The genome's been mapped.
But what does it mean?

Arguably the most significant scientific discovery of the new century, the mapping of the twenty-three pairs of chromosomes that make up the human genome raises almost as many questions as it answers. Questions that will profoundly impact the way we think about disease, about longevity, and about free will. Questions that will affect the rest of your life.

"Genome" offers extraordinary insight into the ramifications of this incredible breakthrough. By picking one newly discovered gene from each pair of chromosomes and telling its story, Matt Ridley recounts the history of our species and its ancestors from the dawn of life to the brink of future medicine. From Huntington's disease to cancer, from the applications of gene therapy to the horrors of eugenics, Matt Ridley probes the scientific, philosophical, and moral issues arising as a result of the mapping of the genome. It will help you understand what this scientific milestone means for you, for your children, and for humankind.

The diversity of contemporary investigative approaches included in this volume provides an exciting account of our current understanding of brain mechanisms responsible for sensory and perceptual experience in the areas of touch, kinesthesia, and pain. Postgraduate research students in sensory physiology, neurology, psychology and anatomy, and researchers themselves will find that this volume addresses many of the key issues in our attempts to understand the neural mechanisms that mediate sensory experience arising from the body as a whole, the so-called somatic senses, in particular for touch and pain. The volume provides a record of the occasion of the St Petersburg IUPS symposium, chaired by the editors of this volume, and includes some added recent contributions from other leading international figures in the field. Brought together under the sponsoring banner of the IUPS Commission for Somatosensory Physiology and Pain, these scientists with their different experimental approaches seek collectively to understand the brain mechanisms that underlie our own nature and experience.

Over the centuries, researchers have found bones and artefacts proving that modern humans have existed for millions of years. Mainstream science, however has suppressed these facts. Prejudices based on current scientific theory act as a 'knowledge filter', giving us a picture of prehistory that is largely inaccurate. This book reveals this hidden history.

**A Sunday Times and New York Times bestseller** Out now: The bestselling book from the creator of the wildly popular science YouTube channel, Kurzgesagt - In a Nutshell, a gorgeously illustrated deep dive into the immune system that will change how you think about your body forever. Please note: the originally supplied fixed format edition of the eBook has now been replaced to address difficulties experienced by some readers. Please delete the previous version from your device and download the new edition. __________ 'A truly brilliant introduction to the human body's vast system for fighting infections and other threats' JOHN GREEN, #1 New York Times bestselling author of The Fault in Our Stars 'Reads as if it's a riveting sci-fi novel . . . a delightful treat for the curious' TIM URBAN, creator of Wait But Why __________ You wake up and feel a tickle in your throat. Your head hurts. You're mildly annoyed as you get the kids ready for school and dress for work yourself. Meanwhile, an utterly epic war is being fought, just below your skin. Millions are fighting and dying for you to be able to complain as you drink your cup of tea and head out the door. So what, exactly, IS your immune system? Second only to the human brain in its complexity, it is one of the oldest and most critical facets of life on Earth. Without it, you would die within days. In Immune, Philipp Dettmer, the brains behind the most popular science channel on YouTube, takes readers on a journey through the fortress of the human body and its defences. There is a constant battle of staggering scale raging within us, full of stories of invasion, strategy, defeat, and noble self-sacrifice. In fact, in the time you've been reading this, your immune system has probably identified and eradicated a cancer cell that started to grow in your body. Each chapter delves deeply into an element of the immune system, including defences like antibodies and inflammation as well as threats like viruses, bacteria, allergies and cancer, as Dettmer reveals why boosting your immune system is actually nonsense, how parasites sneak their way past your body's defences, how viruses - including the coronavirus - work, and what goes on in your wounds when you cut yourself. Enlivened by engaging full-colour graphics and immersive descriptions, Immune turns one of the most intricate, interconnected, and confusing subjects - immunology - into a gripping adventure through an astonishing alien landscape. Challenging what you know and think about your own body and how it defends you against all sorts of maladies and how it might also eventually be your own downfall, Immune is a vital and remarkably fun crash course in what is arguably, and increasingly, the most important system in the body. __________

Until the publication of Charles Darwin's On the Origin of Species, the prevailing theory on 'the species question' was that humans were made up of five separate species, created at different times and in different places. This view - known as the 'polygenic theory' - was particularly favoured by naturalists of the early nineteenth-century 'American School' as it provided a scientific justification for slavery. Darwin's Origin demolished this view. This work fills a gap in recent studies on the history of race and science. Focusing on both the classification systems of human variety and the development of science as the arbiter of truth, Brown looks at the rise of the emerging sciences of life and society - biology and sociology - as well as the debate surrounding slavery and abolition.

Originally published in 1933 Functional Affinities of Man, Monkeys and Apes gives a taxonomic and phylogenetic survey and the findings of diverse experimental investigations of lemurs, monkeys, and apes. The book discusses the inter-relationships of different Primates and emphasizes seldom-used approaches to the question of primate phylogeny. The book attempts to show how little they have been systematically tried, and argues for a regard to the proper place of functional investigations in the study of the classification and evolution of Primates. This book will be of interest to anthropologists, scientists and historians alike.

Originally published in 1928, Studies in Hereditary Ability studies the genealogy of great families of Britain and America and examines how their ancestors influenced their genetics and who they subsequently ended up becoming. The book examines the descent of ability through both maternal and paternal lines, and seeks to argue that from both sides, there stems an equal chance of inheritance. At the time of publication maternal genealogy was relatively unexplored and the book examines the influence of the maternal line on hereditary genetics, as well as the early influence of the mother on a child's environment. The book also examines the links between leadership and intelligence, and maps the genealogy of writers, scientists and artists, and proposes that these notable figures were more likely to have had notable relatives. Although very much of its time, the book will provide a unique and interesting read for social historians, anthropologists and genealogists alike.

Originally published in 1957, The Uniqueness of the Individual is a collection of 9 essays published from the ten years preceding publication. The essays deal with some of the central problems of biology. These are among the questions put and answered from the standpoint of modern experimental biology. What is ageing and how is it measured? What theories have been held to account for it, and with what success? Did ageing evolve, and if so how? Is Lamarckism and adequate explanation of evolutionary process? Does evolution sometimes go wrong? Do human beings evolve in a way peculiar to themselves? Other essays touch upon the problems of scientific method and of growth and transformation. This book will be of interest to natural historians, evolutionists and anthropologists.

Human Biological Diversity is an introductory textbook designed to cover the key contemporary topics in the study of human variation and human biology within the field of physical anthropology. Easily accessible for students with no background in anthropology or biology, this second edition includes two new chapters, one on human variation in the skeleton and dentition and the other on tracing human population affinities. All other chapters have been fully updated to reflect advances in the field and now include pedagogical features to aid readers in their understanding. Written for an introductory level but still containing valuable information that will be of interest to students on upper-level courses, Brown's textbook should be essential reading for all students taking courses on human variation, human biology, human evolution, race, anthropology of race, and general introductions to biological/physical anthropology.

In our fast-paced world of technology and conveniences, the biological origins of women's inequality can be forgotten. This book offers a richer understanding of gender inequality by explaining a key cause-women's reproductive and lactation patterns. Until about 1900, infants nursed every fifteen minutes on average for two years because very frequent suckling prevented pregnancy. The practice evolved because it maximized infant survival. If a forager child was born before its older sibling could take part in the daily food search, the older one died. This practice persisted until the modern era because until after the discovery of the germ theory of disease, human milk was the only food certain to be unspoiled. Lactation patterns excluded women from the activities that led to political leadership. During the twentieth century the ancient mode declined and women entered the labor market en masse. Joan Huber challenges feminists toward a richer understanding of biological origins of inequality-knowledge that can help women achieve greater equality today.

The twenty-first century presents an increasing number of environmental problems, including toxic pollution, global warming, destruction of tropical forests, extinction of biological diversity, and depletion of natural resources. These environmental problems are generally due to human behavior, namely over-consumption of resources and overpopulation. Designing effective policies to address these problems requires a deep understanding of human behavior as well as ecology. This in turn requires considerations of human nature, and the evolutionary "design" of the human mind.
Evolutionary research on human behavior has profound implications for the environmental sciences. The aim of this collection is to bring together a variety of chapters that show how and why. Part 1, "Human Nature and Resource Conservation," addresses environmental problems from different evolutionary perspectives. Part 2, "The Ecological Noble Savage Hypothesis," examines the notion that our environmental problems are due to Western culture, and that our ancestors and people in indigenous societies lived in harmony with nature until the corrupting influences of Western culture. Part 3, "The Tragedy of the Commons," explores the conservation of common-pool or open-access natural resources, such as fisheries, forests, grazing lands, freshwater, and clean air. Part 4, "The Evolution of Discounting and Conspicuous Consumption," looks at the problem of explaining why people are so ecologically short-sighted and why people in developed countries consume so many resources. Part 5, "Overpopulation and Fertility Declines," addresses the evolution of human reproductive decisions. Part 6, "Biophilia," aims to explain why people cherish nature as well as destroy it.
The goal of this volume is to introduce environmental thinkers to evolutionary perspectives on human behavior, and the new interdisciplinary sciences of evolutionary psychology and behavioral ecology. This reader aims to help bridge the artificial division between the biological and social sciences, and provide a synthesis between evolutionary sciences of human behavior and environmental sciences.
Dustin J. Penn is director, Konrad Lorenz Institute, Austrian Academy of Sciences, Vienna. Iver Mysterud is biologist and researcher at the Department of Biology, University of Oslo, Norway.

Biolinguistics is a highly interdisciplinary field that seeks the rapprochement between linguistics and biology. Linking theoretical linguistics, theoretical biology, genetics, neuroscience and cognitive psychology, this book offers a collection of chapters situating the enterprise conceptually, highlighting both the promises and challenges of the field, and chapters focusing on the challenges and prospects of taking interdisciplinarity seriously. It provides concrete illustrations of some of the cutting-edge research in biolinguistics and piques the interest of undergraduate students looking for a field to major in and inspires graduate students on possible research directions. It is also meant to show to specialists in adjacent fields how a particular strand of theoretical linguistics relates to their concerns, and in so doing, the book intends to foster collaboration across disciplines.

Showing that paleoanthropology is a progressive and dynamic field, this book argues that all debates and hypotheses spring from a single general theory: the theory of biological evolution. It presents the debates and research from 150 scholars in the field, and separates the resolution of these debates through three different time periods: 1860-1890, 1890-1935, and post-1935. Topics include: the history of the field; comparative anatomy; the human fossil record; primate phylogeny; human phylogeny; and the nature of paleoanthropology. A book that will appeal to anyone interested in anthropology, it will also interest historians and others in the social sciences.

Science is a force for good in the world-at least usually. But sometimes, when obsession gets the better of scientists, they twist a noble pursuit into something sinister. Under this spell, knowledge isn't everything, it's the only thing-no matter the cost. Bestselling author Sam Kean tells the true story of what happens when unfettered ambition pushes otherwise rational men and women to cross the line in the name of science, trampling ethical boundaries and often committing crimes in the process. The Icepick Surgeon masterfully guides the reader across two thousand years of history, beginning with Cleopatra's dark deeds in ancient Egypt. The book reveals the origins of much of modern science in the transatlantic slave trade of the 1700s, as well as Thomas Edison's mercenary support of the electric chair and the warped logic of the spies who infiltrated the Manhattan Project. But the sins of science aren't all safely buried in the past. Many of them, Kean reminds us, still affect us today. We can draw direct lines from the medical abuses of Tuskegee and Nazi Germany to current vaccine hesitancy, and connect icepick lobotomies from the 1950s to the contemporary failings of mental-health care. Kean even takes us into the future, when advanced computers and genetic engineering could unleash whole new ways to do one another wrong. Unflinching, and exhilarating to the last page, The Icepick Surgeon fuses the drama of scientific discovery with the illicit thrill of a true-crime tale. With his trademark wit and precision, Kean shows that, while science has done more good than harm in the world, rogue scientists do exist, and when we sacrifice morals for progress, we often end up with neither.

Much of what we are comes from our ancestors. Through cultural and biological inheritance mechanisms, our genetic composition, instructions for constructing artifacts, the structure and content of languages, and rules for behavior are passed from parents to children and from individual to individual. "Mapping Our Ancestors" demonstrates how various genealogical or "phylogenetic" methods can be used both to answer questions about human history and to build evolutionary explanations for the shape of history.
Anthropologists are increasingly turning to quantitative phylogenetic methods. These methods depend on the transmission of information regardless of mode and as such are applicable to many anthropological questions. In this way, phylogenetic approaches have the potential for building bridges among the various subdisciplines of anthropology; an exciting prospect indeed. The structure of "Mapping Our Ancestors" reflects the editors' goal of developing a common understanding of the methods and conditions under which ancestral relations can be derived in a range of data classes of interest to anthropologists. Specifically, this volume explores the degree to which patterns of ancestry can be determined from artifactual, genetic, linguistic, and behavioral data and how processes such as selection, transmission, and geography impact the results of phylogenetic analyses.
"Mapping Our Ancestors" provides a solid demonstration of the potential of phylogenetic methods for studying the evolutionary history of human populations using a variety of data sources and thus helps explain how cultural material, language, and biology came to be as they are.
Carl P. Lipo is assistant professor of anthropology at California State University in Long Beach. Michael O'Brien is professor of anthropology and director of the Museum of Anthropology at the University of Missouri. Mark Collard is assistant professor of anthropology at the University of British Columbia, Stephen J. Shennan is a professor and director of the Institute of Archaeology at the University College London. Niles Eldredge is a curator in the department of invertebrates at the American Museum of Natural History, and adjunct professor at the City University of New York.

The view "It's all in our genes and we cannot change it" developed in the past 150 years since Gregor Mendel's experiments with flowering pea plants. However, there is a special form of genetics, referred to as epigenetics, which does not involve any change of our genes but regulates how and when they are used. In the cell nucleus our genes are packed into chromatin, which is a complex of histone proteins and genomic DNA, representing the molecular basis of epigenetics. Our environment and lifestyle decisions influence the epigenetics of our cells and organs, i.e. epigenetics changes dynamically throughout our whole life. Thus, we have the chance to change our epigenetics in a positive as well as negative way and present the onset of diseases, such a type 2 diabetes or cancer. This textbook provides a molecular explanation how our genome is connected with environmental signals. It outlines that epigenetic programming is a learning process that results in epigenetic memory in each of the cells of our body. The central importance of epigenetics during embryogenesis and cellular differentiation as well as in the process of aging and the risk for the development of cancer are discussed. Moreover, the role of the epigenome as a molecular storage of cellular events not only in the brain but also in metabolic organs and in the immune system is described. The book represents an updated but simplified version of our textbook "Human Epigenomics" (ISBN 978-981-10-7614-8). The first five chapters explain the molecular basis of epigenetics, while the following seven chapters provide examples for the impact of epigenetics in human health and disease.

Much of what we are comes from our ancestors. Through cultural and biological inheritance mechanisms, our genetic composition, instructions for constructing artifacts, the structure and content of languages, and rules for behavior are passed from parents to children and from individual to individual. "Mapping Our Ancestors" demonstrates how various genealogical or "phylogenetic" methods can be used both to answer questions about human history and to build evolutionary explanations for the shape of history.
Anthropologists are increasingly turning to quantitative phylogenetic methods. These methods depend on the transmission of information regardless of mode and as such are applicable to many anthropological questions. In this way, phylogenetic approaches have the potential for building bridges among the various subdisciplines of anthropology; an exciting prospect indeed. The structure of "Mapping Our Ancestors" reflects the editors' goal of developing a common understanding of the methods and conditions under which ancestral relations can be derived in a range of data classes of interest to anthropologists. Specifically, this volume explores the degree to which patterns of ancestry can be determined from artifactual, genetic, linguistic, and behavioral data and how processes such as selection, transmission, and geography impact the results of phylogenetic analyses.
"Mapping Our Ancestors" provides a solid demonstration of the potential of phylogenetic methods for studying the evolutionary history of human populations using a variety of data sources and thus helps explain how cultural material, language, and biology came to be as they are.
Carl P. Lipo is assistant professor of anthropology at California State University in Long Beach. Michael O'Brien is professor of anthropology and director of the Museum of Anthropology at the University of Missouri. Mark Collard is assistant professor of anthropology at the University of British Columbia, Stephen J. Shennan is a professor and director of the Institute of Archaeology at the University College London. Niles Eldredge is a curator in the department of invertebrates at the American Museum of Natural History, and adjunct professor at the City University of New York.

The spectacular advances of medicinal chemistry in the last few decades have been triggered by a greater understanding of cellular processes at the molecular level. The understanding of biochemical processes and diseases at molecular level has revolutionized the field. This volume summarizes recent developments in the area of biological inhibitors such as squalene epoxidase inhibitors, dual inhibitors of 5-lipoxygenase and cycloxgenase, inhibition of cholestrol biosynthesis, HIV proteinase inhibitors, nonpeptide antagonists at peptide receptors, and binding interaction of thyroid hormones.

Very Short Introductions: Brilliant, Sharp, Inspiring Physiology is the science of life, and sets out to understand how living things work and what makes them distinct from the non-living. It considers how our bodies are supplied with energy, how they maintain their internal parameters, the ways in which we gather and process information, the ways we take action, and the creation of new generations. This Very Short Introduction explores the field of human physiology, considering how the body works, senses, reacts, and defends itself. As Jamie A. Davies shows, human life (and indeed, all life) is sustained by the interplay of a wide variety of physiological mechanisms and principles. He discusses the physiological experiments and research undertaken to understand these processes, and analyses the ethical issues involved. He also considers the evolution of the scientific field itself, showing how enhanced understandings of physiological knowledge can help inform medical research and care. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.

Searching for meaning in what Nietzsche called "the rainbow colours" around the outer edges of knowledge and imagination, Edward O. Wilson bridges science and philosophy to create a twenty-first-century treatise on human existence. Once criticised for his over-reliance on genetics, Wilson unfurls his most expansive and advanced theories on human behaviour. Whether attempting to explicate "the Riddle of the Human Species", warning of "the Collapse of Biodiversity" or creating a plausible "Portrait of E.T.", Wilson believes that humanity holds a special position in the known universe. Alarmed, however, that we are about to abandon natural selection by redesigning biology and human nature as we wish them, Wilson concludes that advances in science and technology bring us our greatest moral dilemma in millennia.

Exam Board: SQA Level: Higher Subject: Human Biology First Teaching: 2018, First Exam: 2019 The Higher Human Biology Student Book helps teachers and students map their route through the CfE programme, providing comprehensive and authoritative guidance for the course. Full coverage of the new Higher course specifications with list of learning intentions Attractive layout with clear text features Key questions highlight crucial concepts and techniques that need to be grasped by students in order to progress to the next learning intention What the examiner/assessor is looking for to help teachers & students feel secure End of unit material - unit assessment, exam-style questions with worked answers, self-assessment Student Books give a practical, supportive approach to help deliver the new curriculum and offer a blend of sound teaching and learning with assessment guidance.

Plomp's "Aspects of Tone Sensation"--published 25 years ago--dealt with the psychophysics of simple and complex tones. Since that time, auditory perception as a field of study has undergone a radical metamorphosis. Technical and methodological innovations, as well as a considerable increase in attention to the various aspects of auditory experience, have changed the picture profoundly. This book is an attempt to account for this development by giving a comprehensive survey of the present state of the art as a whole. Perceptual aspects of hearing, particularly of understanding speech as the main auditory input signal, are thoroughly reviewed.

The major significance of the German naturalist-physician Johann Friedrich Blumenbach (1752-1840) as a topic of historical study is the fact that he was one of the first anthropologists to investigate humankind as part of natural history. Moreover, Blumenbach was, and continues to be, a central figure in debates about race and racism. How exactly did Blumenbach define race and races? What were his scientific criteria? And which cultural values did he bring to bear on his scheme? Little historical work has been done on Blumenbach's fundamental, influential race work. From his own time till today, several different pronouncements have been made by either followers or opponents, some accusing Blumenbach of being the fountainhead of scientific racism. By contrast, across early nineteenth-century Europe, not least in France, Blumenbach was lionized as an anti-racist whose work supported the unity of humankind and the abolition of slavery. This collection of essays considers how, with Blumenbach and those around him, the study of natural history and, by extension, that of science came to dominate the Western discourse of race.