The bestselling author returns with his biggest book yet in which he teaches us the secret to living a happier life: get rid of as many expectations as possible-of ourselves, our future, our relationships, our career and our family. Expectations are the secret software, running on the hardware of our minds, controlling our emotions, decisions, and actions. How? Think about your life. How much of the sadness you feel derives from what you think should have happened-than with what actually happened? Think about your career. How much of the discontent you feel comes from your belief about where you'd be at this point-than with the progress you've actually made? Think about your relationships. How much of your dissatisfaction with friends, family, significant others, or spouses has to do with your unspoken presumptions-than with the people themselves? Having so many expectations is distorting your perspective, decreasing your happiness and disrupting your joy. You can live a life of true freedom, greater peace and less stress: release as many expectations as possible. This, DeVon Franklin argues, is the secret to a better life now. In a culture obsessed with more, Live Free is a bold counterintuitive book that can start a cultural revolution, Franklin contends. Everyone struggles with unnecessary expectations. But once you learn to let go of them, you can set the stage for the life you've always wanted.

This book presents a comprehensive review of the morphology and function of chromosomes in elderly people. The wide range of topics includes cyclical chromosome properties, mutations, repair, progressive chromosome heterochromatinisation with increasing age, roles of nucleolar organiser regions, sister chromatid exchanges, homologue relationships, heterochromatin regions and other chromosomal features in very old age. This ground-breaking book focuses on heterochromatinisation as a key determinant of the genetic apparatus function during senescence and an area to seek life-prolonging interventions. The book illustrates and updates progress in the field of cytogenetics of ageing.

Healthy Ageing and Aged Care takes an inter-disciplinary approach to supporting older people within the community and in care. It represents current Australian policies and practices and takes a holistic view of the older person, and emphasises the positive aspects of the ageing process, maintaining that people age in healthy ways and continue to be an integral part of their families and communities. This is one of the rewarding aspects of working with older people-assessing accurately and collaboratively putting in place strategies that can maintain the person's quality of life. The goal is for students to be able to develop those skills by engaging with the material in this book.

This book is a contemporary statement of what is known about morphological development of the normal and abnormal human nervous system and puts into perspective the continued importance of changes that occur in the course of foetal development and how these processes may become defective. The first part of the book deals with the development of the central nervous system (CNS) from a morphological point of view including data from the fields of biochemistry, immunology and genetics. The second part reviews the genetic and nongenetic etiology of abnormal CNS development and discusses throughly all patologic syndromes that are related to disturbances of brain development. With the rapid progress in such modern branches of science as neurochemistry, genetics and molecular biology, this book will be invaluable for researchers working in these fields.

This book is dedicated to an update on metabolic disorders and their consequences on the developing nervous system. In the last ten years, major scientific advances in biochemical diagnosis have enabled the identification of many new disease entities, as well as a better classification of clinical symptoms and their correlation to biochemical defects. This volume provides an introduction to basic sciences specifically relevant to this disease group, then focuses on each subgroup in turn: hyperphenylalaninaemias, mitochondrial encephalomyopathies, organic acidoses, urea cycle defects, lysosomal storage and peroxylsomal disorders. Finally, a discussion of long term follow-up and family related issues also reports the results of a four-year research project led by the Mariani Foundation.

New science updates the "blue zones" secrets to healthy longevity with a flexible, holistic approach that incorporates epigenetics, nutrition, and mental health. Through his documentary film series, The Human Longevity Project, Jason Prall traveled to select regions around the world known for their long-lived, healthy populations. He sought to understand not only the longevity secrets of these societies but also the scientific basis underpinning their health wisdom. Through his travels, he came to the realization that while the pursuit of longevity is sexy, it's insufficient and hollow-what most of us really want is an extended life filled with vibrant health, meaning, and purpose. We want to thrive as we age. This book combines his own personal experiences with the knowledge and wisdom gained from interviewing more than 100 health experts and dozens of amazing elders from around the world. You'll discover that when experiential wisdom is supported by the latest scientific research, a more integrated picture emerges of how you can most effectively increase your happiness, health, and longevity. Life is a mysterious process with a natural development, order, and cycle. It is lent to us for a brief moment before the physical body is left behind. If we wish to thrive in the modern world, we must create a mental, emotional, physical, and energetic environment that is congruent with this natural lifecycle. The reality that humanity has created, filled with next-generation technologies and increasing comforts, presents both unique opportunities and novel challenges. We have the option to choose a more harmonious path that establishes greater coherence within ourselves, one another, and the environment. This is the amazing opportunity that lies before us. When we live from alignment, all life benefits.

Motor Learning and Development, Second Edition With Web Resource, provides a foundation for understanding how humans acquire and continue to hone their movement skills throughout the life span. These fundamentals will give students the tools they need to create, apply, and evaluate motor skill programs for learners and clients at all skill and development levels, from elite athletes to those with severe disabilities. The second edition maintains the unique focus of the original, covering the basics of motor learning and development simultaneously. The text has been revised and updated with current research and examples, and it includes the following enhancements: * Three new chapters, Understanding Movement Control, Infant Motor Development, and Devising a Plan, provide more depth on fundamental topics. * A web resource for students includes videos with guiding questions, lab activities for each chapter, and printable versions of the book's sidebars for use as assignments. * Reorganized content in part I allows for deeper understanding of complex topics. * Parts II and III are reorganized to group content by topic rather than by age group, in order to better infuse the two fields of motor learning and motor development. * Updated What Do You Think? and Try This sidebars engage students in applying concepts, and sample answers in the instructor guide help provide feedback on those applications. Motor Learning and Development, Second Edition, combines these two subdisciplines of motor behavior in an accessible and easy-to-follow manner. Part I provides an outline of the fundamental concepts of both motor learning and motor development. Part II explores movement patterns across the life span, from infancy to older adulthood, with a new chapter focusing on infant motor development. Part III examines the changing individual constraints throughout the life span, including physiological, psychological, and sociocultural factors and changes related to age. Finally, part IV prepares students to create and implement developmentally appropriate movement programs, closing with a new chapter, Devising a Plan. Learning aids throughout the book include chapter objectives, glossary terms, and supplemental activities to emphasize the evolution from research to practice. Revised opening vignettes in each chapter demonstrate the breadth of professions that utilize knowledge of and research in motor behavior. The significantly upgraded instructor ancillaries-an instructor guide, test package, and presentation package-are free to course adopters. Motor Learning and Development provides students with the fundamental understanding of movement skills that they need in order to develop, implement, and critically assess motor skill programs.

Node.js, MongoDB and Angular Web Development The definitive guide to using the MEAN stack to build web applications Node.js is a leading server-side programming environment, MongoDB is the most popular NoSQL database, and Angular is the leading framework for MVC-based front-end development. Together, they provide an easy-to-implement, fully integrated web development stack that allows web programmers to create high-performance sites and applications built completely in JavaScript, from server to client. Updated for Angular 2, Angular 4, and subsequent versions, this new edition of Node.js, MongoDB and Angular Web Development shows you how to integrate these three technologies into complete working solutions. It begins with concise, crystal-clear tutorials on each technology and then quickly moves on to building common web applications. You'll learn how to use Node.js and MongoDB to build more scalable, high-performance sites, how to leverage Angular's innovative MVC approach to structure more effective pages and applications, and how to use all three together to deliver outstanding next-generation Web solutions. Implement a highly scalable and dynamic web server using Node.js and Express Implement a MongoDB data store for your web applications Access and interact with MongoDB from Node.js JavaScript code Learn the basics of TypeScript Define custom Angular directives that extend the HTML language Build server-side web services in JavaScript Implement client-side services that can interact with the Node.js web server Build dynamic browser views that provide rich user interaction Add authenticated user accounts and nested comment components to your web applications and pages Contents at a Glance Part I: Getting Started 1 Introducing the Node.js-to-Angular Stack 2 JavaScript Primer Part II: Learning Node.js 3 Getting Started with Node.js 4 Using Events, Listeners, Timers, and Callbacks in Node.js 5 Handling Data I/O in Node.js 6 Accessing the File System from Node.js 7 Implementing HTTP Services in Node.js 8 Implementing Socket Services in Node.js 9 Scaling Applications Using Multiple Processors in Node.js 10 Using Additional Node.js Modules Part III: Learning MongoDB 11 Understanding NoSQL and MongoDB 12 Getting Started with MongoDB 13 Getting Started with MongoDB and Node.js 14 Manipulating MongoDB Documents from Node.js 15 Accessing MongoDB from Node.js 16 Using Mongoose for Structured Schema and Validation 17 Advanced MongoDB Concepts Part IV: Using Express to Make Life Easier 18 Implementing Express in Node.js 19 Implementing Express Middleware Part V: Learning Angular 20 Jumping into TypeScript 21 Getting Started with Angular 22 Angular Components 23 Expressions 24 Data Binding 25 Built-in Directives Part VI: Advanced Angular 26 Custom Directives 27 Events and Change Detection 28 Implementing Angular Services in Web Applications 29 Creating Your Own Custom Angular Services 30 Having Fun with Angular

'Open, honest, straight talking on mental health and motherhood.' - Tik Tok's Dr Julie 'I absolutely love it - it doesn't matter who you are, what you've been through and how much you've changed - there is always room for growth'. - Ant Middleton 'This book will become your bible.' - Gaby Roslin, Virgin Radio In GROW, Sunday Times bestselling author Frankie Bridge opens up about her journey with her maternal mental health. Part narrative exploration, part first aid manual for mothers this book will discuss the hidden growing pains which take place when you become a parent. Its chapters cover the HOW TOs, WHAT IFs?, WILL Is? and WHY DOs? anxious questions all mothers ask themselves when they believe they are doing it wrong whilst also offering a brutally honest account of how hard it can be to grow a baby and raise a child whilst you are still growing into yourself. The book will combine Frankie's mental health journey into motherhood with the notes of psychologist, Maleha Khan, who will unpack the problems she experienced as she became a mother. It will also include additional guidance and parental advice from the UK's leading paediatrician Dr Ed Abrahamson. Fans of OPEN: 'Brave and beautiful... a first aid manual for your mind.' - Adam Kay, bestselling author of This is Going To Hurt 'Very readable. Very relatable. Intensely moving but also full of practical advice.' - Alastair Campbell

No one wants to think about getting older. It's true. At any age, when things are moving along normally day to day and everyone seems fit and well, there seems no reason to think about future problems that your friends and relatives might (and probably will) come across as they age. In fact, it might even seem a little morbid to think such thoughts, or possibly even tempting fate? Yet there will come a time when you must raise these issues and, ideally, this should be before any problems arise. The Essential Family Guide to Caring for Older People is the ultimate source of information and help for families with care responsibilities. Deborah Stone draws on her extensive experience working in elder care to offer practical advice on every aspect of the field indepth. Topics range from how to get help immediately, legal information, care funding options, a guide to useful technology and advice on the main physical and mental health issues that affect older people. Plus guidance is given on dealing with social services and ensuring you choose the right care for your situations. Crucially, the book also offers help on how to cope as a carer with practical advice on juggling family, work and your caring responsibilities while looking after yourself.

The Life Span: Human Development for Helping Professionals, 5th Edition, provides an in-depth look at the science of human development, highlighting theories and research that have useful applications for individuals working in fields such as education, counseling, and social work. The main purpose of this book is to provide the reader with information that can be translated into professional best practice applications. Throughout, the text reflects the contemporary view that life span development is a process deeply embedded within and inseparable from the context of family, social network, and culture. Because the book is designed for graduate students, most topics, especially those that have special relevance to helping professionals, are covered in greater depth than in a typical life span text. The expanded coverage of research in these areas will enhance readers' understanding of the scientific basis for application to practice. Also available with MyLab Education By combining trusted author content with digital tools and a flexible platform, MyLab personalizes the learning experience and improves results for each student. MyLab Education gives helping professionals opportunities to apply theory to practice - better preparing them for success in their future classrooms. Note: You are purchasing a standalone product; MyLab does not come packaged with this content. Students, if interested in purchasing this title with MyLab, ask your instructor to confirm the correct package ISBN and Course ID. Instructors, contact your Pearson representative for more information. If you would like to purchase both the physical text and MyLab Education, search for: 0135205921 / 9780135205921 The Life Span: Human Development for Helping Professionals Plus MyLab Education with Pearson eText -- Access Card Package, 5e Package consists of: 0135208688 / 9780135208687 MyLab Education with Pearson eText -- Access Card -- for The Life Span: Human Development for Helping Professionals, 5/e 0135227763 / 9780135227763 The Life Span: Human Development for Helping Professionals, 5e

A practical guide to how we can positively adapt to a changing world, from the internationally bestselling authors of The 100-Year Life 'The London Business School professors Andrew J. Scott and Lynda Gratton have been predicting how society must adapt for years. Now they have a post-pandemic road map for us all' Sunday Times Smart new technologies. Longer, healthier lives. Human progress has risen to great heights, but at the same time it has prompted anxiety about where we're heading. Are our jobs under threat? If we live to 100, will we ever really stop working? And how will this change the way we love, manage and learn from others? One thing is clear: advances in technology have not been matched by the necessary innovation to our social structures. In our era of unprecedented change, we haven't yet discovered new ways of living. Drawing from the fields of economics and psychology, Andrew J. Scott and Lynda Gratton offer a simple framework based on three fundamental principles (Narrate, Explore and Relate) to give you the tools to navigate the challenges ahead. The New Long Life is the essential guide to a longer, smarter, happier life.

Humans and flies look nothing alike, yet their genetic circuits are remarkably similar. Here, Lewis I. Held, Jr compares the genetics and development of the two to review the evidence for deep homology, the biggest discovery from the emerging field of evolutionary developmental biology. Remnants of the operating system of our hypothetical common ancestor 600 million years ago are compared in chapters arranged by region of the body, from the nervous system, limbs and heart, to vision, hearing and smell. Concept maps provide a clear understanding of the complex subjects addressed, while encyclopaedic tables offer comprehensive inventories of genetic information. Written in an engaging style with a reference section listing thousands of relevant publications, this is a vital resource for scientific researchers, and graduate and undergraduate students.

For developmental scientists, the nature versus nurture debate has been settled for some time. Neither nature nor nurture alone provides the answer. It is nature and nurture in concert that shape developmental pathways and outcomes, from health to behavior to competence. This insight has moved far beyond the assertion that both nature and nurture matter, progressing into the fascinating terrain of how they interact over the course of development. In this volume, students, practitioners, policy analysts, and others with a serious interest in human development will learn what is transpiring in this new paradigm from the developmental scientists working at the cutting edge, from neural mechanisms to population studies, and from basic laboratory science to clinical and community interventions. Early childhood development is the critical focus of this volume, because many of the important nature-nurture interactions occur then, with significant influences on lifelong developmental trajectories.

For developmental scientists, the nature versus nurture debate has been settled for some time. Neither nature nor nurture alone provides the answer. It is nature and nurture in concert that shape developmental pathways and outcomes, from health to behavior to competence. This insight has moved far beyond the assertion that both nature and nurture matter, progressing into the fascinating terrain of how they interact over the course of development. In this volume, students, practitioners, policy analysts, and others with a serious interest in human development will learn what is transpiring in this new paradigm from the developmental scientists working at the cutting edge, from neural mechanisms to population studies, and from basic laboratory science to clinical and community interventions. Early childhood development is the critical focus of this volume, because many of the important nature-nurture interactions occur then, with significant influences on lifelong developmental trajectories.

Despite the undeniable physical, psychological, and social effects of aging, most older persons cope quite well and find considerable satisfaction in their later years. Part of the explanation for this finding is based on what Robert C. Atchley calls "continuity"--the ability of older persons to maintain a strong sense of purpose and self in the face of the changes associated with aging. Continuity can help individuals evolve psychologically and socially in the presence of life events such as retirement, widowhood, and physical disability.

Atchley begins with a thorough explanation of continuity theory, identifying important methodological considerations in its evaluation and use. He then looks at evidence for continuity over time in the ways individuals interpret their experiences and make decisions regarding their living arrangements and lifestyles. He examines continuity as a personal goal that most people use to guide their development as individuals. Atchley finds that many aging adults add transcendence as a personal goal in later adulthood. In a concluding chapter, he revisits the basic elements of continuity theory, summarizing the evidence that supports it.

Drawing on data from a twenty-year longitudinal study that began with more than 1,200 individuals, "Continuity and Adaptation in Aging" explains one of the primary underlying forces that promotes effective adaptation to the aging process. This book will be of interest to researchers and students in gerontology and adult development.

A deliciously funny and sage guide to midlife - an unscientific, flaws-and-all account of one woman's adventures and misadventures through the dark comedy of the wilderness years. Through her own experiences as a fifty-something woman, and those of her three sisters, her indomitable mum and rebellious auntie, Charlotte tackles the big questions every woman seeks answers to at this time of our lives - chiefly: How the hell am I going to get over being young in a world obsessed with youth? Written with warmth, wisdom and irreverence this guide to midlife is perfect for readers of Nora Ephron, Caitlin Moran and India Knight.

This compilation arises from contributions made to the seventh postgraduate course in paediatric neurology held in Pavia, Italy under the auspices of the Mariani Foundation in co-operation with the National Neurologic Institute of Milan. The course concentrated on three main areas: the impact of molecular biology and molecular genetics on aetiology, advances in our understanding pathogenesis, and finally therapy. The choice of the subject was suggested by the remarkable progress has been made in this field during the last decade, mostly due to the recent advances in genetics which now enable a new nosographic approach as well as different diagnostic strategies. Part of this work is dedicated to the rehabilitation of patients affected by neuromuscular diseases.

The essential guide to making sure you have a fabulous later life. You're likely to live longer than you think. Today's fifty-year olds could have an astounding 36 or more years of life. What's your dream life for your later years? When We're 64 is a friendly, practical guide to preparing for what could be the best years of your life - from the essentials on work and how to fund retirement, to volunteering, where to live and what kind of housing you'll need. It covers how to stay healthy - and still live a full life if you get a health condition - and reveals how your attitude to ageing could actually increase your lifespan. There are sections on relationships with family and friends, as well as caring for older relatives and how to tackle loneliness. Packed with expert advice and new evidence and tips on how to age well, this route map will help you plan and prepare for the future.

This book focuses on four of the hallmarks of aging: aspartic acid racemization, advanced glycation end products, telomere shortening and mitochondrial mutations; describing their role in aging and diseases; and their application to age-at-death estimation in forensic sciences in greater depth, displaying the interconnecting pathways among these processes. An additional chapter related to Epigenetics and its role in aging, diseases, and forensic age estimation is also included. This book is aimed at a broad audience: from students being introduced to aging, diseases, and forensic science research to scientists in biomedicine and forensics complementing their knowledge in their respective fields while also increasing their knowledge in other disciplines.

Exploring the potential of poetry and poetic language as a means of conveying perspectives on ageing and later life, this book examines questions such as 'how can we understand ageing and later life?' and 'how can we capture the ambiguities and complexities that the experiences of growing old in time and place entail?' As poetic language illuminates, transfigures and enchants our being in the world, it also offers insights into the existential questions that are amplified as we age, including the vulnerabilities and losses that humble us and connect us. Literary gerontology and narrative gerontology have highlighted the importance of linguistic representations of ageing. While the former has been concerned primarily with the analysis of published literary works, the latter has foregrounded the individual and collective meaning making through narrative resources in old age. There has, however, been less interest in how poetic language, both as a genre and as a practice, can illuminate ageing. This volume suggests a path towards the poetics of ageing by means of presenting analyses of published poetry on ageing written by poets from William Shakespeare to Wallace Stevens; the use of reading and writing poetry among ordinary people in old age; and the poetic nuances that emerge from other literary practices and contexts in relation to ageing - including personal poetic reflections from many of the contributing authors. The volume brings together international scholars from disciplinary backgrounds as diverse as cultural psychology, literary studies, theology, sociology, narrative medicine, cultural gerontology and narrative gerontology, and will deploy a variety of empirical and critical methodologies to explore how poetry and poetic language may challenge dominant discourses and illuminate alternative understandings of ageing.

Diana Moran, aka The Green Goddess, is here to help spread the word about treatments and preventative measures we can all take to tackle osteoporosis. As a sufferer of osteopenia herself (an early form of osteoporosis) Diana Moran is a strong advocate for exercise, early diagnosis, weight bearing exercise, vitamin D and other measures that can be taken to tackle osteoporosis. Written in association with the Royal Osteoporosis Society, this practical book is a must-have for anybody affected by osteoporosis. Packed with advice, friendly tips and ideas, and an overview of current research, and what we can all be doing to help ourselves live well. Also contains specially designed exercises to help encourage a more active lifestyle and strengthen areas of weakness, alongside the important theory, and medical side of osteoporosis. This is an easy to digest, friendly guide for the general reader.

Anti-Aging Pharmacology provides an overview of current research aimed at the pharmacological modulation of aging, including a discussion of the growing number of novel drug classes with promising anti-aging potential. The aging process is the main risk factor for all chronic diseases affecting the elderly. With lifespans extending across the globe, these chronic diseases are placing a larger burden on individuals and health care systems. Therefore, slowing down the aging rate could be more effective in delaying aging-associated chronic disorders than combating them one by one, which is the conventional approach in a current disease-based pharmacological paradigm. This book contains the work of the world's leading researchers in the field, including sections on the conceptual and methodological background of anti-aging pharmacology, the basic classes of anti-aging drugs, phytochemicals, outcomes of anti-aging developments and future directions. This book will be of interest to a wide audience, ranging from pharmacologists, medicinal chemists and academic researchers in gerontology, biomedical sciences and those in medical practice.