Of recent, the structure of the complement system has received considerable attention, including the publication of several three-dimensional structures of complement proteins. This has led to the need for an authoritative resource to provide a complete overview of the basics, as well as an explanation of the cutting-edge work being accomplished in this emerging science. Structural Biology of the Complement System is devoted to the full exploration of structural aspects of the complement system, with special consideration of the links between molecular structure and function. Containing the work of leading authorities across the disciplines of immunology and structural biology, the book serves both as an introductory volume for newcomers to the field and as a comprehensive reference for established researchers, in particular those whose goal is the discovery of anticomplement drugs. Written in a didactic style, this volume is an appropriate resource for students in the fields of immunology and structural biology. Structural Biology of the Complement System comes with downloadable resources containing color figures, a molecular structure visualization program, and files with three-dimensional coordinates of the structures described in the book. These tools allow readers to perform tailored structural manipulation and analysis, while also serving as a starting point for further research.

Much of what we are comes from our ancestors. Through cultural and biological inheritance mechanisms, our genetic composition, instructions for constructing artifacts, the structure and content of languages, and rules for behavior are passed from parents to children and from individual to individual. "Mapping Our Ancestors" demonstrates how various genealogical or "phylogenetic" methods can be used both to answer questions about human history and to build evolutionary explanations for the shape of history.
Anthropologists are increasingly turning to quantitative phylogenetic methods. These methods depend on the transmission of information regardless of mode and as such are applicable to many anthropological questions. In this way, phylogenetic approaches have the potential for building bridges among the various subdisciplines of anthropology; an exciting prospect indeed. The structure of "Mapping Our Ancestors" reflects the editors' goal of developing a common understanding of the methods and conditions under which ancestral relations can be derived in a range of data classes of interest to anthropologists. Specifically, this volume explores the degree to which patterns of ancestry can be determined from artifactual, genetic, linguistic, and behavioral data and how processes such as selection, transmission, and geography impact the results of phylogenetic analyses.
"Mapping Our Ancestors" provides a solid demonstration of the potential of phylogenetic methods for studying the evolutionary history of human populations using a variety of data sources and thus helps explain how cultural material, language, and biology came to be as they are.
Carl P. Lipo is assistant professor of anthropology at California State University in Long Beach. Michael O'Brien is professor of anthropology and director of the Museum of Anthropology at the University of Missouri. Mark Collard is assistant professor of anthropology at the University of British Columbia, Stephen J. Shennan is a professor and director of the Institute of Archaeology at the University College London. Niles Eldredge is a curator in the department of invertebrates at the American Museum of Natural History, and adjunct professor at the City University of New York.

This volume gives the reader a comprehensive overview of the fundamental and biological aspects of aging. First, the field is described from a historical perspective. Then, the author analyzes the three fundamental mechanisms of survival: energy utilization, molecular and cellular redundancy, and the organization of information. The genetics of aging is reviewed rejecting some simple-minded interpretations. A bridge is established between the molecular, cellular, and tissue modifications that have been reported in the literature, and the clinical manifestations of the aging syndrome. Special relevance is given to the problem of the supposed association between cancers and aging, giving a new interpretation of that relationship.

The major significance of the German naturalist-physician Johann Friedrich Blumenbach (1752-1840) as a topic of historical study is the fact that he was one of the first anthropologists to investigate humankind as part of natural history. Moreover, Blumenbach was, and continues to be, a central figure in debates about race and racism. How exactly did Blumenbach define race and races? What were his scientific criteria? And which cultural values did he bring to bear on his scheme? Little historical work has been done on Blumenbach's fundamental, influential race work. From his own time till today, several different pronouncements have been made by either followers or opponents, some accusing Blumenbach of being the fountainhead of scientific racism. By contrast, across early nineteenth-century Europe, not least in France, Blumenbach was lionized as an anti-racist whose work supported the unity of humankind and the abolition of slavery. This collection of essays considers how, with Blumenbach and those around him, the study of natural history and, by extension, that of science came to dominate the Western discourse of race.

The spectacular advances of medicinal chemistry in the last few decades have been triggered by a greater understanding of cellular processes at the molecular level. The understanding of biochemical processes and diseases at molecular level has revolutionized the field. This volume summarizes recent developments in the area of biological inhibitors such as squalene epoxidase inhibitors, dual inhibitors of 5-lipoxygenase and cycloxgenase, inhibition of cholestrol biosynthesis, HIV proteinase inhibitors, nonpeptide antagonists at peptide receptors, and binding interaction of thyroid hormones.

This reference dictionary takes a new approach to the study of physical anthropology by focusing on the concepts involved. As Stevenson notes at the outset, physical or biological anthropology is a synthetic discipline which has borrowed much from evolutionary biology, anatomy, genetics, medicine, zoology, paleontology, and demography. Thus, although none of the concepts are unique to the discipline, their relative importance and the contexts in which they are used may be. Here, Stevenson presents concise entries describing the development of physical anthropological concepts followed by bibliographies including most of the major works in the field. The history of the usage of each concept is traced from its origins--often outside the discipline of physical anthropology--to the contemporary and usually multidisciplinary contexts in which physical anthropologists participate. Entries clearly delineate both the theoretical development of the concepts under discussion and their applications in physical anthropological practice. The comprehensive bibliographies enable the reader to pursue further study of concepts of particular interest. Indispensable to students just beginning their studies in the field, the dictionary will also be an invaluable reference for scholars and researchers.

There is a revolution underway in biology. It is based on a new perception of bodies and genes, in which the former are the end product of the latter within the continuum of evolution. Twenty five years after Richard Dawkins helped revolutionize our thinking about "selfish genes," it is time to re-evaluate. "Revolutionary Biology" explains in simple, vivid terms what this exciting approach has to offer, and then applies its stunning insights to human beings. This novel perspective, galvanizes our understanding of how evolution works, what living things are all about and, not least what it means to be human. The controversial disciplines of sociobiology and evolutionary psychology have generated startling insights into longstanding questions concerning the nature and purpose of families, altruism vs. selfishness, and free will vs. biological determinism. Written by one of its foremost figures, "Revolutionary Biology" is a manifesto and educated layman's guide to this ongoing revolution.

Barash's purpose is to demystify the basic concepts of the genetic revolution and take the reader on a tour--accessible and authoritative--of the principles that underlie this fascinating turn in scientific thought. Much has been written about evolution, animals, and the animal and evolutionary origins of human behavior, yet only recently have biologists begun to appreciate these connections. The key concept is that genes--not species, not groups, and not even individuals--are the apple of evolution's eye. The result has been a major biological paradigm shift that is making itself felt in the social sciences as well. Barash explores the phenomenon of altruism both at the animal level, and the human level.

Barash draws not only on a wealth of biological evidence but on literature, philosophy, and the familiar details of everyday life to communicate the essentials of this increasingly influential approach to the study of the human species. Clearly and engagingly written, "Revolutionary Biology" will be fascinating reading for those seeking an entry into this new science.

Sex has no history, but sexual science does. Starting in the late nineteenth century, people all over the world suddenly began to insist that understandings of sex be based on science. As Japanese and Indian sexologists influenced their German and American counterparts, and vice versa, sexuality, modernity, and imaginings of exotified "Others" became intimately linked. The first anthology to provide a worldwide perspective on the birth and development of the field, A Global History of Sexual Science contends that actors outside of Europe-in Asia, Latin America, and Africa-became important interlocutors in debates on prostitution, birth control, and transvestism. Ideas circulated through intellectual exchange, travel, and internationally produced and disseminated publications. Twenty scholars tackle specific issues, including the female orgasm and the criminalization of male homosexuality, to demonstrate how concepts and ideas introduced by sexual scientists gained currency throughout the modern world.

Plomp's "Aspects of Tone Sensation"--published 25 years ago--dealt with the psychophysics of simple and complex tones. Since that time, auditory perception as a field of study has undergone a radical metamorphosis. Technical and methodological innovations, as well as a considerable increase in attention to the various aspects of auditory experience, have changed the picture profoundly. This book is an attempt to account for this development by giving a comprehensive survey of the present state of the art as a whole. Perceptual aspects of hearing, particularly of understanding speech as the main auditory input signal, are thoroughly reviewed.

Nitric oxide is involved in the regulation of the circulation in physiologic and pathophysiological conditions. Evidence indicates that alterations in endothelial production of nitric oxide may be involved in the pathogenesis of central hypertension, pulmonary hypertension, renal disease and coronary vasopastic disorders. In addition to being involved in regulation of the circulation in physiologic and pathophysiologic conditions, the inducible form of the enzyme may play a role in the refractory hypertension.

The diversity of contemporary investigative approaches included in this volume provides an exciting account of our current understanding of brain mechanisms responsible for sensory and perceptual experience in the areas of touch, kinesthesia, and pain. Postgraduate research students in sensory physiology, neurology, psychology and anatomy, and researchers themselves will find that this volume addresses many of the key issues in our attempts to understand the neural mechanisms that mediate sensory experience arising from the body as a whole, the so-called somatic senses, in particular for touch and pain. The volume provides a record of the occasion of the St Petersburg IUPS symposium, chaired by the editors of this volume, and includes some added recent contributions from other leading international figures in the field. Brought together under the sponsoring banner of the IUPS Commission for Somatosensory Physiology and Pain, these scientists with their different experimental approaches seek collectively to understand the brain mechanisms that underlie our own nature and experience.

Human Biological Diversity is an introductory textbook designed to cover the key contemporary topics in the study of human variation and human biology within the field of physical anthropology. Easily accessible for students with no background in anthropology or biology, this second edition includes two new chapters, one on human variation in the skeleton and dentition and the other on tracing human population affinities. All other chapters have been fully updated to reflect advances in the field and now include pedagogical features to aid readers in their understanding. Written for an introductory level but still containing valuable information that will be of interest to students on upper-level courses, Brown's textbook should be essential reading for all students taking courses on human variation, human biology, human evolution, race, anthropology of race, and general introductions to biological/physical anthropology.

Series Information:
Routledge Studies in Science, Technology and Society

For many years, de Waal has observed chimpanzees soothe distressed neighbors and bonobos share their food. Now he delivers fascinating fresh evidence for the seeds of ethical behavior in primate societies that further cements the case for the biological origins of human fairness. Interweaving vivid tales from the animal kingdom with thoughtful philosophical analysis, de Waal seeks a bottom-up explanation of morality that emphasizes our connection with animals. In doing so, de Waal explores for the first time the implications of his work for our understanding of modern religion. Whatever the role of religious moral imperatives, he sees it as a Johnny-come-lately role that emerged only as an addition to our natural instincts for cooperation and empathy.

But unlike the dogmatic neo-atheist of his book s title, de Waal does not scorn religion per se. Instead, he draws on the long tradition of humanism exemplified by the painter Hieronymus Bosch and asks reflective readers to consider these issues from a positive perspective: What role, if any, does religion play for a well-functioning society today? And where can believers and nonbelievers alike find the inspiration to lead a good life?

Rich with cultural references and anecdotes of primate behavior, The Bonobo and the Atheist engagingly builds a unique argument grounded in evolutionary biology and moral philosophy. Ever a pioneering thinker, de Waal delivers a heartening and inclusive new perspective on human nature and our struggle to find purpose in our lives."

Molecular mechanisms in visual transduction is presently one of the most intensely studied areas in the field of signal transduction research in biological cells. Because the sense of vision plays a primary role in animal biology, and thus has been subject to long evolutionary development, the molecular and cellular mechanisms underlying vision have a high degree of sensitivity and versatility. The aims of visual transduction research are first
to determine which molecules participate, and then to understand how they act in concert to produce the exquisite electrical responses of the photoreceptor cells.
Since the 1940s 1] we have known that rod vision begins with the capture of a quantum of energy, a photon, by a visual pigment molecule, rhodopsin. As the function of photon absorption is to convert the visual pigment molecule into a G-protein activating state, the structural details of the visual pigments must be
explained from the perspective of their role in activating their specific G-proteins. Thus, Chapters 1-3 of this Handbook extensively cover the physico-chemical molecular characteristics of the vertebrate rhodopsins. Following photoconversion and G-protein activation, the phototransduction cascade leads to modifications of the population of closed and open ion channels in the photoreceptor plasma membrane, and thereby to the electrical response. The nature of the channels of vertebrate photoreceptors is examined in Chapter 4, and Chapter 5 integrates the present body of knowledge of the activation steps in the cascade into a quantitative framework. Once the phototransduction cascade is activated, it must be subsequently silenced. The various molecular mechanisms participating in inactivation are
treated in Chapters 1-4 and especially Chapter 5. Molecular biology is now an indispensable tool in signal transduction studies. Numerous vertebrate (Chapter 6) and invertebrate (Chapter 7) visual pigments have been characterized and cloned. The genetics and evolutionary aspects of this great subfamily of G-protein activating receptors are intriguing as they present a natural probe for the intimate relationship between structure and function of the visual pigments. Understanding the spectral characteristics from the molecular composition can be expected to

The book is a festschrift, dedicated to Hans Dieter Kubitscheck, the former head of the Department of Southeast Asian Studies at Humboldt University, Berlin. Ten authors representing different academic disciplines (mainly history and ethnology) as well as four different countries (Indonesia, Vietnam, Laos and Burma/Myanmar) discuss the relations between ethnic minorities and the nation state in Southeast Asia in colonial and modern times.

From a biomedical engineering perspective, this book takes an analytic, quantitative approach to describing the basic components of physiological regulators and control systems (PRCs). In Endogenous and Exogenous Regulation and Control of Physiological Systems, the author provides grounding in the classical methods of designing linear and nonlinear systems. He also offers state-of-the-art material on the potential of PRCs to treat immune system ailments, most notably AIDS and cancer.

The book focuses on certain "wet" physiological regulators, such as those using endocrine hormones as parametric control substances. Endogenous and Exogenous Regulation and Control of Physiological Systems includes simulations that illustrate model validations and the putative control of cancer and HIV proliferation. It explores novel, untried immunotherapies on the cutting-edge of PRC treatment and explores the latest technologies.

This work contributes to a better understanding of the growing subnational involvement in foreign affairs. It offers a general view of the most prominent aspects in the development of subnational foreign action around the world, dealing with topics such as the repercussions upon subnational autonomy of the progressive constitution of diverse international regimes like the European Union, NAFTA, and APEC, or the complex relation between the growing subnational foreign action and the contemporary conditions for the formulation and implementation of foreign policy in federal and quasifederal states.

This work contributes to a better understanding of the growing subnational involvement in foreign affairs. It offers a general view of the most prominent aspects in the development of subnational foreign action around the world, dealing with topics such as the repercussions upon subnational autonomy of the progressive constitution of diverse international regimes like the European Union, NAFTA, and APEC, or the complex relation between the growing subnational foreign action and the contemporary conditions for the formulation and implementation of foreign policy in federal and quasifederal states.

Originally published in 1957, The Uniqueness of the Individual is a collection of 9 essays published from the ten years preceding publication. The essays deal with some of the central problems of biology. These are among the questions put and answered from the standpoint of modern experimental biology. What is ageing and how is it measured? What theories have been held to account for it, and with what success? Did ageing evolve, and if so how? Is Lamarckism and adequate explanation of evolutionary process? Does evolution sometimes go wrong? Do human beings evolve in a way peculiar to themselves? Other essays touch upon the problems of scientific method and of growth and transformation. This book will be of interest to natural historians, evolutionists and anthropologists.

Originally published in 1933 Functional Affinities of Man, Monkeys and Apes gives a taxonomic and phylogenetic survey and the findings of diverse experimental investigations of lemurs, monkeys, and apes. The book discusses the inter-relationships of different Primates and emphasizes seldom-used approaches to the question of primate phylogeny. The book attempts to show how little they have been systematically tried, and argues for a regard to the proper place of functional investigations in the study of the classification and evolution of Primates. This book will be of interest to anthropologists, scientists and historians alike.

The rapid growth of the study of apoptosis-mechanism-driven, regulated cell death-has created an urgent need for reliable documentation of t he different approaches to and methods of studying the various aspects of the field. Apoptosis in Neurobiology is an important resource for researchers in this emerging frontier of biomedical study. This volume allows the uninitiated neuroscientist intellectual and practical acce ss to the study of apoptosis, with special consideration to the nervou s system. The first section concentrates on conceptual approaches to t he study of apoptosis in neurobiology and its significance to the nerv ous system. The second section provides a user-friendly approach to me thods and techniques in the study of apoptosis as applied to neurobiol ogy.

An analysis of cell death in reproductive physiology. It examines topics such as the control of apoptosis in the uterus during decidualization and stern cell factor regulation of apoptosis in mouse primordial germ cells.

In his remarkable ethnography of computer engineers, Gary Downey investigates the interface between the human body and the machine. Drawing on interviews, observations and personal interaction with engineers, Downey documents the everyday power of technologys dominant image in our society.
Downey argues that we need to appreciate how deeply connected we are to The Machine, and that it would be hugely beneficial if we could understand ourselves and machines as partially configured of the other - we as part machines, machines as part humans. In this way, we can begin to see both the power and the limitations of technology.

In his remarkable ethnography of computer engineers, Gary Downey investigates the interface between the human body and the machine. Drawing on interviews, observations and personal interaction with engineers, Downey documents the everyday power of technologys dominant image in our society.
Downey argues that we need to appreciate how deeply connected we are to The Machine, and that it would be hugely beneficial if we could understand ourselves and machines as partially configured of the other - we as part machines, machines as part humans. In this way, we can begin to see both the power and the limitations of technology.