Retinoids have received considerable attention in recent years and due cognizance has been given to their versatility as biological response modifiers, as evidenced by the virtually explosive growth of literature in this field in the past few years. This volume has been designed to give a current state-of-the-art picture of retinoids. The perceived potential of retinoids in the treatment of certain disease stated has initiated attempts at identifying and synthesizing new retinoid derivatives with definable and selective effects on aberrant biological phenomena. Appropriately, therefore, we begin with the chemistry of retinoids and their derivatives together with discussions of their biological activity. Major advances have been made in understanding the mechanisms by which retinoids modulate physiological and phenotypic traits of cells. The transduction of retinoid signaling by the mediation of nuclear receptors of the steroid/thyroid receptor superfamily has now been studied extensively and the cloning and defining the characteristics of these receptors has been a focus of discussion in this volume. Retinoids also markedly modulate the transduction of extracellular signals such as those imparted by growth factors and hormones, and thus actively influence and control cellular proliferative patterns. Retinoids can alter epidermal growth factor receptor expression (Kawaguchi et al., 1994), responsiveness to thyroid hormone (Esfandiari et al., 1994; Pallet et al., 1994), inhibit the proliferative responses of hematopoietic progenitor cells to granulocyte colony stimulating factor (Smeland et al., 1994), and modulate secretion on interleukins by leukaemic cells (Balitrand et al., 1994), among other things. This has obvious implications for pharmacological manipulation of deregulated growth (Dickens and Colletta, 1993; Mulshine et al., 1993). Apoptosis is another component in the regulation of growth control. Apoptotic cell death is influenced by several agents and retinoids may function by interfering with apoptotic pathways of regulation of growth control and quite legitimately, therefore, the importance of this aspect of retinoid function has been duly recognized here.

"If we did not evolve from apes, then where did we come from?" Human Devolution is Michael Cremo's definitive answer to this question. In his characteristic style of meticulous documentation and research, Cremo offers a fresh and scientifically based perspective on human origins, with an emphasis on state-of-the-art consciousness studies. Take a fascinating tour through incredible enigmas of time and space, ranging from Precambrian microfossils to black holes to the planets of demigods, and discover how we devolved from pure consciousness to this earthly realm.

This set includes Volumes 1-7 of 15 short atlases reimagining the classic 5 volume Atlas of Human Central Nervous System Development. A handy paperback edition completes the coverage of the first trimester of human brain development. Serial sections from specimens between 4mm and 60mm are illustrated and annotated in great detail, together with 3D reconstructions. An introduction and glossary summarize these earliest stages of human Central Nervous System development. Key Features 1) Classic anatomical atlases 2) Detailed labeling of the earliest phases of prenatal neurological development 3) Appeals to neuroanatomists, developmental biologists and clinical practitioners. 4) Persistent relevance - brain development is not going to change.

Most of the literature dealing with the origins of modern humans concentrates on the European sequence, where the Levant is referred to in passing as being problematic because it does not fit with the sequence of events documented in Europe. This is the first book that attempts to examine the issues specifically from the Levant, viewing it as central rather than peripheral to the problem. It also discusses in some depth the ramifications of possible interactions between the different hominids in the region.

Rather than viewing the transition from the Middle to Upper Paleolithic as the time at which fully modern adaptive systems came to the forefront, emphasis is placed on the Middle Paleolithic itself in order to test hypotheses that hominids of this period were culturally archaic. Through an analysis of the archaeological evidence, it is concluded that by at least 100,000 years ago people of the period, usually regarded as being somewhat less than human were, on the contrary, fully modern in terms of their behavioral and cultural systems. This conclusion applies to both the Neanderthals and their anatomically modern contemporaries. The author further concludes that the cultural and behavioral differences between the two types were minimal and that there was a potential for interaction and acculturation between them. The possibility is raised that the Near East is the region in which modern human cultural adaptation arose and then dispersed to other regions.

For many years, it has been known that when rats and mice are given a reduced amount of food, their life span is increased and they remain healthy and vigorous at advanced ages.

What is the reason for this change in the usual pattern of aging? The evidence is overwhelming that the life extension results from a slowing of aging processes. And the factor responsible is the decrease in caloric intake. The obvious question: How does this factor work? A good question - and the reason that research on the anti-aging action of caloric restriction is today one of the most studied research areas in biological gerontology. For it is felt that if the biological mechanisms of the anti-aging action of caloric restriction can be uncovered, we would gain an understanding of the basic nature of aging processes, which would, in turn, yield possible interventions in human aging. This book aims to provide the growing number of researchers in this field (faculty, postdoctoral trainees, and graduate students) with a detailed knowledge of what is known about caloric restriction within the frame of gerontology, as well as insights on future of this field.

Over the centuries, researchers have found bones and artefacts proving that modern humans have existed for millions of years. Mainstream science, however has suppressed these facts. Prejudices based on current scientific theory act as a 'knowledge filter', giving us a picture of prehistory that is largely inaccurate. This book reveals this hidden history.

In this volume three of the key figures in the field set out to establish some parameters for the study of creativity. After examining the earlier works on the subject, they present their current research findings, and then attempt to project where the field is likely to go in the decade ahead.

Gardner, the proponent of biological aspects of creativity, ranges widely as he examines Freud's Vienna and the features of medicine that both constrained and challenged his revolutionary idea. Csikszentmihalyi, with his exploration of genes and memes, examines individual issues as well as broader contextual concerns. Feldman concentrates on the notions of coincidence and the transformational imperative. These essays point to the rejuvenation of the field of creativity research, and suggest where the field is likely to move in the future. This work is a major synthesis of value to advanced researchers as well as students and all those concerned with creativity.

Zilinskas and Balint and their contributors examine the divisions between minority groups and the scientific community, particularly in the area of medical and genetic research. Minorities have reasons to be skeptical of medical research in general and genetics research in particular. The sad history of the Tuskegee experiment, in which black men with syphilis were left untreated so that the course of the disease could be studied, undermined confidence in the ethics of medical researchers. More recently, publication of "The Bell Curve" reanimated controversy over purported genetic distinctions among the races that could have powerfully negative social implications.

In contrast, as the essays make clear, the Human Genome Project, conducted in accordance with the highest ethical standards, has the potential to make dramatic positive contributions to the health of all human beings. Members of minority communities in particular--who statistically are at high risk of adverse health outcomes in the United States--have much to gain from innovative medical diagnostics and therapies that will result from the study of human genetics. Therefore, if we are to benefit fully from this new knowledge, it is vital that the distrust, skepticism, and misconceptions relating to genetics research be overcome. This is a provocative collection for scholars, students, researchers, and community leaders involved with minority and public health issues.

An expert palaeoarchaeologist reveals how our understanding of the evolution of our species has been transformed by momentous discoveries and technological advancements. Who are we? How do scientists define Homo sapiens, and how does our species differ from the extinct hominins that came before us? This illuminating book explores how the latest scientific advances, especially in genetics, are revolutionizing our understanding of human evolution. Paul Pettitt reveals the extraordinary story of how our ancestors adapted to unforgiving and relentlessly changing climates, leading to remarkable innovations in art, technology and society that we are only now beginning to comprehend. Drawing on twenty-five years of experience in the field, Paul Pettitt immerses readers in the caves and rockshelters that provide evidence of our African origins, dispersals to the far reaches of Eurasia, Australasia and ultimately the Americas. Popular accounts of the evolution of Homo sapiens emphasize biomolecular research, notably genetics, but this book also draws from the wealth of information from specific excavations and artefacts, including the author's own investigations into the origins of art and how it evolved over its first 25,000 years. He focuses in particular on behaviour, using archaeological evidence to bring an intimate perspective on lives as they were lived in the almost unimaginably distant past.

Arguing that human evolution has come to a stand-still, this book sets out to explore the evolutionary steps that have defined life on this planet. It describes the stages from cosmic to chemical and biological evolution and to the development of civilization and culture. From this scientific approach, the author concludes that new rules of ethics are required in order to maintain and improve the civilization and culture of humanity. Matare argues for corrective genetic interference and explores the moral implications.

This study is based on the following premises: human beings differ in their physiological reactions to their different environments and consequently differ in appearance; individuals who resemble each other in observable characteristics tend to be grouped together geographically; therefore, races exist in man as in any other species.

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