'Gets right to the heart of what makes us what we are. Read it!' Angela Saini, author of Inferior and Superior: The Return of Race Science The popular science equivalent of Who Do You Think You Are? Popular science master Brian Clegg's new book is an entertaining tour through the science of what makes you you. From the atomic level, through life and energy to genetics and personality, it explores how the billions of particles which make up you - your DNA, your skin, your memories - have come to be. It starts with the present-day reader and follows a number of trails to discover their origins: how the atoms in your body were created and how they got to you in space and time, the sources of things you consume, how the living cells of your body developed, where your massive brain and consciousness originated, how human beings evolved and, ultimately, what your personal genetic history reveals.

By showing how and why human nature is what it is, evolutionary theory can help us see better what we need to do to improve the human condition. Following evolutionary theory to its logical conclusion, Death, Hope and Sex uses life history theory and attachment theory to construct a model of human nature in which critical features are understood in terms of the development of alternative reproductive strategies contingent on environmental risk and uncertainty. James Chisholm examines the implications of this model for perspectives on concerns associated with human reproduction, including teen pregnancy, and young male violence. He thus develops new approaches for thorny issues such as the nature-nurture and mind-body dichotomies. Bridging the gap between the social and biological sciences, this far-reaching volume will be a source of inspiration, debate and discussion for all those interested in the evolution of human nature and the potential for an evolutionary humanism.

'From your brain to your fingertips, you emerge from her book entertained and with a deeper understanding of yourself' Richard Dawkins 'A masterful account of why our bodies are the way they are . . . this book really shines . . . Roberts's lightness of touch is joyous, and celebratory' Observer 'Witty, personal and above all informed by passion and deep knowledge, this is the story of you, not just from conception onwards but from the millions of years of evolution that have shaped the way we are today' Adam Rutherford ***SHORTLISTED FOR THE WELLCOME BOOK PRIZE*** Alice Roberts takes you on the most incredible journey, revealing your path from a single cell to a complex embryo to a living, breathing, thinking person. It's a story that connects us with our distant ancestors and an extraordinary, unlikely chain of events that shaped human development and left a mark on all of us. Alice Roberts uses the latest research to uncover the evolutionary history hidden in all of us, from the secrets found only in our embryos and genes - including why as embroyos we have what look like gills - to those visible in your anatomy. This is a tale of discovery, exploring why and how we have developed as we have. This is your story, told as never before.

From the author of the award-winning bestseller The Content of Our Character comes a new essay collection that tells the untold story behind the polarized racial politics in America today. In A Dream Deferred Shelby Steele argues that a second betrayal of black freedom in the United States--the first one being segregation--emerged from the civil rights era when the country was overtaken by a powerful impulse to redeem itself from racial shame. According to Steele,1960s liberalism had as its first and all-consuming goal the expiation of America guilt rather than the careful development of true equality between the races. This "culture of preference" betrayed America's best principles in order to give whites and America institutions an iconography of racial virtue they could use against the stigma of racial shame. In four densely argued essays, Steele takes on the familiar questions of affirmative action, multiculturalism, diversity, Afro-centrism, group preferences, victimization--and what he deems to be the atavistic powers of race, ethnicity, and gender, the original causes of oppression. A Dream Deferred is an honest, courageous look at the perplexing dilemma of race and democracy in the United States--and what we might do to resolve it.

As widespread social transformations have been paralleled by gains in health and life expectancy through public health and other improvements, a variety of new obstacles to health have emerged. Lifestyle-related, behaviorally mediated changes in rates of chronic disease are the most prevalent of these new challenges. This book examines the relationship between human biology and human society, and how behavior, hormones, and health intersect. There is both scientific interest and practical urgency behind the ideas and findings presented here, as the need for a socioecological view of function and well-being has become more apparent. This book documents an emerging understanding of how hormones create the linkage between behavior or social life and health.

With the advent of the Human Genome Project there have been many claims for the genetic origins of complex human behavior including insanity, criminality, and intelligence. But what does it really mean to call something "genetic"? This is the fundamental question that Sahotra Sarkar's book addresses. This important book clarifies the meaning of the term "genetic," shows how molecular studies have affected genetics, and provides the philosophical background necessary to understand the debates over the Human Genome Project. It will be of particular interest to professionals and students in the philosophy of science, the history of science, and the social studies of science, medicine, and technology.

As scholars debate the most appropriate way to teach evolutionary theory, Constance Areson Clark provides an intriguing reflection on similar debates in the not-too-distant past. Set against the backdrop of the Jazz Age, God-or Gorilla explores the efforts of biologists to explain evolution to a confused and conflicted public during the 1920s. Focusing on the use of images and popularization, Clark shows how scientists and anti-evolutionists deployed schematics, cartoons, photographs, sculptures, and paintings to win the battle for public acceptance. She uses representative illustrations and popular media accounts of the struggle to reveal how concepts of evolutionary theory changed as they were presented to, and absorbed into, popular culture. Engagingly written and deftly argued, God-or Gorilla offers original insights into the role of images in communicating-and miscommunicating-scientific ideas to the lay public.

If scientists can successfully clone sheep, will humans be next? Today's headlines read like a science fiction novel! Due Consideration takes a poignant look at the rapidly changing field of biomedicine and the consequences it will have on our lives. Arthur Caplan, one of this nation's leading bioethicists, explores these issues and analyzes moral questions including:
* Will we retain our essential humanity if we modify our biological blueprint?
* Would it be irresponsible to procreate without a thorough genetic examination?
* Who will decide if physical traits like short stature and baldness are considered diseases?
* Can biomedicine make our lives better?
You'll also learn about the most current and controversial topics such as:
* Cloning, abortion and assisted suicide.
* Genetically engineering a human to be immune from infectious diseases.
* The ability to "design" our children from head to toe.
* Diagnosing and treating illnesses during fetal development.
* Programs to prevent the transmission of HIV.
No other book on the market today combines this analytic clarity with the latest from medical journals and media headlines. Now, you can decide for yourself what the future ought to hold in store.

Fat is a vital yet hugely under-rated organ.

Fat has become a dirty word, but we know so little about how it really works. In Fat, expert doctors and obesity researchers Dr Mariëtte Boon and Professor Liesbeth van Rossum present the ground-breaking research which explodes many of the myths and prejudices surrounding body fat and will make us completely rethink our relationship with it.

Making use of the cutting-edge research in this specialist field, this fascinating and entertaining book will explain how fat generates important hormones, communicates with our brains and is, indeed, essential for staying alive. Informative yet accessible, Fat: The Secret Organ is important reading, not only for people who have struggled with their weight, but for everybody who is serious about their health.

Childhood is a uniquely human life-stage, and is both a biological phenomenon and a social construct. Research on children is currently of wide-ranging interest. This groundbreaking book presents reviews of childhood from four major areas of interest--human evolution, sociology/social anthropology, biomedical anthropology and developmental psychology--to form a biosocial, cross-cultural understanding of childhood. The book places a strong emphasis on how childhood varies from culture to culture, offering examples from developed and developing countries, as well as from other animal species. It will be of interest to students and scholars within the fields of human biology, anthropology, sociology, health studies, and developmental psychology.

The study of human bipedalism has been overshadowed by many polarized debates. One dispute concerns whether or not australopithecines were wholly terrestrial or retained a degree of arboreality. Another deliberation focuses on the bipedalism of australopithecines compared to modern humans: was it similar, intermediate in nature, or unique? Because of the preoccupation with discussions such as these, the significant fact that modern human walking is more than locomotion on two legs has been underemphasized.
This volume focuses on the pattern and process of the transition to the modern form of human locomotion, with its adaptations for a striding stiff-legged gait, efficiency of running, and economy of resource transport. This emerging group of contributors spanning the fields of anthropology, biology and anatomy debate issues such as:
-When and in what sequence did these morphological traits appear?
-What were the changes in the bio-behavioral complex of hominin locomotor evolution?
-What were the implications for the enhancement and expansion of hominin mobility?

Why are humans so different from each other and what makes the human species so different from all other living organisms? This introductory book provides a concise and accessible account of human diversity, of its causes and the ways in which anthropologists go about trying to make sense of it. Carles Salazar offers students a thoroughly integrated view by bringing together biological and sociocultural anthropology and including perspectives from evolutionary biology and psychology.

A few gray hairs and a couple of wrinkles are often the first visible signs of aging on our bodies. For most of us, however, aging remains largely a mystery. We can only wonder why we have to age and what casualty of age hovers nearby. Written in everyday language, The Clock of Ages takes us on a tour of the aging human body--all from a research scientist's point of view. From the deliberate creation of organisms that live three times their natural span to the isolation of genes that may allow humans to do the same, The Clock of Ages also examines the latest discoveries in geriatric genetics. Sprinkled throughout the pages are descriptions of the aging of many historical figures, such as Florence Nightingale, Jane Austen, Billy the Kid, Napoleon, and Casanova. These stories underscore the common bond of senescence that unites us all. The Clock of Ages tells us why.

Cells, Aging, and Human Disease is the first book to explore aging all the way from genes to clinical application, analyzing the fundamental cellular changes which underlie human age-related disease. With over 4,000 references, this text explores both the fundamental processes of human aging and the tissue-by-tissue pathology, detailing both breaking research and current state-of-the-art clinical interventions in aging and age-related disease.
Far from merely sharing a common onset late in the lifespan, age-related diseases are linked by fundamental common characteristics at the genetic and cellular levels. Emphasizing human cell mechanisms, the first section presents and analyzes our current knowledege of telomere biology and cell senescence. In superb academic detail, the text brings the reader up to date on telomere maintenance, telomerase dynamics, and current research on cell senescence--and the general model--cell senescence as the central component in human senescence and cancer. For each human malignancy, the chapter reviews and analyzes all available data on telomeres and telomerase, as well as summarizing current work on their clinical application in both diagnosis and cancer therapy.
The second edition, oriented by organs and tissues, explores the actual physiological impact of cell senescence and aging on clinical disease. After a summary of the literature on early aging syndromes--the progerias--the text reviews aging diseases (Alzheimer's dementia, osteoarthritis, atherosclerosis, immune aging, presbyopia, sarcopenia, etc.) in the context of the tissues in which they occur. Each of the ten clinical chapters--skin, cardiovascular system, bone and joints, hematopoetic and immune systems, endocrine, CNS, renal, muscle, GI, and eyes--examines what we know of their pathology, the role of cell sensescence, and medical interventions, both current and potential.

This introductory textbook examines the issues of human reproduction common to a variety of advanced school and beginning university courses. It covers in detail the physiology of the human reproductive system, the production of gametes, fertilisation, pregnancy, birth, lactation and contraception. Sensitive issues such as infertility, abortion and embryo research are discussed with careful consideration of the moral and ethical issues involved.

The early environment in which we grow up has profound, long lasting, and often irreversible consequences for us throughout our lives. Stresses due to undernutrition in early childhood can mean that in adulthood individuals are smaller, more prone to disease, and have a shorter life expectancy than those with normal diets. Disease and poor living conditions in infancy and childhood also have serious implications in adulthood. While environmental effects on human growth and development are well documented, the long term consequences due to processes taking place at the early stages of growth and development have only recently become a focus of intense study. In this volume, leading researchers in nutrition, epidemiology, human biology, anthropology and physiology bring together a uniquely accessible source of information on this fascinating topic.

The rise of the multi-billion dollar ancestry testing industry points to one immutable truth about us as human beings: we want to know where we come from and who our ancestors were. John H. Relethford and Deborah A. Bolnick explore this topic and many more in this second edition of Reflections of Our Past. Where did modern humans come from and how important are the biological differences among us? Are we descended from Neandertals? How should we understand the connections between genetic ancestry, race, and identity? Were Native Americans the first to inhabit the Americas? Can we see evidence of the Viking invasions of Ireland a millennium ago even in the Irish of today? Through engaging examination of issues such as these, and using non-technical language, Reflections of Our Past shows how anthropologists use genetic information to suggest answers to fundamental questions about human history. By looking at genetic variation in the world today and in the past, we can reconstruct the recent and remote events and processes that have created the variation we see, providing a fascinating reflection of our genetic past.

Infectious disease accounts for more death and disability worldwide than either noninfectious disease or injury. This book contains a number of different quantitative approaches to understanding the patterns of such diseases in populations, and the design of control strategies to lessen their effect. The papers are written by experts with varied mathematical expertise and involvement in biological, medical and social sciences. The volume increases interaction between specialties by describing research on many infectious diseases that affect humans, including viral diseases, such as measles and AIDS, and tropical parasitic infections. Sections deal with problems relating to transmissible diseases with long development times (such as AIDS); vaccination strategies; the consequences of treatment interventions; the dynamics of immunity; heterogeneity of populations; and prediction. On each topic, the editors have chosen papers that bring together contrasting approaches via the development of theoretical results, the use of relevant knowledge from applied fields, and the analysis of data.

The main objective of this book is to present some of the fundamental structural aspects in the design of respiratory organs while debating and speculating on when, how and why these states were founded. The author's main thesis is that the modern gas exchangers are products of protracted processes that have entailed adaptation to specific environments and lifestyles. Only those feasible designs that have proven adequately compentent in meeting demands for molecular oxygen have been preserved. The author's approach has been to look into the limiting functional properties as regards the respiratory capacities of gas exchangers while finding out the specific structural adaptations that have evolved to meet the metabolic needs or to look into form and discern how it limits function.

In the mature brain calcium ions play pivotal roles in transmembrane and intracellular transmission of signals. Thus, calcium is involved in numerous neuronal functions including neurotransmitter release, enzyme regulation, modulation of neuronal excitability, gene expression, microtubular transport or synaptic plasticity. Many of these calcium-dependent processes are mediated or modulated by a number of cytosolic calcium-binding proteins. All nerve cells contain the calcium-binding protein calmodulin. Other CaBPs are restricted to certain nerve celltypes, i.e. parvalbumin, calbindin and calretinin.

The problems of understanding and controlling disease present a range of mathematical challenges, from broad theoretical issues to specific practical ones, making epidemiology one of the most vibrant branches of applied biology. Progress in this field requires collaboration among leading researchers with a wide range of mathematical expertise and close involvement in applied fields across the social, medical and biological sciences. This volume surveys the current state of epidemic modeling in relation to basic aims such as understanding, prediction, and evaluation and implementation of control strategies. The book is divided into five parts, covering the conceptual framework, three major problem areas (space, nonlinearity, heterogeneity), and the direct relation of models to data. The contributors discuss a wide range of methodological issues, e.g. comparing different approaches to the modeling of heterogeneity and relations among different types of model; and different data analytic approaches, together with the availability and quality of the data they require.

Why am I always tired? Why can't I sleep at night? Why do I suffer from jetlag?

We all have a body clock, a biological structure that controls how we feel, our mental and physical performance, and whether we are active or asleep. This is nature's response to our rhythmic environment, dominated by day and night. Though the body clock normally adjusts us to daytime activity and night time sleep, it can go wrong or be tricked by lifestyle changes. This can result in jetlag, some forms of insomnia and even depression. Keeping in time with your body clock provides clear and accessible advice on how to live with, and not against, your body clock. In a clear and accessible style, it explains how the body clock works, how and why it can work against you, and the measures you can take to optimise your feeling of health and wellbeing. It also explains the role of the body clock in illness, and how an understanding of this can increase your feeling of health.

An essential book for anyone who wants to better understand their body and optimise their feeling of health and wellbeing.

Human life, and how we came to be, is one of the greatest scientific and philosophical questions of our time. This compact and accessible book presents a modern view of human evolution. Written by a leading authority, it lucidly and engagingly explains not only the evolutionary process, but the technologies currently used to unravel the evolutionary past and emergence of Homo sapiens. By separating the history of palaeoanthropology from current interpretation of the human fossil record, it lays numerous misconceptions to rest, and demonstrates that human evolution has been far from the linear struggle from primitiveness to perfection that we've been led to believe. It also presents a coherent scenario for how Homo sapiens contrived to cross a formidable cognitive barrier to become an extraordinary and unprecedented thinking creature. Elegantly illustrated, Understanding Human Evolution is for anyone interested in the complex and tangled story of how we came to be.

Human Biological Diversity is an introductory textbook designed to cover the key contemporary topics in the study of human variation and human biology within the field of physical anthropology. Easily accessible for students with no background in anthropology or biology, this second edition includes two new chapters, one on human variation in the skeleton and dentition and the other on tracing human population affinities. All other chapters have been fully updated to reflect advances in the field and now include pedagogical features to aid readers in their understanding. Written for an introductory level but still containing valuable information that will be of interest to students on upper-level courses, Brown's textbook should be essential reading for all students taking courses on human variation, human biology, human evolution, race, anthropology of race, and general introductions to biological/physical anthropology.

In 1901 William Bateson, Professor of Biology at Cambridge, published a renewed version of a lecture which he had delivered the year before to the Royal Horticultural Society in London (reprinted in the book as an appendix). In this lecture he recognized the importance of the work completed by Gregor Mendel in 1865, and brought it to the notice of the scientific world. Upon reading Bateson's paper, Archibald Garrod realized the relevance of Mendel's laws to human disease and in 1902 introduced Mendelism to medical genetics. The first part of A Century of Mendelism in Human Genetics takes a historical perspective of the first 50 years of Mendelism, including the bitter argument between the Mendelians and the biometricians. The second part discusses human genetics since 1950, ending with a final chapter examining genetics and the future of medicine. The book considers the genetics of both single-gene and complex diseases, human cancer genetics, genetic linkage, and natural selection in human populations. Besides being of general medical significance, this book will be of particular interest to departments of genetics and of medical genetics, as well as to historians of science and medicine.