Robert Arking's Biology of Aging, 3rd edition, is an introductory text to the biology of aging which gives advanced undergraduate and graduate students a thorough review of the entire field. His prior two editions have also served admirably as a reference text for clinicians and scientists. This new edition captures the extraordinary recent advances in our knowledge of the ultimate and proximal mechanisms underlying the phenomenon of aging. As a result, six important conceptual changes are included here:
DT Clarified distinctions between the biological mechanisms involved in longevity determination and those involved in senescent processes. DT A new conceptual framework around which we can organize all the new facts about aging. This will assist readers to make sense of the information and use the data to form their own ideas. DT Increased knowledge of aging cells has lead to new ideas on how a cell transits from a healthy state to a senescent state, while still allowing for high levels of intra- and inter-specific variability. DT Discussion of senescent mechanisms assists the reader to understand that aging is a non-programmatic loss of function, likely arising from the loss of regulatory signals, and so is modifiable in the laboratory. DT Because the standard evolutionary story does not fully explain the evolution of social organisms, this edition also includes recent work dealing with intergenerational resource transfers. DT Lastly, if aging mechanisms are plastic, then the demand to move these anti-aging interventions into the human arena will inevitably grow. A discussion of the biological and ethical arguments on both sides of the question frames the question in anappropriate manner.
The mass of data related to aging is summarized into fifteen focused chapters, each dealing with some particular aspect of the problem. The last two chapters integrate all this material into a coherent view of how the relevant biological processes change over the life span. This view is expressed in two non-technical figures (you might say that the whole book exists to fully support Figs 9-4 & 14-9), whose meanings are elucidated as the reader progresses through the book.

Over millions of years in the fossil record, hominin teeth preserve a high-fidelity record of their own growth, development, wear, chemistry and pathology. They yield insights into human evolution that are difficult, if not impossible, to achieve through other sources of fossil or archaeological data. Integrating dental findings with current debates and issues in palaeoanthropology, this book shows how fossil hominin teeth shed light on the origins and evolution of our dietary diversity, extended childhoods, long lifespans, and other fundamental features of human biology. It assesses methods to interpret different lines of dental evidence, providing a critical, practical approach that will appeal to students and researchers in biological anthropology and related fields such as dental science, oral biology, evolutionary biology, and palaeontology.

The first comprehensive look at menopause from prehistory to today Are the ways we look at menopause all wrong? Historian Susan Mattern says yes, and The Slow Moon Climbs reveals just how wrong we have been. Taking readers from the rainforests of Paraguay to the streets of Tokyo, Mattern draws on historical, scientific, and cultural research to reveal how our perceptions of menopause developed from prehistory to today. For most of human history, people had no word for menopause and did not view it as a medical condition. Rather, in traditional foraging and agrarian societies, it was a transition to another important life stage. This book, then, introduces new ways of understanding life beyond fertility. Mattern examines the fascinating "Grandmother Hypothesis"-which argues for the importance of elders in the rearing of future generations-as well as other evolutionary theories that have generated surprising insights about menopause and the place of older people in society. She looks at agricultural communities where households relied on postreproductive women for the family's survival. And she explores the emergence of menopause as a medical condition in the Western world. It was only around 1700 that people began to see menopause as a dangerous pathological disorder linked to upsetting symptoms that rendered women weak and vulnerable. Mattern argues that menopause was another syndrome, like hysterical suffocation or melancholia, that emerged or reemerged in early modern Europe in tandem with the rise of a professional medical class. The Slow Moon Climbs casts menopause, at last, in the positive light it deserves-not only as an essential life stage, but also as a key factor in the history of human flourishing.

"Fascinating and exhilarating-Sean B. Carroll at his very best."-Bill Bryson, author of The Body: A Guide for Occupants From acclaimed writer and biologist Sean B. Carroll, a rollicking, awe-inspiring story of the surprising power of chance in our lives and the world Why is the world the way it is? How did we get here? Does everything happen for a reason or are some things left to chance? Philosophers and theologians have pondered these questions for millennia, but startling scientific discoveries over the past half century are revealing that we live in a world driven by chance. A Series of Fortunate Events tells the story of the awesome power of chance and how it is the surprising source of all the beauty and diversity in the living world. Like every other species, we humans are here by accident. But it is shocking just how many things-any of which might never have occurred-had to happen in certain ways for any of us to exist. From an extremely improbable asteroid impact, to the wild gyrations of the Ice Age, to invisible accidents in our parents' gonads, we are all here through an astonishing series of fortunate events. And chance continues to reign every day over the razor-thin line between our life and death. This is a relatively small book about a really big idea. It is also a spirited tale. Drawing inspiration from Monty Python, Kurt Vonnegut, and other great thinkers, and crafted by one of today's most accomplished science storytellers, A Series of Fortunate Events is an irresistibly entertaining and thought-provoking account of one of the most important but least appreciated facts of life.

The topic of stem cells has a high profile in the media. We've made important advances in our scientific understanding, but despite this the clinical applications of stem cells are still in their infancy and most real stem cell therapy carried out today is some form of bone marrow transplantation. At the same time, a scandalous spread of unproven stem cell treatments by private clinics represents a serious problem, with treatments being offered which are backed by limited scientific rationale, and which are at best ineffective, and at worse harmful. This Very Short Introduction introduces stem cells, exploring what they are, and what scientists do with them. Introducing the different types of stem cells, Jonathan Slack explains how they can be used to treat diseases such as retinal degeneration, diabetes, Parkinson's disease, heart disease, and spinal trauma. He also discusses the important technique of bone marrow transplantation and some other types of current stem cell therapy, used for the treatment of blindness and of severe burns. Slack warns against fake stem cell treatments and discusses how to distinguish real from fake treatments. He also describes the latest scientific progress in the field, and looks forward to what we can expect to happen in the next few years Very Short Introductions: Brilliant, Sharp, Inspiring ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.

The science of language evolution appeared at the end of the last century but topically belongs to language origins - the domain of investigation that is concerned with the beginnings and diversification of language. Language evolution as a research area contrasts with the antiquity of language origins, which can be traced back to the earliest forms of traditional reflection. Language evolution emphasises its scientific orientation, whereas throughout most of its history language origins constituted a complex mixture of mythology, philosophy of language, as well as religiously and scientifically inspired speculation. This work is the first book-long attempt to document the whole history of language origins and situate language evolution in this wide intellectual context.

In Bonk, the best-selling author of Stiff turns her outrageous curiosity and insight on the most alluring scientific subject of all: sex. Can a person think herself to orgasm? Why doesn't Viagra help women-or, for that matter, pandas? Can a dead man get an erection? Is vaginal orgasm a myth? Mary Roach shows us how and why sexual arousal and orgasm-two of the most complex, delightful, and amazing scientific phenomena on earth-can be so hard to achieve and what science is doing to make the bedroom a more satisfying place.

Where did we come from? Where are we going? Homo sapiens is the most successful, the most widespread and the most influential species ever to walk the Earth. In the blink of an evolutionary eye we have spread around the globe, taken control of Earth's biological and mineral resources, transformed the environment, discovered the secrets of the universe and travelled into space. Yet just 7 million years ago, we were just another species of great ape making a quiet living in the forests of East Africa. We do not know exactly what this ancestor was like, but it was no more likely than a chimpanzee or gorilla to sail across the ocean, write a symphony, invent a steam engine or ponder the meaning of existence. How did we get from there to here? Human Origins recounts the most astonishing evolutionary tale ever told. Discover how our ancestors made the first tentative steps towards becoming human, how we lost our fur but gained language, fire and tools, how we strode out of Africa, invented farming and cities and ultimately created modern civilisation - perhaps the only one of its kind in the universe. Meet your long-lost ancestors, the other humans who once shared the planet with us, and learn where the story might end. ABOUT THE SERIES New Scientist Instant Expert books are definitive and accessible entry points to the most important subjects in science; subjects that challenge, attract debate, invite controversy and engage the most enquiring minds. Designed for curious readers who want to know how things work and why, the Instant Expert series explores the topics that really matter and their impact on individuals, society, and the planet, translating the scientific complexities around us into language that's open to everyone, and putting new ideas and discoveries into perspective and context.

Having studied medicine at Guy's Hospital, London, John Kidd (1775 1851) established himself as a physician and educator at Oxford, where he lectured widely on chemistry, anatomy, mineralogy and geology. Regius professor of medicine and a fellow of the Royal Society from 1822, he rooted his scientific understanding and teaching in natural theology. Published in 1833 as the second Bridgewater Treatise, the present work attempted to bring science and religion into harmony, drawing on such disciplines as anthropology and comparative anatomy. Seeking to demonstrate the superiority of humans in the natural world, Kidd argues that animals, minerals and plants had been adapted by God to serve mankind. Founded upon a belief in the antediluvian world and the revealed existence of God in nature, the work exemplifies the influence of natural theology within the scientific establishment before the era of Darwin."

A savory account of how the pursuit of delicious foods shaped human evolution Nature, it has been said, invites us to eat by appetite and rewards by flavor. But what exactly are flavors? Why are some so pleasing while others are not? Delicious is a supremely entertaining foray into the heart of such questions. With generous helpings of warmth and wit, Rob Dunn and Monica Sanchez offer bold new perspectives on why food is enjoyable and how the pursuit of delicious flavors has guided the course of human history. They consider the role that flavor may have played in the invention of the first tools, the extinction of giant mammals, the evolution of the world's most delicious and fatty fruits, the creation of beer, and our own sociality. Along the way, you will learn about the taste receptors you didn't even know you had, the best way to ferment a mastodon, the relationship between Paleolithic art and cheese, and much more. Blending irresistible storytelling with the latest science, Delicious is a deep history of flavor that will transform the way you think about human evolution and the gustatory pleasures of the foods we eat.

The present volume continues Koopman's book on the systematics of the Chiroptera from 1994 with three further contributions, namely on the Biology of Flight, the Sensory Organs, and on Chronobiology. Written by internationally wellknown authors these contributions present information on their topics in unique breadth and depth, all of them furnished with an extensive bibliography. The language is either English or German; contributions in the German language having an English summary.

Developmental Juvenile Osteology was created as a core reference text to document the development of the entire human skeleton from early embryonic life to adulthood. In the period since its first publication there has been a resurgence of interest in the developing skeleton, and the second edition of Developmental Juvenile Osteology incorporates much of the key literature that has been published in the intervening time. The main core of the text persists by describing each individual component of the human skeleton from its embryological origin through to its final adult form. This systematic approach has been shown to assist the processes of both identification and age estimation and acts as a core source for the basic understanding of normal human skeletal development. In addition to this core, new sections have been added where there have been significant advances in the field.

"Adventures in Human Being, with its deft mix of the clinical and the lyrical, is a triumph of the eloquent brain and the compassionate heart."--Wall Street Journal We assume we know our bodies intimately, but for many of us they remain uncharted territory, an enigma of bone and muscle, neurons and synapses. How many of us understand the way seizures affect the brain, how the heart is connected to well-being, or the why the foot holds the key to our humanity? In Adventures in Human Being, award-winning author Gavin Francis leads readers on a journey into the hidden pathways of the human body, offering a guide to its inner workings and a celebration of its marvels. Drawing on his experiences as a surgeon, ER specialist, and family physician, Francis blends stories from the clinic with episodes from medical history, philosophy, and literature to describe the body in sickness and in health, in life and in death. When assessing a young woman with paralysis of the face, Francis reflects on the age-old difficulty artists have had in capturing human expression. A veteran of the war in Iraq suffers a shoulder injury that Homer first described three millennia ago in the Iliad. And when a gardener pricks her finger on a dirty rose thorn, her case of bacterial blood poisoning brings to mind the comatose sleeping beauties in the fairy tales we learn as children. At its heart, Adventures in Human Being is a meditation on what it means to be human. Poetic, eloquent, and profoundly perceptive, this book will transform the way you view your body.

Converging evidence from disciplines including sociobiology, evolutionary psychology and human biology forces us to adopt a new idea of what it means to be a human. As cherished concepts such as free will, naive realism, humans as creation's crowning glory fall and our moral roots in ape group dynamics become clearer, we have to take leave of many concepts that have been central to defining our humanness. What emerges is a new human, the homo novus, a human being without illusions. Leading authors from many different fields explore these issues by addressing a range of illusions and providing evidence for the need, despite considerable reluctance, to relinquish some of our most cherished ideas about ourselves.

Researchers have long had an interest in dental morphology as a genetic proxy to reconstruct population history. Much interest was fostered by the use of standard plaques and associated descriptions that comprise the Arizona State University Dental Anthropology System, developed by Christy G. Turner, II and students. This system has served as the foundation for hundreds of anthropological studies for over 30 years. In recognition of that success, this volume brings together some of the world's leading dental morphologists to expand upon the concepts and methods presented in the popular The Anthropology of Modern Human Teeth (Cambridge University Press, 1997), leading the reader from method to applied research. After a preparatory section on the current knowledge of heritability and gene expression, a series of case studies demonstrate the utility of dental morphological study in both fossil and more recent populations (and individuals), from local to global scales.

This manual not only provides reliable, up-to-date protocols for lab use but also the theoretical background of molecular biology, allowing users to better understand the principles underlying these techniques. It covers a wide range of methods, including the purification of nucleic acids, enzymatic modification of DNA, isolation of specific DNA fragments, PCR, cloning techniques, and gene expression. A Springer Lab Manual

Few things are as interesting to us as our own bodies and, by extension, our own identities. In recent years, there has been a growing interest in the relationship between the body, environment and society. Reflecting upon these developments, this book examines the role of the body in human identification, in the forging of identities, and the ways in which it embodies our social worlds. The approach is integrative, taking a uniquely biological perspective and reflecting on current discourse in the social sciences. With particular reference to bioarchaeology and forensic science, the authors focus on the construction and categorisation of the body within scientific and popular discourse, examining its many tissues, from the outermost to the innermost, from the skin to DNA. Synthesising two, traditionally disparate, strands of research, this is a valuable contribution to research on human identification and the embodiment of identity.

The study of signal transduction mechanisms has become one of the most important branches of biomedical science, indispensable to understanding the normal actions of hormones, neurotransmitters and other extracellular signaling molecules as well as many pathophysiological processes, including inflammation and cancer. In this volume, the various techniques for measuring Ca2+ in the cytosol, in the various organelles, and in the immediate surroundings of individual cells are described in practical detail by experts. Also included is a chapter on tracking calmodulin inside cells using fluorescence technology. A Springer Lab Manual

The emergence of the genus Homo is widely linked to the colonization of 'new' highly seasonal savannah habitats. However, until recently, our understanding of the possible impact of seasonality on this shift has been limited because we have little general knowledge of how seasonality affects the lives of primates. This book documents the extent of seasonality in food abundance in tropical woody vegetation, and then presents systematic analyses of the impact of seasonality in food supply on the behavioural ecology of non-human primates. Syntheses in this volume then produce broad generalizations concerning the impact of seasonality on behavioural ecology and reproduction in both human and non-human primates, and apply these insights to primate and human evolution. Written for graduate students and researchers in biological anthropology and behavioural ecology, this is an absorbing account of how seasonality may have affected an important episode in our own evolution.

Biolinguistics is a highly interdisciplinary field that seeks the rapprochement between linguistics and biology. Linking theoretical linguistics, theoretical biology, genetics, neuroscience and cognitive psychology, this book offers a collection of chapters situating the enterprise conceptually, highlighting both the promises and challenges of the field, and chapters focusing on the challenges and prospects of taking interdisciplinarity seriously. It provides concrete illustrations of some of the cutting-edge research in biolinguistics and piques the interest of undergraduate students looking for a field to major in and inspires graduate students on possible research directions. It is also meant to show to specialists in adjacent fields how a particular strand of theoretical linguistics relates to their concerns, and in so doing, the book intends to foster collaboration across disciplines.

This handbook offers guidance on selections of appropriate computational methods and software packages for specific genetic problems. Coverage strikes a balance between methodological expositions and practical guidelines for software selections. Wherever possible, comparisons among competing methods and software are made to highlight the relative advantages and disadvantage of the approaches.

This book offers a clearly written, entertaining and comprehensive source of medical information for both writers and readers of science fiction. Science fiction in print, in movies and on television all too often presents dubious or simply incorrect depictions of human biology and medical issues. This book explores the real science behind such topics as how our bodies adapt to being in space, the real-life feasibility of common plot elements such as suspended animation and medical nanotechnology, and future prospects for improving health, prolonging our lives, and enhancing our bodies through technology. Each chapter focuses on a single important science fiction-related subject, combining concise factual information with examples drawn from science fiction in all media. Chapters conclude with a "Bottom Line" section summarizing the most important points discussed in the chapter and giving science fiction writers practical advice on how to incorporate them into their own creations, including a list of references for further reading. The book will appeal to all readers interested in learning about the latest ideas on a variety of science fiction-related medical topics, and offers an invaluable reference source for writers seeking to increase the realism and readability of their works. Henry G. Stratmann, MD, FACC, FACP is a cardiologist with board certifications in internal medicine, cardiology, and nuclear cardiology. Befor e entering private practice he became Professor of Medicine at St. Louis University School of Medicine and performed clinical medical research. Henry received a BA in chemistry from St. Louis University and his MD at Southern Illinois University School of Medicine. He is currently enrolled at Missouri State University to obtain a BS in physics with a minor in astronomy. His professional publications include being an author or coauthor of many research articles for medical journals, primarily in the field of nuclear cardiology. Henry is also a regular contributor of both stories and science fact articles to Analog Science Fiction and Fact.

This book provides a unique discussion of human evolution from a philosophical viewpoint, looking at the facts and interpretations since Charles Darwin's The Descent of Man. Michael Ruse explores such topics as the nature of scientific theories, the relationships between culture and biology, the problem of progress and the extent to which evolutionary issues pose problems for religious beliefs. He identifies these issues, highlighting the problems for morality in a world governed by natural selection. By taking a philosophical viewpoint, the full ethical and moral dimensions of human evolution are examined. This book engages the reader in a thorough discussion of the issues, appealing to students in philosophy, biology and anthropology.

The development of populations over time, and, on longer timescales, the evolution of species, are both influenced by a complex of interacting, underlying processes. Computer simulation provides a means of experimenting within an idealised framework to allow aspects of these processes and their interactions to be isolated, controlled, and understood. In this 2005 book, computer simulation is used to model migration, extinction, fossilisation, interbreeding, selection and non-hereditary effects in the context of human populations and the observed distribution of fossil and current hominoid species. The simulations described enable the visualisation and study of lineages, genetic diversity in populations, character diversity across species and the accuracy of reconstructions, allowing insights into human evolution and the origins of humankind for graduate students and researchers in the fields of physical anthropology, human evolution, and human genetics.

Building on the success of the second edition, this truly accessible textbook comprehensively covers the 2008 AS and A2 level Human Biology specifications for all the main UK exam boards.The book also has a companion website which is free to book users providing extra resources. Written by authors with many years' experience of teaching, examining and writing, this is an ideal resource for class or independent study. The book includes the following features: How Science Works feature boxes focus on this key element of the new specifications. Stretch and Challenge boxes challenge more able students, enabling them to achieve the highest grades. Science in Context boxes encourage students to relate their learning to the world around them. Summaries at the end of every chapter help students with revision. Test Yourself questions throughout the text enable students to monitor their own progress in preparation for their exams. Remember This boxes highlight the key facts. The website provides the following additional resources: Practice questions (and answers) allow students to test their understanding of the material just covered. How Science Works assignments allow students to prepare for the How Science Works element of the new AS and A2 Human Biology exams.