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Books > Medicine > Pre-clinical medicine: basic sciences > Human reproduction, growth & development > Human growth & development
Science is on the cusp of a revolutionary breakthrough. We now
understand more about ageing - and how to prevent and reverse it -
than ever before. In The Telomerase Revolution, Dr Michael Fossel,
who has been at the cutting edge of ageing research for decades,
describes how telomerase will soon be used as a powerful
therapeutic tool, with the potential to intervene in age-related
disease, dramatically extend life spans and even reverse human
ageing. Telomerase-based treatments are already on offer, and have
shown early promise, but much more potent treatments will become
available over the next decade. This is the definitive work on the
latest science of human ageing, covering both the theory and the
clinical implications, taking readers to the forefront of one of
the most remarkable advances in human medicine.
This book provides concrete scientific basis that we can conceive
the possibility of modifying or even completely canceling aging
process, despite the fact that aging is commonly regarded as the
result of the overall effects of many uncontrollable degenerative
phenomena. The authors illustrate in detail the mechanisms by which
cells and the whole organism age. Actions by which it is possible,
or will be possible within a limited time, to operate for modifying
aging are also debated. The discussion is conducted within the
frame and the concepts of evolutionary medicine, which is also
indispensable for distinguishing between the manifestations of
aging and: (i) diseases that worsen with age, and (ii) acceleration
of normal aging rates, caused by unhealthy lifestyle habits and
other avoidable factors. The book also discusses the impact of
aging on overall mortality and the strange situation that,
according to official statistics, aging does not exist as cause of
death. This book is a turning point between a gerontology and
geriatrics conceived as the study and vain treatment of an
incurable condition and one in which these disciplines examine the
how and why of a physiological phenomenon that can be modified up
to a possible total control. This means transforming the medical
prevention and treatment of physiological aging from the greatest
failure to the greatest success of medicine.
Dementia is a brain disorder that seriously affects a person's
ability to carry out daily activities. The most common form of
dementia among older people is Alzheimer's Disease (AD), which
involves the parts of the brain that control memory, thought and
language. Age is the most important known risk factor for AD. The
number of people with the disease doubles every 5 years beyond age
65. AD is a slow disease, starting with mild memory loss and ending
with severe brain damage. The course the disease takes and how fast
changes occur vary from person to person. On average, AD patients
live from 8 to 10 years after they are diagnosed, though the
disease can last for as many as 20 years. Current research is aimed
at understanding why AD occurs and who is at greatest risk for
developing it, improving the accuracy of diagnosis and ability to
identify who is at risk, developing, discovering and testing new
treatments for behavioural problems in patients with AD. This book
gathers state-of-the-art research from leading scientists
throughout the world which offers important information on
understanding the underlying causes and discovering the most
effective treatments for Alzheimer's Disease.
The age-friendly community movement is a global phenomenon,
currently growing with the support of the WHO and multiple
international and national organizations in the field of aging.
Drawing on an extensive collection of international case studies,
this volume provides an introduction to the movement. The
contributors - both researchers and practitioners - touch on a
number of current tensions and issues in the movement and offer a
wide-ranging set of recommendations for advancing age-friendly
community development. The book concludes with a call for a radical
transformation of a medical and lifestyle model of aging into a
relational model of health and social/individual wellbeing.
The age-friendly community movement is a global phenomenon,
currently growing with the support of the WHO and multiple
international and national organizations in the field of aging.
Drawing on an extensive collection of international case studies,
this volume provides an introduction to the movement. The
contributors - both researchers and practitioners - touch on a
number of current tensions and issues in the movement and offer a
wide-ranging set of recommendations for advancing age-friendly
community development. The book concludes with a call for a radical
transformation of a medical and lifestyle model of aging into a
relational model of health and social/individual wellbeing.
Adolescence is one of the most fascinating and complex transitions
in the human life span. Its breathtaking pace of growth and change
is second only to that of infancy. Over the last two decades, the
research base in the field of adolescence has had its own growth
spurt. New studies have provided fresh insights while theoretical
assumptions have changed and matured. This summary of an important
1998 workshop reviews key findings and addresses the most pressing
research challenges. Table of Contents Front Matter New Research on
Adolescent Development and the Biology of Puberty References
Appendix: Workshop Agenda
Aging: Oxidative Stress and Dietary Antioxidants, Second Edition,
bridges the trans-disciplinary divide and covers the science of
oxidative stress in aging and the therapeutic use of natural
antioxidants in the food matrix in a single volume. The second
edition covers new trials and investigations used to determine the
comprehensive properties of antioxidants, food items and extracts,
as well as any adverse properties they may have. It has been
updated to include new clinical human trials and a new section
dedicated to animal models of aging. Throughtout the book the
processes within the science of oxidative stress are described in
concert with other processes, such as apoptosis, cell signaling,
and receptor mediated responses. This approach recognizes that
diseases are often multifactorial, and oxidative stress is a single
component of this. Gerontologists, geriatricians, nutritionists,
and dieticians are separated by divergent skills and professional
disciplines that need to be bridged to advance preventative as well
as treatment strategies. While gerontologists and geriatricians may
study the underlying processes of aging, they are less likely to be
conversant in the science of nutrition and dietetics. On the other
hand, nutritionists and dietitians are less conversant with the
detailed clinical background and science of gerontology. This book
addresses this gap and brings each of these disciplines to bear on
the processes inherent in the oxidative stress of aging. This will
aid in better research, treatment and outcome for patients.
Late aging associated changes in alcohol sensitivity,
neurobehavioral function, and neuroinflammation, Volume 148, the
latest release in the International Review of Neurobiology series,
highlights new advances in the field, with this new volume
presenting interesting chapters on a variety of timely topics. Each
chapter is written by an international board of authors.
World-wide migration has an unsettling effect on social structures,
especially on aging populations and eldercare. This volume
investigates how taken-for-granted roles are challenged,
intergenerational relationships transformed, economic ties
recalibrated, technological innovations utilized, and spiritual
relations pursued and desired, and asks what it means to care at a
distance and to age abroad. What it does show is that
trans-nationalization of care produces unprecedented convergences
of people, objects and spaces that challenge our assumptions about
the who, how, and where of care.
Mylene's light-hearted advice is all about navigating the world
with confidence.' Daily Mail In this witty and uplifting book
Parisian blogger Mylene Desclaux speaks tenderly and honestly about
turning 50 and what it means for herself and for the other women in
her entourage. Mylene assures us that we are still 'young women' in
our fifties - but with more opportunities. 'By the time we're
fifty, we've generally done all the important things - career,
family. Now we can re-centre and discover a new energy within
ourselves. It's our time to blossom - to reprogramme gently. To
revitalise. We realise that we are the mistresses of our own lives
. . . The desire to do battle disappears. We feel calm. And we know
we're going to have time to make the most of it.' With acerbic
French humour she distils the essence of getting the most out of
your middle age and gives advice on everything from: *
Relationships * Sex * Fashion * Dating * Skincare * Friendships *
Kids * Beauty In WHY FRENCH WOMEN FEEL YOUNG AT 50 you will learn
how to take pleasure from the simple things in life and how to make
the most of your fifties, the Parisian way.
In this worldwide survey, Clive Gamble explores the evolution of
the human imagination, without which we would not have become a
global species. He sets out to determine the cognitive and social
basis for our imaginative capacity and traces the evidence back
into deep human history. He argues that it was the imaginative
ability to 'go beyond' and to create societies where people lived
apart yet stayed in touch that made us such effective world
settlers. To make his case Gamble brings together information from
a wide range of disciplines: psychology, cognitive science,
archaeology, palaeoanthropology, archaeogenetics, geography,
quaternary science and anthropology. He presents a novel deep
history that combines the archaeological evidence for fossil
hominins with the selective forces of Pleistocene climate change,
engages with the archaeogeneticists' models for population
dispersal and displacement, and ends with the Europeans'
rediscovery of the deep history settlement of the Earth.
Biological rhythms time the ebb and flow of virtually every
physiological process, and their mutual coordination guarantees the
integrity of the organism over space and time. Aging leads to the
disintegration of this coordination, as well as to changes in the
amplitude and/or frequency of the underlying rhythms. The results
of this are accelerated loss of health during aging, and in
experimental model systems curtailed lifespan occurs. This book
will examine the machinery that constitutes circadian systems and
how they impact physiologic processes. It will also discuss how
disturbances of circadian rhythms can lead to complex diseases
associated with aging. Much of this treatment will focus on
metabolism and genome stability. Importantly, the chapters in this
book will encompass work in several different models, in addition
to human. The book will conclude with a discussion of modeling
approaches to biologic cycles and chronotherapy, for future
research and translation.
Across the life course, new forms of community, ways of keeping in
contact, and practices for engaging in work, healthcare, retail,
learning and leisure are evolving rapidly. Breaking new ground in
the study of technology and aging, this book examines how
developments in smart phones, the internet, cloud computing, and
online social networking are redefining experiences and
expectations around growing older in the twenty-first century.
Drawing on contributions from leading commentators and researchers
across the world, this book explores key themes such as caregiving,
the use of social media, robotics, chronic disease and dementia
management, gaming, migration, and data inheritance, to name a few.
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