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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology > General

Neonatal Immunity (Hardcover, 2005 ed.): Constantin Bona Neonatal Immunity (Hardcover, 2005 ed.)
Constantin Bona
R4,394 Discovery Miles 43 940 Ships in 12 - 17 working days

A critical review of the classic, as wells as most recent-and quite seminal-findings concerning the phenotypic and molecular characteristics of both fetal and neonatal B and T cells, the cells that mediate antibody and cellular immune responses in newborns and infants. Dr. Bona shows how the antibody response of neonates is modulated by maternal antibodies and how, in certain cases, this can cause transient or life-threatening neonatal autoimmune disease. He also describes the characteristics of neonatal tolerance induced by foreign allo- and self-antigens, which are the basis for understanding impaired infant immune response and which provide a rationale for the development of efficient neonatal vaccines. By making clear the characteristics and differences between the immune system and the immune responses of both newborns and infants, compared to those of adults, Dr. Bona offers insights and challenging hypotheses that promise to help overcome the poor responses of neonates to various antigens.

Vaccination Strategies Against Highly Variable Pathogens (Hardcover, 1st ed. 2020): Lars Hangartner, Dennis R. Burton Vaccination Strategies Against Highly Variable Pathogens (Hardcover, 1st ed. 2020)
Lars Hangartner, Dennis R. Burton
R3,599 Discovery Miles 35 990 Ships in 10 - 15 working days

Vaccines against antigenically stable pathogens, or pathogens that only exist in a limited number of serotypes, have been very successful in the past and have drastically decreased the incidence and lethality of many diseases. However, when it comes to highly variable pathogens or viruses that exist in multiple serotypes, the traditional methods for vaccine development have reached their limits. This volume highlights the development of vaccines against such challenging pathogens. Novel approaches for immunogen design, including structure-guided vaccine development and vaccines targeting glycans, as well as adjuvants and animal models used for testing possible vaccine candidates are outlined and discussed in detail. Given its scope, the book will appeal to scientists in the fields of infectious diseases, microbiology and medicine.

Dengue Virus (Hardcover, 2010 ed.): Alan L. Rothman Dengue Virus (Hardcover, 2010 ed.)
Alan L. Rothman
R4,342 Discovery Miles 43 420 Ships in 10 - 15 working days

Scientific research on dengue has a long and rich history. The literature has been touched by famous names in medicine- Benjamin Rush, Walter Reed, and Albert Sabin, to name a very few- and has been fertile ground for medical historians . The advances made in those early investigations are all the more remarkable for the limited tools available at the time. The demonstration of a viral etiology for dengue fever, the recognition of mosquitoes as the vector for transmission to humans, and the existence of multiple viral variants (serotypes) with only partial cross-protection were all accomplished prior to the ability to culture and characterize the etiologic agent. Research on dengue in this period was typically driven by circumstances. Epidemics of dengue created public health crises, although these were relatively short-lived in any one location, as the population of susceptible individuals quickly shrank. Military considerations became as a major driving force for research. With the introduction of large numbers of non-immune individuals into endemic areas, dengue could cripple military readiness, taking more soldiers out of action than hostile fire. Dengue and dengue hemorrhagic fever, which assumed pandemic proportions during the latter half of the last century, have shown no indication of slowing their growth during this first decade of the twenty-first century. Challenges remain in understanding the basic mechanisms of viral replication and disease pathogenesis, in clinical management of patients, and in control of dengue viral transmission. Nevertheless, new tools and insights have led to major recent scientific advances. As the first candidate vaccines enter large-scale efficacy trials, there is reason to hope that we may soon "turn the corner" on this disease.

Natural Killer T cells - Balancing the Regulation of Tumor Immunity (Hardcover, 2012): Masaki Terabe, Jay A. Berzofsky Natural Killer T cells - Balancing the Regulation of Tumor Immunity (Hardcover, 2012)
Masaki Terabe, Jay A. Berzofsky
R2,869 Discovery Miles 28 690 Ships in 10 - 15 working days

Natural killer T (NKT) cells are CD1d-restricted T cells that respond to lipid, not protein, antigens presented by CD1d, which is a non-classical MHC class I-like molecule. This relatively small but pivotal T cell population bridges the gap between innate and adaptive immunity by rapidly produce large amounts of many kinds of cytokines and by providing the T cell arm of the adaptive immune system a mechanism to detect lipid antigens. NKT cells also have both regulatory and effector functions and have been shown to play critical roles in the regulation of immune responses in many disease settings including cancer. Stimulating the protective functions of NKT cells while inhibiting the negative regulatory activity shows promise for the therapy of cancer and several approaches are in clinical trials. This book reviews what we have learned about NKT cells during last two decades through functional studies in the context of tumor immunology, including clinical trials of NKT cell targeted therapy. This knowledge should also be informative to understand the role of this underappreciated T cell population in many other fields outside of tumor immunology.

Fish immune system and vaccines (Hardcover, 1st ed. 2022): Makesh M., Rajendran K.V. Fish immune system and vaccines (Hardcover, 1st ed. 2022)
Makesh M., Rajendran K.V.
R5,361 Discovery Miles 53 610 Ships in 12 - 17 working days

This book is a collection of comprehensive and latest information on all aspects of vaccination in fish and shellfish. It provides the basic understanding about the immune system of both fish and crustaceans, besides giving the latest information on adjuvants, vaccine delivery methods, adverse effects of vaccines and methods to assess the efficacy of vaccines. Separate chapters on the role of pattern recognition receptors and interferons in fish vaccination, biofilm vaccines and biosafety and regulatory requirements for fish vaccines are also included. Aquaculture, being the fastest growing food producing industry in the world, is looked upon for alleviating the malnutrition especially among the under privileged population. However, intensive aquaculture practices have led to increased incidences of diseases and significant production losses. Among various health management measures employed in aquaculture, vaccination has been proven to be the best approach to protect fish against pathogens. It is considered to be safe and is a key factor for sustainable aquaculture. In this background, apart from the basic understanding of fish and shellfish immune system, updated knowledge on various types of vaccines and the vaccination strategies currently employed in aquaculture are also covered. The book is designed to provide the latest and comprehensive knowledge on all these aspects as a compiled resource material which is useful to students, researchers and other professionals in the field of aquaculture.

Interaction of Nanomaterials with the Immune System (Hardcover, 1st ed. 2020): James C. Bonner, Jared M. Brown Interaction of Nanomaterials with the Immune System (Hardcover, 1st ed. 2020)
James C. Bonner, Jared M. Brown
R4,352 Discovery Miles 43 520 Ships in 10 - 15 working days

This book covers the latest information related to understanding immune responses to engineered nanomaterials (ENMs). Many ENMs used in both the consumer and biomedical fields have been reported to elicit adverse immune responses ranging from innate immune responses such as complement activation to changes in adaptive immunity that influence pathogen responses and promote disease states such as asthma. Interaction of Nanomaterials with the Immune System covers the most up to date information on our understanding of immune responses to ENMs across a wide range of topics including innate immunity, allergic immune responses, adaptive provides the reader with (1) up to date understanding of immune responses to ENMs; (2) current testing methods; and (3) appropriate models including alternative testing strategies for evaluating immunotoxicity of ENMs.

Extracellular Matrix in Tumor Biology (Hardcover, 1st ed. 2017): Rolf A. Brekken, Dwayne Stupack Extracellular Matrix in Tumor Biology (Hardcover, 1st ed. 2017)
Rolf A. Brekken, Dwayne Stupack
R2,848 Discovery Miles 28 480 Ships in 10 - 15 working days

This volume provides an overview on the influence of Extracellular Matrix (ECM) on tumor progression. It covers topics such as signaling induced by structural ECM proteins including collagen and fibronectin, the control of ECM deposition and the turnover in tumors. Also discussed are the migration of cells through basement membranes and the function of proteoglycans including lumican and veriscan in tumor progression. Biomaterial-based in-vitro models as well as C. elegans models of the tumor microenvironment are used to show how these models can lead to a greater understanding of the disease mechanisms that promote cancer progression. The book addresses researchers working on cancer biology or ECM, and oncologists alike.

Essential Aspects of Immunometabolism in Health and Disease (Hardcover, 1st ed. 2022): Niels Olsen Saraiva Camara, Jose C... Essential Aspects of Immunometabolism in Health and Disease (Hardcover, 1st ed. 2022)
Niels Olsen Saraiva Camara, Jose C Alves-Filho, Pedro Manoel Mendes de Moraes-Vieira, Vinicius Andrade-Oliveira
R4,047 Discovery Miles 40 470 Ships in 12 - 17 working days

Immunometabolism has emerged as an intersectional crossroad between metabolism and immune response. Over the past decade, it has become clear that most - if not all - immune cell functions are not separated from cellular metabolism. Although seminal works have addressed the metabolic fate of immune cells during differentiation and function, the physiological status of a given tissue is also dependent on the cell metabolism. The dialogue between immune cells and their microenvironment can also modulate cellular metabolism, which can trigger the onset and progression of a multitude of inflammation-mediated diseases. Thus, uncovering the specific characteristics of the metabolism in different immune cells types and in different conditions, can shed light into the molecular mechanisms of disease and help develop new drugs and therapeutic strategies to treat immune diseases. The edited volume Essentials aspects of Immunometabolism will give the readers a broad view on how metabolic pathways can influence many types of immune cells during activation, differentiation and function, in health and disease. Of note, the structure of the book was created thinking not only on the experienced immunologist but also on undergraduate and graduate students, physicians, and all members of the scientific community interested in this exciting field of research.

BeadChip Molecular Immunohematology - Toward Routine Donor and Patient Antigen Profiling by DNA Analysis (Hardcover, 2011 ed.):... BeadChip Molecular Immunohematology - Toward Routine Donor and Patient Antigen Profiling by DNA Analysis (Hardcover, 2011 ed.)
Joann M. Moulds, Paul M. Ness, Steve R Sloan
R5,565 Discovery Miles 55 650 Ships in 10 - 15 working days

This text is a review of molecular immunohematology (MI). It draws from analyses and case studies around the world and details many techniques used in many labs. It is aimed at anyone interested in how MI is changing blood bank and transfusion medicine.

Immunotoxicity, Immune Dysfunction, and Chronic Disease (Hardcover, 2012): Rodney R. Dietert, Robert W. Luebke Immunotoxicity, Immune Dysfunction, and Chronic Disease (Hardcover, 2012)
Rodney R. Dietert, Robert W. Luebke
R5,192 R4,395 Discovery Miles 43 950 Save R797 (15%) Ships in 12 - 17 working days

Chronic diseases are the leading cause of deaths worldwide and according to the World Economics Council and the Harvard School of Public Health, the cost of chronic diseases is expected to reach a staggering 48% of global gross domestic product by the year 2030. The urgency of the issue was demonstrated in 2011 when for only the second time in its existence, the U.N. General Assembly brought a health issue to the floor for consideration: chronic diseases.

To date, most considerations of the issue have approached the topic from the vantage point that chronic diseases are a myriad of largely unconnected diseases and conditions arising in diverse tissues, organs and physiological systems. This book, "Immunotoxicity, Immune Dysfuction, and Chronic Disease," deviates from that prior model. It considers the interconnectivity of chronic diseases with both environmental insult of the immune system and subsequent immune dysfunction and inflammatory dysregulation as the underlying basis for many, if not most, chronic diseases.

This change in the perception of environment-immune linkages to chronic disease is significant and has immediate implications both for the prevention of disease as well as for the development of more effective therapeutic approaches. Rather than considering environmental factors and types of reported immune alterations ("e.g., " depressed humoral immunity) as is common in books involving immunotoxicity, the present book approaches the environment-immune-disease triad from the standpoint of the disease. Each chapter emphasizes one or more specific immune dysfunction-based chronic disease(s) or condition(s) ("e.g., " asthma, atherosclerosis, multiple sclerosis, lupus) and describes: 1) the suggested environmental risk factors, 2) the underlying immune dysfunction(s) associated with the disease and 3) the overall health consequences of the disease.

This book is an early entry for a new Toxicology book series for Springer titled: Molecular and Integrative Toxicology (MaIT). The series will feature detailed research information, but in the context of a more integrative or holistic framework. As part of this framework, the chapters will contain a section on Key Points as well as Recommendations where appropriate. The goal is to cover the most timely, state-of-the-art issues in toxicology as well as to ensure that the information is maximally accessible for research scientists, teachers, physicians and students. We are particularly grateful to the numerous chapter authors for providing comprehensive and expert disease-oriented contributions. We are also appreciative of their willingness to consider their material not as disparate pieces of what has become a major health crisis, but rather as key pieces in a network of apparently interconnected health challenges."

The Immunoglobulin Receptors and their Physiological and Pathological Roles in Immunity (Hardcover, 1998 ed.): Jan G. J.... The Immunoglobulin Receptors and their Physiological and Pathological Roles in Immunity (Hardcover, 1998 ed.)
Jan G. J. Winkel, M. Hogarth
R5,774 Discovery Miles 57 740 Ships in 10 - 15 working days

Antibodies are crucial to the fine specificity of the immune system. An effective functioning of these molecules requires interaction with immune cells. Receptors for antibodies, Fc receptors, provide this critical link between the humoral and cellular branches of the immune system. This book presents a comprehensive overview of the different Fc receptors currently recognized. The first part of the book contains state-of-the-art overviews on the biological role of FcR. The latest information on FcR heterogeneity, FcR physiology, FcR-ligand recognition, their crucial coordinating role in immunity, interactions with other immunoreceptors, and the role of FcR in immunoglobulin transport and catabolism are discussed. The clinical importance of FcR is developed in the second part of the book. The well-recognized roles of FcR in allergy, inflammation, infectious diseases, autoimmune disorders, and immunotherapeutic importance are reviewed. The information in this book is easily accessible and should be helpful for researchers and clinical specialists as a convenient overview of the field, as well as a comprehensive introduction for students starting in this area of research.

Sphingolipids in Disease (Hardcover, 2013 ed.): Erich Gulbins, Irina Petrache Sphingolipids in Disease (Hardcover, 2013 ed.)
Erich Gulbins, Irina Petrache
R8,917 Discovery Miles 89 170 Ships in 12 - 17 working days

Sphingolipids are lipid components of the plasma membrane of eukaryotic cells with an important function in signaling mechanisms in the cell. This book provides insight into the physiological and pathophysiological role of sphingolipids and in particular its derivative ceramide. The function of Sphingolipids in cell signaling with regard to infectious and lung diseases, cancer, cardiovascular diseases and neuropsychiatric disorders are described and treated in distinct parts. Together with Volume 215 from the same Editors, the collection represents a unique, comprehensive work on Sphingolipids, providing information on both: Sphingolipid basic biology as well as its important function in a (patho)physiological context. The book is written for scientists in pharmacology, biochemistry and cell biology with a focus on biomedical research as well as for clinicians in pharmacology, oncology, cardiology, neurology and infectious disease. "

Autoantibodies in Neurological Diseases (Hardcover, 2002 ed.): Angela Vincent, Gianvito Martino Autoantibodies in Neurological Diseases (Hardcover, 2002 ed.)
Angela Vincent, Gianvito Martino
R1,516 Discovery Miles 15 160 Ships in 10 - 15 working days

The book covers the immunological and clinical aspects of immune-mediated diseases of the central and peripheral nervous system, excluding multiple sclerosis. It includes paraneoplastic neurological disorders, and discusses the immune mechanisms in the growing number of recognised paraneoplastic conditions. It not only provides an overview of the field but also discusses the possible role of immunity in other neurological disorders such as epilepsy. Chapters are written by scientists and clinicians directly involved in each specific area, who have summarized the current understanding of neuroimmunology, with emphasis on the underlying abormalities of the immune responses, the different clinical expression of the diseases and the important use of immunotherapies in treatment. Figures and tables are included in each chapter.

Dengue Virus - Methods and Protocols (Hardcover, 1st ed. 2022): Ronaldo Mohana-Borges Dengue Virus - Methods and Protocols (Hardcover, 1st ed. 2022)
Ronaldo Mohana-Borges
R6,320 R5,374 Discovery Miles 53 740 Save R946 (15%) Ships in 12 - 17 working days

This detailed volume explores various aspects of the dengue virus and its four serotypes (DENV1-4). Beginning with a section on protocols to produce DENV and its proteins that are fundamental for many biophysical, biochemical, immunological, and cellular studies, the book continues by covering protocols to study the interactions between DENV and cellular proteins, DENV immunopathogenesis and diagnosis, as well as recent advances in animal models that can be used in studies of DENV immunopathogenesis and vaccine development. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Dengue Virus: Methods and Protocols serves as an ideal guide for researchers attempting to further understand this critical threat to worldwide public health.

Sepsis - Methods and Protocols (Hardcover, 1st ed. 2021): Wendy E. Walker Sepsis - Methods and Protocols (Hardcover, 1st ed. 2021)
Wendy E. Walker
R6,026 Discovery Miles 60 260 Ships in 12 - 17 working days

This detailed volume presents a variety of animal models that are commonly used to study sepsis and some key procedures to measure specific disease outcomes. The chapters describe well-established surgical and nonsurgical rodent models of sepsis, presented by experts in the field. In addition, the book includes protocols for burn injury and sepsis, modeling the mouse intensive care unit (MICU), and the development of humanized mice, which may be useful tools to increase the translational potential of rodent sepsis research. There is a chapter discussing the use of biomarkers for sepsis diagnosis and prognosis in humans and mice, as well as chapters describing specific methods for biomarker measurement, and the use of analgesics and humane endpoints in rodent sepsis research. Finally, agent-based computational modeling is presented as a valuable complementary approach to study sepsis. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Sepsis: Methods and Protocols serves as an ideal guide for researchers working toward improving the identification and treatment of septic patients.

Mycobacterium ulcerans - Methods and Protocols (Hardcover, 1st ed. 2022): Gerd Pluschke, Katharina Roeltgen Mycobacterium ulcerans - Methods and Protocols (Hardcover, 1st ed. 2022)
Gerd Pluschke, Katharina Roeltgen
R5,036 Discovery Miles 50 360 Ships in 12 - 17 working days

This volume explores the latest techniques used to study Mycobacterium ulcerans, and more specifically M. ulcerans disease (Buruli ulcer). The chapters in this book are organized into three parts and cover methods for the detection of M. ulcerans and the analysis of host-pathogen interaction; the quantification and characterization of mycolactone, the macrolide toxin of M. ulcerans; and drug development against M. ulcerans. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Mycobacterium ulcerans: Methods and Protocols is a valuable resource that helps scientists advance their research on Buruli ulcer, which is still an under-researched field in infection biology.

T-Cell Development - Methods and Protocols (Hardcover, 1st ed. 2015): Remy Bosselut, Melanie S Vacchio T-Cell Development - Methods and Protocols (Hardcover, 1st ed. 2015)
Remy Bosselut, Melanie S Vacchio
R4,220 R3,572 Discovery Miles 35 720 Save R648 (15%) Ships in 12 - 17 working days

This volume provides simple and accessible experiment protocols to explore thymus biology. T-Cell Development: Methods and Protocols is divided into three parts presenting short reviews on T cell development, analysis strategies, protocols for cell preparation, flow cytometry analyses, and multiple aspects of thymocyte biology. As a volume in the highly successful Methods in Molecular Biology series, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Concise and easy-to-use, T-Cell Development: Methods and Protocols aims to ensure successful results in the further study of this vital field.

DNA Vaccines - Methods and Protocols (Hardcover, 3rd ed. 2014): Monica Rinaldi, Daniela Fioretti, Sandra Iurescia DNA Vaccines - Methods and Protocols (Hardcover, 3rd ed. 2014)
Monica Rinaldi, Daniela Fioretti, Sandra Iurescia
R5,413 R4,952 Discovery Miles 49 520 Save R461 (9%) Ships in 12 - 17 working days

DNA Vaccines: Methods and Protocols, Third Edition explores innovative approaches and technologies used to design, deliver, and enhance the efficacy of DNA vaccines. Featuring applications which should be of great value in moving vaccines from research to clinic, this detailed volume includes sections on DNA vaccine design and enhancement, delivery systems, production, purification, and quality, as well as chapters on new vaccine applications. Written in the highly successful Methods in Molecular Biology series format, chapters contain introductions their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, DNA Vaccines: Methods and Protocols, Third Edition serves the important role of further documenting the potential of the DNA vaccination as a platform technology for treatment and prevention of human disease.

Eosinophils - Methods and Protocols (Hardcover, 2nd ed. 2021): Garry M Walsh Eosinophils - Methods and Protocols (Hardcover, 2nd ed. 2021)
Garry M Walsh
R5,144 Discovery Miles 51 440 Ships in 10 - 15 working days

This second edition of Eosinophils: Methods and Protocols updates several techniques from the first edition together with novel in vitro and in vivo-based methodologies. Written by internationally recognized expert authorities, this volume provides vital techniques from eosinophil purification to experimental modelling, with each technique spelled out in clear and straightforward terms, assuming no previous knowledge of the method and without necessitating sourcing additional information elsewhere. Written in the highly successful Methods in Molecular Biology format, chapters include introductions to their respective topics, lists of the essential materials and reagents, step-by-step, readily reproducible laboratory protocols, with tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Eosinophils: Methods and Protocols, Second Edition provides the practical means to extend our knowledge of eosinophil function in health and disease, underpinning research that may in turn lead to new hypotheses for future examinations into the role of this intriguing and enigmatic leukocyte. Chapters 10 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Western Blotting for the Non-Expert (Hardcover, 1st ed. 2021): Biji T. Kurien Western Blotting for the Non-Expert (Hardcover, 1st ed. 2021)
Biji T. Kurien
R2,427 Discovery Miles 24 270 Ships in 12 - 17 working days

This book fills the need for a simplified text covering western blotting protocols aimed not just at high school and college students, but the researcher with little to no experience in these techniques. It provides the principles, basic methodology, and tips and tricks to avoiding the common pitfalls of western blotting. The book also introduces simple protocols that can transform western blotting into a fun method, such as sending secret messages on membranes or using nitrocellulose membrane as a canvas for art. In addition to the techniques, this book also covers the history of western blotting, which originated from the development of the blotting of DNA. It then delves into the importance of protein blotting, brought to the fore by the fact that the procedure has been evolving constantly since its inception in 1979, and the fact that the scientific community is faced with a multitude of ways and means of transferring proteins to membranes..

The New Paradigm of Immunity to Tuberculosis (Hardcover, 2013 ed.): Maziar Divangahi The New Paradigm of Immunity to Tuberculosis (Hardcover, 2013 ed.)
Maziar Divangahi
R4,766 Discovery Miles 47 660 Ships in 12 - 17 working days

This book illustrates the intimate relationship between alveolar macrophages and Mycobacterium tuberculosis (M.tb.), and the former's role in both innate and adaptive immunity against M.tb. It covers research done over the last decade. It also explores the role of macrophage death following infection with M.tb. in determining whether successful immunity is stimulated, or whether clinical disease develops; furthermore, the function of host lipid mediators in macrophage death modality are addressed. The book also illustrates how the balance between prostaglandins and lipoxins determines whether infected macrophages undergo apoptosis or necrosis, which is the ultimate factor in the outcome of infection. Finally, it is a synthesis of the authors' recent studies and the studies of others to offer a new understanding of immunity to tuberculosis.

Dipeptidyl Aminopeptidases in Health and Disease (Hardcover, 2003 ed.): Martin Hildebrandt, Burghard Klapp, Torsten Hoffmann,... Dipeptidyl Aminopeptidases in Health and Disease (Hardcover, 2003 ed.)
Martin Hildebrandt, Burghard Klapp, Torsten Hoffmann, Hans-Ulrich Demuth
R4,452 Discovery Miles 44 520 Ships in 12 - 17 working days

Proceedings of the International Conference on Dipeptidyl Aminopeptidases, held September 26-28, 2002, in Berlin, Germany.

Dipeptidyl Aminopeptidases exert a potent modulatory role at an interface between immune mechanisms, metabolic responses and neuroendocrine pathways. Experimental models and clinical studies addressing the role of these enzymes and the effect of specific inhibitors pave the way to novel therapeutic concepts in immunology, rheumatology, oncology, reproductive medicine and diabetes.

Leading experts in this field have contributed to this book which presents a state-of-the-art view on these enzymes, at a time when our understanding of their function is growing ever more rapidly and therapeutic options become imminent. The sections of the book focus on various topics:

- Structure and function of dipeptidyl aminopeptidases,
- DPP IV-like proteins,
- Immune mechanisms and immune disorders,
- Cancer and angiogenesis,
- Diabetes and metabolism,
- Therapeutic implications.

The Role of Microbes in Autoimmune Diseases - New Mechanisms of Microbial Initiation of Autoimmunity (Hardcover, 1st ed. 2022):... The Role of Microbes in Autoimmune Diseases - New Mechanisms of Microbial Initiation of Autoimmunity (Hardcover, 1st ed. 2022)
Ahed J. Alkhatib
R3,581 Discovery Miles 35 810 Ships in 10 - 15 working days

This book provides a comprehensive, up-to-date review of the state of knowledge on the role of microbes in inducing autoimmune diseases. The initial chapters address the basic concept and clinical implications of immunology, while the following section discusses the role of genetics, epigenetics, hormones, stochastic and environmental factors in the pathogenesis of autoimmunity. The third section introduces readers to various autoimmune disorders and presents the cellular and molecular mechanisms of autoimmune diseases. In closing, the book examines the role of intestinal flora in the development of autoimmune diseases, delineates the underlying mechanism responsible for autoimmunity onset, and examines the potential of microbial therapeutics in the prevention and treatment of autoimmune diseases. Given its scope, the book offers a valuable asset for all scientists and clinicians working in immunology, rheumatology and autoimmune diseases.

Cell-Mediated Effects of Immunoglobulins (Hardcover, 1997 ed.): Wolf H Fridman Cell-Mediated Effects of Immunoglobulins (Hardcover, 1997 ed.)
Wolf H Fridman
R5,739 Discovery Miles 57 390 Ships in 10 - 15 working days

Interaction of antigen-antibody complexes with cells via specific immunoglobulin Fc receptors (FcR) triggers major immunological reactions such as efficient uptake of antigen, phagocytosis of microorganisms, cytotoxicity towards tumor or virus infected cells, mast cell degranulation and inflammation, etc. This book reviews the FcR for the different immunoglobulin isotypes, focusing on the structural bases of their biological functions, and on the regulation of their expression in physiology and pathology.

Handbook of Research on Artificial Immune Systems and Natural Computing - Applying Complex Adaptive Technologies (Hardcover):... Handbook of Research on Artificial Immune Systems and Natural Computing - Applying Complex Adaptive Technologies (Hardcover)
Hongwei Mo
R8,731 Discovery Miles 87 310 Ships in 12 - 17 working days

Today, nature is used as a source of inspiration for the development of new techniques for solving complex problems in various domains, from engineering to biology, with innovative adaptations under investigation. ""The Handbook of Research on Artificial Immune Systems and Natural Computing: Applying Complex Adaptive Technologies"" provides the latest empirical research findings, theoretical frameworks, and technologies of natural computing and artificial immune systems (AIS). An excellent reference source for professionals, researchers, and academicians within the AIS and natural computing fields, this comprehensive collection written by leading international experts proposes new ideas, methods, and theories to solve problems of engineering and science. It features: 24 authoritative contributions by over 45 of the world's leading experts on artificial immune systems and natural computing from 13 countries; comprehensive coverage of each specific topic, highlighting recent trends and describing the latest advances in the field; more than 900 references to existing literature and research on artificial immune systems and natural computing; and, a compendium of over 195 key terms with detailed definitions. It is organized by topic and indexed, making it a convenient method of reference for all IT/IS scholars and professionals. It offers cross-referencing of key terms, figures, and information pertinent to artificial immune systems and natural computing.

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