The sixth edition of this internationally successful text includes the many positive advances in radiation oncology that have occurred over the past decade, and which continue to keep radiation at the cutting edge of cancer therapy. As previously, a multi-national authorship includes some of the top radiation oncologists, biologists, and physicists from North America and Europe, who highlight the core principles of radiobiology.

Table of Contents

Preface

About the editors

List of contributors

Glossary

1. Introduction: The significance of radiobiology and radiotherapy for cancer treatment - Michael C. Joiner, Albert J. van der Kogel, and G. Gordon Steel. 2. Irradiation-induced damage and the DNA damage response - Marianne Koritzinsky, Shane M. Harding, Conchita Vens, and Bradly G. Wouters. 3. Cell death after irradiation – how, when and why cells die - Bradly G. Wouters. 4. Quantifying cell kill and cell survival - Michael C. Joiner. 5. Radiation dose-response relationships - Søren M. Bentzen. 6. Linear energy transfer and relative biological effectiveness - Michael C. Joiner and Jay W. Burmeister. 7. Physics of radiation therapy for the radiobiologist - Jay W. Burmeister and Michael C. Joiner. 8. Tumour growth and response to radiation - Daniel Zips. 9. Fractionation: The Linear-Quadratic approach - Michael C. Joiner and Søren M. Bentzen. 10. The linear-quadratic approach in clinical practice - Søren M. Bentzen and Michael C. Joiner. 11. Modified fractionation - Vincent Grégoire, Michael Baumann, and Mechthild Krause. 12. Early effects in epithelial tissues, the role of stem cells and time factors - Robert P. Coppes, †Wolfgang Dörr, Peter van Luijk and Lara Barazzuol. 13. The dose-rate effect - Albert J. van der Kogel and Michael C. Joiner. 14. Pathogenesis of late normal tissue effects - Lara Barazzuol, Peter van Luijk, Robert P. Coppes, Albert J. van der Kogel, and †Wolfgang Dörr. 15. Volume effects, regional responses, and risk models - Peter van Luijk, Robert P. Coppes, †Wolfgang Dörr, and Albert J. van der Kogel. 16. Biological modifiers of normal tissue effects - Robert P. Coppes and †Wolfgang Dörr. 17. The oxygen effect and therapeutic approaches to tumour hypoxia - Michael R. Horsman, J. Martin Brown, Albert J. van der Kogel, Marianne Koritzinsky, Bradly G. Wouters, and Jens Overgaard. 18. The tumour microenvironment and cellular hypoxia responses - Bradly G. Wouters, Marianne Koritzinsky, J. Martin Brown, and Albert J. van der Kogel. 19. Combined radiotherapy and chemotherapy from the perspective of the Radiation Oncologist - Vincent Grégoire, Chiara Gottardi, Jean-Pascal Machiels, and Michael Baumann. 20. Molecular targeted agents for enhancing tumour response - Ina Kurth, Karin Haustermans, Sofie Isebaert, Henning Willers, and Michael Baumann. 21. Biological individualisation of radiotherapy - Catharine M.L. West, Laure Marignol, and Sarah L. Kerns. 22. Molecular image guided radiotherapy - Vincent Grégoire, Olivier Beuf, Cédric Draulans, Karin Haustermans, and John A. Lee. 23. Retreatment tolerance of normal tissues - Dorota Gabryś and †Wolfgang Dörr. 24. Cancer stem cells in radiotherapy - Robert P. Coppes, Michael Baumann, Mechthild Krause, and Richard P. Hill. 25. Hadron therapy: The clinical aspects - Vincent Grégoire, Jay W. Burmeister, Cai Grau, and Michael C. Joiner. 26. Radiation and the immune system - Dörthe Schaue and William H. McBride. 27. Second cancers after radiotherapy - Klaus Rüdiger Trott and David C. Hodgson.

Index

This book is a volume in the Penn Press Anniversary Collection. To mark its 125th anniversary in 2015, the University of Pennsylvania Press rereleased more than 1,100 titles from Penn Press's distinguished backlist from 1899-1999 that had fallen out of print. Spanning an entire century, the Anniversary Collection offers peer-reviewed scholarship in a wide range of subject areas.

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