The Age-Well Project dived deep into the science of ageing well, and authors Annabel and Susan explained how they overhauled their own lives to prioritise healthy longevity. In The Age-Well Plan, Susan draws on almost a decade of extensive research into healthy longevity and her experience as a health coach to give you the tools you need to live your own age-well life. Her simple, clear and easy-to-follow six-week plan will show you how to make changes -- small and large -- to support healthy ageing, and prioritise the changes most appropriate for your body, lifestyle and circumstances. The first week of the plan guides you to understand your goals as you age and explains how to evaluate your current health and risk factors, in order to devise a bespoke plan for your body and brain. The subsequent weeks focus on the key elements of healthy ageing -- diet, exercise, sleep, engagement and the environment -- to help you build a personalised plan that will kickstart your age-well life.

Written by Caleb Finch, one of the leading scientists of our time, The Biology of Human Longevity - Inflammation, Nutrition, and Aging in the Evolution of Lifespans synthesizes several decades of top research on the topic of human aging and longevity particularly on the recent theories of inflammation and its effects on human health. The book expands a number of existing major theories, including the Barker theory of fetal origins of adult disease to consider the role of inflammation and Harmon's free radical theory of aging to include inflammatory damage. Future increases in lifespan are challenged by the obesity epidemic and spreading global infections which may reverse the gains made in lowering inflammatory exposure. This timely and topical book will be of interest to anyone studying aging from any scientific angle.
* Author Caleb Finch is a highly influential and respected scientist, ranked in the top half of the 1% most cited scientists
* Provides a novel synthesis of existing ideas about the biology of longevity and aging
* Incorporates important research findings from several disciplines, including Gerontology, Genomics, Neuroscience, Immunology, Nutrition

In Skeleton Keys: An Introduction to Human Skeletal Morphology, Development, and Analysis, Second Edition, Jeffrey H. Schwartz presents a detailed yet highly accessible introduction to the study of the human skeleton. This unique volume examines the skeleton from its developmental basis to the expression of individual variation. It reviews a variety of different approaches used to determine an individual's sex, age, and pathological history and challenges readers to think critically about how to analyze a human skeleton rather than learning formulas for quick results. An ideal text for courses in human osteology, skeletal analysis, and bioarchaeology, this book is also a helpful reference for professionals.
Thoroughly revised and updated, the second edition of Skeleton Keys features:
* A unique CD-ROM containing hundreds of color images of skeletons and skeletal elements--demonstrating morphology, pathology, and nonmetric variation--that can be used as classroom projections or for individual study
* Coverage of the most recent developments in the field, including the molecular regulation of bone and tooth formation
* Expanded studies in each area of analysis: sex, age, nonmetric variation, pathology, biodistance and bioarchaeology, and stable isotope analysis
* Additional photographic images, especially in the pathology and sexing chapters
* Two separate and extensively illustrated chapters on the skull, one dealing with articulated elements and one with isolated bones (these topics were covered in one chapter in the first edition)
* Integration of material--such as anthropometric landmarks--from appendices in the previous edition into relevant chapters astables
* More accessible language throughout and an extensive glossary

Late aging associated changes in alcohol sensitivity, neurobehavioral function, and neuroinflammation, Volume 148, the latest release in the International Review of Neurobiology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics. Each chapter is written by an international board of authors.

It can be argued that ATP is the most important molecule in cells. Not only is ATP the key energy source for cells, but it is also the source of phosphate groups that are transferred to a variety of substrate proteins via the action of elaborate families of protein kinases. An equally elaborate array of protein phosphatases can remove phosphate groups from proteins. It is now well established that protein phosphorylation is a widely used mechanism for cells to selectively modulate the function of a variety of proteins including enzymes, ion channels and pumps and structural proteins. In this volume of ACAG leading experts describe the evidence that protein phosphorylation is altered in aging and age-related disease. Protein phosphorylation controls fundamental processes such as transcription and translation, regulation of the cell cycle, signalling within and between cells, cell motility, synaptic function and so on. Recent findings are revealing how phosphorylation dependent signalling cascades may control lifespan with a prime example being the insulin-signalling pathway first described in c-elegans and now emerging as an important regulator of lifespan of mammals also. Many of the functional changes that occur during aging such as impaired learning and memory and altered energy metabolism are controlled by protein phosphorylation and it is, therefore, important to understand how mechanisms of protein phosphorylation may either mediate aging or provide adaptive responses that allow successful disease-free aging. The authors in addition to considering the roles of protein phosphorylation in aging describe the evidence that abnormalities in protein phosphorylation contribute to the pathogenesis of major age-related diseases including diabetes, atherosclerosis and neurodegenerative disorders such as Alzheimer's and Parkinson's diseases.

This book is an an up-to-date survey and summary of present knowledge and future expectations regarding the environmental causes of congenital malformations in human beings, beginning with the earliest discoveries of the 20th century up to the latest ideas and problems at its end, presents views and comments on the progress made over the century in understanding human prenatal maldevelopment.

The lipids of cellular membranes not only serve roles in controlling the structure and fluidity of the membrane, but are increasingly recognized for their roles as signalling molecules and modifiers of membrane protein function. Recent studies described in this volume reveal striking changes in membrane lipids during aging and in age-related diseases such as cancer, cardiovascular disease and neurodegenerative disorders. Lipids including inositol phospholipids, cholesterol, sphingolipids and ceramides play important roles in signalling cellular responses to stress and specific stimuli such as growth factors, cytokines and neurotransmitters. One or more of these lipid mediators has been linked to the pathogenesis of age-related diseases.

This book provides a comprehensive review of specific membrane lipid mediators and their roles in aging and age-related disease.

The essential guide to making sure you have a fabulous later life. You're likely to live longer than you think. Today's fifty-year olds could have an astounding 36 or more years of life. What's your dream life for your later years? When We're 64 is a friendly, practical guide to preparing for what could be the best years of your life - from the essentials on work and how to fund retirement, to volunteering, where to live and what kind of housing you'll need. It covers how to stay healthy - and still live a full life if you get a health condition - and reveals how your attitude to ageing could actually increase your lifespan. There are sections on relationships with family and friends, as well as caring for older relatives and how to tackle loneliness. Packed with expert advice and new evidence and tips on how to age well, this route map will help you plan and prepare for the future.

This new book will enable family practitioners, obstetricians and pediatricians to answer the concerns of the families in their care. It is the first book to make information on this important topic so easily accessible to clinicians. The book is firmly rooted in clinical practice and based on many years of experience, much of it involving the development and implementation of new techniques for examining the fetus in utero. The techniques now available are assessed and better ways to identify pregnancies which are eligible to their application are proposed. The authors describe both the sampling and laboratory techniques available. Other sections cover both predictable and unpredictable pregnancy risks from genetic diseases to abnormal ultrasound, including the possibilities for laboratory evaluation, and the risks and limitations. Throughout the book, the special status of the fetus as a patient is emphasized and the concerns and questions of families are considered, making this the first fully comprehensive and authoritative volume on fetal medicine.

A deliciously funny and sage guide to midlife - an unscientific, flaws-and-all account of one woman's adventures and misadventures through the dark comedy of the wilderness years. Through her own experiences as a fifty-something woman, and those of her three sisters, her indomitable mum and rebellious auntie, Charlotte tackles the big questions every woman seeks answers to at this time of our lives - chiefly: How the hell am I going to get over being young in a world obsessed with youth? Written with warmth, wisdom and irreverence this guide to midlife is perfect for readers of Nora Ephron, Caitlin Moran and India Knight.

This compilation arises from contributions made to the seventh postgraduate course in paediatric neurology held in Pavia, Italy under the auspices of the Mariani Foundation in co-operation with the National Neurologic Institute of Milan. The course concentrated on three main areas: the impact of molecular biology and molecular genetics on aetiology, advances in our understanding pathogenesis, and finally therapy. The choice of the subject was suggested by the remarkable progress has been made in this field during the last decade, mostly due to the recent advances in genetics which now enable a new nosographic approach as well as different diagnostic strategies. Part of this work is dedicated to the rehabilitation of patients affected by neuromuscular diseases.

Aging has long since been ascribed to the gradual accumulation of DNA mutations in the genome of somatic cells. However, it is only recently that the necessary sophisticated technology has been developed to begin testing this theory and its consequences. Vijg critically reviews the concept of genomic instability as a possible universal cause of aging in the context of a new, holistic understanding of genome functioning in complex organisms resulting from recent advances in functional genomics and systems biology. It provides an up-to-date synthesis of current research, as well as a look ahead to the design of strategies to retard or reverse the deleterious effects of aging. This is particularly important in a time when we are urgently trying to unravel the genetic component of aging-related diseases. Moreover, there is a growing public recognition of the imperative of understanding more about the underlying biology of aging, driven by continuing demographic change.

Ever wondered what's really going on in your body as you age? Can you really eat to beat cancer or prevent heart disease? These questions and more are answered in Eat Better, Live Longer, helping you make achievable, sensible, science-based changes to your diet from day one. Discover the secrets of long life from centenarians around the world, and explore the 10 simple but meaningful adaptations you can make both to what you eat and to how you eat to follow in their footsteps. A four-week eating plan, with over 110 nutrient-packed recipes, helps you learn to make smarter choices about foods that can reduce your risk of certain diseases and lessen the effects of others. Use this new-found knowledge together with details on how each part of your body changes as you age and which nutrients you need to support support all-round health, helping you live a longer, happier life. Future-proof your life with this science-based superfood approach to discovering what is really happening to your body as you are aging.

Science is on the cusp of a revolutionary breakthrough. We now understand more about ageing - and how to prevent and reverse it - than ever before. In The Telomerase Revolution, Dr Michael Fossel, who has been at the cutting edge of ageing research for decades, describes how telomerase will soon be used as a powerful therapeutic tool, with the potential to intervene in age-related disease, dramatically extend life spans and even reverse human ageing. Telomerase-based treatments are already on offer, and have shown early promise, but much more potent treatments will become available over the next decade. This is the definitive work on the latest science of human ageing, covering both the theory and the clinical implications, taking readers to the forefront of one of the most remarkable advances in human medicine.

"Advanced Analysis of Motor Development" explores how research is conducted in testing major issues and questions in motor development. It also looks at the evolution of research in the field, its current status, and possible future directions. This text is one of the few to examine motor development models and theories analytically while providing a context for advanced students in motor development so they can understand current and classic research in the field.

Traditionally, graduate study in motor development has been approached through a compilation of readings from various sources. This text meets the need for in-depth study in a more cohesive manner by presenting parallels and highlighting relationships among research studies that independent readings might not provide. In addition, "Advanced Analysis of Motor Development" builds a foundation in the theories and approaches in the field and demonstrates how they drive contemporary research in motor development.

A valuable text for graduate students beginning their own research projects or making the transition from student to researcher, this text focuses on examining and interpreting research in the field. Respected researchers Haywood, Roberton, and Getchell explain the history and evolution of the field and articulate key research issues. As they examine each of the main models and theories that have influenced the field, they share how motor development research can be applied to the fields of physical education, special education, physical therapy, and rehabilitation sciences.

With its emphasis on critical inquiry, "Advanced Analysis of Motor Development" will help students examine important topics and questions in the field in a more sophisticated manner. They will learn to analyze research methods and results as they deepen their understanding of developmental phenomena. For each category of movement skills covered (posture and balance, foot locomotion, ballistic skills, and manipulative skills), the authors first offer a survey of the pertinent research and then present an in-depth discussion of the landmark studies. In analyzing these studies, students will come to appreciate the detail of research and begin to explore possibilities for their own future research. Throughout the text, special elements help students focus on analysis. Tips for Novice Researchers sidebars highlight issues and questions raised by research and offer suggestions for further exploration and study. Comparative tables detail the differences in the purpose, methods, and results of key studies to help students understand not only what the studies found but also the relevance of those findings.

With "Advanced Analysis of Motor Development," readers will discover how research focusing on the major issues and central questions in motor development is produced and begin to conceptualize their own research. Readers will encounter the most important models and theories; dissect some of the seminal and recent articles that test these models and theories; and examine issues such as nature and nurture, discontinuity and continuity, and progression and regression. "Advanced Analysis of Motor Development" will guide students to a deeper understanding of research in life span motor development and enable them to examine how the complexities of motor development can be addressed in their respective professions.

Lifespan Development: Biopsychosocial Perspectives provides students with complete explorations of each developmental stage of the lifespan, beginning with conception and concluding with an examination of successful aging. The book presents human development theory and research within a biopsychosocial framework, presenting information regarding biological, psychological, and social functioning during each significant period of the lifespan. The first chapter of the text presents readers with an introduction to human development, addressing the meaning of age and aging, the four key principles of human development, the social factors that influence the study of human development, and more. The succeeding chapters progress in step with the human lifespan, beginning with conception and prenatal development, moving through infancy, childhood, adolescence, and adulthood, and concluding with chapters devoted to later life. The biopsychosocial perspective of the text emphasizes the transactional nature of biological, psychological, and social influences on the developing individual with a focus on positive development and the implications on health and wellness. It emphasizes the applied nature of the biopsychosocial perspective. Each chapter begins with a real-life scenario, challenging students to take the perspectives of individuals and practitioners dealing with issues at every stage of development. Designed to provide readers with a holistic understanding of the complex progression of human life and aging, Lifespan Development is an ideal text for courses in psychology and human development.

Aging: Oxidative Stress and Dietary Antioxidants, Second Edition, bridges the trans-disciplinary divide and covers the science of oxidative stress in aging and the therapeutic use of natural antioxidants in the food matrix in a single volume. The second edition covers new trials and investigations used to determine the comprehensive properties of antioxidants, food items and extracts, as well as any adverse properties they may have. It has been updated to include new clinical human trials and a new section dedicated to animal models of aging. Throughtout the book the processes within the science of oxidative stress are described in concert with other processes, such as apoptosis, cell signaling, and receptor mediated responses. This approach recognizes that diseases are often multifactorial, and oxidative stress is a single component of this. Gerontologists, geriatricians, nutritionists, and dieticians are separated by divergent skills and professional disciplines that need to be bridged to advance preventative as well as treatment strategies. While gerontologists and geriatricians may study the underlying processes of aging, they are less likely to be conversant in the science of nutrition and dietetics. On the other hand, nutritionists and dietitians are less conversant with the detailed clinical background and science of gerontology. This book addresses this gap and brings each of these disciplines to bear on the processes inherent in the oxidative stress of aging. This will aid in better research, treatment and outcome for patients.