The Human Genome Diversity Project (HGDP) was launched in 1991 by a group of population geneticists whose aim was to map genetic diversity in hundreds of human populations by tracing the similarities and differences between them. It quickly became controversial and was accused of racism and 'bad science' because of the special interest paid to sampling cell material from isolated and indigenous populations. The author spent a year carrying out participant observation in two of the laboratories involved and provides fascinating insights into daily routines and technologies used in those laboratories and also into issues of normativity, standardization and naturalisation. Drawing on debates and theoretical perspectives from across the social sciences, M'charek explores the relationship between the tools used to produce knowledge and the knowledge thus produced in a way that illuminates the HGDP but also contributes to our broader understanding of the contemporary life sciences and their social implications.

The secrets of our genetic heritage are finally being unlocked. The massive scientific effort to sequence the human genome is in fact just the beginning of a long journey as the extraordinary genetic diversity that exists between individuals becomes clear. Work in this field is yielding profound insights into the wider implications for understanding biology, human health and history. It promises much: to understand our evolutionary origins, to define us as individuals, to predict our risk of disease and to more effectively understand, treat and prevent illness. Genetics can help us understand both rare inherited disorders and common multifactorial disease like asthma, heart disease and diabetes. Huge investments are being made and great advances have been achived, but the challenges remain daunting. This book provides an authoritative overview of this topical and very rapidly advancing field of biomedical research.
Human Genetic Diversity provides a concise, authoritative overview of human genetic diversity. It documents the insights that human genetics have brought to an understanding of human evolution and history, focusing on the implications of human genetic diversity for disease susceptibility and treatment. The book describes the genetic basis for diseases such as HIV, AIDS, Crohn's disease, asthma and type I diabetes. It also examines the emerging field of pharmacogenomics and individualized medicine.
Human genetic variation has implications across a broad range of disciplines (both biological and medical) and this text neatly consolidates work in diverse fields to highlight common themes and principles. An accessible style and the extensive use of illustrations promote its relevance to a broad audience ranging from those interested in human and population genetics to molecular biologists, evolutionary biologists, biological anthropologists and individuals working in the health sciences and clinical medicine.

In order to gain an understanding of the dynamics of human individual and average growth patterns it is essential that the right methods are selected. There are a variety of methods available to analyse individual growth patterns, to estimate variation in different growth measures in populations and to relate genetic and environmental factors to individual and average growth. This volume provides an overview of modern techniques for the assessment and collection of growth data and methods of analysis for individual and population growth data. The book contains the basic mathematical and statistical tools required to understand the concepts of the methods under discussion and worked examples of analyses, but it is neither a mathematical treatise, nor a recipe book for growth data analysis. Aimed at junior and senior researchers involved in the analysis of human growth data, this book will be an essential reference for anthropologists, auxologists and paediatricians.

The transition in anthropological and biomedical research methods over the past 50 years, from anthropometric and craniometric measurements to large-scale microarray genetic studies has resulted in continued revision of opinions and ideas relating to the factors and forces that drive human variation.

Human Variation: From the Laboratory to the Field brings together the contributions of 22 scientists working in four continents to identify and address challenges imposed by variability. It reviews the way we examine and analyze human variation, paying specific attention to genetics, growth and development, and physiology. In presenting new evidence and findings, it also discusses current developments in methodology and analytical techniques, detailing both field and laboratory approaches, and looking at how the two perspectives complement each other.

In bridging that gap between laboratory trials and studies of the human in context, this book covers a number of interesting research areas including ?

• Human adaptation to natural and artificial light, including variations in circadian photosensitivity and effects of light on GI activity
• Cold tolerance and lifestyle in modern society
• Genetics of body weight and obesity
• Human adaptability to emotional and intellectual mental stresses
• Geography, migration, climate, and environmental plasticity as contributors to human variation
• Impact of natural environmental stressors including pollution on physiological and morphological processes

This book is the latest volume in a series of works from the Society for the Study of Human Biology (SSHB), which for half a century has advanced and promoted research in the biology of human populations in all of its branches including human viability, genetics, human adaptability, and ecology, and evolution. It holds two scientific meetings a year. This volume represents work presented during its most recent gathering.

Written primarily for 16-19-year-old students, this primer covers the anatomy and physiology of the key organ systems in the human body. It provides students with an overview of the anatomical details and physiological principles of the organ systems of the body and discusses the pathophysiology of common diseases that can affect them. It also considers how surgical approaches can be used to manage commonly presenting diseases of these systems. In addition, the primer explores surgery and anaesthesia both in a historical and contemporary context, examining how surgical and anaesthetic approaches have advanced over the centuries and how they continue to evolve to make surgery safer and more effective. The primer aims to extend students' knowledge and inspire them to take their school-level learning further. It explores topics that are familiar from the curriculum and also introduces new ideas, giving students a first taste of the study of biology beyond school-level, and demonstrating how concepts frequently encountered at school are relevant to and applied in current research. This is the ideal text to support students who are considering making the transition from studying biology at school to university. Digital formats and resources The book is available for students and institutions to purchase in a variety of formats, and is supported by online resources: * The e-book offers a mobile experience and convenient access along with functionality tools, navigation features, and links that offer extra learning support: www.oxfordtextbooks.co.uk/ebooks * Online resources include multiple choice questions for students to check their understanding, and, for registered adopters, figures and tables from the book

This major volume of original essays maps the place of emotion in human nature, through a discussion of the relation between consciousness and body; by analysing the importance of emotion for human agency by pointing to the ways in which practical rationality may be enhanced, as well as hindered, by emotions; and by exploring questions of value in making sense of emotions at a political, ethical and personal level. Leading researchers in the field reflect on the nature of human feelings, how and why we understand what other people feel, and the way in which our values become involved in specific emotional phenomena, such as guilt, fear, shame, amusement, or love. This collection addresses important questions in the philosophy of mind and comments on the implications of research in biology, cognitive psychology, psychoanalysis, and narrative theory for the philosophical understanding of emotions.

Human Population Dynamics introduces theoretical frameworks and methodologies from different traditional disciplines to demonstrate how changes in human population structure can be addressed from several different academic perspectives. The book contains contributions from world-renowned researchers in demography, social and biological anthropology, genetics, biology, sociology, ecology, history and human geography. In particular, the contributors emphasize the lability of many population structures and boundaries, as viewed from their area of expertise.

A number of researchers have tried to characterise the anatomy and behavioural systems of early hominid and early modern human populations in an attempt to understand how we became what we are. Can archaeology, palaeo-anthropology and genetics tell us how and when human cultures developed the traits that make our societies different from those of our closest living relatives? In which cases are these differences substantial, and when do they simply reflect our definitions of culture, species, the image we have of their evolution or of ourselves? From Tools to Symbols, a collection of twenty-seven selected papers from a South African-French conference organised in honour of the well-known palaeo-anthropologist Phillip Tobias, provides a multidisciplinary overview of this field of study. It is based on collaborative research conducted in sub-Saharan Africa by South African, French, American and German scholars in the last twenty years, and represents an excellent synthesis of the palaeontological and archaeological evidence of the last five million years of human evolution.

'Pontzer's findings have huge implications for our attitudes to exercise, diet and public health' Mark Webster, Sunday Times A myth-busting tour of the body's hidden foundations from a pioneering evolutionary biologist 'Public health strategies stubbornly cling to the simplistic armchair engineer's view of metabolism, hurting efforts to combat obesity, diabetes, heart disease, cancer, and the other diseases that are most likely to kill us' Herman Pontzer's ground-breaking research has revealed how, contrary to received wisdom, exercise does not increase our metabolism. Instead, we burn calories within a very narrow range: nearly 3,000 calories per day, no matter our activity level. In this book, he draws on twenty years of cutting-edge science to take a closer look at what happens to the energy we consume. Burn explores the ways in which metabolism controls every aspect of our health - from fertility to immune function - and reveals the truth about the dynamic system that sustains us. Filled with facts and memorable anecdotes, this book will change the way you think about food, exercise and what really matters for your health.

The human genetic make-up of Latin America is a reflection of successive waves of colonization and immigration. There have been few works dealing with the biology of human populations at a continental scale, and while much data is available on the genetics of Latin American populations, most information remains scattered throughout the literature. This volume examines Latin American human populations in relation to their origins, environment, history, demography and genetics, drawing on aspects of nutrition, physiology, and morphology for an integrated and multidisciplinary approach. The result is a fascinating account of a people characterized by a turbulent history, marked heterogeneity, and unique genetic traits.

This book spans two million years of human evolution and explores the impact of economics on human evolution and natural history. The theory of evolution by natural selection has always relied in part on progress in areas of science outside of biology. By applying economic principles at the borderlines of biology, Haim Ofek shows how some of the outstanding issues in human evolution, such as the increase in human brain size and the expansion of the environmental niche humans occupied, can be answered. He identifies distinct economic forces at work, beginning with the transition from the feed-as-you-go strategy of primates, through hunter-gathering and the domestication of fire to the development of agriculture. This highly readable book will inform and intrigue general readers and those in fields such as evolutionary biology and psychology, economics, and anthropology.

"Man the Hunted" argues that primates, including the earliest members of the human family, have evolved as the prey of any number of predators, including wild cats and dogs, hyenas, snakes, crocodiles, and even birds. The authors' studies of predators on monkeys and apes are supplemented here with the observations of naturalists in the field and revealing interpretations of the fossil record. Eyewitness accounts of the "man the hunted" drama being played out even now give vivid evidence of its prehistoric significance.

This provocative view of human evolution suggests that countless adaptations that have allowed our species to survive--from larger brains to speech--stem from a considerably more vulnerable position on the food chain than we might like to imagine. The myth of early humans as fearless hunters dominating the earth obscures our origins as just one of many species that had to be cautious, depend on other group members, communicate danger, and come to terms with being merely one cog in the complex cycle of life.

The expanded edition includes a new chapter that describes the ever-increasing evidence of predation on humans and other primates and claims that the earliest humans were neither hunters nor even the accomplished scavengers that many authorities have claimed.

Contents

Foreword by Ian Tattersall

1. Just Another Item on the Menu
2. Debunking "Man the Hunter"
3. Who's Eating Whom?
4. Lions and Tigers and Bears, Oh My!
5. Coursing Hyenas and Hungry Dogs
6. Missionary Position
7. Terror from the Sky
8. We Weren't Just Waiting Around to be Eaten!
9. Gentle Savage or Bloodthirsty Brute?
10. Man the Hunted
11. The Final Word

Analyses of the ecology, biology and society of past and present-day hunter-gatherers are at the core of this interdisciplinary volume. Since the seminal work of Man the Hunter in 1968, new research in these three areas has become increasingly specialized, and the lines of communication among academic disciplines have all but broken down. This volume aims to reestablish an interdisciplinary debate, presenting critical issues commanding an ongoing interest in hunter-gatherer research, covering the evolution and history, demography, biology, technology, social organization, art, and language of diverse groups. As a reference text, this book will be useful to scholars and students of social anthropology, archaeology, biological anthropology, and human sciences.

The threat of unstoppable plagues, such as AIDS and Ebola, is always with us. In Europe, the most devastating plagues were those from the Black Death pandemic in the 1300s to the Great Plague of London in 1665. For the past 100 years it has been accepted that Yersinia pestis, the infective agent of bubonic plague, was responsible for these epidemics. This book combines modern concepts of epidemiology and molecular biology with computer-modeling. Applying these concepts to the analysis of historical epidemics, the authors show that they were not, in fact, outbreaks of bubonic plague. Biology of Plagues offers a completely new interdisciplinary interpretation of the plagues of Europe, and establishes them within a geographical, historical, and demographic framework. This fascinating detective work will be of interest to readers in the social and biological sciences, and lessons learned will underline the implications of historical plagues for modern-day epidemiology.

"Soul, Psyche, Brain" is a collection of essays that address the relationships between neuroscience, religion and human nature. The book highlights some startling new developments in neuroscience that have many people rethinking spirituality, the mind-body connection, and cognition in general. "Soul, Psyche, Brain" explores questions like: What are the neurological effects of meditation and prayer? How does the mind develop psychological and spiritual self-awareness? And what are the practical implications of brain-mind science for religious faith and moral reasoning?

As we enter the twenty-first century, a number of medical, environmental, and social changes have profoundly affected human reproduction. This book discusses some of the more dramatic changes in an accessible manner, illustrating the ways in which human biology and culture can affect fertility. It provides a unique interdisciplinary perspective on the subject. Topics of discussion include medical technological advances that equip us with potential cures for many causes of infertility; diseases, such as AIDS, that have a devastating impact on the reproductive and social lives of humans; increasing industrialization and the development of fabricated materials that pollute our environment in unforeseen ways with possibly devastating effects on human health and fertility; and social revolutions that profoundly alter human relationships, such as nonmarital unions between heterosexual couples, same-sex relationships, and adoption and surrogacy.

In our fast-paced world of technology and conveniences, the biological origins of women's inequality can be forgotten. This book offers a richer understanding of gender inequality by explaining a key cause-women's reproductive and lactation patterns. Until about 1900, infants nursed every fifteen minutes on average for two years because very frequent suckling prevented pregnancy. The practice evolved because it maximized infant survival. If a forager child was born before its older sibling could take part in the daily food search, the older one died. This practice persisted until the modern era because until after the discovery of the germ theory of disease, human milk was the only food certain to be unspoiled. Lactation patterns excluded women from the activities that led to political leadership. During the twentieth century the ancient mode declined and women entered the labor market en masse. Joan Huber challenges feminists toward a richer understanding of biological origins of inequality-knowledge that can help women achieve greater equality today.

By showing how and why human nature is what it is, evolutionary theory can help us see better what we need to do to improve the human condition. Following evolutionary theory to its logical conclusion, Death, Hope and Sex uses life history theory and attachment theory to construct a model of human nature in which critical features are understood in terms of the development of alternative reproductive strategies contingent on environmental risk and uncertainty. James Chisholm examines the implications of this model for perspectives on concerns associated with human reproduction, including teen pregnancy, and young male violence. He thus develops new approaches for thorny issues such as the nature-nurture and mind-body dichotomies. Bridging the gap between the social and biological sciences, this far-reaching volume will be a source of inspiration, debate and discussion for all those interested in the evolution of human nature and the potential for an evolutionary humanism.

From the author of the award-winning bestseller The Content of Our Character comes a new essay collection that tells the untold story behind the polarized racial politics in America today. In A Dream Deferred Shelby Steele argues that a second betrayal of black freedom in the United States--the first one being segregation--emerged from the civil rights era when the country was overtaken by a powerful impulse to redeem itself from racial shame. According to Steele,1960s liberalism had as its first and all-consuming goal the expiation of America guilt rather than the careful development of true equality between the races. This "culture of preference" betrayed America's best principles in order to give whites and America institutions an iconography of racial virtue they could use against the stigma of racial shame. In four densely argued essays, Steele takes on the familiar questions of affirmative action, multiculturalism, diversity, Afro-centrism, group preferences, victimization--and what he deems to be the atavistic powers of race, ethnicity, and gender, the original causes of oppression. A Dream Deferred is an honest, courageous look at the perplexing dilemma of race and democracy in the United States--and what we might do to resolve it.

As widespread social transformations have been paralleled by gains in health and life expectancy through public health and other improvements, a variety of new obstacles to health have emerged. Lifestyle-related, behaviorally mediated changes in rates of chronic disease are the most prevalent of these new challenges. This book examines the relationship between human biology and human society, and how behavior, hormones, and health intersect. There is both scientific interest and practical urgency behind the ideas and findings presented here, as the need for a socioecological view of function and well-being has become more apparent. This book documents an emerging understanding of how hormones create the linkage between behavior or social life and health.

With the advent of the Human Genome Project there have been many claims for the genetic origins of complex human behavior including insanity, criminality, and intelligence. But what does it really mean to call something "genetic"? This is the fundamental question that Sahotra Sarkar's book addresses. This important book clarifies the meaning of the term "genetic," shows how molecular studies have affected genetics, and provides the philosophical background necessary to understand the debates over the Human Genome Project. It will be of particular interest to professionals and students in the philosophy of science, the history of science, and the social studies of science, medicine, and technology.

The study of human bipedalism has been overshadowed by many polarized debates. One dispute concerns whether or not australopithecines were wholly terrestrial or retained a degree of arboreality. Another deliberation focuses on the bipedalism of australopithecines compared to modern humans: was it similar, intermediate in nature, or unique? Because of the preoccupation with discussions such as these, the significant fact that modern human walking is more than locomotion on two legs has been underemphasized.
This volume focuses on the pattern and process of the transition to the modern form of human locomotion, with its adaptations for a striding stiff-legged gait, efficiency of running, and economy of resource transport. This emerging group of contributors spanning the fields of anthropology, biology and anatomy debate issues such as:
-When and in what sequence did these morphological traits appear?
-What were the changes in the bio-behavioral complex of hominin locomotor evolution?
-What were the implications for the enhancement and expansion of hominin mobility?

Childhood is a uniquely human life-stage, and is both a biological phenomenon and a social construct. Research on children is currently of wide-ranging interest. This groundbreaking book presents reviews of childhood from four major areas of interest--human evolution, sociology/social anthropology, biomedical anthropology and developmental psychology--to form a biosocial, cross-cultural understanding of childhood. The book places a strong emphasis on how childhood varies from culture to culture, offering examples from developed and developing countries, as well as from other animal species. It will be of interest to students and scholars within the fields of human biology, anthropology, sociology, health studies, and developmental psychology.

Everyone has questions about death. In Will My Cat Eat My Eyeballs?, best-selling author and mortician Caitlin Doughty answers the most intriguing questions she's ever received about what happens to our bodies when we die. In a brisk, informative, and morbidly funny style, Doughty explores everything from ancient Egyptian death rituals and the science of skeletons to flesh-eating insects and the proper depth at which to bury your pet if you want Fluffy to become a mummy. Now featuring an interview with a clinical expert on discussing these issues with young people-the source of some of our most revealing questions about death-Will My Cat Eat My Eyeballs? confronts our common fear of dying with candid, honest, and hilarious facts about what awaits the body we leave behind.

A few gray hairs and a couple of wrinkles are often the first visible signs of aging on our bodies. For most of us, however, aging remains largely a mystery. We can only wonder why we have to age and what casualty of age hovers nearby. Written in everyday language, The Clock of Ages takes us on a tour of the aging human body--all from a research scientist's point of view. From the deliberate creation of organisms that live three times their natural span to the isolation of genes that may allow humans to do the same, The Clock of Ages also examines the latest discoveries in geriatric genetics. Sprinkled throughout the pages are descriptions of the aging of many historical figures, such as Florence Nightingale, Jane Austen, Billy the Kid, Napoleon, and Casanova. These stories underscore the common bond of senescence that unites us all. The Clock of Ages tells us why.