This volume looks at the relationship between specific aspects of Third World cities and human health. Rapid and extensive urbanization of the less developed nations is perhaps the most dramatic demographic phenomenon of our times, but its impact on human biology is not well understood. Here, a cross-section of work is presented on this subject allowing human biologists, urban planners, public health workers and other specialists to assess our knowledge and the current approaches available to increase it. Contributions fall into two groups: studies of urban ecology including the social, economic and physical domains, and studies of biological responses to the urban environment. Health is not merely the absence of specific diseases, but is construed more broadly to include a wide range of biological parameters that are correlated with various states of sub-optimal health. These include patterns of child growth and development, frequencies of specific diseases, nutritional status, immunological characteristics and physiological parameters. This important volume will be of interest to a wide range of researchers and academics, including human biologists, anthropologists, healthcare professionals, human geographers, urban and regional planners, and economists.

As widespread social transformations have been paralleled by gains in health and life expectancy through public health and other improvements, a variety of other challenges to health have emerged, particularly in lifestyle related, behaviourally mediated changes in rates of chronic disease. Hormones, Health and Behavior looks at the relationship of human biology and human society at the intersection of behavior, hormones and health. There is both scientific interest and practical urgency behind the ideas and findings presented here, as the need for a socio-ecological view of function and well-being has become more apparent. This book documents an emerging understanding of how hormones create linkage between behavior or social life and health. It will inform graduate students and researchers interested in human sciences, human development, anthropology, epidemiology, public environmental and reproductive health.

Physical activity and exercise affect many dimensions of health. This book presents a wide-ranging account of the key issues of the biology of physical activity and health. The context is set by considering the comparative and temporal aspects of activity in humans. There follows an examination of the concepts and methodological issues associated with activity, exercise, health and fitness, as well as their interrelationships. Particular attention is given to activity in children, adolescents and the elderly, activity and weight maintenance, and the psychological effects of activity. This topical volume will be of interest to human biologists, biological anthropologists, human physiologists, sports scientists, psychologists, and healthcare professionals involved in preventative medicine, public health, geriatrics, occupational health and community medicine.

The first insights into the site and mechanisms of RNA process- ing to functional mRNA in eukaryotic cells came from the group of Georgiev (Lukanidin et al. 1972) who demonstrated the association of rapidly labelled, heterogeneous nuclear RNA (hnRNA) with a limited number of specific proteins in the cell nucleus. These "informofers", i. e. packaged precursors of mRNA (pre-mRNA or hnRNA), are in a form presumably amenable to the action of nucleases. With the availability of better analytical techniques, the considerable heterogeneity of hnRNA associated proteins was revealed (Niessing and Sekeris 1970), suggesting a role that was more composite, rather than solely structural, for these proteins. Later studies investigated the RNA binding behavior of these proteins (Schenkel et al. 1988, 1989; Wilk et al. 1983). For a long time, the small nuclear RNAs, well characterized with respect to primary structure (reviewed by Reddy and Busch 1983), were naively ignored regarding their function. Several events then set the stage for a detailed study of the intricate mechanisms of the splicing process and other steps involved in hnRNA processing: (1) The demonstration of a second class of nuclear ribonucleoproteins (RNPs), composed of small nuclear RNAs (snRNAs) and another characteristic group ofheterogene- ous proteins (Lerner et al. 1980; Guialis et al. 1983); (2) the detec- tion of the association of snRNPs with hnRNPs by virtue of base pairing between hnRNA and snRNA (Flytzanis et al.

What are the health consequences of a transition from an active 'hunter-gatherer' lifestyle to that of sedentary modern living? In this book, the impact of 'modernization' is assessed in various populations in the circumpolar regions. The hazards of living in polar regions, and the adaptations shown culturally, behaviourally and physically by the indigenous peoples are examined and the effect of changes in habitual activity, diet, and general lifestyle due to more urban living patterns on the body composition, pulmonary function and susceptibility to disease discussed. The implications of this switch are important not only for all those concerned about the survival of indigenous communities around the world, but for all of us living in an increasingly sedentary, urban environment. Anthropologists, physiologists and those interested in population fitness will find this a comprehensive and valuable volume.

This volume considers the genetic variability of human populations, particularly in the tropics: its origins and maintenance, and its contribution to the phenotypic variability of complex characters. The first section deals with the ways of analysing genetic variation and provides a valuable review of relevant developments in molecular biology. The origin and maintenance of genetic diversity is considered in the second section with data presented for Pacific, African, Asian and Central American populations. The final section concerns characters in which the genetic contribution to variability is complex and shows how such characters may be used to elucidate biological problems of affinity and differentiation, of adaptation and survival. Published as part of the Decade of the Tropics research programme of the International Union of Biological Sciences, this volume will be of particular interest to human geneticists, physical and biological anthropologists.

In 1901 William Bateson, Professor of Biology at Cambridge, published a renewed version of a lecture which he had delivered the year before to the Royal Horticultural Society in London (reprinted in the book as an appendix). In this lecture he recognized the importance of the work completed by Gregor Mendel in 1865, and brought it to the notice of the scientific world. Upon reading Bateson's paper, Archibald Garrod realized the relevance of Mendel's laws to human disease and in 1902 introduced Mendelism to medical genetics.

The first part of A Century of Mendelism in Human Genetics takes a historical perspective of the first 50 years of Mendelism, including the bitter argument between the Mendelians and the biometricians. The second part discusses human genetics since 1950, ending with a final chapter examining genetics and the future of medicine. The book considers the genetics of both single-gene and complex diseases, human cancer genetics, genetic linkage, and natural selection in humanpopulations.

Besides being of general medical significance, this book will be of particular interest to departments of genetics and of medical genetics, as well as to historians of science and medicine.

This book shows that Holocene human ecosystems are complex adaptive systems in which humans interacted with their environment in a nested series of spatial and temporal scales. Using panarchy theory, it integrates paleoecological and archaeological research from the Eastern Woodlands of North America providing a paradigm to help resolve long-standing disagreements between ecologists and archaeologists about the importance of prehistoric Native Americans as agents for ecological change. The authors present the concept of a panarchy of complex adaptive cycles as applied to the development of increasingly complex human ecosystems through time. They explore examples of ecological interactions at the level of gene, population, community, landscape and regional hierarchical scales, emphasizing the ecological pattern and process involving the development of human ecosystems. Finally, they offer a perspective on the implications of the legacy of Native Americans as agents of change for conservation and ecological restoration efforts today.

Surnames are inherited in much the same way as are biological traits. Since surnames were generally adopted - in Europe during Medieval times - their distribution has become very uneven: analysis of the present geographic patterns provides an insight into the kind of redistribution of genes that has resulted from all the migrations of the intervening years. Using non-technical language and a minimum of mathematics, this book presents a lucid description and evaluation of these studies of the genetic structure of human populations. A special feature is the appendix which presents computer-generated maps and distribution diagrams of 100 common surnames in England and Wales.

This fourth edition of the best-selling textbook, Human Genetics and Genomics, clearly explains the key principles needed by medical and health sciences students, from the basis of molecular genetics, to clinical applications used in the treatment of both rare and common conditions. A newly expanded Part 1, Basic Principles of Human Genetics, focuses on introducing the reader to key concepts such as Mendelian principles, DNA replication and gene expression. Part 2, Genetics and Genomics in Medical Practice, uses case scenarios to help you engage with current genetic practice. Now featuring full-color diagrams, Human Genetics and Genomics has been rigorously updated to reflect today s genetics teaching, and includes updated discussion of genetic risk assessment, single gene disorders and therapeutics. Key learning features include: * Clinical snapshots to help relate science to practice * Hot topics boxes that focus on the latest developments in testing, assessment and treatment * Ethical issues boxes to prompt further thought and discussion on the implications of genetic developments * Sources of information boxes to assist with the practicalities of clinical research and information provision * Self-assessment review questions in each chapter Accompanied by the Wiley E-Text digital edition (included in the price of the book), Human Genetics and Genomics is also fully supported by a suite of online resources at www.korfgenetics.com, including: * Factsheets on 100 genetic disorders, ideal for study and exam preparation * Interactive Multiple Choice Questions (MCQs) with feedback on all answers * Links to online resources for further study * Figures from the book available as PowerPoint slides, ideal for teaching purposes The perfect companion to the genetics component of both problem-based learning and integrated medical courses, Human Genetics and Genomics presents the ideal balance between the bio-molecular basis of genetics and clinical cases, and provides an invaluable overview for anyone wishing to engage with this fast-moving discipline.

Since the 18th century, one phenomenon, the proportion of the sexes at birth among human beings, has contributed to various developments such as the calculus of probabilities, administrative statistics, the moral and social sciences, the statistics of variability, post-Darwinian biology and Durkheimian sociology. This fact is brought to the critical attention of readers who rarely work together -- mathematicians, biologists, historians, social scientists and historians of the sciences -- along a three centuries European journey, meeting Sussmilch, Condorcet, Laplace, Fourier, Girou de Buzareingues, Poisson, Quetelet, Darwin, Dusing, Gini, Halbwachs or Fisher.

After a deconstruction of the past and present conditions of scientific understanding of human sex-ratio at birth, the authors are proposing a reconstruction of the dynamics of the phenomenon based on stochastics. This is an attempt in renewing our links with the oldest traditions of scholarly thinking, but too a kind of "well-tempered" reflexivity in today s work of objectivization.

Appendixes get to the reader the first expression of a trend of the sex ratio at birth to adjust towards balance between the sexes by Condorcet in 1793-1794; a comparison of passages that Darwin devoted in 1871 and 1874 to similar issues; and a sociological attempt of Halbwachs published in 1933."

'Spellbinding . . . More than any other book, [Sentient] has made me think differently about the world this year.' - Financial Times Best Books of the Year The peacock mantis shrimp can throw a punch that can fracture aquarium walls. The great grey owl can hear many decibels lower than the human ear. The star-nosed mole's miraculous nose allows it to catch worms in as little as 120 milliseconds. In Sentient, Jackie Higgins assembles a menagerie of zoological creatures - from land, air, sea and all four corners of the globe - to understand what it means to be human. In it, we also meet the four-eyed spookfish and its dark vision, the vampire bat and its remarkable powers of touch, as well as the common octopus, the Goliath catfish and the duck-billed platypus. Each zoological marvel illustrates the surprising sensory powers that lie within us and enables us to engage with the world in ways we never knew possible. 'Lyrical and lucid . . . Higgins makes popular science accessible.' - Observer

This paperback edition of The End of the World, with a completely new preface, is a sobering assessment of the many disasters that scientists have predicted and speculated on as leading to apocalypse. In the first comprehensive survey, potential catastrophes - ranging from deadly diseases to high-energy physics experiments - are explored to help us understand the risks.

What makes a biological entity an individual? Jack Wilson shows that past philosophers have failed to explicate the conditions an entity must satisfy to be a living individual. He explores the reason for this failure and explains why we should limit ourselves to examples involving real organisms rather than thought experiments. This book explores and resolves paradoxes that arise when one applies past notions of individuality to biological examples beyond the conventional range and presents an analysis of identity and persistence. The book's main purpose is to bring together two lines of research, theoretical biology and metaphysics, which have dealt with the same subject in isolation from one another. Wilson explains an alternative theory about biological individuality which solves problems which cannot be addressed by either field alone. He presents a more fine-grained vocabulary of individuation based on diverse kinds of living things, allowing him to clarify previously muddled disputes about individuality in biology.

Anthropological genetics is a field that has been in existence since the 1960s and has been growing within medical schools and academic departments, such as anthropology and human biology, ever since. With the recent developments in DNA and computer technologies, the field of anthropological genetics has been redefined. This volume deals with the molecular revolution and how DNA markers can provide insight into the processes of evolution, the mapping of genes for complex phenotypes and the reconstruction of the human diaspora. In addition to this, there are explanations of the technological developments and how they affect the fields of forensic anthropology and population studies, alongside the methods of field investigations and their contribution to anthropological genetics. This book brings together leading figures from the field to provide an up-to-date introduction to anthropological genetics, aimed at advanced undergraduates to professionals, in genetics, biology, medicine and anthropology.

In 1883, Francis Galton, a cousin of Charles Darwin, coined the word "eugenics" to express his dream of perfecting the human race by applying the laws of genetic heredity. Adapting Darwin's theory of evolution to human society, eugenics soon became a powerful, international movement, committed to using the principles of heredity and statistics to encourage healthy and discourage unhealthy reproduction. Early in the twentieth century and across the world, doctors, social reformers, and politicians turned to the new science of eugenics as a means to improve and strengthen their populations. Eugenics advocates claimed their methods would result in healthier, fitter babies and would dramatically limit human suffering. The reality was a different story. In the name of scientific progress and of human improvement, eugenicists targeted the weak and the sick, triggering coercive legislation on issues as disparate as race, gender, immigration, euthanasia, abortion, sterilization, intelligence, mental illness, and disease control. Nationalists eagerly embraced eugenics as a means to legitimize their countries' superiority and racialized assumptions, and the Nazis notoriously used eugenics to shape their "final solution." In this lucid volume, Philippa Levine tackles the intricate and controversial history of eugenics, masterfully synthesizing the enormous range of policies and experiments carried out in the name of eugenics around the world throughout the twentieth century. She questions the widespread belief that eugenics disappeared after World War II and evaluates the impact of eugenics on current reproductive and genetic sciences. Charting the development of such controversial practices as artificial insemination, sperm donation, and population control, this book offers a powerful, extraordinarily timely reflection on the frequent interplay between genetics and ethics. Eugenics may no longer be a household word, but we feel its effects even today.

Primate and Human Evolution provides a synthesis of the evolution and adaptive significance of human anatomical, physiological and behavioral traits. Using paleontology and modern human variation and biology, it compares hominid traits to those of other catarrhine primates both living and extinct, presenting a new hominization model that does not depend solely on global climate change, but on predictable trends observed in catarrhines. Dealing with the origins of hominid tool use and tool manufacture, it compares tool behavior in other animals and incorporates information from the earliest archaeological record. Examining the use of non-human primates and other mammals in modeling the origins of early human social behavior, Susan Cachel argues that human intelligence does not arise from complex social interactions, but from attentiveness to the natural world. This book will be a rich source of inspiration for all those interested in the evolution of all primates, including ourselves.

The emergence of the genus Homo is widely linked to the colonization of new highly seasonal savannah habitats. However, until now, our understanding of the possible impact of seasonality on this shift has been limited because we have little general knowledge of how seasonality affects the lives of primates. This book documents the extent of seasonality in food abundance in tropical woody vegetation, and then presents systematic analyses of the impact of seasonality in food supply on the behavioural ecology of non-human primates. Syntheses in this volume then produce for the first time broad generalizations concerning the impact of seasonality on behavioural ecology and reproduction in both human and non-human primates, and apply these insights to primate and human evolution. Written for graduate students and researchers in biological anthropology and behavioural ecology, this is an absorbing account of how seasonality may have affected an important episode in our own evolution.

The human genetic make-up of Latin America is a reflection of successive waves of colonization and immigration. To date there have been few works dealing with the biology of human populations at a continental scale, and while much information is available on the genetics of Latin American populations, most data remain scattered throughout the literature. This volume examines for the first time Latin American human populations in relation to their origins, environment, history, demography and genetics, drawing on aspects of nutrition, physiology and morphology for an integrated and multidisciplinary approach. The result is a fascinating account of a people characterized by a turbulent history, marked heterogeneity and unique genetic traits. Of interest to students and researchers of genetics, evolution, biological anthropology and the social sciences, this book will also appeal to anyone concerned with the multifaceted evolution of our species and constitutes an important volume not only for anthropological genetics, but also for Latin American research.

The Metaphysics of Apes, first published in 2005, traces the discovery and interpretation of the human-like great apes and the ape-like earliest ancestors of present-day humans. It shows how, from the days of Linnaeus to recent research, the sacred and taboo-ridden animal-human boundary was time and again challenged and adjusted. The unique dignity of humans, a central idea and value in the West, was, and to some extent still is, centrally on the minds of taxonomists, ethnologists, primatologists, and archaeologists. It has guided their research to a considerable extent. The basic presupposition was that humans are not entirely part of nature but, as symbolizing minds and as moral persons, transcend nature. This book was the first to offer an anthropological analysis of the burgeoning anthropological disciplines in terms of their own cultural taboos and philosophical preconceptions.

The Human Genome Diversity Project (HGDP) was launched in 1991 by a group of population geneticists whose aim was to map genetic diversity in hundreds of human populations by tracing the similarities and differences between them. It quickly became controversial and was accused of racism and 'bad science' because of the special interest paid to sampling cell material from isolated and indigenous populations. The author spent a year carrying out participant observation in two of the laboratories involved and provides fascinating insights into daily routines and technologies used in those laboratories and also into issues of normativity, standardization and naturalisation. Drawing on debates and theoretical perspectives from across the social sciences, M'charek explores the relationship between the tools used to produce knowledge and the knowledge thus produced in a way that illuminates the HGDP but also contributes to our broader understanding of the contemporary life sciences and their social implications.

This volume features a collection of essays by primatologists, anthropologists, biologists, and psychologists who offer some answers to the question of what makes us human, i. e. , what is the nature and width of the gap that separates us from other primates? The chapters of this volume summarize the latest research on core aspects of behavioral and cognitive traits that make humans such unusual animals. All contributors adopt an explicitly comparative approach, which is based on the premise that comparative studies of our closest biological relatives, the nonhuman primates, provide the logical foundation for identifying human univ- sals as well as evidence for evolutionary continuity in our social behavior. Each of the chapters in this volume provides comparative analyses of relevant data from primates and humans, or pairs of chapters examine the same topic from a human or primatological perspective, respectively. Together, they cover six broad topics that are relevant to identifying potential human behavioral universals. Family and social organization. Predation pressure is thought to be the main force favoring group-living in primates, but there is great diversity in the size and structure of social groups across the primate order. Research on the behavioral ecology of primates and other animals has revealed that the distribution of males and females in space and time can be explained by sex-speci?c adaptations that are sensitive to factors that limit their ?tness: access to resources for females and access to potential mates for males.

The secrets of our genetic heritage are finally being unlocked. The massive scientific effort to sequence the human genome is in fact just the beginning of a long journey as the extraordinary genetic diversity that exists between individuals becomes clear. Work in this field is yielding profound insights into the wider implications for understanding biology, human health and history. It promises much: to understand our evolutionary origins, to define us as individuals, to predict our risk of disease and to more effectively understand, treat and prevent illness. Genetics can help us understand both rare inherited disorders and common multifactorial disease like asthma, heart disease and diabetes. Huge investments are being made and great advances have been achived, but the challenges remain daunting. This book provides an authoritative overview of this topical and very rapidly advancing field of biomedical research.
Human Genetic Diversity provides a concise, authoritative overview of human genetic diversity. It documents the insights that human genetics have brought to an understanding of human evolution and history, focusing on the implications of human genetic diversity for disease susceptibility and treatment. The book describes the genetic basis for diseases such as HIV, AIDS, Crohn's disease, asthma and type I diabetes. It also examines the emerging field of pharmacogenomics and individualized medicine.
Human genetic variation has implications across a broad range of disciplines (both biological and medical) and this text neatly consolidates work in diverse fields to highlight common themes and principles. An accessible style and the extensive use of illustrations promote its relevance to a broad audience ranging from those interested in human and population genetics to molecular biologists, evolutionary biologists, biological anthropologists and individuals working in the health sciences and clinical medicine.

In order to gain an understanding of the dynamics of human individual and average growth patterns it is essential that the right methods are selected. There are a variety of methods available to analyse individual growth patterns, to estimate variation in different growth measures in populations and to relate genetic and environmental factors to individual and average growth. This volume provides an overview of modern techniques for the assessment and collection of growth data and methods of analysis for individual and population growth data. The book contains the basic mathematical and statistical tools required to understand the concepts of the methods under discussion and worked examples of analyses, but it is neither a mathematical treatise, nor a recipe book for growth data analysis. Aimed at junior and senior researchers involved in the analysis of human growth data, this book will be an essential reference for anthropologists, auxologists and paediatricians.

The transition in anthropological and biomedical research methods over the past 50 years, from anthropometric and craniometric measurements to large-scale microarray genetic studies has resulted in continued revision of opinions and ideas relating to the factors and forces that drive human variation.

Human Variation: From the Laboratory to the Field brings together the contributions of 22 scientists working in four continents to identify and address challenges imposed by variability. It reviews the way we examine and analyze human variation, paying specific attention to genetics, growth and development, and physiology. In presenting new evidence and findings, it also discusses current developments in methodology and analytical techniques, detailing both field and laboratory approaches, and looking at how the two perspectives complement each other.

In bridging that gap between laboratory trials and studies of the human in context, this book covers a number of interesting research areas including ?

• Human adaptation to natural and artificial light, including variations in circadian photosensitivity and effects of light on GI activity
• Cold tolerance and lifestyle in modern society
• Genetics of body weight and obesity
• Human adaptability to emotional and intellectual mental stresses
• Geography, migration, climate, and environmental plasticity as contributors to human variation
• Impact of natural environmental stressors including pollution on physiological and morphological processes

This book is the latest volume in a series of works from the Society for the Study of Human Biology (SSHB), which for half a century has advanced and promoted research in the biology of human populations in all of its branches including human viability, genetics, human adaptability, and ecology, and evolution. It holds two scientific meetings a year. This volume represents work presented during its most recent gathering.