboratory to the clinic is the dissection of the biology and elucidation of the significance of proliferate breast disease and the identification of true, "high risk" or "preneoplastic" legions within the previously ill-defined spectrum of fibrocystic or benign breast disease. One anticipates that discoveries made here will also lead to earlier detection, intervention and prevention of life-threatening cancer.
Even, however, as we look with optimism to the eventual eradication of breast cancer, we are once again forced to face the reality that we have not yet achieved our goal. Thus, we are saddened by the much too premature death of Dr. Helene Smith from breast cancer. Helena's work was at the forefront of efforts to understand the biology of human breast cancer at the molecular level. Her insight, open-mindedness, and refusal to sacrifice relevance for convenience will continue to set the standard for all breast cancer researchers. This volume is dedicated to her memory.

A breakthrough theory that tools and technology are the real drivers of human evolution. Although humans are one of the great apes, along with chimpanzees, gorillas, and orangutans, we are remarkably different from them. Unlike our cousins who subsist on raw food, spend their days and nights outdoors, and wear a thick coat of hair, humans are entirely dependent on artificial things, such as clothing, shelter, and the use of tools, and would die in nature without them. Yet, despite our status as the weakest ape, we are the masters of this planet. Given these inherent deficits, how did humans come out on top? In this fascinating new account of our origins, leading archaeologist Timothy Taylor proposes a new way of thinking about human evolution through our relationship with objects. Drawing on the latest fossil evidence, Taylor argues that at each step of our species' development, humans made choices that caused us to assume greater control of our evolution. Our appropriation of objects allowed us to walk upright, lose our body hair, and grow significantly larger brains. As we push the frontiers of scientific technology, creating prosthetics, intelligent implants, and artificially modified genes, we continue a process that started in the prehistoric past, when we first began to extend our powers through objects. Weaving together lively discussions of major discoveries of human skeletons and artifacts with a reexamination of Darwin's theory of evolution, Taylor takes us on an exciting and challenging journey that begins to answer the fundamental question about our existence: what makes humans unique, and what does that mean for our future?