A few gray hairs and a couple of wrinkles are often the first visible signs of aging on our bodies. For most of us, however, aging remains largely a mystery. We can only wonder why we have to age and what casualty of age hovers nearby. Written in everyday language, The Clock of Ages takes us on a tour of the aging human body--all from a research scientist's point of view. From the deliberate creation of organisms that live three times their natural span to the isolation of genes that may allow humans to do the same, The Clock of Ages also examines the latest discoveries in geriatric genetics. Sprinkled throughout the pages are descriptions of the aging of many historical figures, such as Florence Nightingale, Jane Austen, Billy the Kid, Napoleon, and Casanova. These stories underscore the common bond of senescence that unites us all. The Clock of Ages tells us why.

Why are humans so different from each other and what makes the human species so different from all other living organisms? This introductory book provides a concise and accessible account of human diversity, of its causes and the ways in which anthropologists go about trying to make sense of it. Carles Salazar offers students a thoroughly integrated view by bringing together biological and sociocultural anthropology and including perspectives from evolutionary biology and psychology.

Cells, Aging, and Human Disease is the first book to explore aging all the way from genes to clinical application, analyzing the fundamental cellular changes which underlie human age-related disease. With over 4,000 references, this text explores both the fundamental processes of human aging and the tissue-by-tissue pathology, detailing both breaking research and current state-of-the-art clinical interventions in aging and age-related disease.
Far from merely sharing a common onset late in the lifespan, age-related diseases are linked by fundamental common characteristics at the genetic and cellular levels. Emphasizing human cell mechanisms, the first section presents and analyzes our current knowledege of telomere biology and cell senescence. In superb academic detail, the text brings the reader up to date on telomere maintenance, telomerase dynamics, and current research on cell senescence--and the general model--cell senescence as the central component in human senescence and cancer. For each human malignancy, the chapter reviews and analyzes all available data on telomeres and telomerase, as well as summarizing current work on their clinical application in both diagnosis and cancer therapy.
The second edition, oriented by organs and tissues, explores the actual physiological impact of cell senescence and aging on clinical disease. After a summary of the literature on early aging syndromes--the progerias--the text reviews aging diseases (Alzheimer's dementia, osteoarthritis, atherosclerosis, immune aging, presbyopia, sarcopenia, etc.) in the context of the tissues in which they occur. Each of the ten clinical chapters--skin, cardiovascular system, bone and joints, hematopoetic and immune systems, endocrine, CNS, renal, muscle, GI, and eyes--examines what we know of their pathology, the role of cell sensescence, and medical interventions, both current and potential.

This introductory textbook examines the issues of human reproduction common to a variety of advanced school and beginning university courses. It covers in detail the physiology of the human reproductive system, the production of gametes, fertilisation, pregnancy, birth, lactation and contraception. Sensitive issues such as infertility, abortion and embryo research are discussed with careful consideration of the moral and ethical issues involved.

The early environment in which we grow up has profound, long lasting, and often irreversible consequences for us throughout our lives. Stresses due to undernutrition in early childhood can mean that in adulthood individuals are smaller, more prone to disease, and have a shorter life expectancy than those with normal diets. Disease and poor living conditions in infancy and childhood also have serious implications in adulthood. While environmental effects on human growth and development are well documented, the long term consequences due to processes taking place at the early stages of growth and development have only recently become a focus of intense study. In this volume, leading researchers in nutrition, epidemiology, human biology, anthropology and physiology bring together a uniquely accessible source of information on this fascinating topic.

In the mature brain calcium ions play pivotal roles in transmembrane and intracellular transmission of signals. Thus, calcium is involved in numerous neuronal functions including neurotransmitter release, enzyme regulation, modulation of neuronal excitability, gene expression, microtubular transport or synaptic plasticity. Many of these calcium-dependent processes are mediated or modulated by a number of cytosolic calcium-binding proteins. All nerve cells contain the calcium-binding protein calmodulin. Other CaBPs are restricted to certain nerve celltypes, i.e. parvalbumin, calbindin and calretinin.

Infectious disease accounts for more death and disability worldwide than either noninfectious disease or injury. This book contains a number of different quantitative approaches to understanding the patterns of such diseases in populations, and the design of control strategies to lessen their effect. The papers are written by experts with varied mathematical expertise and involvement in biological, medical and social sciences. The volume increases interaction between specialties by describing research on many infectious diseases that affect humans, including viral diseases, such as measles and AIDS, and tropical parasitic infections. Sections deal with problems relating to transmissible diseases with long development times (such as AIDS); vaccination strategies; the consequences of treatment interventions; the dynamics of immunity; heterogeneity of populations; and prediction. On each topic, the editors have chosen papers that bring together contrasting approaches via the development of theoretical results, the use of relevant knowledge from applied fields, and the analysis of data.

The rise of the multi-billion dollar ancestry testing industry points to one immutable truth about us as human beings: we want to know where we come from and who our ancestors were. John H. Relethford and Deborah A. Bolnick explore this topic and many more in this second edition of Reflections of Our Past. Where did modern humans come from and how important are the biological differences among us? Are we descended from Neandertals? How should we understand the connections between genetic ancestry, race, and identity? Were Native Americans the first to inhabit the Americas? Can we see evidence of the Viking invasions of Ireland a millennium ago even in the Irish of today? Through engaging examination of issues such as these, and using non-technical language, Reflections of Our Past shows how anthropologists use genetic information to suggest answers to fundamental questions about human history. By looking at genetic variation in the world today and in the past, we can reconstruct the recent and remote events and processes that have created the variation we see, providing a fascinating reflection of our genetic past.

The main objective of this book is to present some of the fundamental structural aspects in the design of respiratory organs while debating and speculating on when, how and why these states were founded. The author's main thesis is that the modern gas exchangers are products of protracted processes that have entailed adaptation to specific environments and lifestyles. Only those feasible designs that have proven adequately compentent in meeting demands for molecular oxygen have been preserved. The author's approach has been to look into the limiting functional properties as regards the respiratory capacities of gas exchangers while finding out the specific structural adaptations that have evolved to meet the metabolic needs or to look into form and discern how it limits function.

The problems of understanding and controlling disease present a range of mathematical challenges, from broad theoretical issues to specific practical ones, making epidemiology one of the most vibrant branches of applied biology. Progress in this field requires collaboration among leading researchers with a wide range of mathematical expertise and close involvement in applied fields across the social, medical and biological sciences. This volume surveys the current state of epidemic modeling in relation to basic aims such as understanding, prediction, and evaluation and implementation of control strategies. The book is divided into five parts, covering the conceptual framework, three major problem areas (space, nonlinearity, heterogeneity), and the direct relation of models to data. The contributors discuss a wide range of methodological issues, e.g. comparing different approaches to the modeling of heterogeneity and relations among different types of model; and different data analytic approaches, together with the availability and quality of the data they require.

Why am I always tired? Why can't I sleep at night? Why do I suffer from jetlag?

We all have a body clock, a biological structure that controls how we feel, our mental and physical performance, and whether we are active or asleep. This is nature's response to our rhythmic environment, dominated by day and night. Though the body clock normally adjusts us to daytime activity and night time sleep, it can go wrong or be tricked by lifestyle changes. This can result in jetlag, some forms of insomnia and even depression. Keeping in time with your body clock provides clear and accessible advice on how to live with, and not against, your body clock. In a clear and accessible style, it explains how the body clock works, how and why it can work against you, and the measures you can take to optimise your feeling of health and wellbeing. It also explains the role of the body clock in illness, and how an understanding of this can increase your feeling of health.

An essential book for anyone who wants to better understand their body and optimise their feeling of health and wellbeing.

It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better understood. The development of methods for isolation and co-culturing various types of liver cells has established that they communicate and cooperate via secretion of various intercellular mediators. This monograph summarizes multiple data that suggest the important role of cellular cross-talk for the functions of both normal and diseased liver. Special features of the book include concise presentation of the majority of detailed data in 19 tables. Original schemes allow for the clear illustration of complicated intercellular relationships. This is the first ever presentation of the newly emerging field of liver biology, which is important for hepatic function in health and disease and opens new avenues for therapeutic interventions.

Human Biological Diversity is an introductory textbook designed to cover the key contemporary topics in the study of human variation and human biology within the field of physical anthropology. Easily accessible for students with no background in anthropology or biology, this second edition includes two new chapters, one on human variation in the skeleton and dentition and the other on tracing human population affinities. All other chapters have been fully updated to reflect advances in the field and now include pedagogical features to aid readers in their understanding. Written for an introductory level but still containing valuable information that will be of interest to students on upper-level courses, Brown's textbook should be essential reading for all students taking courses on human variation, human biology, human evolution, race, anthropology of race, and general introductions to biological/physical anthropology.

Reproduction plays a huge part in many people's lives, but often little is understood about the biological processes involved and the larger impact of reproductive choices. This book offers an accessible, comprehensive introduction to this fascinating subject. Irina Pollard takes a unique, interdisciplinary perspective, describing in detail the biology of human reproduction, but also covering in depth the impact of procreational behavior on human social structures, the environment, and health. This compelling and authoritative account is the first to draw together in a single volume these two disparate yet intimately connected strands of the story of human reproduction. The book covers fertility and infertility, sexual behavior and pheromones, sperm creation, maternal physiology during pregnancy, fetal development, the biology of breast feeding, and the impact of parental behavior on the physiology of the newborn, as well as population dynamics, artificial control of fertility, the AIDS epidemic, the effects of nutrition and exercise on reproductive behavior, and the causes of birth defects, including abuse of substances such as nicotine, alcohol, and caffeine. This book is an ideal text for undergraduate and graduate students studying biology, medicine, anthropology, human ecology, population dynamics, and public health. It is also an engrossing and enlightening source of information for a wide range of general readers including prospective parents, pregnant mothers, teenagers, and anyone wishing a concise, up-to-date review of human reproductive biology.

Reproduction plays a huge part in many people's lives, but often little is understood about the biological processes involved and the larger impact of reproductive choices. This book offers an accessible, comprehensive introduction to this fascinating subject. Irina Pollard takes a unique, interdisciplinary perspective, describing in detail the biology of human reproduction, but also covering in depth the impact of procreational behavior on human social structures, the environment, and health. This compelling and authoritative account is the first to draw together in a single volume these two disparate yet intimately connected strands of the story of human reproduction. The book covers fertility and infertility, sexual behavior and pheromones, sperm creation, maternal physiology during pregnancy, fetal development, the biology of breast feeding, and the impact of parental behavior on the physiology of the newborn, as well as population dynamics, artificial control of fertility, the AIDS epidemic, the effects of nutrition and exercise on reproductive behavior, and the causes of birth defects, including abuse of substances such as nicotine, alcohol, and caffeine. This book is an ideal text for undergraduate and graduate students studying biology, medicine, anthropology, human ecology, population dynamics, and public health. It is also an engrossing and enlightening source of information for a wide range of general readers including prospective parents, pregnant mothers, teenagers, and anyone wishing a concise, up-to-date review of human reproductive biology.

In 1901 William Bateson, Professor of Biology at Cambridge, published a renewed version of a lecture which he had delivered the year before to the Royal Horticultural Society in London (reprinted in the book as an appendix). In this lecture he recognized the importance of the work completed by Gregor Mendel in 1865, and brought it to the notice of the scientific world. Upon reading Bateson's paper, Archibald Garrod realized the relevance of Mendel's laws to human disease and in 1902 introduced Mendelism to medical genetics. The first part of A Century of Mendelism in Human Genetics takes a historical perspective of the first 50 years of Mendelism, including the bitter argument between the Mendelians and the biometricians. The second part discusses human genetics since 1950, ending with a final chapter examining genetics and the future of medicine. The book considers the genetics of both single-gene and complex diseases, human cancer genetics, genetic linkage, and natural selection in human populations. Besides being of general medical significance, this book will be of particular interest to departments of genetics and of medical genetics, as well as to historians of science and medicine.

Seasonality has effects on a wide range of human functions and activities, and is important in the understanding of human environment relationships. In this volume, distinguished contributors, including human biologists, anthropologists, physiologists and nutritionists consider many of the different ways in which seasonality influences human biology and behaviour. Topics addressed include the influence of seasonality on hominid evolution, seasonal climatic effects on human physiology, fertility and physical growth, seasonality in morbidity, mortality and nutritional state, and seasonal factors in food production, modernisation and work organisation in Third World economics. This book will be of interest to graduate students and researchers in human biology, anthropology and nutrition.

Have you ever done something stupid, dangerous or self-sabotaging just to get one over someone else? Most of us have. Simon McCarthy-Jones draws on psychology, current affairs, literature and genetics to illuminate – whether we admit it or not – our spiteful side. What is that part of us that secretly wants our friends to fail? Did Americans put Trump in the White House just to stick it to Hillary Clinton? And then there are the legion of stories about toxic behaviour in supermarkets and over the privet hedge, ramping up to incendiary divorces, vicious business practices, backbiting politics and scorched-earth terrorism. There’s a hopeful message too – the upside of our dark side. Spite can drive us forward, and Simon provides a fresh perspective on the concept by showing the evolutionary benefits of spite as a social leveller, an enabler of defiance, a wellspring of freedom and a vital weapon in our everyday armoury.

Preparatory work for this monograph started in 1988 and 1989. The motive was provided by certain incongruities in the illustra- tion of descensus testis for the chapter "Entwicklung der Genital- organe" in the book Humanembryologie. The evoked discussion was reason enough for our own re- search on the phenomenon and uncertainties of testicular des- cent in human. The basis ofthese investigations was the collection of human embryos founded by Prof. Hinrichsen in 1970 at the Department of Anatomy and Embryology, Ruhr-University Bo- chum. The preparation of the material used in this paper has been done with the help of many staff members of our department to whom we feel obliged. We are especially indebted to Prof. Hin- richsen who prepared the foetuses and took the first steps of this project. We wish also to acknowledge Dr. Heinz Jiirgen Jacob for careful fixation and microdissection of specimens intended for scanning electron microscopy. Weare also grateful to Mrs. Vera Mannheim for her involvement and her sensitivity in making scanning electron micrographs, and Mrs. Antje Jaeger for provid- ing an expert and skilful photographic technique especially in the setting up of micrographs. Our thanks are also due to Mrs. Marion Kohn for skilful technical assistance and to all those technical assistants who worked in our department during the past 25 years and who were engaged in providing the serial sec- tions. The English text has been thoroughly revised by Prof. Dr.

This volume looks at the relationship between specific aspects of Third World cities and human health. Rapid and extensive urbanization of the less developed nations is perhaps the most dramatic demographic phenomenon of our times, but its impact on human biology is not well understood. Here, a cross-section of work is presented on this subject allowing human biologists, urban planners, public health workers and other specialists to assess our knowledge and the current approaches available to increase it. Contributions fall into two groups: studies of urban ecology including the social, economic and physical domains, and studies of biological responses to the urban environment. Health is not merely the absence of specific diseases, but is construed more broadly to include a wide range of biological parameters that are correlated with various states of sub-optimal health. These include patterns of child growth and development, frequencies of specific diseases, nutritional status, immunological characteristics and physiological parameters. This important volume will be of interest to a wide range of researchers and academics, including human biologists, anthropologists, healthcare professionals, human geographers, urban and regional planners, and economists.

Physical activity and exercise affect many dimensions of health. This book presents an up-to-date and wide ranging account of the key issues of the biology of physical activity and health. The context is set by considering the comparative and temporal aspects of activity in humans. There follows an examination of the concepts and methodological issues associated with activity, exercise, health, and fitness, as well as their interrelationships. Particular attention is given to activity in children, adolescents and the elderly, activity and weight maintenance, and the psychological effects of activity. The book ends with an overview of current and future leisure life styles.

'From your brain to your fingertips, you emerge from her book entertained and with a deeper understanding of yourself' Richard Dawkins 'A masterful account of why our bodies are the way they are . . . this book really shines . . . Roberts's lightness of touch is joyous, and celebratory' Observer 'Witty, personal and above all informed by passion and deep knowledge, this is the story of you, not just from conception onwards but from the millions of years of evolution that have shaped the way we are today' Adam Rutherford ***SHORTLISTED FOR THE WELLCOME BOOK PRIZE*** Alice Roberts takes you on the most incredible journey, revealing your path from a single cell to a complex embryo to a living, breathing, thinking person. It's a story that connects us with our distant ancestors and an extraordinary, unlikely chain of events that shaped human development and left a mark on all of us. Alice Roberts uses the latest research to uncover the evolutionary history hidden in all of us, from the secrets found only in our embryos and genes - including why as embroyos we have what look like gills - to those visible in your anatomy. This is a tale of discovery, exploring why and how we have developed as we have. This is your story, told as never before.

Nutrition has become a hot topic, in the media as well at the market place. But how much of the information given to the consumer is hype and how much is accurate? In Taking the Fear out of Eating, published in 1993, two established scientists have distilled the information from thousands of scientific studies into a succinct, easily read description of what is known, what is merely suspected and, equally important, what is not known, about nutrition and how food choices might affect health. The book takes a hard look at both sides of the controversy about the connection between food and health, with particular emphasis on diet and the chronic diseases of cancer and heart disease. Food is, of course, essential to our survival but our food supply is often portrayed as dangerous - loaded with additives, pesticides, salt, sugar, fat and cholesterol. Taking the Fear out of Eating puts these topics into perspective in an authoritative and entertaining manner. It is not intended as a 'self-help' book but rather as a means to make the reader a participating partner with health professionals.

Nutrition has become a hot topic, in the media as well at the market place. But how much of the information given to the consumer is hype and how much is accurate? In Taking the Fear out of Eating, published in 1993, two established scientists have distilled the information from thousands of scientific studies into a succinct, easily read description of what is known, what is merely suspected and, equally important, what is not known, about nutrition and how food choices might affect health. The book takes a hard look at both sides of the controversy about the connection between food and health, with particular emphasis on diet and the chronic diseases of cancer and heart disease. Food is, of course, essential to our survival but our food supply is often portrayed as dangerous - loaded with additives, pesticides, salt, sugar, fat and cholesterol. Taking the Fear out of Eating puts these topics into perspective in an authoritative and entertaining manner. It is not intended as a 'self-help' book but rather as a means to make the reader a participating partner with health professionals.

When Did I Begin? investigates the theoretical, moral, and biological issues surrounding the debate over the beginning of human life. With the continuing controversy over the use of in vitro fertilization techniques and experimentation with human embryos, these issues have been forced into the arena of public debate. Following a detailed analysis of the history of the question, Reverend Ford argues that a human individual could not begin before definitive individuation occurs with the appearance of the primitive streak about two weeks after fertilization. This, he argues, is when it becomes finally known whether one or more human individuals are to form from a single egg. Thus, he questions the idea that the fertilized egg itself could be regarded as the beginning of the development of the human individual. The author also differs sharply, however, from those who would delay the beginning of the human person until the brain is formed, or until birth or the onset of conscious states.