The world can often feel like a very scary, complicated and messy place. It's not always clear what is the correct thing to say, the best thing to do or the right way to be. HOPE THIS HELPS offers an easy guide that can help you feel and do better, and gives guidance on things that can appear incredibly difficult to navigate. Centring tolerance, kindness and empathy, the book takes us back to our roots as a human race of simply wanting to connect, be heard and enjoy life. Written in short, bite-sized entries, you can turn straight to the section you need depending on the challenge you're facing. Benjy Kusi will provide insight on . . . - Why it's not selfish to choose yourself - Why it's OK to change your opinion as you learn - Why impact means more than intent - Why we should listen to others more - How we can be kinder online And much, much more. More than anything this book reminds you that not everyone can be everything all the time, but the little things each of us can do to make the world slightly better can amount to something incredible. We hope this helps.

Examining cultures as diverse as long-house dwellers in North Borneo, African farmers, Welsh housewives, and postindustrial American workers, this volume dramatically redefines the anthropological study of menstrual customs. It challenges the widespread image of a universal 'menstrual taboo' as well as the common assumption of universal female subordination which underlies it. Contributing important new material and perspectives to our understanding of comparative gender politics and symbolism, it is of particular importance to those interested in anthropology, women's studies, religion, and comparative health systems.

Studies of mammary gland biology are essential in the fight against breast cancer. Moreover, the mammary gland represents an excellent model system for investigation of physiological and pathological processes that occur throughout the body. The branching morphogenesis that occurs during puberty and the alveogenesis processes during pregnancy, for example, recapitulate steps that occur in many tissues during embryogenesis and are also relevant to tumor invasion and metastasis. Similarly, analyses of breast cancer progression and the cell types that contribute to it yield findings applicable not only to breast cancer but widely to other cancers as well.
Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology reviews our understanding of mammary gland development, physiology, and tumor formation, emphasizing the value of the organ as a model system. The contributors examine the roles of hormones, growth factors, oncogenes, and the extracellular matrix in normal development and cancer. In addition, they discuss the nature of the mammary gland stem cell population and review the gene expression programs activated and chromatin modifications that occur as the different cell lineages present differentiate. The book also contains chapters covering the many experimental approaches that have been used in this field, including transplantation, genetic engineering, RNA interference and genomics, three dimensional culture models, and live cell imaging. It will thus be of interest to all researchers working in cell, developmental, and cancer biology, as well as those focused specifically on mammary gland biology and breast cancer.

The book offers a comprehensive review of current research regarding the influences of environmental factors involved in human health and ageing. Many environmental compounds promote excessive oxidative stress, which is the primary cause of accelerated ageing and which also contributes to the development of human diseases. The basic concepts of ageing theories are discussed, as is the promotion of oxidative stress which has been identified as one of the most important mechanisms responsible for the toxic effects of the majority of environmental pollutants. Antioxidants play an important role in the defence against pollutant-induced toxicity.

During the last decades as the population has become older, the demand for acute hospital care for elderly people has increased and gerontologically adjusted services have become the norm for the highest standard of care. Compared with younger adults, elderly patients have more severe illnesses, including worsened functional impairment and more frequent and longer hospitalisations. Additionally, diagnosis is often challenging because clinical presentations of common disorders may often be atypical in the elderly. When prescribing medications, physicians have to take into account the pharmacokinetic and pharmacodynamic changes observed with ageing. This book fills the gap in the literature available on acute geriatric care.

Personalisation in British social care is linked to both the principle and process that every adult who receives support, whether provided by statutory services or funded by them, will have choice and control over the shape of that support in all care settings. This adult social care policy agenda is firmly focused on the development of personalisation of support. The overall aim is for social care service users to have control over how money allocated to their care is spent. This book examines the social welfare system in Britain, with a particular focus on personal budgets and the quality of care received.

The U.S. population aged 65 and older, grew steadily through most of the last century. U.S. Census Bureau population projections to 2030 indicate that further and more dramatic growth is still to come. This increase is, in part, due to longer life expectancies and the ageing of the baby boom generation. This book explores the older population as it increases in size and proportion, and as individuals continue to live longer post-retirement. Topics discussed include the changes in where older Americans live, or the "geographic distribution" of the older population; older workers employment and retirement trends; income of Americans 65 or older; poverty among older Americans; and obesity among older Americans.

The idea of assessment in the fields of physical exercise and health refers to a process of attributing values or concepts. This attribution is certainly key for the prescription of physical exercise but it is not its most important role. This book presents and discusses research which shows physical exercise and health professionals the importance of a program of measurement and assessment which enables to safely prescribe physical exercise to elderly people, since this prescription must be supported by a scientific basis in order to be considered a credible and responsible piece of work.

This book reviews research on presently known theories and mechanisms responsible for the rate of ageing and maximum longevity of different animals including birds, mammals and humans (to explain "how" do we age and the velocity of the ageing process). In addition, this book deals with the historical evolutionary explanations of ageing and longevity ("why" do we age). The mechanisms discussed include mitochondria and oxygen free radicals, the presence of macromolecules constitutively highly resistant to deleterious modification in the tissues of long-lived animals, insulin/IGF-1 like signalling, telomere shortening, dietary restrictions, and other proposed molecular mechanisms.

This book presents a comprehensive review of the morphology and function of chromosomes in elderly people. The wide range of topics includes cyclical chromosome properties, mutations, repair, progressive chromosome heterochromatinisation with increasing age, roles of nucleolar organiser regions, sister chromatid exchanges, homologue relationships, heterochromatin regions and other chromosomal features in very old age. This ground-breaking book focuses on heterochromatinisation as a key determinant of the genetic apparatus function during senescence and an area to seek life-prolonging interventions. The book illustrates and updates progress in the field of cytogenetics of ageing.

The essential guide to making sure you have a fabulous later life. You're likely to live longer than you think. Today's fifty-year olds could have an astounding 36 or more years of life. What's your dream life for your later years? When We're 64 is a friendly, practical guide to preparing for what could be the best years of your life - from the essentials on work and how to fund retirement, to volunteering, where to live and what kind of housing you'll need. It covers how to stay healthy - and still live a full life if you get a health condition - and reveals how your attitude to ageing could actually increase your lifespan. There are sections on relationships with family and friends, as well as caring for older relatives and how to tackle loneliness. Packed with expert advice and new evidence and tips on how to age well, this route map will help you plan and prepare for the future.

The advances of basic sciences combined with the perspectives of developmental neurology have recently modified the traditional outlook on the evolution of motor behavior. The maturation of neuro-anatomic structures is studied nowadays as just one facet of a complex process: the various elements of innate global patterns, the acquisition of antigravitary schemes as well as manipulative and praxic skills, control of posture and gait, ocular motility and motricity, converge to create the present picture of a continuous adaptive interaction between the child's genotype and its environment. This book stimulates the debate and the exchange of concepts between researchers and clinical specialists.

The Age-Well Project dived deep into the science of ageing well, and authors Annabel and Susan explained how they overhauled their own lives to prioritise healthy longevity. In The Age-Well Plan, Susan draws on almost a decade of extensive research into healthy longevity and her experience as a health coach to give you the tools you need to live your own age-well life. Her simple, clear and easy-to-follow six-week plan will show you how to make changes -- small and large -- to support healthy ageing, and prioritise the changes most appropriate for your body, lifestyle and circumstances. The first week of the plan guides you to understand your goals as you age and explains how to evaluate your current health and risk factors, in order to devise a bespoke plan for your body and brain. The subsequent weeks focus on the key elements of healthy ageing -- diet, exercise, sleep, engagement and the environment -- to help you build a personalised plan that will kickstart your age-well life.

Mylene's light-hearted advice is all about navigating the world with confidence.' Daily Mail In this witty and uplifting book Parisian blogger Mylene Desclaux speaks tenderly and honestly about turning 50 and what it means for herself and for the other women in her entourage. Mylene assures us that we are still 'young women' in our fifties - but with more opportunities. 'By the time we're fifty, we've generally done all the important things - career, family. Now we can re-centre and discover a new energy within ourselves. It's our time to blossom - to reprogramme gently. To revitalise. We realise that we are the mistresses of our own lives . . . The desire to do battle disappears. We feel calm. And we know we're going to have time to make the most of it.' With acerbic French humour she distils the essence of getting the most out of your middle age and gives advice on everything from: * Relationships * Sex * Fashion * Dating * Skincare * Friendships * Kids * Beauty In WHY FRENCH WOMEN FEEL YOUNG AT 50 you will learn how to take pleasure from the simple things in life and how to make the most of your fifties, the Parisian way.

As life expectancy continues to increase, so does the need to understand the factors that increase health and vitality. "Physiology of Exercise and Healthy Aging" applies the science of exercise physiology to an analysis of the aging process and identifies the positive effects that regular exercise and physical activity have not only on longevity but also on delaying specific diseases, decreasing morbidity, and increasing quality of life. It presents theories on aging, the aging process, the structural and functional changes that characterize advancing age, exercise programming concerns for the aged, drug use and abuse by seniors, and the benefits of exercise and physical activity.

This text offers a more expansive discussion of the particulars of exercise physiology of aging persons than is found in other texts on the subject. With "Physiology of Exercise and Healthy Aging," readers will gain a thorough understanding of the role of physical activity on the aging process, the principles of exercise and assessment considerations for elderly adults, and training for special needs of older adults. Information is presented in the context of three groups found in the aging and health spectrum: average aging individuals, frail elderly, and master athletes. This information is organized within a three-part structure:

-Part I explores age-related changes in the major physiological systems. The effects of physical activity on these systems, as well as necessary adaptations for those with impaired abilities in each system, are also discussed.

-Part II deals with the interactive roles of nutrition; age-related diseases, such as diabetes and osteoporosis; and physical activity.

-Part III presents the physiologic adaptability that may be expected with training and physical activity of older adults. It also addresses the practical issues that must be considered when working with this population, including training for aerobic, anerobic, and muscular fitness; exercise adherence and safety measures; and potential substance abuse of commonly used medications.In addition to the presentation of foundational concepts of physiology as they relate to the process of aging, chapters of" Physiology of Exercise and Healthy Aging" contain exercise regimens related to the chapter topic, other forms of physical activity that have proven beneficial to the aging population, and contraindicated exercises. Physiological responses to acute and chronic exercise perturbations are examined, including studies of cardiorespiratory fitness, muscle metabolism and strength, neurophysiology and the senses, and the effects of exercise on older adults with the diseases of aging, including type 2 diabetes, osteoporosis, arthritis, and cardiovascular disease. Chapter-opening quotes provide the insights of selected thinkers, scientists, and fitness professionals on the topic discussed.

Practitioners who work with older adults will find programming recommendations in each chapter to help translate the science into practice. An appendix offers easy access to forms and assessments, including a Three-Day Nutritional Assessment form and a Client History form. The language used throughout the text embraces the science of exercise physiology but also welcomes practitioners to apply the information presented.

For student readers, "Physiology of Exercise and Healthy Aging" incorporates these helpful features to assist learning and retention:

-Chapter-opening outlines offer quick reference to topics.

-Chapter-ending Questions to Consider provide tools for self-study and reflection.

-Numerous tables and figures reinforce chapter concepts and add visual or statistical information related to the process of aging, fall prevention, international demographics, and theories of aging.

-References provide additional opportunities for reading and research with selected books, articles, and Web sites.

-Appendixes contain information on specific Web sites and numerous tests and forms that may be photocopied for use with clients or patients or for course projects."Physiology of Exercise and Healthy Aging "contains a thorough discussion of the unique effects of aging on the human body and illustrates the power of exercise as a preventive tool to reduce or offset the deleterious effects of aging in order to increase the quality of life enjoyed by our aging population. With this text, both students and professionals will grasp the advantages of appropriate physical activity for the elderly and how to safely administer exercise programs that contribute to the increased health and quality of life for older adults.

Research results indicate that older adults have a higher rate of fatality and injury in motor vehicle crashes than any other age group except for teenagers. With the ageing of the American population, concern arises regarding potential increases in rates of crash involvement and injury. This book examines the association of the impairing effects of multiple medication use, drug/drug interactions and drug/disease interactions on motor vehicle crashes in individuals age fifty years and greater.

In this worldwide survey, Clive Gamble explores the evolution of the human imagination, without which we would not have become a global species. He sets out to determine the cognitive and social basis for our imaginative capacity and traces the evidence back into deep human history. He argues that it was the imaginative ability to 'go beyond' and to create societies where people lived apart yet stayed in touch that made us such effective world settlers. To make his case Gamble brings together information from a wide range of disciplines: psychology, cognitive science, archaeology, palaeoanthropology, archaeogenetics, geography, quaternary science and anthropology. He presents a novel deep history that combines the archaeological evidence for fossil hominins with the selective forces of Pleistocene climate change, engages with the archaeogeneticists' models for population dispersal and displacement, and ends with the Europeans' rediscovery of the deep history settlement of the Earth.

'Open, honest, straight talking on mental health and motherhood.' - Tik Tok's Dr Julie 'I absolutely love it - it doesn't matter who you are, what you've been through and how much you've changed - there is always room for growth'. - Ant Middleton 'This book will become your bible.' - Gaby Roslin, Virgin Radio In GROW, Sunday Times bestselling author Frankie Bridge opens up about her journey with her maternal mental health. Part narrative exploration, part first aid manual for mothers this book will discuss the hidden growing pains which take place when you become a parent. Its chapters cover the HOW TOs, WHAT IFs?, WILL Is? and WHY DOs? anxious questions all mothers ask themselves when they believe they are doing it wrong whilst also offering a brutally honest account of how hard it can be to grow a baby and raise a child whilst you are still growing into yourself. The book will combine Frankie's mental health journey into motherhood with the notes of psychologist, Maleha Khan, who will unpack the problems she experienced as she became a mother. It will also include additional guidance and parental advice from the UK's leading paediatrician Dr Ed Abrahamson. Fans of OPEN: 'Brave and beautiful... a first aid manual for your mind.' - Adam Kay, bestselling author of This is Going To Hurt 'Very readable. Very relatable. Intensely moving but also full of practical advice.' - Alastair Campbell

The University of Florida has an ambitious goal: to harness the power of its faculty, staff, students, and alumni to solve some of society's most pressing problems and to become a resource for the state of Florida, the nation, and the world. In the upcoming decades, an unprecedented demographic shift will take place; the eighty-five and over population is projected to climb far higher than any other age group. To keep the current elderly population healthy and help prevent future generations from experiencing poor health outcomes, researchers are studying crucial connections between skeletal muscles and whole-body health. The University of Florida is at the forefront of this research, utilizing its nationally recognized excellence in the fields of muscle biology and exercise physiology to discover unique ways to preserve muscle health in the aging and those with diseases. Find out how the proteins within muscle can be manipulated to reduce recovery times for individuals who are bedridden. Learn how older, elite athletes have resisted the inevitable degeneration that comes with aging, and how intermittent fasting may help you live longer and healthier. Step inside the lab where a researcher is uncovering the origins of cancer cachexia a wasting syndrome responsible for 20 percent of cancer deaths worldwide to improve the lives of patients. The loss of skeletal muscle through disease, disuse, or aging is associated with a host of poor health outcomes, but promising new avenues of research are being studied every day at the University of Florida to make for a healthier tomorrow.

Ever wondered what's really going on in your body as you age? Can you really eat to beat cancer or prevent heart disease? These questions and more are answered in Eat Better, Live Longer, helping you make achievable, sensible, science-based changes to your diet from day one. Discover the secrets of long life from centenarians around the world, and explore the 10 simple but meaningful adaptations you can make both to what you eat and to how you eat to follow in their footsteps. A four-week eating plan, with over 110 nutrient-packed recipes, helps you learn to make smarter choices about foods that can reduce your risk of certain diseases and lessen the effects of others. Use this new-found knowledge together with details on how each part of your body changes as you age and which nutrients you need to support support all-round health, helping you live a longer, happier life. Future-proof your life with this science-based superfood approach to discovering what is really happening to your body as you are aging.

Node.js, MongoDB and Angular Web Development The definitive guide to using the MEAN stack to build web applications Node.js is a leading server-side programming environment, MongoDB is the most popular NoSQL database, and Angular is the leading framework for MVC-based front-end development. Together, they provide an easy-to-implement, fully integrated web development stack that allows web programmers to create high-performance sites and applications built completely in JavaScript, from server to client. Updated for Angular 2, Angular 4, and subsequent versions, this new edition of Node.js, MongoDB and Angular Web Development shows you how to integrate these three technologies into complete working solutions. It begins with concise, crystal-clear tutorials on each technology and then quickly moves on to building common web applications. You'll learn how to use Node.js and MongoDB to build more scalable, high-performance sites, how to leverage Angular's innovative MVC approach to structure more effective pages and applications, and how to use all three together to deliver outstanding next-generation Web solutions. Implement a highly scalable and dynamic web server using Node.js and Express Implement a MongoDB data store for your web applications Access and interact with MongoDB from Node.js JavaScript code Learn the basics of TypeScript Define custom Angular directives that extend the HTML language Build server-side web services in JavaScript Implement client-side services that can interact with the Node.js web server Build dynamic browser views that provide rich user interaction Add authenticated user accounts and nested comment components to your web applications and pages Contents at a Glance Part I: Getting Started 1 Introducing the Node.js-to-Angular Stack 2 JavaScript Primer Part II: Learning Node.js 3 Getting Started with Node.js 4 Using Events, Listeners, Timers, and Callbacks in Node.js 5 Handling Data I/O in Node.js 6 Accessing the File System from Node.js 7 Implementing HTTP Services in Node.js 8 Implementing Socket Services in Node.js 9 Scaling Applications Using Multiple Processors in Node.js 10 Using Additional Node.js Modules Part III: Learning MongoDB 11 Understanding NoSQL and MongoDB 12 Getting Started with MongoDB 13 Getting Started with MongoDB and Node.js 14 Manipulating MongoDB Documents from Node.js 15 Accessing MongoDB from Node.js 16 Using Mongoose for Structured Schema and Validation 17 Advanced MongoDB Concepts Part IV: Using Express to Make Life Easier 18 Implementing Express in Node.js 19 Implementing Express Middleware Part V: Learning Angular 20 Jumping into TypeScript 21 Getting Started with Angular 22 Angular Components 23 Expressions 24 Data Binding 25 Built-in Directives Part VI: Advanced Angular 26 Custom Directives 27 Events and Change Detection 28 Implementing Angular Services in Web Applications 29 Creating Your Own Custom Angular Services 30 Having Fun with Angular

The U.S. population is getting older, and Americans are living longer, on average, than they ever have before. As they age, people are healthier and more active than the generations before them and have fewer functional limitations such as difficulty walking or blindness. Studies show that people are happier on average as they advance into their later decades and enjoy high levels of accumulated knowledge and experience. Getting older is a time of social, emotional, mental, and physical change. Retirement might change how a person interacts socially every day, affecting a persons mood and well-being. Cognitive aging--the normal process of cognitive change as a person gets older--can begin, or a permanent change in physical function may arise. Technology offers a path for people who are navigating these changes potentially to prevent or minimise the risks associated with them and to enhance peoples ability to live their lives fully. The Presidents Council of Advisors on Science and Technology (PCAST), seeks to identify technologies and policies that will maximise the independence, productivity, and engagement of Americans in their later years. This book focuses on four key changes older Americans often experience: hearing loss; loss of social engagement and connectivity; cognitive change; and physical change.

The menstrual cycle is the scientific term for the physiological changes that occur in fertile women and other female primates for the purposes of sexual reproduction. In this book, the authors discuss the signs and symptoms, psychological/behavioural changes and abnormalities of the menstrual cycle. Topics include the evolution of the menstrual cycle with a focus on the role of the luteal phase, extended sexual receptivity and the concept of concealed ovulation; functional and structural brain alterations associated with menstrual pain; premenstrual dysphoric disorder (PMDD) and premenstrual syndrome (PMS); the fluctuations on appetite and food intake that occur during the female reproductive cycle; and assessing energy intake and physical activity energy expenditure during the menstrual cycle.