Brain Lateralization and Developmental Disorders provides a comprehensive review of key findings and speculations from previous research on atypical cerebral lateralization in the most common neurodevelopmental disorders: stuttering, dyslexia, autism and intellectual disability. Emphasis is placed on recent studies, as well as descriptions of the author's personal research which will provide a promising new direction for future research on these issues. In this text, Asenova presents four separate studies aiming to examine hemispheric asymmetries in neurodevelopmental disorders. These include the subtypes of developmental stuttering, the subtypes of developmental dyslexia, mild, non-syndromic intellectual disability with comorbid speech and language deficits and autism spectrum disorder with comorbid severe language impairment. The use of uniform research methods, including dichotic verbal perception tasks and lateral preference performance tests, has led to findings that suggest that this new approach could be a key factor in overcoming the ambiguity of findings from previous studies. By focusing on the discussion of key issues concerning the role of atypical laterality in the genesis of neurodevelopmental psychopathology in both past research and Asenova's own studies, Brain Lateralization and Developmental Disorders is a valuable reading for students and researchers in neurodevelopmental psychopathology, as well as in developmental neuropsychology and developmental neuroscience.

Brain Lateralization and Developmental Disorders provides a comprehensive review of key findings and speculations from previous research on atypical cerebral lateralization in the most common neurodevelopmental disorders: stuttering, dyslexia, autism and intellectual disability. Emphasis is placed on recent studies, as well as descriptions of the author's personal research which will provide a promising new direction for future research on these issues. In this text, Asenova presents four separate studies aiming to examine hemispheric asymmetries in neurodevelopmental disorders. These include the subtypes of developmental stuttering, the subtypes of developmental dyslexia, mild, non-syndromic intellectual disability with comorbid speech and language deficits and autism spectrum disorder with comorbid severe language impairment. The use of uniform research methods, including dichotic verbal perception tasks and lateral preference performance tests, has led to findings that suggest that this new approach could be a key factor in overcoming the ambiguity of findings from previous studies. By focusing on the discussion of key issues concerning the role of atypical laterality in the genesis of neurodevelopmental psychopathology in both past research and Asenova's own studies, Brain Lateralization and Developmental Disorders is a valuable reading for students and researchers in neurodevelopmental psychopathology, as well as in developmental neuropsychology and developmental neuroscience.

This book gives an overview of the potential and the practical details that need to be resolved in order to make human germline engineering possible. It presents the ethical and social concerns, and implications of our fast-approaching capability to alter our own germline and take an active role in the future evolution of our own species. It provides explanations of how we have arrived at the capability to clone higher animals, and discusses the implications for human therapies and for our own future when these techniques are applied to the human germline.

The effects of the bone morphogenetic proteins (BMPs) family on bone formation are well documented, but the transforming growth factor (TGF)-beta ( ) isoforms are much less studied. The product of 20 years of study, Induction of Bone Formation in Primates: The Transforming Growth Factor- 3 sums up editor Ugo Ripamonti's research into the osteogenic activity of the three mammalian TGF- isoforms, particularly in primates. It explores how the mammalian TGF- isoforms have the potential to shed light on the apparent redundancy of bone induction signaling. The book unearths the profound and important bone inductive activity of the TGF- 3 isoform. It includes accounts of extensive research in non-human primates from craniofacial tissue regeneration, heterotopic tissue induction, and chapters on periodontal tissue regeneration and synergistic induction of bone formation. It also discusses the future clinical role of the TGF- isoform, including in human studies. This book contributes to the fascinating history of BMP and TGF- research at the intersection of molecular biology, tissue induction, bone regeneration, and craniofacial surgery. It provides a revolutionary awakening to new possibilities in skeletal reconstruction, tissue engineering, and molecular and cellular biology.

This book provides a state-of-the-art overview of key areas of subcellular aging research in human cells. The reader is introduced to the historical development and progress in biomedical aging research and learns, for example, about the role of microRNAs, circRNAs, mitochondria and extracellular vesicles in cellular senescence. The reader will also learn more about how gap junctions, the nuclear pore complex and the proteasome are affecting the ageing processes. In addition, novel therapeutic opportunities through modulation of cellular senescence are discussed. The book follows on from Parts I and II of Biochemistry and Cell Biology of Ageing (Volumes 90 and 91 of the Subcellular Biochemistry book series) by covering interesting and significant biomedical ageing topics not included in the earlier volumes. Comprehensive and cutting-edge, this book is a valuable resource for experienced researchers and early career scientist alike, who are interested in learning more about the fascinating and challenging question of why and how our cells age.

With the accelerating discovery of human genes, public health professionals are increasingly confronted with a large body of scientific information that will guide public health action. Because the broad mission of public health is to fulfill society's interest in assuring conditions in which people can be healthy, the integration of new genetic information in public health research, policy and program development is unavoidable. Public health leadership is urgently needed to use genetic information to improve health and prevent disease, and to address ethical, legal and social issues resulting from inappropriate use of such information. In the not too-distant future, disease prevention and health promotion programs will routinely consider whether or not to use genetic information to help target behavioral, medical or environmental intervention activities in order to maximize benefit and minimize costs and harm to individuals. In anticipation of the expected growth at the interface of genetics and public health, this book delineates a framework for the integration of advances in human genetics into public health practice. It provides a comprehensive review of public health genetics, including chapters on important general issues such as newborn and other genetic screening, the delivery of genetic services, and the ethical, legal and social implications of the use of genetics within public health. It also reviews relevant clinical topics, the historical background, cross-cultural aspects, and communication issues. Contributors come from a wide range of fields including epidemiology, biostatistics, health policy and management, health services research, behavioral and social sciences, ethics, law, health economics, and laboratory sciences.

University Success Oral Communication is designed for English language learners preparing for mainstream academic environments. A flexible three-part approach includes intensive and systematic skill development tied to learning outcomes along with authentic lectures delivered by top professors from Stanford University. The Oral Communication strand provides real-life learning experiences for students who need to achieve academic autonomy. - Each part is a self-contained module allowing teachers to focus on the highest-value skills and content. Topics are aligned around science, technology, engineering, arts, and mathematics (STEAM) content. - Parts 1 and 2 include short lectures and classroom discussions that allow students to build their essential listening, speaking, and critical thinking skills. - Part 3 includes authentic extended lectures that enable students to apply and expand the skills acquired in Parts 1 and 2. - Additional online lectures, skill and vocabulary practices, collaboration activities, and assessments. - Strategies for academic success and soft skills delivered via online videos. - NEW! You can now create unique custom University Success content packs with Pearson Collections

When Near Becomes Far explores the representations and depictions of old age in the rabbinic Jewish literature of late antiquity (150-600 CE). Through close literary readings and cultural analysis, the book reveals the gaps and tensions between idealized images of old age on the one hand, and the psychologically, physiologically, and socially complicated realities of aging on the other hand. The authors argue that while rabbinic literature presents a number of prescriptions related to qualities and activities that make for good old age, the respect and reverence that the elderly should be awarded, and harmonious intergenerational relationship, it also includes multiple anecdotes and narratives that portray aging in much more nuanced and poignant ways. These anecdotes and narratives relate, alongside fantasies about blissful or unnoticeable aging, a host of fears associated with old age: from the loss of physical capability and beauty to the loss of memory and mental acuity, and from marginalization in the community to being experienced as a burden by one's children. Each chapter of the book focuses on a different aspect of aging in the rabbinic world: bodily appearance and sexuality, family relations, intellectual and cognitive prowess, honor and shame, and social roles and identity. As the book shows, in their powerful and sensitive treatments of aging, rabbinic texts offer some of the richest and most audacious observations on aging in ancient world literature, many of which still resonate today.

The third edition of Human Malformations and Related Anomalies is a comprehensive reference and clinical guide to significant human malformations. Authored by 40 authorities in genetics and dysmorphology, this streamlined new edition offers an authoritative and richly illustrated guide to clinical presentation, associated anomalies, treatment, and prognosis.

Node.js, MongoDB and Angular Web Development The definitive guide to using the MEAN stack to build web applications Node.js is a leading server-side programming environment, MongoDB is the most popular NoSQL database, and Angular is the leading framework for MVC-based front-end development. Together, they provide an easy-to-implement, fully integrated web development stack that allows web programmers to create high-performance sites and applications built completely in JavaScript, from server to client. Updated for Angular 2, Angular 4, and subsequent versions, this new edition of Node.js, MongoDB and Angular Web Development shows you how to integrate these three technologies into complete working solutions. It begins with concise, crystal-clear tutorials on each technology and then quickly moves on to building common web applications. You'll learn how to use Node.js and MongoDB to build more scalable, high-performance sites, how to leverage Angular's innovative MVC approach to structure more effective pages and applications, and how to use all three together to deliver outstanding next-generation Web solutions. Implement a highly scalable and dynamic web server using Node.js and Express Implement a MongoDB data store for your web applications Access and interact with MongoDB from Node.js JavaScript code Learn the basics of TypeScript Define custom Angular directives that extend the HTML language Build server-side web services in JavaScript Implement client-side services that can interact with the Node.js web server Build dynamic browser views that provide rich user interaction Add authenticated user accounts and nested comment components to your web applications and pages Contents at a Glance Part I: Getting Started 1 Introducing the Node.js-to-Angular Stack 2 JavaScript Primer Part II: Learning Node.js 3 Getting Started with Node.js 4 Using Events, Listeners, Timers, and Callbacks in Node.js 5 Handling Data I/O in Node.js 6 Accessing the File System from Node.js 7 Implementing HTTP Services in Node.js 8 Implementing Socket Services in Node.js 9 Scaling Applications Using Multiple Processors in Node.js 10 Using Additional Node.js Modules Part III: Learning MongoDB 11 Understanding NoSQL and MongoDB 12 Getting Started with MongoDB 13 Getting Started with MongoDB and Node.js 14 Manipulating MongoDB Documents from Node.js 15 Accessing MongoDB from Node.js 16 Using Mongoose for Structured Schema and Validation 17 Advanced MongoDB Concepts Part IV: Using Express to Make Life Easier 18 Implementing Express in Node.js 19 Implementing Express Middleware Part V: Learning Angular 20 Jumping into TypeScript 21 Getting Started with Angular 22 Angular Components 23 Expressions 24 Data Binding 25 Built-in Directives Part VI: Advanced Angular 26 Custom Directives 27 Events and Change Detection 28 Implementing Angular Services in Web Applications 29 Creating Your Own Custom Angular Services 30 Having Fun with Angular

Is Menstruation Obsolete? argues that regular monthly bleeding is not the "natural" state of women, and that it actually places them at risk of several medical conditions of varying severity. The authors maintain that while menstruation may be culturally significant, it is not medically meaningful. Moreover, they propose that suppressing menstruation has remarkable health advantages. Because of cultural changes, shorter durations of breast feeding, and birth control, the reproductive patterns of modern women no longer resemble that of their Stone age ancestors. Women have moved from the age of incessant reproduction to the age of incessant menstruation. Consequently, they often suffer from clinical disorders related to menstruation: anemia, endometriosis, and PMS, just to name a few. The authors encourage readers to recognize what has gone previously unnoticed that this monthly discomfort is simply not obligatory. They present compelling evidence that the suppression of menstruation is a viable option for women today, and that it can be easily attained through the use of birth control pills. In fact, they reveal that contraceptive manufacturers, knowing that many women equate menstruation with femininity and that without monthly bleeding would fear that they were pregnant, engineered pill dosage regimens to ensure the continuation of their cycles. Indeed, throughout history societies have assigned menstruation powerful meaning, and Is Menstruation Obsolete? presents a fascinating history of how menstruation inspired doctors to try therapeutic bleeding for a variety of ailments, and how this therapy remained dominant in Western medicine until the early 20th century. Is Menstruation Obsolete? offers women a fresh view of menstruation, providing them with the information they need to make progressive choices about their health. This is a message whose time has come.

Pre-order Sarah Ockwell-Smith's essential guide to child psychology and development. BEGINNINGS is modern month-by-month reference guide for parents of 0-5-year-olds. It will answer all the questions that parents have about their baby, toddler and preschooler's physical and psychological development. Topics Covered: *How a baby grows and develops, month by month, during pregnancy *Physical development, month by month, in the newborn period *Brain development from birth to five years *How sleep develops and changes throughout the first five years *The development of self and personality *Social development, attachment and peer relationships *Temperaments and the development of emotion regulation *The development of memory *Current and classic theories in child psychology *Learning to sit, crawl, cruise and walk. *Language acquisition and early literacy skills *Early mark making - learning to draw and form letters *Schemas - how children learn about the world around them. *Food preferences and eating experiences in early childhood *Play - including suggestions for entertainment at each age *How parents and carers can encourage optimal brain development

This text offers a readable and friendly presentation of the important methods, findings, and theories of human aging, while actively involving the reader in meaningful exercises and critical thinking. Students are repeatedly challenged to apply information in the text to the older adults in their own lives. Specifically, suggestions for enhancing the lives of their older relatives are offered and encouraged. These include guidelines for discussions they might have regarding social, emotional, and environmental changes as well encouraging intellectual and social interaction. In this Edition: Emphasis on the science of the study of aging and why questions in aging are difficult to answer, how social scientists attempt to handle such difficulties, and the successes and failures social scientists have had thus far in answering those questions. The text also demonstrates how current research findings are now being applied in the real world and/or how they might be applied in the future. Cross-cultural comparisons and ethnic group comparisons are included wherever possible. Each chapter begins with "Senior View," which introduces students to a real person and gives them a chance to hear what older adults think and say about important issues related to the chapter and a chance to compare those opinions to the research findings. Each chapter ends with "Making Choices," emphasizing the important behavioral, emotional, and social choices that students can make now to prolong a healthy, happy life. "Chapter Projects" offer the opportunity for active learning, as students investigate for themselves an issue related to the chapter. Instructors can expand these projects for students who want to learn more, or for independent study. "Focus on Aging" boxes compliment the material in the text, providing additional insight and examples, and encouraging critical thinking. Every chapter includes discussion questions, study questions, chapter exercises, and related online resources.

Biology of Aging, Second Edition presents the biological principles that have led to a new understanding of the causes of aging and describes how these basic principles help one to understand the human experience of biological aging, longevity, and age-related disease. Intended for undergraduate biology students, it describes how the rate of biological aging is measured; explores the mechanisms underlying cellular aging; discusses the genetic pathways that affect longevity in various organisms; outlines the normal age-related changes and the functional decline that occurs in physiological systems over the lifespan; and considers the implications of modulating the rate of aging and longevity. The book also includes end-of-chapter discussion questions to help students assess their knowledge of the material. Roger McDonald received his Ph.D. from the University of Southern California and is Professor Emeritus in the Department of Nutrition at the University of California, Davis. Dr. McDonald's research focused on mechanisms of cellular aging and the interaction between nutrition and aging. His research addressed two key topics in the field: the relationship between dietary restriction and lifespan, and the effect of aging on circadian rhythms and hypothalamic regulation. You can contact Dr. McDonald at [email protected]. Related Titles Ahmad, S. I., ed. Aging: Exploring a Complex Phenomenon (ISBN 978-1-1381-9697-1) Moody, H. R. & J. Sasser. Gerontology: The Basics (ISBN 978-1-1387-7582-4) Timiras, P. S. Physiological Basis of Aging and Geriatrics (ISBN 978-0-8493-7305-3)

The graying of the U.S. population draws increasing focus to historically unattended segments of society, including sexual and gender minorities. In this first comprehensive volume to address the challenges of aging in the gay, lesbian, bisexual, transgender, and intersex populations, this text presents what is currently known about aging GLBT individuals and what services are needed to support them.

The editors first provide an introductory overview comparing caregiving in GLBT and normative aging communities. In chapters devoted to the issues of each alternative sexuality and gender identity community, top experts in the field discuss biomedical, psychological, social/sexual, spiritual, socioeconomic, and service topics related to that community's aging needs.

GLBT populations face unique challenges as they age. Despite the often severe difficulties they encounter, many live out their final years with the dignity and grace that all of us deserve. With a combination of the latest biological and social science research, moving case studies and first-person accounts, practical advice for health professionals, and research literature citations, this book represents a major step forward in addressing concerns of aging GLBT populations.

Integrating research, practice, and policy, this text is for students and professionals in gerontology, medicine, social work, psychology, nursing, public health, and related fields who wish to learn more about the life experiences and concerns of sexual- and gender-minority-identified older patients.

This text provides an interesting and informative account of the child's journey from the womb to the world outside, through childhood and into adolescence. It is based on the belief that it is vital for those training to work with children who have problems to understand what is typical or atypical in children's development.The first half of the book, discussing normal patterns of growth and development, is cross-referenced to equivalent chapters in the second half, which discuss the atypical route. These connections serve to emphasize the continuities between, and similarities of, children with typical and atypical conditions. Among the difficulties covered are: Pervasive developmental disorders Genetic disorders Physical impairments Learning difficulties Brain damage Emotional and behavioural disorders Personality disorders. Physical and mental illnessesThe text also deliberately links developmental and clinical psychology approaches in order to help readers connect their theoretical understanding of the physical and psychological problems of childhood with the practicalities of assessment, rehabilitation and treatment.

The Science of Hormesis in Health and Longevity provides a comprehensive review of mild stress-induced physiological hormesis and its role in the maintenance and promotion of health. Coverage includes the underlying mechanisms of hormesis, including details of stress-response signaling, an enriched environment, positive challenges and dose-response mechanisms, amongst others. Research from top experts is presented to provide suggestions for developing novel therapeutic strategies, along with lifestyle interventions to promote health and homoeostasis. Researchers in aging and physiology, gerontologists, clinicians and medical students will find this a valuable addition for their work.

WHEN LIFE ON THE BRINK IS ALL YOU KNOW…

Substance-fuelled partying, endless women and a slew of smash records are music hotshot Adam Fairhead’s lifeblood. But when an avoidable accident occurs under his drug-addled watch, he is forced to re-evaluate the life he has created. Increasingly disillusioned with what once seemed so pulsatingly cool, Adam begins to question everything.

This extensive book provides an up-to-date overview by leading international authorities, spanning the disciplines of neuroscience, psychology, ophthalmology, optometry, and paediatrics, of normal and pathological infant visual development. It covers the development of retinal receptors; infant sensitivity to detail, colour, contrast, and movement; binocularity, eye movements, and refraction, and cognitive processing. Childrens' visual deficits, including amblyopia and cataract are covered.

The effects of the bone morphogenetic proteins (BMPs) family on bone formation are well documented, but the transforming growth factor (TGF)-beta ( ) isoforms are much less studied. The product of 20 years of study, Induction of Bone Formation in Primates: The Transforming Growth Factor- 3 sums up editor Ugo Ripamonti's research into the osteogenic activity of the three mammalian TGF- isoforms, particularly in primates. It explores how the mammalian TGF- isoforms have the potential to shed light on the apparent redundancy of bone induction signaling. The book unearths the profound and important bone inductive activity of the TGF- 3 isoform. It includes accounts of extensive research in non-human primates from craniofacial tissue regeneration, heterotopic tissue induction, and chapters on periodontal tissue regeneration and synergistic induction of bone formation. It also discusses the future clinical role of the TGF- isoform, including in human studies. This book contributes to the fascinating history of BMP and TGF- research at the intersection of molecular biology, tissue induction, bone regeneration, and craniofacial surgery. It provides a revolutionary awakening to new possibilities in skeletal reconstruction, tissue engineering, and molecular and cellular biology.

This book looks at the major changes that have occurred in the theory and practice of speech therapy for children with developmental speech disorders. It looks at current issues and their clinical implications, but the overall aim of the book is to set clinical practice firmly in a theoretical framework. While it is therefore essentially a practical book for practitioners, it also engages in the academic investigation of the nature of the different types of developmental speech disorders and their consequences for the children. This discussion provides the framework in which to consider clinical management and specific clinical techniques.

A recurrent theme throughout each chapter is the impact of linguistics upon our understanding and management of children' s problems in learning to pronounce. There is no doubt that the linguistic revolution in speech and language pathology has produced an entirely new perspective on these disorders by identifying the phonological dimension of speech development.

Of equal importance is the expansion of knowledge about children' s language development. Much more information is now available about phonological development in terms of what the developmental changes are and when they occur. This information is valuable in assessment and diagnosis. The book also includes a number of competing theories explaining how children develop their pronunciation patterns. These theories provide the premises upon which to establish a principled theory of therapy.

To reflect these issues and their clinical implications the book is divided into three sections. The first section explores the framework within which to discuss developmental speech disorders.The second section covers three specific types of pathological conditions with which developmental speech disorders are associated. The third section examines the problems of children who have no evident major disabling condition and yet they experience severe difficulties learning to pronounce and subsequently, more often than not, learning to read and write.

In Neurosis and Human Growth, Dr. Horney discusses the neurotic process as a special form of the human development, the antithesis of healthy growth. She unfolds the different stages of this situation, describing neurotic claims, the tyranny or inner dictates and the neurotic's solutions for relieving the tensions of conflict in such emotional attitudes as domination, self-effacement, dependency, or resignation. Throughout, she outlines with penetrating insight the forces that work for and against the person's realization of his or her potentialities. First Published in 1950. Routledge is an imprint of Taylor & Francis, an informa company.

Research documents that rural elders are poorer, live in less adequate housing, and have far fewer health and service options available to them than their urban counterparts, yet there is a critical lack of current and detailed information on the problems facing rural elders and on the professional practices that serve this population. This text fills this gap by introducing readers to rural areas and their residents and discussing the issues, programs, and policies designed to meet their needs. Through a multidisciplinary lens, it examines and defines specific competencies required for successful work with older adults and their families in these communities.

The text presents a research-driven, competency-based approach for the health and human service professionals who work with older rural residents. It discusses both the problems facing older adults and their families and evidence-based solutions regarding policy and best practices. Key issues examined include health and wellness, transportation, housing, long-term care, income, employment, and retirement, along with the needs of special populations (ethnic minorities, immigrants, and the LGBT population). Case examples reinforce an interdisciplinary model that addresses practice with rural elders that encompasses professional competencies, values and ethics, and the roles of a spectrum of health and human service professionals. The text also examines current policies affecting health and social services to rural elders and recommendations for policy change to build an effective health and human service workforce in rural communities. Links to Podcast interviews with scholars and respected professionals working in the field and "Spotlight" excerpts from the text reinforce information. In addition, the text provides discussion questions, PowerPoint slides, a test question bank, and suggested activities and exercises.

Key Features: Fills a vacuum regarding information on health and social services for rural elders Provides current and comprehensive knowledge about issues besetting this population and programs and policies designed to meet their needs Examines and defines specific competencies required for effective health and social services Based on a research-driven, competency-based, interdisciplinary approach to policy and best practice Includes links to Podcast interviews with scholars and respected professionals in the field

"Aging: Oxidative Stress and Dietary Antioxidants" bridges the trans-disciplinary divide and covers in a single volume the science of oxidative stress in aging and the potentially therapeutic use of natural antioxidants in the diet or food matrix. The processes within the science of oxidative stress are described in concert with other processes, such as apoptosis, cell signaling, and receptor mediated responses. This approach recognizes that diseases are often multifactorial, and oxidative stress is a single component of this.

Gerontologists, geriatricians, nutritionists, and dieticians are separated by divergent skills and professional disciplines that need to be bridged in order to advance preventative as well as treatment strategies. While gerontologists and geriatricians may study the underlying processes of aging, they are less likely to be conversant in the science of nutrition and dietetics. On the other hand, nutritionists and dietitians are less conversant with the detailed clinical background and science of gerontology. This book addresses this gap and brings each of these disciplines to bear on the processes inherent in the oxidative stress of aging.
Nutritionists can apply information related to mitochondrial oxidative stress in one disease to diet-related strategies in another unrelated disease Dietitians can prescribe new foods or diets containing anti-oxidants for conditions resistant to conventional pharmacological treatments Dietitians, after learning about the basic biology of oxidative stress, will be able to suggest new treatments to their multidisciplinary teamsNutritionists and dietitians will gain an understanding of cell signaling and be able to suggest new preventative or therapeutic strategies with anti-oxidant rich foods

Humans and flies look nothing alike, yet their genetic circuits are remarkably similar. Here, Lewis I. Held, Jr compares the genetics and development of the two to review the evidence for deep homology, the biggest discovery from the emerging field of evolutionary developmental biology. Remnants of the operating system of our hypothetical common ancestor 600 million years ago are compared in chapters arranged by region of the body, from the nervous system, limbs and heart, to vision, hearing and smell. Concept maps provide a clear understanding of the complex subjects addressed, while encyclopaedic tables offer comprehensive inventories of genetic information. Written in an engaging style with a reference section listing thousands of relevant publications, this is a vital resource for scientific researchers, and graduate and undergraduate students.