This fourth edition of the best-selling textbook, Human Genetics and Genomics, clearly explains the key principles needed by medical and health sciences students, from the basis of molecular genetics, to clinical applications used in the treatment of both rare and common conditions. A newly expanded Part 1, Basic Principles of Human Genetics, focuses on introducing the reader to key concepts such as Mendelian principles, DNA replication and gene expression. Part 2, Genetics and Genomics in Medical Practice, uses case scenarios to help you engage with current genetic practice. Now featuring full-color diagrams, Human Genetics and Genomics has been rigorously updated to reflect today s genetics teaching, and includes updated discussion of genetic risk assessment, single gene disorders and therapeutics. Key learning features include: * Clinical snapshots to help relate science to practice * Hot topics boxes that focus on the latest developments in testing, assessment and treatment * Ethical issues boxes to prompt further thought and discussion on the implications of genetic developments * Sources of information boxes to assist with the practicalities of clinical research and information provision * Self-assessment review questions in each chapter Accompanied by the Wiley E-Text digital edition (included in the price of the book), Human Genetics and Genomics is also fully supported by a suite of online resources at www.korfgenetics.com, including: * Factsheets on 100 genetic disorders, ideal for study and exam preparation * Interactive Multiple Choice Questions (MCQs) with feedback on all answers * Links to online resources for further study * Figures from the book available as PowerPoint slides, ideal for teaching purposes The perfect companion to the genetics component of both problem-based learning and integrated medical courses, Human Genetics and Genomics presents the ideal balance between the bio-molecular basis of genetics and clinical cases, and provides an invaluable overview for anyone wishing to engage with this fast-moving discipline.

This book shows that Holocene human ecosystems are complex adaptive systems in which humans interacted with their environment in a nested series of spatial and temporal scales. Using panarchy theory, it integrates paleoecological and archaeological research from the Eastern Woodlands of North America providing a paradigm to help resolve long-standing disagreements between ecologists and archaeologists about the importance of prehistoric Native Americans as agents for ecological change. The authors present the concept of a panarchy of complex adaptive cycles as applied to the development of increasingly complex human ecosystems through time. They explore examples of ecological interactions at the level of gene, population, community, landscape and regional hierarchical scales, emphasizing the ecological pattern and process involving the development of human ecosystems. Finally, they offer a perspective on the implications of the legacy of Native Americans as agents of change for conservation and ecological restoration efforts today.

Surnames are inherited in much the same way as are biological traits. Since surnames were generally adopted - in Europe during Medieval times - their distribution has become very uneven: analysis of the present geographic patterns provides an insight into the kind of redistribution of genes that has resulted from all the migrations of the intervening years. Using non-technical language and a minimum of mathematics, this book presents a lucid description and evaluation of these studies of the genetic structure of human populations. A special feature is the appendix which presents computer-generated maps and distribution diagrams of 100 common surnames in England and Wales.

This paperback edition of The End of the World, with a completely new preface, is a sobering assessment of the many disasters that scientists have predicted and speculated on as leading to apocalypse. In the first comprehensive survey, potential catastrophes - ranging from deadly diseases to high-energy physics experiments - are explored to help us understand the risks.

What makes a biological entity an individual? Jack Wilson shows that past philosophers have failed to explicate the conditions an entity must satisfy to be a living individual. He explores the reason for this failure and explains why we should limit ourselves to examples involving real organisms rather than thought experiments. This book explores and resolves paradoxes that arise when one applies past notions of individuality to biological examples beyond the conventional range and presents an analysis of identity and persistence. The book's main purpose is to bring together two lines of research, theoretical biology and metaphysics, which have dealt with the same subject in isolation from one another. Wilson explains an alternative theory about biological individuality which solves problems which cannot be addressed by either field alone. He presents a more fine-grained vocabulary of individuation based on diverse kinds of living things, allowing him to clarify previously muddled disputes about individuality in biology.

Anthropological genetics is a field that has been in existence since the 1960s and has been growing within medical schools and academic departments, such as anthropology and human biology, ever since. With the recent developments in DNA and computer technologies, the field of anthropological genetics has been redefined. This volume deals with the molecular revolution and how DNA markers can provide insight into the processes of evolution, the mapping of genes for complex phenotypes and the reconstruction of the human diaspora. In addition to this, there are explanations of the technological developments and how they affect the fields of forensic anthropology and population studies, alongside the methods of field investigations and their contribution to anthropological genetics. This book brings together leading figures from the field to provide an up-to-date introduction to anthropological genetics, aimed at advanced undergraduates to professionals, in genetics, biology, medicine and anthropology.

'Spellbinding . . . More than any other book, [Sentient] has made me think differently about the world this year.' - Financial Times Best Books of the Year The peacock mantis shrimp can throw a punch that can fracture aquarium walls. The great grey owl can hear many decibels lower than the human ear. The star-nosed mole's miraculous nose allows it to catch worms in as little as 120 milliseconds. In Sentient, Jackie Higgins assembles a menagerie of zoological creatures - from land, air, sea and all four corners of the globe - to understand what it means to be human. In it, we also meet the four-eyed spookfish and its dark vision, the vampire bat and its remarkable powers of touch, as well as the common octopus, the Goliath catfish and the duck-billed platypus. Each zoological marvel illustrates the surprising sensory powers that lie within us and enables us to engage with the world in ways we never knew possible. 'Lyrical and lucid . . . Higgins makes popular science accessible.' - Observer

Primate and Human Evolution provides a synthesis of the evolution and adaptive significance of human anatomical, physiological and behavioral traits. Using paleontology and modern human variation and biology, it compares hominid traits to those of other catarrhine primates both living and extinct, presenting a new hominization model that does not depend solely on global climate change, but on predictable trends observed in catarrhines. Dealing with the origins of hominid tool use and tool manufacture, it compares tool behavior in other animals and incorporates information from the earliest archaeological record. Examining the use of non-human primates and other mammals in modeling the origins of early human social behavior, Susan Cachel argues that human intelligence does not arise from complex social interactions, but from attentiveness to the natural world. This book will be a rich source of inspiration for all those interested in the evolution of all primates, including ourselves.

The emergence of the genus Homo is widely linked to the colonization of new highly seasonal savannah habitats. However, until now, our understanding of the possible impact of seasonality on this shift has been limited because we have little general knowledge of how seasonality affects the lives of primates. This book documents the extent of seasonality in food abundance in tropical woody vegetation, and then presents systematic analyses of the impact of seasonality in food supply on the behavioural ecology of non-human primates. Syntheses in this volume then produce for the first time broad generalizations concerning the impact of seasonality on behavioural ecology and reproduction in both human and non-human primates, and apply these insights to primate and human evolution. Written for graduate students and researchers in biological anthropology and behavioural ecology, this is an absorbing account of how seasonality may have affected an important episode in our own evolution.

The human genetic make-up of Latin America is a reflection of successive waves of colonization and immigration. To date there have been few works dealing with the biology of human populations at a continental scale, and while much information is available on the genetics of Latin American populations, most data remain scattered throughout the literature. This volume examines for the first time Latin American human populations in relation to their origins, environment, history, demography and genetics, drawing on aspects of nutrition, physiology and morphology for an integrated and multidisciplinary approach. The result is a fascinating account of a people characterized by a turbulent history, marked heterogeneity and unique genetic traits. Of interest to students and researchers of genetics, evolution, biological anthropology and the social sciences, this book will also appeal to anyone concerned with the multifaceted evolution of our species and constitutes an important volume not only for anthropological genetics, but also for Latin American research.

The Metaphysics of Apes, first published in 2005, traces the discovery and interpretation of the human-like great apes and the ape-like earliest ancestors of present-day humans. It shows how, from the days of Linnaeus to recent research, the sacred and taboo-ridden animal-human boundary was time and again challenged and adjusted. The unique dignity of humans, a central idea and value in the West, was, and to some extent still is, centrally on the minds of taxonomists, ethnologists, primatologists, and archaeologists. It has guided their research to a considerable extent. The basic presupposition was that humans are not entirely part of nature but, as symbolizing minds and as moral persons, transcend nature. This book was the first to offer an anthropological analysis of the burgeoning anthropological disciplines in terms of their own cultural taboos and philosophical preconceptions.

The Human Genome Diversity Project (HGDP) was launched in 1991 by a group of population geneticists whose aim was to map genetic diversity in hundreds of human populations by tracing the similarities and differences between them. It quickly became controversial and was accused of racism and 'bad science' because of the special interest paid to sampling cell material from isolated and indigenous populations. The author spent a year carrying out participant observation in two of the laboratories involved and provides fascinating insights into daily routines and technologies used in those laboratories and also into issues of normativity, standardization and naturalisation. Drawing on debates and theoretical perspectives from across the social sciences, M'charek explores the relationship between the tools used to produce knowledge and the knowledge thus produced in a way that illuminates the HGDP but also contributes to our broader understanding of the contemporary life sciences and their social implications.

This volume features a collection of essays by primatologists, anthropologists, biologists, and psychologists who offer some answers to the question of what makes us human, i. e. , what is the nature and width of the gap that separates us from other primates? The chapters of this volume summarize the latest research on core aspects of behavioral and cognitive traits that make humans such unusual animals. All contributors adopt an explicitly comparative approach, which is based on the premise that comparative studies of our closest biological relatives, the nonhuman primates, provide the logical foundation for identifying human univ- sals as well as evidence for evolutionary continuity in our social behavior. Each of the chapters in this volume provides comparative analyses of relevant data from primates and humans, or pairs of chapters examine the same topic from a human or primatological perspective, respectively. Together, they cover six broad topics that are relevant to identifying potential human behavioral universals. Family and social organization. Predation pressure is thought to be the main force favoring group-living in primates, but there is great diversity in the size and structure of social groups across the primate order. Research on the behavioral ecology of primates and other animals has revealed that the distribution of males and females in space and time can be explained by sex-speci?c adaptations that are sensitive to factors that limit their ?tness: access to resources for females and access to potential mates for males.

The secrets of our genetic heritage are finally being unlocked. The massive scientific effort to sequence the human genome is in fact just the beginning of a long journey as the extraordinary genetic diversity that exists between individuals becomes clear. Work in this field is yielding profound insights into the wider implications for understanding biology, human health and history. It promises much: to understand our evolutionary origins, to define us as individuals, to predict our risk of disease and to more effectively understand, treat and prevent illness. Genetics can help us understand both rare inherited disorders and common multifactorial disease like asthma, heart disease and diabetes. Huge investments are being made and great advances have been achived, but the challenges remain daunting. This book provides an authoritative overview of this topical and very rapidly advancing field of biomedical research.
Human Genetic Diversity provides a concise, authoritative overview of human genetic diversity. It documents the insights that human genetics have brought to an understanding of human evolution and history, focusing on the implications of human genetic diversity for disease susceptibility and treatment. The book describes the genetic basis for diseases such as HIV, AIDS, Crohn's disease, asthma and type I diabetes. It also examines the emerging field of pharmacogenomics and individualized medicine.
Human genetic variation has implications across a broad range of disciplines (both biological and medical) and this text neatly consolidates work in diverse fields to highlight common themes and principles. An accessible style and the extensive use of illustrations promote its relevance to a broad audience ranging from those interested in human and population genetics to molecular biologists, evolutionary biologists, biological anthropologists and individuals working in the health sciences and clinical medicine.

In order to gain an understanding of the dynamics of human individual and average growth patterns it is essential that the right methods are selected. There are a variety of methods available to analyse individual growth patterns, to estimate variation in different growth measures in populations and to relate genetic and environmental factors to individual and average growth. This volume provides an overview of modern techniques for the assessment and collection of growth data and methods of analysis for individual and population growth data. The book contains the basic mathematical and statistical tools required to understand the concepts of the methods under discussion and worked examples of analyses, but it is neither a mathematical treatise, nor a recipe book for growth data analysis. Aimed at junior and senior researchers involved in the analysis of human growth data, this book will be an essential reference for anthropologists, auxologists and paediatricians.

The transition in anthropological and biomedical research methods over the past 50 years, from anthropometric and craniometric measurements to large-scale microarray genetic studies has resulted in continued revision of opinions and ideas relating to the factors and forces that drive human variation.

Human Variation: From the Laboratory to the Field brings together the contributions of 22 scientists working in four continents to identify and address challenges imposed by variability. It reviews the way we examine and analyze human variation, paying specific attention to genetics, growth and development, and physiology. In presenting new evidence and findings, it also discusses current developments in methodology and analytical techniques, detailing both field and laboratory approaches, and looking at how the two perspectives complement each other.

In bridging that gap between laboratory trials and studies of the human in context, this book covers a number of interesting research areas including ?

• Human adaptation to natural and artificial light, including variations in circadian photosensitivity and effects of light on GI activity
• Cold tolerance and lifestyle in modern society
• Genetics of body weight and obesity
• Human adaptability to emotional and intellectual mental stresses
• Geography, migration, climate, and environmental plasticity as contributors to human variation
• Impact of natural environmental stressors including pollution on physiological and morphological processes

This book is the latest volume in a series of works from the Society for the Study of Human Biology (SSHB), which for half a century has advanced and promoted research in the biology of human populations in all of its branches including human viability, genetics, human adaptability, and ecology, and evolution. It holds two scientific meetings a year. This volume represents work presented during its most recent gathering.

Bestselling author David Ewing Duncan takes the ultimate high-tech medical exam, investigating the future impact of what's hidden deep inside all of us
David Ewing Duncan takes ""guinea pig"" journalism to the cutting edge of science, building on award-winning articles he wrote for Wired and National Geographic, in which he was tested for hundreds of chemicals and genes associated with disease, emotions, and other traits. Expanding on these tests, he examines his genes, environment, brain, and body, exploring what they reveal about his and his family's future health, traits, and ancestry, as well as the profound impact of this new self-knowledge on what it means to be human.
David Ewing Duncan (San Francisco, CA) is the Chief Correspondent of public radio's Biotech Nation and a frequent commentator on NPR's Morning Edition. He is a contributing editor to Portfolio, Discover, and Wired and a columnist for Portfolio. His books include the international bestseller Calendar: Humanity's Epic Struggle to Determine a True and Accurate Year (978-0-380-79324-2). He is a former special producer and correspondent for ABC's Nightline, and appears regularly on CNN and programs such as Today and Good Morning America.

This major volume of original essays maps the place of emotion in human nature, through a discussion of the relation between consciousness and body; by analysing the importance of emotion for human agency by pointing to the ways in which practical rationality may be enhanced, as well as hindered, by emotions; and by exploring questions of value in making sense of emotions at a political, ethical and personal level. Leading researchers in the field reflect on the nature of human feelings, how and why we understand what other people feel, and the way in which our values become involved in specific emotional phenomena, such as guilt, fear, shame, amusement, or love. This collection addresses important questions in the philosophy of mind and comments on the implications of research in biology, cognitive psychology, psychoanalysis, and narrative theory for the philosophical understanding of emotions.

Human Population Dynamics introduces theoretical frameworks and methodologies from different traditional disciplines to demonstrate how changes in human population structure can be addressed from several different academic perspectives. The book contains contributions from world-renowned researchers in demography, social and biological anthropology, genetics, biology, sociology, ecology, history and human geography. In particular, the contributors emphasize the lability of many population structures and boundaries, as viewed from their area of expertise.

A number of researchers have tried to characterise the anatomy and behavioural systems of early hominid and early modern human populations in an attempt to understand how we became what we are. Can archaeology, palaeo-anthropology and genetics tell us how and when human cultures developed the traits that make our societies different from those of our closest living relatives? In which cases are these differences substantial, and when do they simply reflect our definitions of culture, species, the image we have of their evolution or of ourselves? From Tools to Symbols, a collection of twenty-seven selected papers from a South African-French conference organised in honour of the well-known palaeo-anthropologist Phillip Tobias, provides a multidisciplinary overview of this field of study. It is based on collaborative research conducted in sub-Saharan Africa by South African, French, American and German scholars in the last twenty years, and represents an excellent synthesis of the palaeontological and archaeological evidence of the last five million years of human evolution.

The human genetic make-up of Latin America is a reflection of successive waves of colonization and immigration. There have been few works dealing with the biology of human populations at a continental scale, and while much data is available on the genetics of Latin American populations, most information remains scattered throughout the literature. This volume examines Latin American human populations in relation to their origins, environment, history, demography and genetics, drawing on aspects of nutrition, physiology, and morphology for an integrated and multidisciplinary approach. The result is a fascinating account of a people characterized by a turbulent history, marked heterogeneity, and unique genetic traits.

This book spans two million years of human evolution and explores the impact of economics on human evolution and natural history. The theory of evolution by natural selection has always relied in part on progress in areas of science outside of biology. By applying economic principles at the borderlines of biology, Haim Ofek shows how some of the outstanding issues in human evolution, such as the increase in human brain size and the expansion of the environmental niche humans occupied, can be answered. He identifies distinct economic forces at work, beginning with the transition from the feed-as-you-go strategy of primates, through hunter-gathering and the domestication of fire to the development of agriculture. This highly readable book will inform and intrigue general readers and those in fields such as evolutionary biology and psychology, economics, and anthropology.

Biology of Aging, Second Edition presents the biological principles that have led to a new understanding of the causes of aging and describes how these basic principles help one to understand the human experience of biological aging, longevity, and age-related disease. Intended for undergraduate biology students, it describes how the rate of biological aging is measured; explores the mechanisms underlying cellular aging; discusses the genetic pathways that affect longevity in various organisms; outlines the normal age-related changes and the functional decline that occurs in physiological systems over the lifespan; and considers the implications of modulating the rate of aging and longevity. The book also includes end-of-chapter discussion questions to help students assess their knowledge of the material. Roger McDonald received his Ph.D. from the University of Southern California and is Professor Emeritus in the Department of Nutrition at the University of California, Davis. Dr. McDonald's research focused on mechanisms of cellular aging and the interaction between nutrition and aging. His research addressed two key topics in the field: the relationship between dietary restriction and lifespan, and the effect of aging on circadian rhythms and hypothalamic regulation. You can contact Dr. McDonald at [email protected]. Related Titles Ahmad, S. I., ed. Aging: Exploring a Complex Phenomenon (ISBN 978-1-1381-9697-1) Moody, H. R. & J. Sasser. Gerontology: The Basics (ISBN 978-1-1387-7582-4) Timiras, P. S. Physiological Basis of Aging and Geriatrics (ISBN 978-0-8493-7305-3)

"Man the Hunted" argues that primates, including the earliest members of the human family, have evolved as the prey of any number of predators, including wild cats and dogs, hyenas, snakes, crocodiles, and even birds. The authors' studies of predators on monkeys and apes are supplemented here with the observations of naturalists in the field and revealing interpretations of the fossil record. Eyewitness accounts of the "man the hunted" drama being played out even now give vivid evidence of its prehistoric significance.

This provocative view of human evolution suggests that countless adaptations that have allowed our species to survive--from larger brains to speech--stem from a considerably more vulnerable position on the food chain than we might like to imagine. The myth of early humans as fearless hunters dominating the earth obscures our origins as just one of many species that had to be cautious, depend on other group members, communicate danger, and come to terms with being merely one cog in the complex cycle of life.

The expanded edition includes a new chapter that describes the ever-increasing evidence of predation on humans and other primates and claims that the earliest humans were neither hunters nor even the accomplished scavengers that many authorities have claimed.

Contents

Foreword by Ian Tattersall

1. Just Another Item on the Menu
2. Debunking "Man the Hunter"
3. Who's Eating Whom?
4. Lions and Tigers and Bears, Oh My!
5. Coursing Hyenas and Hungry Dogs
6. Missionary Position
7. Terror from the Sky
8. We Weren't Just Waiting Around to be Eaten!
9. Gentle Savage or Bloodthirsty Brute?
10. Man the Hunted
11. The Final Word