In this paradigm-shifting book from acclaimed Harvard Medical School doctor and one of TIME magazine's 100 most influential people on earth, Dr. David Sinclair reveals that everything we think we know about ageing is wrong, and shares the surprising, scientifically-proven methods that can help readers live younger, longer. For decades, the medical community has looked to a variety of reasons for why we age, and the consensus is that no one dies of old age; they die of age-related diseases. That's because ageing is not a disease - it is inevitable. But what if everything you think you know about ageing is wrong? What if ageing is a disease? And that disease is curable. In LIFESPAN, Dr. David Sinclair, one of the world's foremost authorities on genetics and ageing, argues just that. He has dedicated his life's work to chasing more than a longer lifespan - he wants to enable people to live longer, healthier, and disease-free well into our hundreds. In this book, he reveals a bold new theory of ageing, one that pinpoints a root cause of ageing that lies in an ancient genetic survival circuit. This genetic trick - a circuit designed to halt reproduction in order to repair damage to the genome -has enabled earth's early microcosms to survive and evolve into more advanced organisms. But this same survival circuit is the reason we age: as genetic damage accumulates over our lifespans from UV rays, environmental toxins, and unhealthy diets, our genome is overwhelmed, causing gray hair, wrinkles, achy joints, heart issues, dementia, and, ultimately, death. But genes aren't our destiny; we have more control over them than we've been taught to believe. We can't change our DNA, but we can harness the power of the epigenome to realise the true potential of our genes. Drawing on his cutting-edge findings at the forefront of medical research, Dr. Sinclair will provide a scientifically-proven roadmap to reverse the genetic clock by activating our vitality genes, so we can live younger longer. Readers will discover how a few simple lifestyle changes - like intermittent fasting, avoiding too much animal protein, limiting sugar, avoiding x-rays, exercising with the right intensity, and even trying cold therapy - can activate our vitality genes. Dr. Sinclair ends the book with a look to the near future, exploring what the world might look like - and what will need to change - when we are all living well to 120 or more. Dr. Sinclair takes what we have long accepted as the limits of human potential and mortality and turns them into choices. THE EVOLUTION OF AGEING is destined to be the biggest book on genes, biology, and longevity of this decade.

The first edition of "Textbook of Men's Health" did much to establish and define the scope of the emerging subspecialty of aging men's health. This revised and updated edition offers a unique overview of the male health and offers valuable insights for improved management and critical care.The central mission of the new edition is to unpick normal physiologic aging in men from pathologic processes, eschewing any material that is routinely available in the standard textbooks of medicine and geriatrics in order to maintain a uniquely male perspective. This means a focus on the age-related decline in sex steroids and other hormones and the pathological and clinical consequences. Wherever possible, the book records consensus on diagnostic criteria, emphasizes evidence-based medicine and highlights translational science. Thisnbsp;revised and updated edition, with new sections on basic sciences and sexual dysfunction, unpicks normal physiologic aging in men from pathologic processes, in order to maintain a uniquely male perspective. This revised and updated edition, with new sections on basic sciences and sexual dysfunction, unpicks normal physiologic aging in men from pathologic processes, in order to maintain a uniquely male perspective. The first edition of Textbook of Men's Health did much to establish and define the scope of the emerging subspecialty of aging men's health. This revised and updated edition offers a unique overview of the male health and offers valuable insights for improved management and critical care. The central mission of the new edition is to unpick normal physiologic aging in men from pathologic processes, eschewing any material that is routinely available in the standard textbooks of medicine and geriatrics in order to maintain a uniquely male perspective. This means a focus on the age-related decline in sex steroids and other hormones and the pathological and clinical consequences. Wherever possible, the bo

Cognitive aging is a flourishing area of research. A significant amount of new data, a number of new theoretical notions, and many new research issues have been generated in the past ten years. This new edition reviews new findings and theories, enables the reader to assess where the field is today, and evaluates its points of growth. The chapters are organized to run from reviews of current work on neuroimaging, neuropsychology, genetics and the concept of brain reserve, through the 'mainstream' topics of attention, memory, knowledge and language, to a consideration of individual differences and of cognitive aging in a lifespan context. This edition continues to feature the broad range of its predecessors, while also providing critical assessments of current theories and findings.

A closer look at your patient's family situation can help you develop a more effective treatment plan Family Behavioral Issues in Health and Illness is a basic but thorough introduction to the impact family dynamics can have on a person's health. Ideal as a supplemental training text for healthcare professionals, this unique book examines the connections between family and health, presenting a concise summary of family systems theory, basic family assessment, and the family life cycle. The book provides an understanding of how the patterns and systems found in a diverse range of family styles can create special health issues, and how the ability to assess and anticipate those issues can ensure the most comprehensive patient care and cost-effective management of time and resources. As long as families continue to be the primary environment where patients learn and develop their beliefs and overall attitudes about life, it remains essential that any primary healthcare model includes a strong background in family dynamics and the critical, pivotal points of family life. Family Behavioral Issues in Health and Illness addresses the most important aspects of family to consider when providing care, presenting practical, real-life case studies that examine the resilience, strengths, and possibilities of families, as well as the problems and dysfunctions. The book looks at how significant events, such as marriage, divorce, birth, and death affect families, and how a knowledge of special family issues, including parenting, abuse, disability, and chronic illness prepares the healthcare professional to provide effective care for traditional, single-parent, multiracial, blended, adoptive, and same-gender families. Family Behavioral Issues in Health and Illness examines: boundaries, roles, and rules triangulation subsystems scapegoating parentification healthy families the family genogram spiritual crises of family members infertility families without children intergenerational families the family in later life coping with alcoholism, dementia, bereavement, and/or mental illness and much more Family Behavioral Issues in Health and Illness is an essential reference for healthcare professionals, educators, parents, and family members. The book provides a practical understanding of family relationships that helps healthcare providers guide patients toward a more complete well-being.

Just what is the andropause? Although acceptance of the andropause concept by the medical community is growing, it is still a hotly debated issue. But as a busy clinician you have patients to treat and you need information. So where can you find the information you need to understand, diagnose, and treat this condition? A comprehensive, detailed clinical resource, Androgen Deficiency in the Adult Male: Causes, Diagnosis, and Treatment distills the knowledge acquired by author Malcolm Carruthers in his 20 years of research and clinical experience in diagnosing and treating the andropause.

Carruthers documents the history of testosterone treatment from antiquity to the awarding of the Nobel Prize Adolf Butenandt and Leopold Ruzicka for synthesizing testosterone and patenting its production some 4,000 years later. He discusses the causes of androgen deficiency, the male menopause or andropause, and its differential diagnosis. The text includes reviews of the literature in each section and a fund of bibliographic references gleaned from the author's years of research in this field. This combination of features makes Androgen Deficiency and the Aging Male: Causes, Diagnosis and Treatment a technically thorough clinical guide, a complete and detailed reference volume, and a cohesive and readable textbook.

The health of a population is most accurately reflected in the rate of growth of its children. It is this theme which underlies the analysis and presentation of what is by far the largest compilation of growth data ever assembled. The first edition, published in 1976, included all known reliable recent results on height, weight, skinfolds and other body measurements from all parts of the globe. In this edition, the very numerous measurements taken between 1976 and 1988 have been included as well as the results of the large number of new studies made on rate of maturation as evinced by bone age and pubertal development stages. Many sections of the book dwell on disentangling the effects of the environment and heredity on growth, and thus answer the question of whether one universal standard suffices for all peoples of the world, or whether different populations (such as races or nations) should each have their own optimal growth standards. Written by practical people with experience of the problems in developing countries, this book explains in simple terms the different sorts of growth surveys, how to set about making them, and which sort to choose. All who are professionally concerned with child health should read it.

This innovative reference explores a wide selection of topics associated with aging, providing a solid understanding of the significance and molecular basis of the aging process and charting the course of future research in the area. Stresses the interplay of mitochondria, mitochondrial DNA, oxidants, and antioxidants! Featuring the research of over 55 experts in the area, Understanding the Process of Aging -covers the functions of nitric oxide and peroxynitrite in mitochondria -integrates several views on the role of mitochondria in the development of apoptosis -gives a quantitative analysis of mutations of mitochondrial DNA during human aging -highlights mitochondrial free radical production -introduces new roles of ubiquinone in mitochondrial functions -offers new antioxidant-based complementary therapeutic strategies -details aspects of intact cells and whole organisms in health and disease -and more! Featuring over 1800 references, tables, drawings, and photographs, Understanding the Process of Aging benefits nutritionists and dieticians, geriatricians, cell and molecular biologists, chemists and biochemists, pharmacologists, biotechnologists, neurologists, cardiologists, oncologists, dermatologists, and graduate and medical school students in these disciplines.

Each volume in the "Autonomic Nervous System" series deals with a different area of autonomic control in health and disease. This, the second volume, provides an overview on the nature of the factors that exert constraints on the differentiation and maturation of the autonomic nervous system. Subjects covered include: development of autonomic neurones; molecules affecting nerve growth and survival; regeneration after injury; and the degree to which the wiring of the nervous system is rigid or fixed.

Look 15 years younger in 2020 with Eva Fraser's easy facial workout ___________ Facial Yoga is THE non-surgical way to achieve a facelift - and help you look 15 years younger! 'Facial exercises may significantly reduce signs of ageing' New York Times In the ORIGINAL facial fitness classic, Eva Fraser shows you how straightforward exercises can help eliminate dark circles, firm your jaw line, tone your neck, plump cheeks and so much more . . . leaving your skin with a natural, youthful glow. For nearly 40 years, Eva Fraser has been practicing her facial workout techniques - and the results are remarkable. The premise is simple: the muscles in your face, if left inactive, will become as saggy as those in any other part of your body. In order to tone them up, they need to be exercised. This book includes information on why the face ages, how skin works and what can be done about it, as well as the easy exercise plan that Eva swears by. ___________ What do readers think? 'They really do work!' 5* Reader Review 'I have only been doing them for 4 weeks and they have made a difference' 5* Reader Review 'Eva Fraser gives a fool proof method to a younger face' 5* Reader Review 'A chemical free way to firm up those looks!' 5* Reader Review

This extensive book provides an up-to-date overview by leading international authorities, spanning the disciplines of neuroscience, psychology, ophthalmology, optometry, and paediatrics, of normal and pathological infant visual development. It covers the development of retinal receptors; infant sensitivity to detail, colour, contrast, and movement; binocularity, eye movements, and refraction, and cognitive processing. Childrens' visual deficits, including amblyopia and cataract are covered.

This book looks at the major changes that have occurred in the theory and practice of speech therapy for children with developmental speech disorders. It looks at current issues and their clinical implications, but the overall aim of the book is to set clinical practice firmly in a theoretical framework. While it is therefore essentially a practical book for practitioners, it also engages in the academic investigation of the nature of the different types of developmental speech disorders and their consequences for the children. This discussion provides the framework in which to consider clinical management and specific clinical techniques.

A recurrent theme throughout each chapter is the impact of linguistics upon our understanding and management of children' s problems in learning to pronounce. There is no doubt that the linguistic revolution in speech and language pathology has produced an entirely new perspective on these disorders by identifying the phonological dimension of speech development.

Of equal importance is the expansion of knowledge about children' s language development. Much more information is now available about phonological development in terms of what the developmental changes are and when they occur. This information is valuable in assessment and diagnosis. The book also includes a number of competing theories explaining how children develop their pronunciation patterns. These theories provide the premises upon which to establish a principled theory of therapy.

To reflect these issues and their clinical implications the book is divided into three sections. The first section explores the framework within which to discuss developmental speech disorders.The second section covers three specific types of pathological conditions with which developmental speech disorders are associated. The third section examines the problems of children who have no evident major disabling condition and yet they experience severe difficulties learning to pronounce and subsequently, more often than not, learning to read and write.

Does Aging Stop? reveals the most paradoxical finding of recent aging research: the cessation of demographic aging. The authors show that aging stops at the level of the individual organism, and explain why evolution allows this. The implications of this counter-intuitive conclusion are profound, and aging research now needs to accept three uncomfortable truths. First, aging is not a cumulative physiological process. Second, the fundamental theory that is required to explain, manipulate, and probe the phenomena of aging comes from evolutionary biology. Third, strong-inference experimental strategies for aging must be founded in evolutionary research, not cell or molecular biology.
The result of fifteen years of research bringing together new applications of evolutionary theory, new models for demography, and massive experimentation, Does Aging Stop? advances an entirely new foundation for the scientific study of aging.

Aging: Oxidative Stress and Dietary Antioxidants, Second Edition, bridges the trans-disciplinary divide and covers the science of oxidative stress in aging and the therapeutic use of natural antioxidants in the food matrix in a single volume. The second edition covers new trials and investigations used to determine the comprehensive properties of antioxidants, food items and extracts, as well as any adverse properties they may have. It has been updated to include new clinical human trials and a new section dedicated to animal models of aging. Throughtout the book the processes within the science of oxidative stress are described in concert with other processes, such as apoptosis, cell signaling, and receptor mediated responses. This approach recognizes that diseases are often multifactorial, and oxidative stress is a single component of this. Gerontologists, geriatricians, nutritionists, and dieticians are separated by divergent skills and professional disciplines that need to be bridged to advance preventative as well as treatment strategies. While gerontologists and geriatricians may study the underlying processes of aging, they are less likely to be conversant in the science of nutrition and dietetics. On the other hand, nutritionists and dietitians are less conversant with the detailed clinical background and science of gerontology. This book addresses this gap and brings each of these disciplines to bear on the processes inherent in the oxidative stress of aging. This will aid in better research, treatment and outcome for patients.

If you are feeling stuck, need help achieving your goals or want to make positive changes in any area of your life, this is the book for you. Alanis Cooper has been using manifesting to change her life since 2020, and in this book, she shares her secrets, and gives you the tools to manifest whatever it is you are looking for. From the rule of attraction, to scripting, visualisation, meditation and more, this book will help you begin a daily practice that will change your life forever. Divided into sections covering all the big topics, month by month (friends, family, romance, personal development and more), this book will make manifesting work for you to get the life you want, starting now.

The Sunday Times Top Ten Bestseller TV and radio presenter Kate Garraway has a lot on her mind. She's turned 50, and suddenly seems to have MANY questions about EVERYTHING. Should she get plastic surgery? Will the menopause ruin her life? What's the secret to making love last? Can anyone really deal with the idea of death? And why, oh why, did nobody tell her how important big knickers would be?! As she tries to find what's useful amongst the deluge of advice we are bombarded with, Kate discovers a lesson on why women in their midlife and beyond should be loved and celebrated, especially by themselves...

Late aging associated changes in alcohol sensitivity, neurobehavioral function, and neuroinflammation, Volume 148, the latest release in the International Review of Neurobiology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics. Each chapter is written by an international board of authors.

determined by an inability to move in response to touch. C. elegans develop through four larval stages following hatching and prior to adulthood. Adult C. elegans are reproductive for about the rst week of adulthood followed by approximately two weeks of post-reproductive adulthood prior to death. Life span is most commonly measured in the laboratory by maintaining the worms on the surface of a nutrie- agar medium (Nematode Growth Medium, NGM) with E. coli OP50 as the bacterial food source (REF). Alternative culture conditions have been described in liquid media; however, these are not widely used for longevity studies. Longevity of the commonly used wild type C. elegans hermaphrodite (N2) varies ? from 16 to 23 days under standard laboratory conditions (20 C, NGM agar, E. coli OP50 food source). Life span can be increased by maintaining animals at lower ambient temperatures and shortened by raising the ambient temperature. Use of a killed bacterial food source, rather than live E. coli, increases lifespan by 2-4 days, and growth of adult animals in the absence of bacteria (axenic growth or bac- rial deprivation) increases median life span to 32-38 days [3, 23, 24]. Under both standard laboratory conditions and bacterial deprivation conditions, wild-derived C. elegans hermaphrodites exhibit longevity comparable to N2 animals [25].

This book investigates the various processes that are affected by the age of an organism. Several new tools for the analysis of biological aging have been introduced recently, and this volume provides methods and protocols for these new techniques in addition to its coverage of established procedures. Researchers seeking new technology and techniques will find this volume of tremendous benefit as they move towards new directions.

"Tissue Morphogenesis: Methods and Protocols "highlights major techniques, both experimental and computational, for the study of tissue morphogenesis, divided into several sections, with specific focus on techniques to image, manipulate, model and analyze tissue morphogenesis. Chapters focus on imagining analysis of tissue morphogenesis, culture models of tissue morphogenesis, manipulating cells and tissues in vivo, novel model systems to investigate issue morphogenesis and computational models. Written in the highly successful "Methods in Molecular Biology "series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls.

Authoritative and practical," ""Tissue Morphogenesis: Methods and Protocols" serves as a primary resource for both fundamental and practical understanding of the techniques used to uncover the basis of tissue morphogenesis.

Many books on ageing attempt to cover the whole field of gerontology. However, since gerontology is now such a diversified and rapidly expanding subject, the results of such attempts tend to be either incomprehensible compendia or encyc10pedias of disheartening size. The present book aims to be both more modest and more ambitious. It focuses on a single object (Drosophila), but attempts to off er a synthesis of all the gerontological work that has been done on it. It also aims to show the extent to which this work has led to an understanding of the biological phenomena of ageing, longevity, senescence and death in higher organisms, inc1uding man. Finally it attempts, on the basis of current knowledge, to mark out the paths that the next generation of researchers will most probably follow. Drosophila has been used as a model organism to advance our basic knowledge of the fundamentals of genetics and gerontology. It may be noted that the pioneering work on the genetics of ageing, which used Drosophila, began very early in this century, within the first decade of the rediscovery of Mendel's laws.

The second edition of "Growth, Maturation, and Physical Activity" has been expanded with almost 300 new pages of material, making it the most comprehensive text on the biological growth, maturation, physical performance, and physical activity of children and adolescents. The new edition retains all the best features of the original text, including the helpful outlines at the beginning of each chapter that allow students to review major concepts.

This edition features updates on basic content, expanded and modified chapters, and the latest research findings to meet the needs of upper undergraduate and graduate students as well as researchers and professionals working with children and young adults. The second edition also includes these new features:

-10 lab activities that encourage students to investigate subject matter outside of class and save teachers time

-A complete reference list at the end of each chapter

-Chapter-ending summaries to make the review process easy for students

-New chapters that contain updates on thermoregulation, methods for the assessment of physical activity, undernutrition, obesity, children with clinical conditions, and trends in growth and performance

-Discussions that span current problems in public health, such as the quantification of physical activity and energy expenditure, persistent undernutrition in developing countries, and the obesity epidemic in developed countriesThe authors are three of the world's foremost authorities on children's growth and development. In 29 chapters, they address introductory concepts and prenatal growth, postnatal growth, functional development, biological maturation, influencing factors in growth, maturation and development, and specific applications to public health and sport. In addition, secular trends in growth, maturation, and performance over the past 150 years are considered. You'll be able to recognize risk factors that may affect young athletes; you'll also be able to make informed decisions about appropriate physical activities, program delivery, and performance expectations.

"Growth, Maturation, and Physical Activity, Second Edition, " covers many additional topics, including new techniques for the assessment of body composition, the latest advances in the study of skeletal muscle, the human genome, the hormonal regulation of growth and maturation, clarification of dietary reference intakes, and the study of risk factors for several adult diseases.

This is the only text to focus on the biological growth and maturation process of children and adolescents as it relates to physical activity and performance. With over 300 new pages of material, this text expertly builds on the successful first edition.

In The Menopause Manifesto internationally renowned, New York Times bestselling author Dr Jen Gunter brings you empowerment through knowledge by countering stubborn myths and misunderstandings about menopause with hard facts, real science, fascinating historical perspective and expert advice.

The only thing predictable about menopause is its unpredictability. Factor in widespread misinformation, a lack of research, and the culture of shame around women's bodies, and it's no wonder women are unsure what to expect during the menopause transition and beyond.

Menopause is not a disease - it's a planned change, like puberty. And just like puberty, we should be educated on what's to come years in advance, rather than the current practice of leaving people on their own with bothersome symptoms and too much conflicting information. Knowing what is happening, why and what to do about it is both empowering and reassuring.

Frank and funny, Dr Jen debunks misogynistic attitudes and challenges the over-mystification of menopause to reveal everything you really need to know about:

• Perimenopause
• Hot flashes
• Sleep disruption
• Sex and libido
• Depression and mood changes
• Skin and hair issues
• Outdated therapies
• Breast health
• Weight and muscle mass
• Health maintenance screening
• And much more

This book is the third in a series with the International Association for the Scientific Study of Intellectual Disabilities (Series Editor: Matthew P. Janicki). These publications are designed to address the issues of health, adult development and aging among persons with intellectual disabilities.

For many years it has been recognized that some adults with intellectual disabilities are at elevated risk for mental and behavioral health problems. Often the aging process can complicate the identification, diagnosis, treatment and prevention of this type of dual diagnosis and present complex challenges to clinicians and carers. This book is designed as a practical resource for those involved with the support, care and treatment of persons with intellectual disabilities, and should prove particularly useful as this community achieves increased longevity. The book is divided into three parts: Prevalence and Characteristics; Diagnosis and Treatment; and Service System Issues.

As the older population in the United States is becoming more racially and ethnically diverse, it is important to understand the characteristics, the potential, and the needs of this population. In this new and fully revised edition of Aging and Diversity, Chandra Mehrotra and Lisa Wagner address key topics in diversity and aging, discussing how the aging experience is affected by not only race and ethnicity but also gender, religious affiliation, social class, rural-urban community location, and sexual orientation and gender identity. Taking this broad view of human diversity allows the authors to convey some of the rich complexities facing our aging population - complexities that provide both challenges to meet the needs of a diverse population of elders and opportunities to learn how to live in a pluralistic society. Mehrotra and Wagner present up-to-date knowledge and scholarship about aging and diversity in a way that engages readers in active learning, placing ongoing emphasis on developing readers' knowledge and skills, fostering higher order thinking, and encouraging exploration of personal values and attitudes.