With the advent of the Human Genome Project there have been many claims for the genetic origins of complex human behavior including insanity, criminality, and intelligence. But what does it really mean to call something "genetic"? This is the fundamental question that Sahotra Sarkar's book addresses. This important book clarifies the meaning of the term "genetic," shows how molecular studies have affected genetics, and provides the philosophical background necessary to understand the debates over the Human Genome Project. It will be of particular interest to professionals and students in the philosophy of science, the history of science, and the social studies of science, medicine, and technology.

Childhood is a uniquely human life-stage, and is both a biological phenomenon and a social construct. Research on children is currently of wide-ranging interest. This groundbreaking book presents reviews of childhood from four major areas of interest--human evolution, sociology/social anthropology, biomedical anthropology and developmental psychology--to form a biosocial, cross-cultural understanding of childhood. The book places a strong emphasis on how childhood varies from culture to culture, offering examples from developed and developing countries, as well as from other animal species. It will be of interest to students and scholars within the fields of human biology, anthropology, sociology, health studies, and developmental psychology.

The study of human bipedalism has been overshadowed by many polarized debates. One dispute concerns whether or not australopithecines were wholly terrestrial or retained a degree of arboreality. Another deliberation focuses on the bipedalism of australopithecines compared to modern humans: was it similar, intermediate in nature, or unique? Because of the preoccupation with discussions such as these, the significant fact that modern human walking is more than locomotion on two legs has been underemphasized.
This volume focuses on the pattern and process of the transition to the modern form of human locomotion, with its adaptations for a striding stiff-legged gait, efficiency of running, and economy of resource transport. This emerging group of contributors spanning the fields of anthropology, biology and anatomy debate issues such as:
-When and in what sequence did these morphological traits appear?
-What were the changes in the bio-behavioral complex of hominin locomotor evolution?
-What were the implications for the enhancement and expansion of hominin mobility?

A few gray hairs and a couple of wrinkles are often the first visible signs of aging on our bodies. For most of us, however, aging remains largely a mystery. We can only wonder why we have to age and what casualty of age hovers nearby. Written in everyday language, The Clock of Ages takes us on a tour of the aging human body--all from a research scientist's point of view. From the deliberate creation of organisms that live three times their natural span to the isolation of genes that may allow humans to do the same, The Clock of Ages also examines the latest discoveries in geriatric genetics. Sprinkled throughout the pages are descriptions of the aging of many historical figures, such as Florence Nightingale, Jane Austen, Billy the Kid, Napoleon, and Casanova. These stories underscore the common bond of senescence that unites us all. The Clock of Ages tells us why.

Why are humans so different from each other and what makes the human species so different from all other living organisms? This introductory book provides a concise and accessible account of human diversity, of its causes and the ways in which anthropologists go about trying to make sense of it. Carles Salazar offers students a thoroughly integrated view by bringing together biological and sociocultural anthropology and including perspectives from evolutionary biology and psychology.

Cells, Aging, and Human Disease is the first book to explore aging all the way from genes to clinical application, analyzing the fundamental cellular changes which underlie human age-related disease. With over 4,000 references, this text explores both the fundamental processes of human aging and the tissue-by-tissue pathology, detailing both breaking research and current state-of-the-art clinical interventions in aging and age-related disease.
Far from merely sharing a common onset late in the lifespan, age-related diseases are linked by fundamental common characteristics at the genetic and cellular levels. Emphasizing human cell mechanisms, the first section presents and analyzes our current knowledege of telomere biology and cell senescence. In superb academic detail, the text brings the reader up to date on telomere maintenance, telomerase dynamics, and current research on cell senescence--and the general model--cell senescence as the central component in human senescence and cancer. For each human malignancy, the chapter reviews and analyzes all available data on telomeres and telomerase, as well as summarizing current work on their clinical application in both diagnosis and cancer therapy.
The second edition, oriented by organs and tissues, explores the actual physiological impact of cell senescence and aging on clinical disease. After a summary of the literature on early aging syndromes--the progerias--the text reviews aging diseases (Alzheimer's dementia, osteoarthritis, atherosclerosis, immune aging, presbyopia, sarcopenia, etc.) in the context of the tissues in which they occur. Each of the ten clinical chapters--skin, cardiovascular system, bone and joints, hematopoetic and immune systems, endocrine, CNS, renal, muscle, GI, and eyes--examines what we know of their pathology, the role of cell sensescence, and medical interventions, both current and potential.

This introductory textbook examines the issues of human reproduction common to a variety of advanced school and beginning university courses. It covers in detail the physiology of the human reproductive system, the production of gametes, fertilisation, pregnancy, birth, lactation and contraception. Sensitive issues such as infertility, abortion and embryo research are discussed with careful consideration of the moral and ethical issues involved.

This transformative guide completely breaks down our current understanding of biological sex and gender diversity. Introducing readers to seven variations of human sex, commonly considered intersex, the book challenges the myth that sex and gender are exclusively binary and explores the inherent diversity of biological sex and its relationship to gender identity and expression, and the impact this has on society. Examining historical, linguistic and socio-cultural understandings of sex and gender, as well as genetic and scientific definitions, the book is an important resource for dismantling gender and sexuality-based discrimination and promoting understanding and inclusivity. Co-written by one of the world's leading intersex activists and a highly respected scholar in biological sciences, and accompanied with detailed anatomical illustrations throughout, this pioneering text is the essential introduction to gender and sex diversity for gender studies, women's studies, biology and genetics courses, as well as professionals working with intersex and trans communities.

The early environment in which we grow up has profound, long lasting, and often irreversible consequences for us throughout our lives. Stresses due to undernutrition in early childhood can mean that in adulthood individuals are smaller, more prone to disease, and have a shorter life expectancy than those with normal diets. Disease and poor living conditions in infancy and childhood also have serious implications in adulthood. While environmental effects on human growth and development are well documented, the long term consequences due to processes taking place at the early stages of growth and development have only recently become a focus of intense study. In this volume, leading researchers in nutrition, epidemiology, human biology, anthropology and physiology bring together a uniquely accessible source of information on this fascinating topic.

Infectious disease accounts for more death and disability worldwide than either noninfectious disease or injury. This book contains a number of different quantitative approaches to understanding the patterns of such diseases in populations, and the design of control strategies to lessen their effect. The papers are written by experts with varied mathematical expertise and involvement in biological, medical and social sciences. The volume increases interaction between specialties by describing research on many infectious diseases that affect humans, including viral diseases, such as measles and AIDS, and tropical parasitic infections. Sections deal with problems relating to transmissible diseases with long development times (such as AIDS); vaccination strategies; the consequences of treatment interventions; the dynamics of immunity; heterogeneity of populations; and prediction. On each topic, the editors have chosen papers that bring together contrasting approaches via the development of theoretical results, the use of relevant knowledge from applied fields, and the analysis of data.

Human life, and how we came to be, is one of the greatest scientific and philosophical questions of our time. This compact and accessible book presents a modern view of human evolution. Written by a leading authority, it lucidly and engagingly explains not only the evolutionary process, but the technologies currently used to unravel the evolutionary past and emergence of Homo sapiens. By separating the history of palaeoanthropology from current interpretation of the human fossil record, it lays numerous misconceptions to rest, and demonstrates that human evolution has been far from the linear struggle from primitiveness to perfection that we've been led to believe. It also presents a coherent scenario for how Homo sapiens contrived to cross a formidable cognitive barrier to become an extraordinary and unprecedented thinking creature. Elegantly illustrated, Understanding Human Evolution is for anyone interested in the complex and tangled story of how we came to be.

The rise of the multi-billion dollar ancestry testing industry points to one immutable truth about us as human beings: we want to know where we come from and who our ancestors were. John H. Relethford and Deborah A. Bolnick explore this topic and many more in this second edition of Reflections of Our Past. Where did modern humans come from and how important are the biological differences among us? Are we descended from Neandertals? How should we understand the connections between genetic ancestry, race, and identity? Were Native Americans the first to inhabit the Americas? Can we see evidence of the Viking invasions of Ireland a millennium ago even in the Irish of today? Through engaging examination of issues such as these, and using non-technical language, Reflections of Our Past shows how anthropologists use genetic information to suggest answers to fundamental questions about human history. By looking at genetic variation in the world today and in the past, we can reconstruct the recent and remote events and processes that have created the variation we see, providing a fascinating reflection of our genetic past.

A 'kluge' is an engineering term for a makeshift solution, an inelegant construction that somehow works. This is Gary Marcus's analogy for the way the human mind has evolved. Arguing against a whole tradition that praises our human minds as the most perfect result of evolution, Marcus shows how imperfect and ill-adapted our brains really are. They have had to adapt from the environment of our early hominid origins to a complex world in which our penchant for short-term satisfactions is literally fatal. We are prone to rages, addictions and other habits that limit our capacity for rational action in every sphere, from food to politics. A breathtaking, witty and revolutionary book.

The main objective of this book is to present some of the fundamental structural aspects in the design of respiratory organs while debating and speculating on when, how and why these states were founded. The author's main thesis is that the modern gas exchangers are products of protracted processes that have entailed adaptation to specific environments and lifestyles. Only those feasible designs that have proven adequately compentent in meeting demands for molecular oxygen have been preserved. The author's approach has been to look into the limiting functional properties as regards the respiratory capacities of gas exchangers while finding out the specific structural adaptations that have evolved to meet the metabolic needs or to look into form and discern how it limits function.

The problems of understanding and controlling disease present a range of mathematical challenges, from broad theoretical issues to specific practical ones, making epidemiology one of the most vibrant branches of applied biology. Progress in this field requires collaboration among leading researchers with a wide range of mathematical expertise and close involvement in applied fields across the social, medical and biological sciences. This volume surveys the current state of epidemic modeling in relation to basic aims such as understanding, prediction, and evaluation and implementation of control strategies. The book is divided into five parts, covering the conceptual framework, three major problem areas (space, nonlinearity, heterogeneity), and the direct relation of models to data. The contributors discuss a wide range of methodological issues, e.g. comparing different approaches to the modeling of heterogeneity and relations among different types of model; and different data analytic approaches, together with the availability and quality of the data they require.

In the mature brain calcium ions play pivotal roles in transmembrane and intracellular transmission of signals. Thus, calcium is involved in numerous neuronal functions including neurotransmitter release, enzyme regulation, modulation of neuronal excitability, gene expression, microtubular transport or synaptic plasticity. Many of these calcium-dependent processes are mediated or modulated by a number of cytosolic calcium-binding proteins. All nerve cells contain the calcium-binding protein calmodulin. Other CaBPs are restricted to certain nerve celltypes, i.e. parvalbumin, calbindin and calretinin.

Why am I always tired? Why can't I sleep at night? Why do I suffer from jetlag?

We all have a body clock, a biological structure that controls how we feel, our mental and physical performance, and whether we are active or asleep. This is nature's response to our rhythmic environment, dominated by day and night. Though the body clock normally adjusts us to daytime activity and night time sleep, it can go wrong or be tricked by lifestyle changes. This can result in jetlag, some forms of insomnia and even depression. Keeping in time with your body clock provides clear and accessible advice on how to live with, and not against, your body clock. In a clear and accessible style, it explains how the body clock works, how and why it can work against you, and the measures you can take to optimise your feeling of health and wellbeing. It also explains the role of the body clock in illness, and how an understanding of this can increase your feeling of health.

An essential book for anyone who wants to better understand their body and optimise their feeling of health and wellbeing.

Human Biological Diversity is an introductory textbook designed to cover the key contemporary topics in the study of human variation and human biology within the field of physical anthropology. Easily accessible for students with no background in anthropology or biology, this second edition includes two new chapters, one on human variation in the skeleton and dentition and the other on tracing human population affinities. All other chapters have been fully updated to reflect advances in the field and now include pedagogical features to aid readers in their understanding. Written for an introductory level but still containing valuable information that will be of interest to students on upper-level courses, Brown's textbook should be essential reading for all students taking courses on human variation, human biology, human evolution, race, anthropology of race, and general introductions to biological/physical anthropology.

Reproduction plays a huge part in many people's lives, but often little is understood about the biological processes involved and the larger impact of reproductive choices. This book offers an accessible, comprehensive introduction to this fascinating subject. Irina Pollard takes a unique, interdisciplinary perspective, describing in detail the biology of human reproduction, but also covering in depth the impact of procreational behavior on human social structures, the environment, and health. This compelling and authoritative account is the first to draw together in a single volume these two disparate yet intimately connected strands of the story of human reproduction. The book covers fertility and infertility, sexual behavior and pheromones, sperm creation, maternal physiology during pregnancy, fetal development, the biology of breast feeding, and the impact of parental behavior on the physiology of the newborn, as well as population dynamics, artificial control of fertility, the AIDS epidemic, the effects of nutrition and exercise on reproductive behavior, and the causes of birth defects, including abuse of substances such as nicotine, alcohol, and caffeine. This book is an ideal text for undergraduate and graduate students studying biology, medicine, anthropology, human ecology, population dynamics, and public health. It is also an engrossing and enlightening source of information for a wide range of general readers including prospective parents, pregnant mothers, teenagers, and anyone wishing a concise, up-to-date review of human reproductive biology.

Reproduction plays a huge part in many people's lives, but often little is understood about the biological processes involved and the larger impact of reproductive choices. This book offers an accessible, comprehensive introduction to this fascinating subject. Irina Pollard takes a unique, interdisciplinary perspective, describing in detail the biology of human reproduction, but also covering in depth the impact of procreational behavior on human social structures, the environment, and health. This compelling and authoritative account is the first to draw together in a single volume these two disparate yet intimately connected strands of the story of human reproduction. The book covers fertility and infertility, sexual behavior and pheromones, sperm creation, maternal physiology during pregnancy, fetal development, the biology of breast feeding, and the impact of parental behavior on the physiology of the newborn, as well as population dynamics, artificial control of fertility, the AIDS epidemic, the effects of nutrition and exercise on reproductive behavior, and the causes of birth defects, including abuse of substances such as nicotine, alcohol, and caffeine. This book is an ideal text for undergraduate and graduate students studying biology, medicine, anthropology, human ecology, population dynamics, and public health. It is also an engrossing and enlightening source of information for a wide range of general readers including prospective parents, pregnant mothers, teenagers, and anyone wishing a concise, up-to-date review of human reproductive biology.

In 1901 William Bateson, Professor of Biology at Cambridge, published a renewed version of a lecture which he had delivered the year before to the Royal Horticultural Society in London (reprinted in the book as an appendix). In this lecture he recognized the importance of the work completed by Gregor Mendel in 1865, and brought it to the notice of the scientific world. Upon reading Bateson's paper, Archibald Garrod realized the relevance of Mendel's laws to human disease and in 1902 introduced Mendelism to medical genetics. The first part of A Century of Mendelism in Human Genetics takes a historical perspective of the first 50 years of Mendelism, including the bitter argument between the Mendelians and the biometricians. The second part discusses human genetics since 1950, ending with a final chapter examining genetics and the future of medicine. The book considers the genetics of both single-gene and complex diseases, human cancer genetics, genetic linkage, and natural selection in human populations. Besides being of general medical significance, this book will be of particular interest to departments of genetics and of medical genetics, as well as to historians of science and medicine.

It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better understood. The development of methods for isolation and co-culturing various types of liver cells has established that they communicate and cooperate via secretion of various intercellular mediators. This monograph summarizes multiple data that suggest the important role of cellular cross-talk for the functions of both normal and diseased liver. Special features of the book include concise presentation of the majority of detailed data in 19 tables. Original schemes allow for the clear illustration of complicated intercellular relationships. This is the first ever presentation of the newly emerging field of liver biology, which is important for hepatic function in health and disease and opens new avenues for therapeutic interventions.

Seasonality has effects on a wide range of human functions and activities, and is important in the understanding of human environment relationships. In this volume, distinguished contributors, including human biologists, anthropologists, physiologists and nutritionists consider many of the different ways in which seasonality influences human biology and behaviour. Topics addressed include the influence of seasonality on hominid evolution, seasonal climatic effects on human physiology, fertility and physical growth, seasonality in morbidity, mortality and nutritional state, and seasonal factors in food production, modernisation and work organisation in Third World economics. This book will be of interest to graduate students and researchers in human biology, anthropology and nutrition.

This volume looks at the relationship between specific aspects of Third World cities and human health. Rapid and extensive urbanization of the less developed nations is perhaps the most dramatic demographic phenomenon of our times, but its impact on human biology is not well understood. Here, a cross-section of work is presented on this subject allowing human biologists, urban planners, public health workers and other specialists to assess our knowledge and the current approaches available to increase it. Contributions fall into two groups: studies of urban ecology including the social, economic and physical domains, and studies of biological responses to the urban environment. Health is not merely the absence of specific diseases, but is construed more broadly to include a wide range of biological parameters that are correlated with various states of sub-optimal health. These include patterns of child growth and development, frequencies of specific diseases, nutritional status, immunological characteristics and physiological parameters. This important volume will be of interest to a wide range of researchers and academics, including human biologists, anthropologists, healthcare professionals, human geographers, urban and regional planners, and economists.

Physical activity and exercise affect many dimensions of health. This book presents an up-to-date and wide ranging account of the key issues of the biology of physical activity and health. The context is set by considering the comparative and temporal aspects of activity in humans. There follows an examination of the concepts and methodological issues associated with activity, exercise, health, and fitness, as well as their interrelationships. Particular attention is given to activity in children, adolescents and the elderly, activity and weight maintenance, and the psychological effects of activity. The book ends with an overview of current and future leisure life styles.