Welcome to Loot.co.za!
Sign in / Register |Wishlists & Gift Vouchers |Help | Advanced search
|
Your cart is empty |
|||
Books > Medicine > Pre-clinical medicine: basic sciences > Human reproduction, growth & development > Human growth & development
Biological rhythms time the ebb and flow of virtually every physiological process, and their mutual coordination guarantees the integrity of the organism over space and time. Aging leads to the disintegration of this coordination, as well as to changes in the amplitude and/or frequency of the underlying rhythms. The results of this are accelerated loss of health during aging, and in experimental model systems curtailed lifespan occurs. This book will examine the machinery that constitutes circadian systems and how they impact physiologic processes. It will also discuss how disturbances of circadian rhythms can lead to complex diseases associated with aging. Much of this treatment will focus on metabolism and genome stability. Importantly, the chapters in this book will encompass work in several different models, in addition to human. The book will conclude with a discussion of modeling approaches to biologic cycles and chronotherapy, for future research and translation.
In this worldwide survey, Clive Gamble explores the evolution of the human imagination, without which we would not have become a global species. He sets out to determine the cognitive and social basis for our imaginative capacity and traces the evidence back into deep human history. He argues that it was the imaginative ability to 'go beyond' and to create societies where people lived apart yet stayed in touch that made us such effective world settlers. To make his case Gamble brings together information from a wide range of disciplines: psychology, cognitive science, archaeology, palaeoanthropology, archaeogenetics, geography, quaternary science and anthropology. He presents a novel deep history that combines the archaeological evidence for fossil hominins with the selective forces of Pleistocene climate change, engages with the archaeogeneticists' models for population dispersal and displacement, and ends with the Europeans' rediscovery of the deep history settlement of the Earth.
Across the life course, new forms of community, ways of keeping in contact, and practices for engaging in work, healthcare, retail, learning and leisure are evolving rapidly. Breaking new ground in the study of technology and aging, this book examines how developments in smart phones, the internet, cloud computing, and online social networking are redefining experiences and expectations around growing older in the twenty-first century. Drawing on contributions from leading commentators and researchers across the world, this book explores key themes such as caregiving, the use of social media, robotics, chronic disease and dementia management, gaming, migration, and data inheritance, to name a few.
With the conclusion of adolescence, a child develops into a teenager that may experiment with dating, smoking and drinking, and they may make important decisions without parental knowledge or guidance. These teenagers may also engage in risky behaviour, which may pose as a threat to their well-being and successful transition into adulthood. With this in mind, how can we can prevent adolescent risk behaviour? Traditionally, prevention scientists propose three forms of prevention. Primarily, attempts to reduce the harmful consequences of risk behaviour, such as treatment of risk behaviour (ie: mental disorders or substance abuse) are ideal. For some problematic behaviour which has already occurred, a better approach is to identify those who are at-risk as early as possible (ie: secondary prevention). For example, youth workers may identify those who have suicidal ideation and intervene as early as possible so that they will not harm themselves. In this book, the authors assess whether a community-based program in Hong Kong was effective in promoting adolescent development and explore what factors were associated with the program effects. The authors hope that the studies included in this book can help to reveal the successful experience of the project and provide some pointers for the development of programs for adolescents with greater psychosocial needs.
The U.S. population is getting older, and Americans are living longer, on average, than they ever have before. As they age, people are healthier and more active than the generations before them and have fewer functional limitations such as difficulty walking or blindness. Studies show that people are happier on average as they advance into their later decades and enjoy high levels of accumulated knowledge and experience. Getting older is a time of social, emotional, mental, and physical change. Retirement might change how a person interacts socially every day, affecting a persons mood and well-being. Cognitive aging--the normal process of cognitive change as a person gets older--can begin, or a permanent change in physical function may arise. Technology offers a path for people who are navigating these changes potentially to prevent or minimise the risks associated with them and to enhance peoples ability to live their lives fully. The Presidents Council of Advisors on Science and Technology (PCAST), seeks to identify technologies and policies that will maximise the independence, productivity, and engagement of Americans in their later years. This book focuses on four key changes older Americans often experience: hearing loss; loss of social engagement and connectivity; cognitive change; and physical change.
This volume provides key molecular biological protocols and experimental strategies currently employed to study the various stages of mammary gland development. Chapters are divided into four parts covering genetically modified mouse models that exhibit prenatal and pubertal mammary gland phenotypes, 2D and 3D-model culture systems, methodologies for mammary stem cell isolation, and translational applications that provide a bridge between experimental studies of mammary gland development and the study of human breast cancer. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Mammary Gland Development: Methods and Protocols will be useful for researchers whose primary interest is in mammary gland development; developmental biologists, epithelial cell biologists, and those with an interest in molecular mechanisms underlying breast cancer.
This book brings together in one volume the current state of ageing research in the nematode Caenorhabditis elegans. The authors are leading researchers in the field, placing this topic in the context of human ageing, describing how and why basic discoveries in this simple organism have impacted our prospects for intervention in the ageing process. The authors cover a broad range of topics with regards to organismal and reproductive ageing including anatomical, physiological and biochemical changes, as well as genetic and environmental interventions that promote longevity and ameliorate age-related disease. Ageing is the single most important factor determining the onset of human disease in developed countries. With current worldwide demographic trends indicating that the number of individuals over the age of 65 will continue to rise, it is clear that an understanding of the processes that underpin ageing and age-related disease represents a key challenge in the biomedical sciences. In recent years there have been huge advances in our understanding of the ageing process and many of these have stemmed from genetic analysis of C. elegans. With no analogous book in this subject area this work will be of interest to a wide audience, ranging from academic researchers to the general public.
Examining cultures as diverse as long-house dwellers in North Borneo, African farmers, Welsh housewives, and postindustrial American workers, this volume dramatically redefines the anthropological study of menstrual customs. It challenges the widespread image of a universal 'menstrual taboo' as well as the common assumption of universal female subordination which underlies it. Contributing important new material and perspectives to our understanding of comparative gender politics and symbolism, it is of particular importance to those interested in anthropology, women's studies, religion, and comparative health systems.
This book covers the origins and subsequent history of research results in which attempts have been made to clarify issues related to cellular ageing, senescence, and age-related pathologies including cancer. Cellular Ageing and Replicative Senescence revisits more than fifty-five years of research based on the discovery that cultured normal cells are mortal and the interpretation that this phenomenon is associated with the origins of ageing. The mortality of normal cells and the immortality of cancer cells were also reported to have in vivo counterparts. Thus began the field of cytogerontology. Cellular Ageing and Replicative Senescence is organized into five sections: history and origins; serial passaging and progressive ageing; cell cycle arrest and senescence; system modulation; and recapitulation and future expectations. These issues are discussed by leading thinkers and researchers in biogerontology and cytogerontology. This collection of articles provides state-of-the-art information, and will encourage students, teachers, health care professionals and others interested in the biology of ageing to explore the fascinating and challenging question of why and how our cells age, and what can and cannot be done about it.
Bestselling author and counselor Michael Gurian offers a comprehensive look at the emotional, spiritual, and cognitive dimensions of aging--and how to celebrate life after fifty. Called "the people's philosopher" for his ability to apply scientific ideas to our ordinary lives, Michael Gurian, bestselling author of "The Wonder of Boys," sees life after fifty as an enormously fruitful, exciting, and fulfilling time. Drawing on scientific research as well as anecdotes that respond to the needs of his many clients, he goes beyond the physical-centered view of aging and presents a new, holistic paradigm embracing opportunities that come with life after fifty. "The Wonder of Aging" focuses on the physical, mental, relational, and spiritual aspects of aging, discussing topics such as sex, how men and women age differently, the effects of aging on the brain, and what to expect in the last chapter of life. The book divides life after fifty into three stages: the Age of Transformation, from our late forties to sixty; the Age of Distinction, from sixty to seventy-five; and the Age of Completion, which involves completing one's life journey. In addition, this essential guide provides meditations and exercises to help you map out the aging process and is rich with case histories from Gurian's research and experience as a therapist. Written with Gurian's contagiously optimistic outlook on life, "The Wonder of Aging" provides a full, constructive, and comforting roadmap to what to expect--and how to celebrate--the second half of your life.
determined by an inability to move in response to touch. C. elegans develop through four larval stages following hatching and prior to adulthood. Adult C. elegans are reproductive for about the rst week of adulthood followed by approximately two weeks of post-reproductive adulthood prior to death. Life span is most commonly measured in the laboratory by maintaining the worms on the surface of a nutrie- agar medium (Nematode Growth Medium, NGM) with E. coli OP50 as the bacterial food source (REF). Alternative culture conditions have been described in liquid media; however, these are not widely used for longevity studies. Longevity of the commonly used wild type C. elegans hermaphrodite (N2) varies ? from 16 to 23 days under standard laboratory conditions (20 C, NGM agar, E. coli OP50 food source). Life span can be increased by maintaining animals at lower ambient temperatures and shortened by raising the ambient temperature. Use of a killed bacterial food source, rather than live E. coli, increases lifespan by 2-4 days, and growth of adult animals in the absence of bacteria (axenic growth or bac- rial deprivation) increases median life span to 32-38 days [3, 23, 24]. Under both standard laboratory conditions and bacterial deprivation conditions, wild-derived C. elegans hermaphrodites exhibit longevity comparable to N2 animals [25].
This book investigates the various processes that are affected by the age of an organism. Several new tools for the analysis of biological aging have been introduced recently, and this volume provides methods and protocols for these new techniques in addition to its coverage of established procedures. Researchers seeking new technology and techniques will find this volume of tremendous benefit as they move towards new directions.
"Tissue Morphogenesis: Methods and Protocols "highlights major techniques, both experimental and computational, for the study of tissue morphogenesis, divided into several sections, with specific focus on techniques to image, manipulate, model and analyze tissue morphogenesis. Chapters focus on imagining analysis of tissue morphogenesis, culture models of tissue morphogenesis, manipulating cells and tissues in vivo, novel model systems to investigate issue morphogenesis and computational models. Written in the highly successful "Methods in Molecular Biology "series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical," ""Tissue Morphogenesis: Methods and Protocols" serves as a primary resource for both fundamental and practical understanding of the techniques used to uncover the basis of tissue morphogenesis.
"Living in an age of constant gratification, economic influx and fragile egos, happiness has become increasingly elusive, yet it remains the Holy Grail, we search for all our lives. The purpose of this book is to suggest a cure for the ordinary day to day unhappiness which most people suffer from in today's world due to no obvious reasons. Since the goal of every human being on this Earth is to attain Happiness, it is hoped that after reading the book thoroughly and analysing as well as grasping the seven most important and practical steps suggested by the author, such as: - Change is constant - Live in the present - Live free from Attachment - Good Health - You can stall ageing - Be Content which will lead to Happiness - Love and Cheer up to be contented in your day-to-day life - Always think Positively and have Happy thoughts- Laughter/Humour is God's gift to Happiness, one can successfully tackle one's problems in life and achieve one's ultimate goal, i.e., to Remain Happy and Cheerful!
Many books on ageing attempt to cover the whole field of gerontology. However, since gerontology is now such a diversified and rapidly expanding subject, the results of such attempts tend to be either incomprehensible compendia or encyc10pedias of disheartening size. The present book aims to be both more modest and more ambitious. It focuses on a single object (Drosophila), but attempts to off er a synthesis of all the gerontological work that has been done on it. It also aims to show the extent to which this work has led to an understanding of the biological phenomena of ageing, longevity, senescence and death in higher organisms, inc1uding man. Finally it attempts, on the basis of current knowledge, to mark out the paths that the next generation of researchers will most probably follow. Drosophila has been used as a model organism to advance our basic knowledge of the fundamentals of genetics and gerontology. It may be noted that the pioneering work on the genetics of ageing, which used Drosophila, began very early in this century, within the first decade of the rediscovery of Mendel's laws.
How we age is much more of a choice than you may think. Many people reach a stage when they are looking for something different. Others feel that time is running out, or they are "losing their looks." The answers to these anxieties rarely lie in a jar or a pill. As a healthy lifestyle is important in looking and feeling good, so our attitude is important in giving meaning and direction to our lives, and even improving our looks. Combining the latest research on health, ageing and well-being with 30 years experience of working with people, we present a constructive antidote to the myths and stereotypes around ageing, and a guide to an exciting, fulfilling future.
The average age of the world's population is increasing at an unprecedented rate and this increase is changing the world. This "Silver tsunami" emphasizes the need to provide advanced training in epidemiology and increase the cadre of experts in the study of aging. This book is designed to summarize unique methodological issues relevant to the study of aging, biomarkers of aging and the biology/physiology of aging and in-depth discussions of the etiology and epidemiology of common geriatric syndromes and diseases. Contributing authors in the book represent many disciplines, not only epidemiology and clinical geriatrics, but also demography, health services, research, cardiovascular disease, diabetes, psychiatry, neurology, social services, musculoskeletal diseases and cancer. The aim of the book is to provide a broad multidisciplinary background for any student/researcher interested in aging. The material in the book is organized and comprehensive. It represents the most up-to-date information on the scientific issues in aging research written by academics who specialize in research and training in the broad field of aging. The structure and organization of the book reflects our course series in the Epidemiology of Aging starting with the broad issues of demography and methodology, and then addressing specific health conditions and geriatric conditions common to older persons.
Teratology is the study of chemical-induced birth defects. This book is a comprehensive guide to the procedures and methods commonly employed in the safety testing of all classes of chemical for teratogenicity (also referred to as embryotoxicity, developmental toxicity or prenatal toxicity). The various international regulatory requirements are explained in detail, in order that the reader may perform all of the necessary studies for the successful registration or marketing authorisation of a new pharmaceutical, industrial chemical, crop protection product or food additive. Written in the highly successful Methods in Molecular Biology (TM) series format, each chapter gives clear complete instructions on how to perform the task in hand. The authors are respected experts in their field, all with hands-on experience of the procedures described. Teratogenicity Testing: Methods and Protocols gives crucial guidance and tips on how to deal with unexpected results and overcome regulatory difficulties.
This volume discusses the current state of research findings related to healthy brain aging by integrating human clinical studies and translational research in animal models. Several chapters offer a unique overview of successful aging, age-related cognitive decline and its associated structural and functional brain changes, as well as how these changes are influenced by reproductive aging. Insights provided by preclinical studies in mouse models and advanced neuroimaging techniques in humans are also presented.
As individuals age, their ability to respond to andclear pathogens and to control unwanted immune reactions declines, leading to a greater incidence of certain infectious diseases, autoimmunity and general immune dysfunctions. Most remarkably, the efficacy of vaccines is frequently decreased in elderly persons. Therefore, age-associated dysfunctions of the humoral and cellular immune responses have a strong clinical impact. Improving our understanding of the aged immune system is crucial in developing effective prevention and treatment programs that will facilitate healthy aging and improve the quality of life of the elderly population. The aim of this volume is to summarize current knowledge on the cellular and molecular aspects of the aging immune system, with an emphasis on infectious diseases and new therapeutic approaches. "
Americans age 65 and over are an important and growing segment of our population. Many federal agencies provide data on aspects of older Americans' lives, but it can be difficult to fit the pieces together. Thus, it has become increasingly important for policymakers and the general public to have an accessible, easy-to-understand portrait that shows how older Americans are faring. This book provides a comprehensive picture of our older population's health and well-being.
In this book, the authors present topical research in the study of the mental aspects, social welfare and health of the ageing population. Topics discussed include assessing the quality of life of the elderly population; age-related ophthalmic disease; assessment of the at-risk older driver; social services for the elderly in Hong Kong; increased lifespan for people with intellectual disabilities and locomotor disability in the aged.
The "Handbook of Sociology of Aging" is the most comprehensive, engaging, and up-to-date treatment of developments within the field over the past 30 years. The volume represents an indispensable source of the freshest and highest standard scholarship for scholars, policy makers, and aging professionals alike. The "Handbook of Sociology of Aging "contains 45 far-reaching chapters, authored by nearly 80 of the most renowned experts, on the most pressing topics related to aging today. With its recurring attention to the social forces that shape human aging, and the social consequences and policy implications of it, the contents will be of interest to everyone who cares about what aging means for individuals, families, and societies. The chapters of the "Handbook of Sociology of Aging" illustrate the field's extraordinary breadth and depth, which has never before been represented in a single volume. Its contributions address topics that range from foundational matters, such as classic and contemporary theories and methods, to topics of longstanding and emergent interest, such as social diversity and inequalities, social relationships, social institutions, economies and governments, social vulnerabilities, public health, and care arrangements. The volume closes with a set of personal essays by senior scholars who share their experiences and hopes for the field, and an essay by the editors that provides a roadmap for the decade ahead. The "Handbook of Sociology of Aging" showcases the very best that sociology has to offer the study of human aging.
|
You may like...
Lifespan - The Revolutionary Science of…
David A Sinclair
Paperback
(1)
Applications of Nonlinear Dynamics To…
Karl M. Newell, Peter C.M. Molenaar
Paperback
The New Long Life - A Framework for…
Andrew J Scott, Lynda Gratton
Paperback
Lifespan - Why We Age - and Why We Don't…
Dr David A Sinclair
Hardcover
(1)
|