The study of self-consciousness helps humans understand themselves and restores their identities. But self-consciousness has been a mystery since the beginning of history, and this mystery cannot be resolved by conventional natural science. In Self-Consciousness, author Masakazu Shoji takes the mystery out of self-consciousness by proposing the idea that the human brain and body are a biological machine. A former VLSI microprocessor designer and semiconductor physicist, Shoji was guided by the ideas of ancient sages to create a conceptual design of a human machine brain model. He explains how it works, how it senses itself and the outside world, and how the machine creates the sense of existence of the subject SELF to itself, just as a living human brain does. A follow-up to Shoji's previous book, Neuron Circuits, Electronic Circuits, and Self-Consciousness, this new volume examines self-consciousness from three unconventional viewpoints to present a complex theory of the mind and how self-consciousness develops.

Richard D. Alexander is an accomplished entomologist who turned his attention to solving some of the most perplexing problems associated with the evolution of human social systems. Using impeccable Darwinian logic and elaborating, extending and adding to the classic theoretical contributions of pioneers of behavioral and evolutionary ecology like George Williams, William Hamilton and Robert Trivers, Alexander developed the most detailed and comprehensive vision of human social evolution of his era. His ideas and hypotheses have inspired countless biologists, anthropologists, psychologists and other social scientists to explore the evolution of human social behavior in ever greater detail, and many of his seminal ideas have stood the test of time and come to be pillars of our understanding of human social evolution. This volume presents classic papers or chapters by Dr. Alexander, each focused on an important theme from his work. Introductions by Dr. Alexander's former students and colleagues highlight the importance of his work to the field, describe more recent work on the topic, and discuss current issues of contention and interest.

This book is aimed at any basic scientist or clinician scientist teaching a course or conducting research on the basic science underlying the major neurological diseases. It provides an excellent overview of cutting-edge research on the fundamental disorders of the nervous system, including physiological and molecular aspects of dysfunction. The major categories of neurological disease are covered, and the chapters provide specific information about particular diseases exemplifying each of these categories. Sufficient clinical information is included to put into perspective the basic mechanisms discussed. The book assembles a world-class team of section editors and chapters written by acknowledged experts in their respective fields.
* Provides cutting edge information about fundamental mechanisms underlying neurological diseases
* Amply supplied with tables, illustrations and references
* Includes supporting clinical information putting the mechanisms of disease into perspective

"If we did not evolve from apes, then where did we come from?" Human Devolution is Michael Cremo's definitive answer to this question. In his characteristic style of meticulous documentation and research, Cremo offers a fresh and scientifically based perspective on human origins, with an emphasis on state-of-the-art consciousness studies. Take a fascinating tour through incredible enigmas of time and space, ranging from Precambrian microfossils to black holes to the planets of demigods, and discover how we devolved from pure consciousness to this earthly realm.

A successful Wall Street trader turned neuroscientist reveals how risk taking and stress transform our body chemistry
Before he became a world-class scientist, John Coates ran a derivatives trading desk in New York City. He used the expression "the hour between dog and wolf" to refer to the moment of Jekyll-and-Hyde transformation traders passed through when under pressure. They became cocky and irrationally risk-seeking when on a winning streak, tentative and risk-averse when cowering from losses. In a series of groundbreaking experiments, Coates identified a feedback loop between testosterone and success--one that can cloud men's judgment in high-pressure decision-making. Coates demonstrates how our bodies produce the fabled gut feelings we so often rely on, how stress in the workplace can impair our judgment and even damage our health, and how sports science can help us toughen our bodies against the ravages of stress. Revealing the biology behind bubbles and crashes, "The Hour Between Dog and Wolf "sheds new and surprising light on issues that affect us all.

This book looks at how the human brain got the capacity for language and how language then evolved. Its four parts are concerned with different views on the emergence of language, with what language is, how it evolved in the human brain, and finally how this process led to the properties of language. Part I considers the main approaches to the subject and how far language evolved culturally or genetically. Part II argues that language is a system of signs and considers how these elements first came together in the brain. Part III examines the evidence for brain mechanisms to allow the formation of signs. Part IV shows how the book's explanation of language origins and evolution is not only consistent with the complex properties of languages but provides the basis for a theory of syntax that offers insights into the learnability of language and to the nature of constructions that have defied decades of linguistic analysis, including including subject-verb inversion in questions, existential constructions, and long-distance dependencies. Denis Bouchard's outstandingly original account will interest linguists of all persuasions as well as cognitive scientists and others interested in the evolution of language.

Collectively, the chapters in this work will provide the reader with novel insight into the inter-relationships of the function of different organelles in the sequences of events that lead to cellular dysfunction and degeneration in the aging human population. The chapters are rich in information for cell and molecular biologists pursuing studies of the different diseases covered. In addition, the clinician will find value in understanding mechanisms underlying age-related disease as such an understanding will lead to novel therapeutic approaches for an array of age-related diseases.

Molecular mechanisms in visual transduction is presently one of the most intensely studied areas in the field of signal transduction research in biological cells. Because the sense of vision plays a primary role in animal biology, and thus has been subject to long evolutionary development, the molecular and cellular mechanisms underlying vision have a high degree of sensitivity and versatility. The aims of visual transduction research are first
to determine which molecules participate, and then to understand how they act in concert to produce the exquisite electrical responses of the photoreceptor cells.
Since the 1940s 1] we have known that rod vision begins with the capture of a quantum of energy, a photon, by a visual pigment molecule, rhodopsin. As the function of photon absorption is to convert the visual pigment molecule into a G-protein activating state, the structural details of the visual pigments must be
explained from the perspective of their role in activating their specific G-proteins. Thus, Chapters 1-3 of this Handbook extensively cover the physico-chemical molecular characteristics of the vertebrate rhodopsins. Following photoconversion and G-protein activation, the phototransduction cascade leads to modifications of the population of closed and open ion channels in the photoreceptor plasma membrane, and thereby to the electrical response. The nature of the channels of vertebrate photoreceptors is examined in Chapter 4, and Chapter 5 integrates the present body of knowledge of the activation steps in the cascade into a quantitative framework. Once the phototransduction cascade is activated, it must be subsequently silenced. The various molecular mechanisms participating in inactivation are
treated in Chapters 1-4 and especially Chapter 5. Molecular biology is now an indispensable tool in signal transduction studies. Numerous vertebrate (Chapter 6) and invertebrate (Chapter 7) visual pigments have been characterized and cloned. The genetics and evolutionary aspects of this great subfamily of G-protein activating receptors are intriguing as they present a natural probe for the intimate relationship between structure and function of the visual pigments. Understanding the spectral characteristics from the molecular composition can be expected to

This volume of "Advances in Cell Aging and Gerontology" critically reviews the rapidly advancing area of telomerase research with a focus at the molecular and cellular levels. The clearly established function of telomerase is to maintain chromosome ends during successive rounds of cell division by adding a six base DNA repeat on to the telomeric ends of chromosomes. As presented in the chapters of this volume, the mechanisms that regulate telomerase expression and activity are complex. Moreover, emerging data suggest additional roles for telomerase in the regulation of cell differentiation and survival.

It is expected that this quite comprehensive volume will provide a valuable resource for graduate students and postdocs in the telomerase field and for established investigators in other fields who are beginning to study telomerase in their particular research program. With an increasing number of proteins being brought into the fold of telomerase research (e.g., DNA damage and repair response proteins, heat-shock proteins, and proteins in various signal transduction cascades) many new scientists are beginning to study this enzyme from novel vantage points.

This book reconstructs what the earliest grammars might have been and shows how they could have led to the languages of modern humankind.
Like other biological phenomena, language cannot be fully understood without reference to its evolution, whether proven or hypothesized," wrote Talmy Givon in 2002. As the languages spoken 8,000 years ago were typologically much the same as they are today and as no direct evidence exists for languages before then, evolutionary linguists are at a disadvantage compared to their counterparts in biology. Bernd Heine and Tania Kuteva seek to overcome this obstacle by combining grammaticalization theory, one of the main methods of historical linguistics, with work in animal communication and human evolution. The questions they address include: do the modern languages derive from one ancestral language or from more than one? What was the structure of language like when it first evolved? And how did the properties associated with modern human languages arise, in particular syntax and the recursive use of language structures? The authors proceed on the assumption that if language evolution is the result of language change then the reconstruction of the former can be explored by deploying the processes involved in the latter. Their measured arguments and crystal-clear exposition will appeal to all those interested in the evolution of language, from advanced undergraduates to linguists, cognitive scientists, human biologists, and archaeologists.

During the past several years there has been a shortage of flight opportunities for biological and medical projects. And those that were available usually had severe restrictions on instrumentation, number of subjects, duration, time allotted for performing the experiments, a possibility for repetition of experiments. It is our hope and expectation that this will change once the international Space Station is in full operation. The advantages of a permanent space station, already demonstrated by the Russian Mir station, are continuous availability of expert crew and a wide range of equipment, possibility of long-term experiments where this is waranted, increased numbers of subjects through larger laboratory space, proper controls in the large 1-G centrifuge, easier repeatability of experiments when needed.
The limited number of flight opportunities during recent years probably explains why it has taken so long to acquire a sufficient number of high quality contributions for this seventh volume of Advances in Space Biology and Medicine. While initially the series wassailed at annually appearing volumes, we are now down to a biannual appearance. Hopefully, it will be possible to return to annual volumes in the future when results from space station experimentation at beginning to pour in.
The first three chapters of this volume deal with muscle. Fejtek and Wassersug provide a survey of all studies on muscle of rodents flown in space, and include an interesting demography of this aspect of space research. Riley reviews our current knowledge of the effects of long-term spaceflight and re-entry on skeletal muscle, and considers the questions still to be answered before we can be satisfied that long-term space missions, such as on the space station, can be safely undertaken. Stein reviews our understanding of the nutritional and hormonal aspects of muscle loss in spaceflight, and concludes that the protein loss in space could be deleterious to health during flight and after return. Strollo summarizes our understanding of the major endocrine systems on the ground, then considers what we know about their functioning in space, concluding that there is much to be learned about the changes taking place during spaceflight. The many problems of providing life support (oxygen regeneration and food supply) during extended stay on the Moon, on Mars, or in space by means of plant cultivation are discussed by Salisbury. The challenges of utilizing electrophoresis in microgravity for the separation of cells and proteins are illustrated and explained by Bauer and colleagues. Finally, the chapter on teaching of space life sciences by Schmitt shows that this field of science has come of age, but also that its multidisciplinary character poses interesting challenges to teaching it.

Gray's Anatomy, published in the UK in 1858 under the original title Anatomy: Descriptive and Surgical, is a detailed English textbook on human anatomy, focused on teaching medical students human anatomy for practical knowledge during surgery. This unique first edition includes more than 300 pages of illustrations by H.V. Carter, M.D. Each image is labeled with the corresponding bones, muscles, nerves, and organs. In addition, the book is separated into chapters based on the systems of the body for easy use. While Gray's Anatomy may no longer be a suitable study guide for modern physicians, it is considered a classic work on the subject and is a great reference for those interested in the origins of the study of human anatomy. HENRY GRAY (1827-1861) was a renowned British anatomist who studied at St George's Hospital Medical School in London. His focus was on the endocrine glands and spleen until he approached fellow colleague Henry Vandyke Carter to help him write a comprehensive and accessible anatomy textbook. The team worked for more than a year studying unclaimed cadavers to help write the text. It was published in England in 1858 and in America only one year later. Gray published the first two editions before it was acquired by Longman's in 1863, shortly after Gray's early death from smallpox.

The leading scholars in the rapidly-growing field of language evolution give readable accounts of their theories on the origins of language and reflect on the most important current issues and debates. As well as providing a guide to their own published research in this area they highlight what they see as the most relevant research of others. The authors come from a wide range of disciplines involved in language evolution including linguistics, cognitive science, computational science, primatology, and archaeology.

An expert palaeoarchaeologist reveals how our understanding of the evolution of our species has been transformed by momentous discoveries and technological advancements. Who are we? How do scientists define Homo sapiens, and how does our species differ from the extinct hominins that came before us? This illuminating book explores how the latest scientific advances, especially in genetics, are revolutionizing our understanding of human evolution. Paul Pettitt reveals the extraordinary story of how our ancestors adapted to unforgiving and relentlessly changing climates, leading to remarkable innovations in art, technology and society that we are only now beginning to comprehend. Drawing on twenty-five years of experience in the field, Paul Pettitt immerses readers in the caves and rockshelters that provide evidence of our African origins, dispersals to the far reaches of Eurasia, Australasia and ultimately the Americas. Popular accounts of the evolution of Homo sapiens emphasize biomolecular research, notably genetics, but this book also draws from the wealth of information from specific excavations and artefacts, including the author's own investigations into the origins of art and how it evolved over its first 25,000 years. He focuses in particular on behaviour, using archaeological evidence to bring an intimate perspective on lives as they were lived in the almost unimaginably distant past.

Living organisms exhibit specific responses when confronted with sudden changes in their environmental conditions. The ability of the cells to acclimate to their new environment is the integral driving force for adaptive modification of the cells. Such adaptation involves a number of cellular and biochemical alteration including metabolic homeostasis and reprogramming of gene expression. Changes in metabolic pathways are generally short-lived and reversible, while the consequences of gene expression are a long-term process and may lead to permanent alternation in the pattern of adaptive responses.
The heart possesses remarkable ability to adapt itself against any stressful situation by increasing resistance to the adverse consequences. Stress composes the foundation of many degenerative heart diseases including atherosclerosis, spasm, thrombosis, cardiomyopathy, and congestive heart failure. Based on the concept that excessive stress may play a crucial role in the pathogenesis of ischemic heart disease, attempts were made to design methods for preventing of myocardial injury. Creation of stress reactions by repeated ischemia and reperfusion or subjecting the hearts to heat or oxidative stress enables them to meet the future stress challenge. Repeated stress exposures adapt the heart to withstand more severe stress reactions probably by upregulating the cellular defense and direct accumulation of intracellular mediators, which presumably constitute the material basis of increased adaptation to stress. Thus, the powerful cardioprotective effect of adaptation is likely to originate at the cellular and molecular levels that compose fundamental processes in the prophylaxis of such diseases.
Volume six of the Advances in Organ Biology series contains state-of-the-art reviews on myocardial preservation and cellular adaptation from the leading authorities in this subject.