A breakthrough theory that tools and technology are the real drivers of human evolution. Although humans are one of the great apes, along with chimpanzees, gorillas, and orangutans, we are remarkably different from them. Unlike our cousins who subsist on raw food, spend their days and nights outdoors, and wear a thick coat of hair, humans are entirely dependent on artificial things, such as clothing, shelter, and the use of tools, and would die in nature without them. Yet, despite our status as the weakest ape, we are the masters of this planet. Given these inherent deficits, how did humans come out on top? In this fascinating new account of our origins, leading archaeologist Timothy Taylor proposes a new way of thinking about human evolution through our relationship with objects. Drawing on the latest fossil evidence, Taylor argues that at each step of our species' development, humans made choices that caused us to assume greater control of our evolution. Our appropriation of objects allowed us to walk upright, lose our body hair, and grow significantly larger brains. As we push the frontiers of scientific technology, creating prosthetics, intelligent implants, and artificially modified genes, we continue a process that started in the prehistoric past, when we first began to extend our powers through objects. Weaving together lively discussions of major discoveries of human skeletons and artifacts with a reexamination of Darwin's theory of evolution, Taylor takes us on an exciting and challenging journey that begins to answer the fundamental question about our existence: what makes humans unique, and what does that mean for our future?

Breast cancer research has never been in such an exciting and hopeful phase as today. From a clinical perspective, the discovery of genetic markers of risk in a proportion of familial breast cancer cases has opened up new vistas for understanding and ultimately preventing this disease. On the other hand, aggressive - even daring - therapies are being proven to be effective against advanced breast cancer. For the breast cancer experimentalist, this is also a time of great advance. Although animal and cell culture breast cancer models have proven to be of great use, there are now increasing opportunities to test the concepts developed in these models in actual clinical samples and cases. It is gratifying to see how well these concepts "translate" into the clinical setting. A very active area of research that is linking the laboratory to the clinic is the dissection of the biology and elucidation of the significance of proliferate breast disease and the identification of true, "high risk" or "preneoplastic" legions within the previously ill-defined spectrum of fibrocystic or benign breast disease. One anticipates that discoveries made here will also lead to earlier detection, intervention and prevention of life-threatening cancer.
Even, however, as we look with optimism to the eventual eradication of breast cancer, we are once again forced to face the reality that we have not yet achieved our goal. Thus, we are saddened by the much too premature death of Dr. Helene Smith from breast cancer. Helena's work was at the forefront of efforts to understand the biology of human breast cancer at the molecular level. Her insight, open-mindedness, and refusal to sacrifice relevance for convenience will continue to set the standard for all breast cancer researchers. This volume is dedicated to her memory.

Osteoarchaeology: A Guide to the Macroscopic Study of Human Skeletal Remains covers the identification of bones and teeth, taphonomy, sex, ancestry assessment, age estimation, the analysis of biodistances, growth patterns and activity markers, and paleopathology. The book aims to familiarize the reader with the main applications of osteoarchaeology and provide the necessary knowledge required for the implementation of a broad range of osteological methods. It is ideal as a complement to existing textbooks used in upper level undergraduate and graduate courses on osteoarchaeology, human osteology, and, to some extent, forensic anthropology. Pedagogical features include ample illustrations, case study material, revision exercises, and a glossary. Additional features comprise macros that facilitate data processing and analysis, as well as an extensive chapter on applied statistics.

One of the world's leading geneticists, Bryan Sykes has helped thousands find their ancestry in the British Isles. Saxons, Vikings, and Celts, which resulted from a systematic ten-year DNA survey of more than 10,000 volunteers, traces the true genetic makeup of the British Isles and its descendants, taking readers from the Pontnewydd cave in North Wales to the resting place of "The Red Lady" of Paviland and the tomb of King Arthur. Genealogy has become a popular pastime of Americans interested in their heritage, and this is the perfect work for anyone interested in finding their heritage in England, Scotland, or Ireland.

Retinoids have received considerable attention in recent years and due cognizance has been given to their versatility as biological response modifiers, as evidenced by the virtually explosive growth of literature in this field in the past few years. This volume has been designed to give a current state-of-the-art picture of retinoids. The perceived potential of retinoids in the treatment of certain disease stated has initiated attempts at identifying and synthesizing new retinoid derivatives with definable and selective effects on aberrant biological phenomena. Appropriately, therefore, we begin with the chemistry of retinoids and their derivatives together with discussions of their biological activity. Major advances have been made in understanding the mechanisms by which retinoids modulate physiological and phenotypic traits of cells. The transduction of retinoid signaling by the mediation of nuclear receptors of the steroid/thyroid receptor superfamily has now been studied extensively and the cloning and defining the characteristics of these receptors has been a focus of discussion in this volume. Retinoids also markedly modulate the transduction of extracellular signals such as those imparted by growth factors and hormones, and thus actively influence and control cellular proliferative patterns. Retinoids can alter epidermal growth factor receptor expression (Kawaguchi et al., 1994), responsiveness to thyroid hormone (Esfandiari et al., 1994; Pallet et al., 1994), inhibit the proliferative responses of hematopoietic progenitor cells to granulocyte colony stimulating factor (Smeland et al., 1994), and modulate secretion on interleukins by leukaemic cells (Balitrand et al., 1994), among other things. This has obvious implications for pharmacological manipulation of deregulated growth (Dickens and Colletta, 1993; Mulshine et al., 1993). Apoptosis is another component in the regulation of growth control. Apoptotic cell death is influenced by several agents and retinoids may function by interfering with apoptotic pathways of regulation of growth control and quite legitimately, therefore, the importance of this aspect of retinoid function has been duly recognized here.

This set includes Volumes 1-7 of 15 short atlases reimagining the classic 5 volume Atlas of Human Central Nervous System Development. A handy paperback edition completes the coverage of the first trimester of human brain development. Serial sections from specimens between 4mm and 60mm are illustrated and annotated in great detail, together with 3D reconstructions. An introduction and glossary summarize these earliest stages of human Central Nervous System development. Key Features 1) Classic anatomical atlases 2) Detailed labeling of the earliest phases of prenatal neurological development 3) Appeals to neuroanatomists, developmental biologists and clinical practitioners. 4) Persistent relevance - brain development is not going to change.

Most of the literature dealing with the origins of modern humans concentrates on the European sequence, where the Levant is referred to in passing as being problematic because it does not fit with the sequence of events documented in Europe. This is the first book that attempts to examine the issues specifically from the Levant, viewing it as central rather than peripheral to the problem. It also discusses in some depth the ramifications of possible interactions between the different hominids in the region.

Rather than viewing the transition from the Middle to Upper Paleolithic as the time at which fully modern adaptive systems came to the forefront, emphasis is placed on the Middle Paleolithic itself in order to test hypotheses that hominids of this period were culturally archaic. Through an analysis of the archaeological evidence, it is concluded that by at least 100,000 years ago people of the period, usually regarded as being somewhat less than human were, on the contrary, fully modern in terms of their behavioral and cultural systems. This conclusion applies to both the Neanderthals and their anatomically modern contemporaries. The author further concludes that the cultural and behavioral differences between the two types were minimal and that there was a potential for interaction and acculturation between them. The possibility is raised that the Near East is the region in which modern human cultural adaptation arose and then dispersed to other regions.

Learn how nutrition has driven--and continues to drive--human evolution

This pioneering text draws from molecular nutrition, nutritional sciences, dietetics, genetics, genomics, and anthropology to examine how chemical nutrients and genetics shape the human species. It presents a vital portrait of the fundamental role that nutrition has played and continues to play in shaping who and what human beings are, where we evolved from, and where we might be headed as a species.

The author's innovative molecular biological approach moves the field of nutrition well beyond its traditional dietetic and anthropological origins to the front lines of genomic research. Following a presentation of molecular biology concepts that are essential for the study of human nutrition, the author explores such key topics as:

Bioinformatics and the -omics revolution

Recent human evolution

Molecular mechanisms of gene-nutrient interactions

Role of nutrients and genomics in disease

Evolution of micronutrient metabolism, protein structure, and human disease

Nutrients and the human life cycle

Mismatch of contemporary dietary patterns and our genetic makeup

Laboratory tools for nutrigenomics and human evolutionary studies

Figures and illustrations provided throughout the text help readers grasp and visualize complex concepts and processes with ease. For readers interested in pursuing particular topics in greater depth, an extensive list of current references is provided.

This text is ideal for undergraduate and graduate students in human nutrition, dietetics, metabolism, molecular biology, and many other allied health sciences. Nowhere else can readers find such an integratedblend of medical, nutritional, and biochemical disciplines to aid in understanding the role of nutrients in human evolution.

**NEW YORK TIMES BESTSELLER** Why do human beings behave as they do? 'Awe-inspiring... You will learn more about human nature than in any other book I can think of' Henry Marsh, bestselling author of And Finally. We are capable of savage acts of violence but also spectacular feats of kindness: is one side of our nature destined to win out over the other? Every act of human behaviour has multiple layers of causation, spiralling back seconds, minutes, hours, days, months, years, even centuries, right back to the dawn of time and the origins of our species. In the epic sweep of history, how does our biology affect the arc of war and peace, justice and persecution? How have our brains evolved alongside our cultures? This is the exhilarating story of human morality and the science underpinning the biggest question of all: what makes us human? 'One of the best scientist-writers of our time' Oliver Sacks

For many years, it has been known that when rats and mice are given a reduced amount of food, their life span is increased and they remain healthy and vigorous at advanced ages.

What is the reason for this change in the usual pattern of aging? The evidence is overwhelming that the life extension results from a slowing of aging processes. And the factor responsible is the decrease in caloric intake. The obvious question: How does this factor work? A good question - and the reason that research on the anti-aging action of caloric restriction is today one of the most studied research areas in biological gerontology. For it is felt that if the biological mechanisms of the anti-aging action of caloric restriction can be uncovered, we would gain an understanding of the basic nature of aging processes, which would, in turn, yield possible interventions in human aging. This book aims to provide the growing number of researchers in this field (faculty, postdoctoral trainees, and graduate students) with a detailed knowledge of what is known about caloric restriction within the frame of gerontology, as well as insights on future of this field.

In this volume three of the key figures in the field set out to establish some parameters for the study of creativity. After examining the earlier works on the subject, they present their current research findings, and then attempt to project where the field is likely to go in the decade ahead.

Gardner, the proponent of biological aspects of creativity, ranges widely as he examines Freud's Vienna and the features of medicine that both constrained and challenged his revolutionary idea. Csikszentmihalyi, with his exploration of genes and memes, examines individual issues as well as broader contextual concerns. Feldman concentrates on the notions of coincidence and the transformational imperative. These essays point to the rejuvenation of the field of creativity research, and suggest where the field is likely to move in the future. This work is a major synthesis of value to advanced researchers as well as students and all those concerned with creativity.

Zilinskas and Balint and their contributors examine the divisions between minority groups and the scientific community, particularly in the area of medical and genetic research. Minorities have reasons to be skeptical of medical research in general and genetics research in particular. The sad history of the Tuskegee experiment, in which black men with syphilis were left untreated so that the course of the disease could be studied, undermined confidence in the ethics of medical researchers. More recently, publication of "The Bell Curve" reanimated controversy over purported genetic distinctions among the races that could have powerfully negative social implications.

In contrast, as the essays make clear, the Human Genome Project, conducted in accordance with the highest ethical standards, has the potential to make dramatic positive contributions to the health of all human beings. Members of minority communities in particular--who statistically are at high risk of adverse health outcomes in the United States--have much to gain from innovative medical diagnostics and therapies that will result from the study of human genetics. Therefore, if we are to benefit fully from this new knowledge, it is vital that the distrust, skepticism, and misconceptions relating to genetics research be overcome. This is a provocative collection for scholars, students, researchers, and community leaders involved with minority and public health issues.

Arguing that human evolution has come to a stand-still, this book sets out to explore the evolutionary steps that have defined life on this planet. It describes the stages from cosmic to chemical and biological evolution and to the development of civilization and culture. From this scientific approach, the author concludes that new rules of ethics are required in order to maintain and improve the civilization and culture of humanity. Matare argues for corrective genetic interference and explores the moral implications.